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Atomically precise nickel-sulfur clusters for efficient electrochemical 2,5-hydroxymethylfurfural oxidation

Nano Research 2025年第1期18卷 140-148页

作者： Fen Wang Lu-Yu liu Sha-Sha Cui ting-ting li Xiao-Meng Yang Zhijuan liu Yanyong Wang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China State Key Laboratory of Chem/Bio-sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Nickel sulfide exhibits excellent catalytic activity in the electrochemical 2,5-hydroxymethylfurfural oxidation reaction(HMFOR).However,due to the polydispersity of nanoparticles,it is difficult to establish a clear structure-activity relationship at the atomic *** this work,we have successfully synthesized atomically precise Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)clusters(PET:2-phenylethanethiol)for ***^(2+)and S_(2)-with atomic ratio of 1:2 was mainly existed in Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)to form Ni-S *** electrochemical test results have suggested both Ni_(6)(PET)_(12)and Ni_(4)(PET)_(8)displayed outstanding electrocatalytic ability for *** Ni_(6)(PET)_(12)exhibited better electrocatalytic ability than Ni_(4)(PET)_(8)with higher current density,lower overpotential and faster reaction *** superior electrochemical ability of Ni_(6)(PET)_(12)may be due to the enhanced adsorption towards HMF molecule with strong interaction towards hydroxyl group and furan ***,it found that the Ni^(2+)species in Ni_(6)(PET)_(12)could rapidly oxidized into Ni^(3+)species,which could spontaneously capture electron and proton from HMF for *** theoretical calculation demonstrated that the Ni_(6)(PET)_(12)process lower free energy barrier than Ni_(4)(PET)_(8)to display excellent electrocatalytic *** work is of great significance for designing efficient electrocatalysts for HMFOR.

关键词： atomically precise nickel nanoclusters 2 5-hydroxymethylfurfural electro-oxidation Ni3+species

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The three-dimensional hydrodynamics of tadpole model’s solitary swimming and parallel schooling

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Journal of Hydrodynamics 2020年第3期32卷 548-560页

作者： ting-ting li Wen-rong Hu Xu-yang Chen Department of Engineering Mechanics Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Jiao Tong University and Chiba University International Cooperative Research Center(SJTU-CUICRC) Shanghai Jiao Tong UniversityShanghai 200240China MOE Key Laboratory of Hydrodynamics Shanghai Jiao Tong UniversityShanghai 200240China Department of Mechanical Engineering Tokyo Institute of TechnologyTokyoJapan

Tadpole swimming, including a solitary tadpole swimming and schooling side-by-side in an in-phase mode, is investigated numerically in the present paper. The three-dimensional Navier-Stokes equations for the unsteady incompressible viscous flow are solved. A dynamic mesh fitting the tadpole’s deforming body surface is adopted. The results showed that for a solitary tadpole swimming, two vortex rings are shed in each undulating period. However, as the resultant force on the tadpole is drag, the vortex rings are obviously asymmetric, shaped like “C”. When the resultant force in the swimming direction approaches zero, the axes of the vortex rings are nearly vertical to the swimming direction. Distorted vortex rings are found when the resultant force on the tadpole is thrust. When the tadpole model obtains the optimum propulsive efficiency, its swimming speed and undulating frequency are close to the values observed in nature. For tadpoles swimming side-by-side in an in-phase mode, the vortex structures in the wake may merge, split and recombine. Compared with a solitary tadpole swimming, only a small hydrodynamic advantage occur with schooling in parallel, which may be one of the reasons why tadpoles rarely, if ever swim, side by side for any amount of time or distance in nature. The effect of the undulating frequency on the tadpoles schooling is similar to that on a solitary tadpole. In addition, with an increase in the Reynolds number, the thrust force and the propulsive efficiency both increase, while the power consumption decreases. We also found that the tadpole benefits from the vortex pair shedding from its blunt snout, which can strengthen the vortex intensity in the wake and improve the pressure distribution.

关键词： 3-D tadpole parallel schooling numerical simulation

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Local intraseasonal air-sea relationship over the North Indian Ocean and western North Pacific during the spring-to-summer transition

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Atmospheric and Oceanic Science Letters 2017年第1期10卷 65-72页

作者： HU Wen-ting li ting State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics（LASG） Institute of Atmospheric PhysicsChinese Academy of Science

This study investigates the local air-sea relationship associated with the two dominant intraseasonal oscillation（ISO） components during the spring-to-summer transition and compares their properties using multiple air-sea variables in the period *** amplitude of percentage variance in SST in periods of 10-20 and 30-60 days are comparable,but the locations of the maxima differ.A strong percentage variance in the 10-20-day SST is evident in the equatorial western Pacific,whereas for the 30-60-day SST the strongest ratio occurs in the North Indian Ocean（NIO）,South China Sea（SCS）,and North *** the NIO,SCS,and Philippine Sea,there are significant correlations between SST and precipitation for both 10-20-day and 30-60-day *** contrast,the correlations between SST and surface heat fluxes cover a broader region and have larger ***,the atmospheric variables and surface heat fluxes show larger variations within the higher frequency ***,the amplitude of the correlation coefficients between SST and surface heat fluxes,and SST and rainfall,is greater in the lower frequency *** corresponding time lags for the different variables reveal that a strong local air-sea interaction is indicated over the NIO,SCS,and western North Pacific,from April to June in both timescales;however,the strength of the air-sea relationship depends on the region and variable.

关键词： Air-sea relationship intraseasonal oscillation spring-to-summer transition North Indian Ocean western North Pacific

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Antioxidant axis Nrf2-keap1-ARE in inhibition of alcoholic liver fibrosis by IL-22

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World Journal of Gastroenterology 2017年第11期23卷 2002-2011页

作者： Ya-Hui Ni li-Juan Huo ting-ting li Department of Gastroenterology First Hospital of Shanxi Medical UniversityTaiyuan 030001Shanxi ProvinceChina

AIM To explore the effect of interleukin(IL)-22 on in vitro model of alcoholic liver fibrosis hepatic stellate cells(HSCs), and whether this is related to regulation of *** HSC-T6 cells were incubated with 25, 50, 100, 200 and 400 μmol/L acetaldehyde. After 24 and 48 h, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay was used to detect proliferation of HSCs to choose the best concentration and action time. We used the optimal concentration of acetaldehyde(200 μmol/L) to stimulate HSCs for 24 h, and treated the cells with a final concentration of 10, 20 or 50 ng/m L IL-22. The cell proliferation rate was detected by MTT assay. The cell cycle was analyzed by flow cytometry. The expression of nuclear factor-related factor(Nrf)2 and α-smooth muscle antigen was detected by western blotting and immunocytochemistry. The levels of malondialdehyde(MDA) and glutathione(GSH) were measured by spectrophotometry. RESULTS In the MTT assay, when HSCs were incubated with acetaldehyde, activity and proliferation were higher than in the control group, and were most obvious after 48 h treatment with 200 μmol/L acetaldehyde. The number of cells in G0/G1 phases was decreased and the number in S phase was increased in comparison with the control group. When treated with different concentrations of IL-22, HSC-T6 cell activity and proliferation rate were markedly decreased in a dosedependent manner, and cell cycle progression was arrested from G1 to S phase. Western blotting and immunocytochemistry demonstrated that expression of Nrf2 total protein was not significantly affected. Expression of Nrf2 nuclear protein was low in thecontrol group, increased slightly in the model group(or acetaldehyde-stimulated group), and increased more obviously in the IL-22 intervention groups. The levels of MDA and GSH in the model group were significantly enhanced in comparison with those in the control group. In cells treated with IL-22, the MDA level was attenuat

关键词： Interleukin-22 Alcoholic liver fibrosis Hepatic stellate cells Nrf2 Oxidative stress

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Toll-like receptor signaling in colorectal cancer:carcinogenesis to cancer therapy

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World Journal of Gastroenterology 2014年第47期20卷 17699-17708页

作者： ting-ting li Shuji Ogino Zhi Rong Qian Department of Geriatric Gastroenterology Chinese PLA General Hospital Department of Medical Oncology Dana-Farber Cancer Institute and Harvard Medical SchoolBostonMA 02215United States Department of Pathology Brigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02215United States Department of Epidemiology Harvard School of Public HealthBostonMA 02215United States

Toll-like receptors (TLRs) are germ line encoded innate immune sensors that recognize conserved microbial structures and host alarmins, and signal expression of major histocompatibility complex proteins, costimulatory molecules, and inflammatory mediators by macrophages, neutrophils, dendritic cells, and other cell types. These protein receptors are characterized by their ability to respond to invading pathogens promptly by recognizing particular TLR ligands, including flagellin and lipopolysaccharide of bacteria, nucleic acids derived from viruses, and zymosan of fungi. There are 2 major TLR pathways; one is mediated by myeloid differentiation factor 88 (MYD88) adaptor proteins, and the other is independent of MYD88. The MYD88-dependent pathway involves early-phase activation of nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NF-κB1) and all the TLRs, except TLR3, have been shown to activate this pathway. TLR3 and TLR4 act via MYD88-independent pathways with delayed activation of NF-κB signaling. TLRs play a vital role in activating immune responses. TLRs have been shown to mediate inflammatory responses and maintain epithelial barrier homeostasis, and are highly likely to be involved in the activation of a number of pathways following cancer therapy. Colorectal cancer (CRC) is one of the most common cancers, and accounts for almost half a million deaths annually worldwide. Inflammation is considered a risk factor for many common malignancies including cancers of the colorectum. The key molecules involved in inflammation-driven carcinogenesis include TLRs. As sensors of cell death and tissue remodeling, TLRs may have a universal role in cancer; stimulation of TLRs to activate the innate immune system has been a legitimate therapeutic strategy for some years. TLRs 3/4/7/8/9 are all validated targets for cancer therapy, and a number of companies are developing agonists and vaccine adjuvants. On the other hand, antagonists may fav

关键词： Toll-like receptor Colorectal cancer Carcinogenesis Prognosis Cancer therapy

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Impact of Antimicrobial Stewardship Programs on Antibiotic Use and Drug Resistance:Analysis of Data from Maternal and Child Health Care Hospitals in Hubei Province,China

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Current Medical Science 2022年第5期42卷 1106-1110页

作者： Ya-zheng ZHAO ting-ting li Wei FU Department of Pharmacy Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

ObjectiveTo evaluate the impact of Antimicrobial Stewardship Programs(ASPs)on antibiotic use and drug *** was a retrospective,multicenter,management intervention *** data from 85 maternity hospitals(maternal and child health care hospitals)in Hubei province from 2012 to 2019 were *** indicators related to antimicrobial drug use included the utilization rate of different grades of antimicrobial drugs,the intensity of antimicrobial agent use,the rational use of prophylactic antimicrobial agents before class I surgical incision,and pathogenic detection and consultation rates before antimicrobial drug *** the implementation,the purchase of antimicrobial agents in hospitals has been maintained within the prescribed range,and the defined daily dose system(DDDs)of antimicrobial agents has been reduced,prophylactic use and accurate treatment of antimicrobial agents related to class I surgical incision have been more *** the implementation of ASPs,the detection rate of imipenem-resistant Acinetobacter baumannii,cefotaxime-resistant Escherichia coli,and methicillin-resistant Staphylococcus aureus has been decreased in China from national bacterial resistance surveillance *** have positive effects on antibiotic use and drug resistance in 85 maternity hospitals(maternal and child health care hospitals).

关键词： Antimicrobial Stewardship Program antimicrobial resistance maternal and child health care hospitals

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An efficient chlorination of aromatic compounds using a catalytic amount of iodobenzene

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Chinese Chemical Letters 2013年第6期24卷 535-538页

作者： ting-ting li Cui Xu Chang-Bin Xiang Jie Yan College of Chemical Engineering and Materials Sciences Zhejiang University of Technology Foreign Language School Zhejiang Shuren University

An efficient method was developed for chlorination of aromatic compounds with electron-donating groups using iodobenzene as the catalyst and m-chloroperbenzoic acid as the terminal oxidant in the presence of 4-methylbenzenesulfonic acid in THF at room temperature for 24 h,and a series of the monochlorinated compounds was obtained in good *** this protocol,the catalyst iodobenzene was first oxidized into the hypervalent iodine intermediate,which then treated with lithium chloride and finally reacted with aromatic compounds to form the chlorinated compounds.

关键词： Hypervalent iodine intermediate Chlorination Catalytic oxidation Synthesis

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Resonance-enhanced multiphoton ionization spectroscopy on the B'~2Σ^+ and B^2Π states of NS

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Chinese Science Bulletin 2007年第5期52卷 596-602页

作者： WANG ting-ting li ChunYan ZHENG XianFeng CHEN Yang Hefei National Laboratory for Physical Sciences at Microscale Department of Chemical Physics University of Science and Technology of China Hefei 230026 China

Resonance-enhanced multiphoton ionization (REMPI) spectra of N32S and N34S have been recorded in the range of 35700―40200 cm?1. The radical was generated by a pulsed dc discharge of a mixture of SF6 and N2 under a supersonic free jet condition. All the 16 observed bands of N32S radicals have been as-signed, among which 12 bands belong to three transition progressions (v'=0-4, 0), (v'=1-4, 1) and (v'=2-4, 2) from the X2Π ground state to the B'2Σ+ upper state and the rest correspond to (9, 0), (10, 0), (11, 0) and (12, 0) bands of B2Π-X2Π transition, respectively. Analysis of the rotationally resolved spectra yields exhaustive spectroscopic constants of both the X2Π ground state and the B'2Σ+ excited state. The electronic transition bands of the isotopic molecule N34S have been rotationally analyzed for the first time and the rotational constants of the ground and upper states have been determined simultaneously.

关键词： NS自由基共振增强多光子电离光谱电子跃迁基态转动常数

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NUMERICAL SIMULATION OF TURBULENT JETS WITH LATERAL INJECTION INTO A CROSSFLOW

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Journal of Hydrodynamics 2006年第3期18卷 319-323页

作者： GUO ting-ting li Shao-hua XU Zhong Department of＇Energy and mechanical Engineering Northeast Dianli University Jilin 132012 China School of Energy and Power Engineering Xi＇an Jiaotong UniversityXi＇an 710049China

In this paper, Numerical simulations of mean velocity and turbulent kinetic energy fields are presented for three-dimensional lateral jet in crossflow, at the injection angles of -60° and -30 °. The RNG κ- ε turbulence model, with the two-layer wall function method, is adopted to simulate the characteristics of this flow at the jet-to-crossflow velocity ratios, 1, 2 and 4. The results show that the injection angle and jet-to-crossflow velocity ratio can change the flow fields, and the range upstream affected by jet injected laterally increase and the curvature of jet trajectories varies along the flow direction. Furthermore, the separation events in the lee of the jet exit and behind the jet bending-segment have been found, and the mechanisms of two vortex systems are analyzed.

关键词： turbulent jet turbulence model numerical simulation flow field

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Significant differences of function and expression of microRNAs between ground state and serum-cultured pluripotent stem cells

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Journal of Genetics and Genomics 2017年第4期44卷 179-189页

作者： Ying Yan Xi Yang ting-ting li Kai-li Gu Jing Hao Qiang Zhang Yangming Wang Beijing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular Medicine Peking University Beijing 100871 China Department of Biomedical 1nformatics School of Basic Medical Sciences Peking University Health Science Center Beijing 100871 China

Serum- and 2i-cultured embryonic stem cells （ESCs） show different epigenetic landscapes and tran- scriptomic profiles. The difference in the function and expression of microRNAs （miRNAs） between these two states remains unclear. Here, we showed that 2i- and serum-cultured ESCs exhibited distinctive miRNA expression profiles with 〉100 miRNAs differentially expressed, and the expression changes were largely due to transcriptional regulation. We further characterized the function of miRNAs differentially expressed under two conditions and found that ESCs exhibited higher degree of dependency on miRNAs for rapid proliferation; since Dgcr8-/- or Dicerl-I- but not wild-type ESCs showed slower growth rate and more accumulation in the G1 phase under 2i than serum condition. More interestingly, introduction of various self-renewal-silencing miRNAs in wild-type or Dgcr8/- ESCs failed to silence the self-renewal in 2i medium, but regained the ability to silence the self-renewal upon the addition of serum. Our findings reveal significant differences in the expression and function of miRNAs between serum- and 2i- cultured ESCs.

关键词： Embryonic stem cells microRNAs Ground pluripotency state Self-renewal

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