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PSRDP:A Parallel Processing Method for Pulsar Baseband Data

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Research in Astronomy and Astrophysics 2024年第1期24卷 300-310页

作者： Ya-Zhou Zhang Hai-Long Zhang Jie Wang Xin-Chen Ye Shuang-Qiang Wang Xu Du Han wu ting Zhang Shao-Cong Guo Meng Zhang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China Southeast University Nanjing 211189China School of Cyber Science and Engineering Qufu Normal UniversityQufu 273165China

To address the problem of real-time processing of ultra-wide bandwidth pulsar baseband data,we designed and implemented a pulsar baseband data processing algorithm(PSRDP)based on GPU parallel computing *** can perform operations such as baseband data unpacking,channel separation,coherent dedispersion,Stokes detection,phase and folding period prediction,and folding integration in GPU *** tested the algorithm using the J0437-4715 pulsar baseband data generated by the CASPSR and Medusa backends of the Parkes,and the J0332+5434 pulsar baseband data generated by the self-developed backend of the Nan Shan Radio *** obtained the pulse profiles of each baseband *** experimental analysis,we have found that the pulse profiles generated by the PSRDP algorithm in this paper are essentially consistent with the processing results of Digital Signal Processing Software for Pulsar Astronomy(DSPSR),which verified the effectiveness of the PSRDP ***,using the same baseband data,we compared the processing speed of PSRDP with DSPSR,and the results showed that PSRDP was not slower than DSPSR in terms of *** theoretical and technical experience gained from the PSRDP algorithm research in this article lays a technical foundation for the real-time processing of QTT(Qi Tai radio Telescope)ultra-wide bandwidth pulsar baseband data.

关键词： (stars:)pulsars:general methods:data analysis techniques:miscellaneous

Extended survival with metastatic pancreatic cancer under fruquintinib treatment after failed chemotherapy:Two case reports

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World Journal of Clinical Cases 2024年第7期12卷 1296-1304页

作者： Dan wu Qiong Wang Shuai Yan Xia Sun Ya Qin Ming Yuan Nan-Yao Wang Xian-ting Huang Department of Oncology Jiangyin People's HospitalWuxi 214400Jiangsu ProvinceChina

BACKGROUND Pancreatic cancer is a highly malignant *** decades of treatment progress,the current five-year survival rate for patients is still less than 10%.For later-line treatment,the treatment options are even more ***-angiogenic drugs can improve progression-free survival in patients with advanced pancreatic *** data show that fruquintinib might improve the prognosis of advanced pancreatic cancer by targeting angiogenesis and lymphopoiesis,improving the abnormal vascular structure,and modulating the tumour immune *** SUMMARY We present two cases of third-line fruquintinib monotherapy that brought an extraprolonged progress-free survival(PFS)of 10 *** 1 took adjuvant gemcitabine-based and first-line nab-paclitaxel-based chemotherapy and then used local radiotherapy combined with programmed cell death 1 receptor(PD-1).Each line lasted approximately 7 ***,the patient took third-line fruquintinib,which was followed by stable disease for 10 months,during which no additional adverse effect was *** patient later refused to take fruquintinib due to difficulty urinating and lower abdominal pain after the coronavirus disease 2019(COVID-19)*** patient died in February *** 2 also took two prior lines of chemotherapy and then local radiotherapy combined with *** confirmed disease progression,the patient experienced a continuous partial response after using fruquintinib monotherapy in the third *** the patient had COVID-19 in December 2022,fruquintinib was *** patient died in January 2023 due to disease *** Both cases achieved a PFS benefit from later-line single-agent fruquintinib *** its better safety profile,fruquintinib may be worth exploring and studying in more depth as a later-line treatment for pancreatic cancer patients.

关键词： Pancreatic cancer Anti-vascular endothelial growth factor receptor Fruquintinib Case report

Profound loss of microbial necromass carbon in permafrost thaw-subsidence in the central Tibetan Plateau

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Advances in Climate Change Research 2024年第4期15卷 647-657页

作者： Wen-ting ZHOU Quan-Lian LI Shi-Chang KANG Xiao-Dong wu Tian MA Xiao-Bo wu Xin XIONG Tanuj SHUKLA Maheswar RUPAKHETI Dipesh RUPAKHETI Da-He QIN Xiu-Feng YIN Cryosphere Research Station on the Qinghai-Tibet Plateau State Key Laboratory of Cryospheric ScienceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Norhwest Instiute of Eco-Evironment and ResourcesChinese Academy of Scienes Lanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems and College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou730020China Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332900China Research Institute for Sustainability-Helmholtz Centre Potsdam Potsdam 14467Germany Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China

Climate warming is causing rapid permafrost degradation,including thaw-induced subsidence,potentially resulting in heightened carbon ***,our understanding of the levels and variations of carbon components in permafrost,particularly during the degradation process,remains *** uncertainties arising from this process lead to inaccurate assessments of the climate effects during permafrost *** vast expanses of permafrost in the Tibetan Plateau,there is limited research available on SOC components,particularly in the central Tibetan *** remarkable variations in hydrothermal conditions across different areas of the Tibetan Plateau,the existing limited studies make it challenging to assess the overall SOC components in the permafrost across the Tibetan Plateau and simulate their future *** this study,we examined the properties of soil organic carbon(SOC)and microbial necromass carbon(MicrobialNC)in a representative permafrost thaw-subsidence area at the southern edge of continuous permafrost in the central Tibetan *** results indicate that prior to the thaw-subsidence,the permafrost had a SOC content of 72.68±18.53 mg g^(-1),with MicrobialNC accounting for 49.6%.The thaw-subsidence of permafrost led to a 56.4%reduction in SOC,with MicrobialNC accounting for 70.0%of the lost *** constitutes the primary component of permafrost SOC,and it is the main component that is lost during thaw-subsidence *** in MicrobialNC are primarily correlated with factors pH,plant input,and microbial *** present study holds crucial implications for both the ecological and biogeochemical processes associated with carbon release from permafrost,and it furnishes essential data necessary for modeling the global response of permafrost to climate *** on this study and previous research,permafrost thawing in the Tibetan Plateau causes substantial loss of ***,there's remarkable heterogeneit

关键词： Tibetan Plateau Thaw-subsidence Soil organic carbon Microbial necromass carbon Amino sugars

Meiotic transcriptional reprogramming mediated by cell-cell communications in humans and mice revealed by scATACseq and scRNA-seq

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Zoological Research 2024年第3期45卷 601-616页

作者： Hai-Quan Wang Xiao-Long wu Jing Zhang Si-ting Wang Yong-Juan Sang Kang Li Chao-Fan Yang Fei Sun Chao-Jun Li State Key Laboratory of Reproductive Medicine and Offspring Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Medical School Nanjing UniversityNanjingJiangsu 210093China Zhejiang University School of Medicine HangzhouZhejiang 310016China Department of Urology and Andrology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310000China Model Animal Research Center of Medical School Nanjing UniversityNanjingNanjingJiangsu 210093China Liangzhu Laboratory Zhejiang UniversityHangzhouZhejiang 311121China

Meiosis is a highly complex process significantly influenced by transcriptional ***,studies on the mechanisms that govern transcriptomic changes during meiosis,especially in prophase I,are ***,we performed single-cell ATAC-seq of human testis tissues and observed reprogramming during the transition from zygotene to pachytene *** event,conserved in mice,involved the deactivation of genes associated with meiosis after reprogramming and the activation of those related to spermatogenesis before their functional ***,we identified 282 transcriptional regulators(TRs)that underwent activation or deactivation subsequent to this *** suggested that physical contact signals from Sertoli cells may regulate these TRs in spermatocytes,while secreted ENHO signals may alter metabolic patterns in these *** results further indicated that defective transcriptional reprogramming may be associated with non-obstructive azoospermia(NOA).This study revealed the importance of both physical contact and secreted signals between Sertoli cells and germ cells in meiotic progression.

关键词： Single-cell RNA-seq Single-cell ATAC-seq Spermatogenesis Meiosis Transcriptional reprogramming Cell-cell communication

Rethinking development and major research plans of Industrial Internet in China

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Fundamental Research 2024年第1期4卷 3-7页

作者： Chunxiao Jiang Yang Cong Jiming Chen Chenghong Wang Guozheng wu Ruizhen Zhao Zhiheng Wang Bin Xiao ting Chen Beijing National Research Center for Information Science and Technology Tsinghua UniversityBeijing 100084China Tsinghua Space Center Tsinghua UniversityBeijing 100084China State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang 110016China College of Control Science and Engineering Zhejiang UniversityHangzhou 310027China Division III Department of Information SciencesNational Natural Science Foundation of ChinaBeijing 100085China Division II Department of Information SciencesNational Natural Science Foundation of ChinaBeijing 100085China Chongqing Key Laboratory of Image Cognition School of Computer Science and TechnologyChongqing University of Posts and TelecommunicationsChongqing 400065China University of Electronic Science and Technology of China Chengdu 611731China

This paper gives a definition of the Industrial Internet and expounds on the academic connotation of the future Industrial *** this foundation,we outline the development and current status of the Industrial Internet in China and ***,we detail the avant-garde paradigms encompassed within the National Natural Science Foundation of China(NSFC)’s“Future Industrial Internet Fundamental Theory and Key Technologies”research plan and its corresponding management *** research initiative endeavors to enhance interdisciplinary collaborations,aiming for a synergistic alignment of industry,academia,research,and practical *** primary focus of the research plan is on the pivotal scientific challenges inherent to the future industrial *** is poised to traverse the“first mile”,encompassing foundational research and pioneering innovations specific to the industrial internet,and seamlessly bridges to the“last mile”,ensuring the effective commercialization of scientific and technological breakthroughs into tangible industrial market *** anticipated contributions from this initiative are projected to solidify both the theoretical and practical scaffolding essential for the cultivation of a globally competitive industrial internet infrastructure in China.

关键词： Industrial Internet Academic connotation Major research plan Scientific problem Policy advice

FLNB haploinsufficiency-related short stature:a new syndrome or an expanded spectrum of Larsen syndrome

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World Journal of Pediatrics 2024年第9期20卷 976-980页

作者： Qing Wang Hong-Ying Wang Shui-Yan wu Xue-Qian Wang Hai-Ying wu Rong-Rong Xie Feng-Yun Wang Xiu-Li Chen Lin-Qi Chen Hai-Tao Lv ting Chen Department of Endocrinology Genetics and MetabolismChildren’s Hospital of Soochow UniversitySuzhouChina Suzhou Clinical Center for Rare Diseases in Children Children’s Hospital of Soochow UniversitySuzhouChina Intensive Care Unit Children’s Hospital of Soochow UniversitySuzhouChina Department of Cardiology Children’s Hospital of Soochow UniversitySuzhouChina Department of Pediatrics Kunshan Sixth People’s HospitalSuzhouJiangsuChina

FLNB encodes the protein filamin B(FLNB),which is expressed in chondrocytes of the human growth plate[1].To date,pathogenic mutations in the FLNB gene have solely been found to cause skeletal deformities,indicating th... 详细信息

关键词： insufficiency skeletal expanded

Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer

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Signal Transduction and Targeted Therapy 2024年第1期9卷 295-307页

作者： Xiaoxiao Liu Xing Zhang Zhiying Shao Xiaorong Zhong Xin Ding Liang wu Jie Chen Ping He Yan Cheng Kunrui Zhu Dan Zheng Jing Jing ting Luo Institute for Breast Health Medicine Cancer CenterBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Department of Radiation Oncology Cancer CenterAffiliated Hospital of Xuzhou Medical UniversityJiangsu Center for the Collaboration and Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical University221000 XuzhouChina Department of Orthopedics Trauma and Reconstructive SurgeryUniversity Hospital RWTH AachenAachen 52074Germany Cancer Institute Xuzhou Medical University221000 XuzhouJiangsuChina Division of Nephrology and Transplantation Department of Internal MedicineUniversity Medical Center Rotterdam Erasmus MCRotterdam 3015 GDThe Netherlands Institute for Breast Health Medicine Department of General SurgeryBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Institute for Breast Health Medicine West China HospitalSichuan University610041 ChengduSichuanChina

Human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC)has been the most challenging subtype of BC,consisting of 20%of BC with an apparent correlation with poor *** that pyrotinib,a new HER2 inhibitor,has led to dramatic improvements in prognosis,the efficacy of pyrotinib monotherapy remains largely restricted due to its acquired ***,identifying a new potential antitumor drug in combination with pyrotinib to amplify therapeutic efficacy is a pressing ***,we reported a novel combination of pyrotinib with chrysin and explored its antitumor efficacy and the underlying mechanism in HER2-positive *** determined that pyrotinib combined with chrysin yielded a potent synergistic effect to induce more evident cell cycle arrest,inhibit the proliferation of BT-474 and SK-BR-3 BC cells,and repress in vivo tumor growth in xenograft mice *** may be attributed to enhanced autophagy induced by endoplasmic reticulum ***,the combined treatment of pyrotinib and chrysin induced ubiquitination and glucose-6-phosphate dehydrogenase(G6PD)degradation by upregulating zinc finger and BTB/POZ domain-containing family protein 16(ZBTB16)in tumorigenesis of ***,we identified that miR-16-5p was a potential upstream regulator of ZBTB16,and it showed a significant inverse correlation with *** of miR-16-5p overexpression by restoring ZBTB16 significantly potentiated the overall antitumor efficacy of pyrotinib combined with chrysin against HER2-positive ***,these findings demonstrate that the combined treatment of pyrotinib and chrysin enhances autophagy in HER2-positive BC through an unrecognized miR-16-5p/ZBTB16/G6PD axis.

关键词： HER2 synergistic Together

Terpyridine-based metallo-cuboctahedron nanomaterials for efficient photocatalytic degradation of persistent organic pollutants

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Nano Research 2024年第8期17卷 6833-6840页

作者： Qixia Bai Yan Huang Zhihong Chen Yilin Pan Xiaohan Zhang Qingwu Long Qiaoan Yang Tun wu ting-Zheng Xie Mingjian Wang Hongguang Luo Chun Hu Pingshan Wang Zhe Zhang Key Laboratory for Water Quality and Conservation of the Pearl River Delta(Ministry of Education) Institute of Environmental Research at Greater Bay AreaGuangzhou UniversityGuangzhou 510006China College of Light Chemical Industry and Materials Engineering Shunde PolytechnicFoshan 528333China Guangdong Guangye Inspection&Testing Group Co. Ltd.Guangzhou 510006China

Metal–organic cage photocatalysts with nanoscale dimensions have received wide attention in the field of photocatalytic environmental pollutant treatment due to their large cavities,easy modification,high tunability,and enriched active ***,we prepared a series of dihydroanthracene-cored terpyridine-based metallo-cuboctahedron nanomaterials through a selfassembly method,which exhibited satisfactory degradation performance for persistent organic pollutants under visible light *** particular,under light conditions,S1-Zn,one of the prepared nanomaterials,produced photogenerated holes oxidizing water molecules to∙OH,which attacked ibuprofen(IBU)for up to 95% ***,the corresponding photogenerated electrons reduced the dissolved oxygen in water,producing 66.2μmol/L hydrogen *** obtained supramolecular photocatalytic materials have a stable structure with non-precious metals and do not require a sacrificial *** metal sites of metallo-cuboctahedrons adsorb pollutants and transfer captured holes to them,accelerating degradation and promoting simultaneous H_(2)O_(2) *** work not only proposes a simple and efficient synthesis method for supramolecular photocatalysts but also opens up opportunities for efficient,low-cost,and multifunctional materials for environmental persistent organic pollutants treatment.

关键词： supramolecular cages self-assembly photocatalytic pollutant degradation H2O2 production

Application of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography imaging in recurrent anastomotic tumors after surgery in digestive tract tumors

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2474-2483页

作者： Deng-Feng Ge Hao Ren Zi-Chen Yang Shou-Xiang Zhao Zhen-ting Cheng Da-Da wu Bin Zhang Department of Cardiothoracic Surgery Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Gastrointestinal Surgery Shanghai Sixth People’s HospitalShanghai 250063China

BACKGROUND This study was to investigate the application value of whole-body dynamic ^(18)F-fluorodeoxyglucose(FDG)positron emission tomography/computed tomogra-phy(PET/CT)imaging in recurrent anastomotic tumors of digestive tract after gastric and esophageal cancer *** patients with gastric and esophageal cancer have a high risk of tumor recurrence,and traditional imaging methods have certain limitations in early detection of recurrent ***-body dynamic ^(18)F-FDG PET/CT imaging,due to its high sensitivity and specifi-city,can provide comprehensive information on tumor metabolic activity,which is expected to improve the early diagnosis rate of postoperative recurrent tumors,and provide an important reference for clinical treatment *** A retrospective analysis was performed on 53 patients with upper digestive tract tumors after operation and systemic dynamic ^(18)F-FDG PET/CT imaging indi-cating abnormal FDG uptake by anastomosis,including 29 cases of gastric cancer and 24 cases of esophageal *** to the follow-up results of gas-troscopy and other imaging examinations before and after PET/CT examination,the patients were divided into an anastomotic recurrence group and anastomotic inflammation *** multi-parameter analysis software was used to obtain the metabolic rate(MRFDG),volume of distribution maximum(DVmax)of anastomotic lesions,and MRmean and DVmean of normal liver *** lesion/background ratio(LBR)was calculated by dividing the MRFDG and DVmax of the anastomotic lesion by the MRmean and DVmean of the normal liver tissue,respectively,to obtain LBR-MRFDG and *** independent sample t test was used for statistical analysis,and a receiver operating characteristic curve was used to analyze the differential diagnostic efficacy of each parameter for anastomotic recurrence and *** The dynamic ^(18)F-FDG PET/CT imaging parameters MRFDG,DVmax,LBR-MRFDG,and LBR-DVmax of post

关键词： Gastric cancer Esophageal cancer Anastomosis Dynamic positron emission tomography Differential diagnosis Metabolic rate