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Interaction between internal solitary waves and the seafloor in the deep sea

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Deep Underground Science and Engineering 2024年第2期3卷 149-162页

作者： Zhuangcai Tian Jinjian Huang Jiaming Xiang Shaotong Zhang Jinran Wu Xiaolei Liu tingting luo Jianhua Yue State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering China University of Mining and TechnologyXuzhouChina Research Center for Deep Ocean Science and Underwater Engineering China University of Mining and TechnologyXuzhouChina Frontiers Science Center for Deep Ocean Multispheres and Earth System Key Lab of Submarine Geosciences and Prospecting TechniquesMOECollege of Marine GeosciencesOcean University of ChinaQingdaoChina Institute for Learning Sciences&Teacher Education Australian Catholic UniversityBrisbaneQueenslandAustralia Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of ChinaQingdaoChina Department of Chemical and Biomolecular Engineering National University of SingaporeSingaporeSingapore School of Resources and Geosciences China University of Mining and TechnologyXuzhouChina

Internal solitary wave(ISW),as a typical marine dynamic process in the deep sea,widely exists in oceans and marginal seas *** interaction between ISW and the seafloor mainly occurs in the bottom boundary *** the seabed boundary layer of the deep sea,ISW is the most important dynamic *** study analyzed the current status,hotspots,and frontiers of research on the interaction between ISW and the seafloor by *** on the action of ISW on the seabed,such as transformation and reaction,a large amount of research work and results were systematically analyzed and *** this basis,this study analyzed the wave–wave interaction and interaction between ISW and the bedform or slope of the seabed,which provided a new perspective for an in‐depth understanding of the interaction between ISW and the ***,the latest research results of the bottom boundary layer and marine engineering stability by ISW were introduced,and the unresolved problems in the current research work were *** study provides a valuable reference for further research on the hazards of ISW to marine engineering geology.

关键词： bottom boundary layer interaction internal solitary wave seafloor sediment

Numerical study on gas production via a horizontal well from hydrate reservoirs with different slope angles in the South China Sea

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Deep Underground Science and Engineering 2024年第2期3卷 171-181页

作者： tingting luo Jianlin Song Xiang Sun Fanbao Cheng Madhusudhan Bangalore Narasimha Murthy Yulu Chen Yi Zhao Yongchen Song School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhouChina Institute of Rock and Soil Mechanics Chinese Academy of SciencesWuhanChina Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education Dalian University of TechnologyDalianChina Faculty of Engineering and the Environment University of SouthamptonSouthamptonUK

It is important to study the effect of hydrate production on the physical and mechanical properties of low-permeability clayey–silty reservoirs for the largescale exploitation of hydrate reservoirs in the South China *** this study,a multiphysical-field coupling model,combined with actual exploration drilling data and the mechanical experimental data of hydrate cores in the laboratory,was established to investigate the physical and mechanical properties of low-permeability reservoirs with different slope angles during 5-year hydrate production by the depressurization method via a horizontal *** result shows that the permeability of reservoirs severely affects gas production rate,and the maximum gas production amount of a 20-m-long horizontal well can reach186.8 m3/day during the 5-year hydrate *** with smaller slope angles show higher gas production *** depressurization propagation and hydrate dissociation mainly develop along the direction parallel to the ***,the mean effective stress of reservoirs is concentrated in the near-wellbore area with the on-going hydrate production,and gradually decreases with the increase of the slope *** from the effective stress distribution law,the total reservoir settlement amount first decreases and then increases with the increase of the slope *** maximum settlement of reservoirs with a 0°slope angle is up to 3.4 m,and the displacement in the near-wellbore area is as high as2.2 m after 5 years of hydrate *** is concluded that the pore pressure drop region of low-permeability reservoirs in the South China Sea is limited,and various slope angles further lead to differences in effective stress and strain of reservoirs during hydrate production,resulting in severe uneven settlement of reservoirs.

关键词： effective stress low‐permeability reservoirs natural gas hydrate production numerical simulation settlement slope angle the South China

A cell transcriptomic profile p ovides insights into adipocytes of porcine mammary gland across development

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Journal of Animal Science and Biotechnology 2024年第1期15卷 182-200页

作者： Yongliang Fan Long Jin Zhiping He Tiantian Wei tingting luo Jiaman Zhang Can Liu Changjiu Dai Chao A Yan Liang Xuan Tao Xuebin Lv Yiren Gu Mingzhou Li State Key Laboratory of Swine and Poultry Breeding Industry College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Key Laboratory of Qinghai‑Tibetan Plateau Animal Genetic Resource Reservation and Utilization Southwest Minzu UniversityChengdu 610041China Animal Breeding and Genetics Key Laboratory of Sichuan Province Sichuan Animal Science AcademyChengdu 610000China

Background Studying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous, and its physiological function dependents on the gene expression of multiple cell types. Most studies focused on epithelial cells, disregarding the role of neighboring *** Here, we constructed the largest transcriptomic dataset of porcine mammary gland cells thus far. The dataset captured 126,829 high-quality nuclei from physiological mammary glands across five developmental stages(d 90 of gestation, G90;d 0 after lactation, L0;d 20 after lactation, L20;2 d post natural involution, PI2;7 d post natural involution, PI7). Seven cell types were identified, including epithelial cells, adipocytes, endothelial cells, fibroblasts cells, immune cells, myoepithelial cells and precursor cells. Our data indicate that mammary glands at different developmental stages have distinct phenotypic and transcriptional signatures. During late gestation(G90), the differentiation and proliferation of adipocytes were inhibited. Meanwhile, partly epithelial cells were completely differentiated. Pseudo-time analysis showed that epithelial cells undergo three stages to achieve lactation, including cellular differentiation, hormone sensing, and metabolic activation. During lactation(L0 and L20), adipocytes area accounts for less than 0.5% of mammary glands. To maintain their own survival, the adipocyte exhibited a poorly differentiated state and a proliferative capacity. Epithelial cells initiate lactation upon hormonal stimulation. After fulfilling lactation mission, their undergo physiological death under high intensity lactation. Interestingly, the physiological dead cells seem to be actively cleared by immune cells via CCL21-ACKR4 pathway. This biological process may be an important mechanism for maintaining homeostasis of the mammary gland. During natural involution(PI2 and PI7), epithelial cell populatio

关键词： Adipocytes Cell–cell interaction Development Mammary gland snRNA-seq

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无创DNA产前检测血浆质控物的研究进展

中华检验医学杂志 2024年第5期47卷 585-588页

作者：罗婷婷曾艳钱燕娣绍兴市妇幼保健院绍兴312000

无创产前基因检测(NIPT)是应用高通量基因测序技术检测孕妇外周血中胎儿游离DNA片段,以评估胎儿常见染色体非整倍体(T21、T18、T13)风险的一种产前筛查方式,为防治出生缺陷做出了极大的贡献。为确保检测结果的准确可靠,须在检测中加入... 详细信息

无创产前基因检测(NIPT)是应用高通量基因测序技术检测孕妇外周血中胎儿游离DNA片段,以评估胎儿常见染色体非整倍体(T21、T18、T13)风险的一种产前筛查方式,为防治出生缺陷做出了极大的贡献。为确保检测结果的准确可靠,须在检测中加入质控物对检测全过程进行严格的质量控制。但目前大多数检测平台的血浆提取过程中缺乏血浆质控物。在不同平台的室间质评中,也需要通用的血浆质控物。为解决这个质控问题,近年来出现了6种NIPT血浆质控物的制备策略,根据其基质和阳性DNA的来源不同,分别具有不同的适用范围和优缺点。

关键词：产前诊断无创产前基因检测质控物自制质量控制

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含天然气水合物饱和粉质沉积物三轴剪切试验

石油学报 2024年第6期45卷 1019-1030页

作者：骆汀汀张宸毅杨维好孙翔宋永臣中国矿业大学深地工程智能建造与健康运维全国重点实验室江苏徐州221116 中国科学院武汉岩土力学研究所湖北武汉430071 大连理工大学海洋能源利用与节能教育部重点实验室辽宁大连116024

为开发中国南海粉质储层中丰富的天然气水合物能源,对水饱和状态下含天然气水合物粉质沉积物进行力学特性研究。根据南海水合物岩心粒径曲线人工配制了粉质沉积物,并基于“先生成-再饱和-后固结”方法制备了水饱和状态下含天然气水合物... 详细信息

为开发中国南海粉质储层中丰富的天然气水合物能源,对水饱和状态下含天然气水合物粉质沉积物进行力学特性研究。根据南海水合物岩心粒径曲线人工配制了粉质沉积物,并基于“先生成-再饱和-后固结”方法制备了水饱和状态下含天然气水合物粉质沉积物,并在较低有效围压条件下开展了一系列三轴排水剪切试验。研究结果表明:(1)较低有效围压下粉质沉积物破坏强度随水合物饱和度增加呈现近似线性增长,水饱和状态下含相同饱和度水合物沉积物的破坏强度明显低于气饱和状态下其强度;(2)饱和度为40%的天然气水合物使粉质沉积物黏聚力增长了约4倍,内摩擦角则增长了约5.2°;(3)当有效围压增大时,纯粉质沉积物体应变持续减小,含水合物粉质沉积物体应变则先增后减;粉质沉积物体应变均随水合物饱和度增大而减小,而其体应变差值则逐渐缩小;(4)水合物胶结作用会降低沉积物初始固结程度,而沉积物剪切变形特性主要受到初始固结程度、水合物胶结作用和有效应力因素综合影响。因此,水合物饱和度降低导致的黏聚力降低、二次固结和剪切变形可能是中国南海天然气水合物开采诱发粉质储层变形的重要原因。

关键词：天然气水合物粉质沉积物水饱和状态三轴剪切试验强度变形特性黏聚力

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新媒体时代党建工作创新策略研究

社会与公益 2024年第6期 15-17页

作者：罗婷婷中共织金县委党校

党建工作是政治教育的基础,基于“两个一百年”奋斗目标,创新党建工作具有非常重要的意义。基于新媒体时代,人们获取信息的路径和渠道越来越宽广,容易受到多元文化的影响,导致政治思想、意识形态处于被干扰的状态。因此,党组织作为人民... 详细信息

党建工作是政治教育的基础,基于“两个一百年”奋斗目标,创新党建工作具有非常重要的意义。基于新媒体时代,人们获取信息的路径和渠道越来越宽广,容易受到多元文化的影响,导致政治思想、意识形态处于被干扰的状态。因此,党组织作为人民群众的“领头羊”,必须树立良好的形象,筑牢思想防线,为人民群众做好领导与示范的工作,以此凝聚战斗力,推动社会稳定、和谐的发展,为保障国家安全提供可靠的保障和支撑。

关键词：党建工作创新思想防线新媒体时代 “两个一百年”奋斗目标多元文化创新党建工作和谐的发展领头羊

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Compression schemes for concept classes induced by three types of discrete undirected graphical models

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Statistical Theory and Related Fields 2023年第4期7卷 287-295页

作者： tingting luo Benchong Li School of Mathematics and Statistics Xidian UniversityXi’anPeople’s Republic of China

Sample compression schemes were first proposed by Littlestone and Warmuth in ***-rected graphical model is a powerful tool for classification in statistical *** this paper,we consider labelled compression schemes for concept classes induced by discrete undirected graphical *** the undirected graph of two vertices with no edge,where one vertex takes two values and the other vertex can take any finite number of values,we propose an algorithm to establish a labelled compression scheme of size VC dimension of associated concept ***,we extend the result to other two types of undirected graphical models and show the existence of labelled compression schemes of size VC dimension for induced concept *** work of this paper makes a step forward in solving sample compression problem for concept class induced by a general discrete undirected graphical model.

关键词： Discrete undirected graphical models concept classes VC dimension sample compression schemes

从“初病气结在经,久病血伤入络”探讨偏头痛的病因病机

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江西中医药 2024年第9期55卷 14-17页

作者：张伟陈婷婷林君霞罗婷婷福建中医药大学附属福州市中医院福州350001 福建中医药大学福州350122

以叶天士“初病气结在经,久病血伤入络”理论为基础,探讨偏头痛病机由经入络、从气结到血伤的动态演变过程,初期气结为主,治疗时应注意辨经脉、邪气的不同,及时疏散肝经气结,防止壅塞脉道,预防入里传变;后期因实致虚,络脉血伤,见脉络空... 详细信息

以叶天士“初病气结在经,久病血伤入络”理论为基础,探讨偏头痛病机由经入络、从气结到血伤的动态演变过程,初期气结为主,治疗时应注意辨经脉、邪气的不同,及时疏散肝经气结,防止壅塞脉道,预防入里传变;后期因实致虚,络脉血伤,见脉络空虚,顽痰死血混处,证属虚实夹杂,病多胶结难愈,治疗时应当搜风通络以治标,补虚荣脉以治本,祛邪而不伤正,扶正以助祛邪。

关键词：偏头痛气结经络病因病机

GBS、衣原体联合解脲支原体检测对胎膜早破患者妊娠结局的预测作用

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分子诊断与治疗杂志 2024年第3期16卷 398-402页

作者：罗婷婷施云张丽上海交通大学医学院附属新华医院产房上海200092

目的研究B族链球菌(GBS)、衣原体联合解脲支原体(UU)检测对胎膜早破患者妊娠结局的预测作用。方法选取上海交通大学医学院附属新华医院2021年2月至2023年1月收治的胎膜早破产妇168例为观察组,另选取同期进行孕检且结果正常的165名孕... 详细信息

目的研究B族链球菌(GBS)、衣原体联合解脲支原体(UU)检测对胎膜早破患者妊娠结局的预测作用。方法选取上海交通大学医学院附属新华医院2021年2月至2023年1月收治的胎膜早破产妇168例为观察组,另选取同期进行孕检且结果正常的165名孕妇为对照组。对比两组GBS、衣原体、UU阳性率;分析GBS、衣原体、UU单一检测对观察组不良妊娠结局的预测结果;分析GBS、衣原体、UU三者联合对观察组孕妇不良妊娠结局的预测结果。结果观察组GBS阳性率、衣原体阳性率、UU阳性率均比对照组高,差异均有统计学意义(P<0.05)。GBS阴性122例,GBS阳性46例,GBS阳性胎膜早破孕妇不良妊娠结局发生率比对照组高,差异有统计学意义(P<0.05)。衣原体阴性128例,衣原体阳性40例,衣原体阳性胎膜早破孕妇不良妊娠结局发生率比对照组高,差异有统计学意义(P<0.05)。UU阴性117例,UU阳性51例,UU阳性胎膜早破孕妇不良妊娠结局发生率比对照组高,差异有统计学意义(P<0.05)。168例胎膜早破孕妇中,GBS、衣原体和UU均为阴性117例,GBS、衣原体和UU为单一一个或两个为阳性11例,GBS、衣原体和UU均为阳性40例;GBS、衣原体和UU均为阳性胎膜早破孕妇不良妊娠结局发生率均比单一或两个感染及阴性胎膜早破孕妇高,差异有统计学意义(P<0.05)。结论胎膜早破孕妇的GBS、衣原体和UU阳性率均高于正常妊娠孕妇,且GBS、衣原体和UU联合检测可更准确地预测母体和胎儿不良结局。

关键词： B族链球菌衣原体解脲支原体胎膜早破妊娠结局