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Risk factors of non-arteritic anterior ischaemic optic neuropathy and central retinal artery occlusion

International Journal of Ophthalmology(English edition) 2024年第5期17卷 869-876页

作者： Chu-Han Ma Cong-Yao Wang ting-ting dai ting-ting Chen Wen-Hui Zhu Department of Ophthalmology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina

AIM:To investigate the difference in risk factors between non-arteritic anterior ischaemic optic neuropathy(NAION)and central retinal artery occlusion(CRAO)and develop a predictive diagnostic ***:The study included 37 patients with monocular NAION,20 with monocular CRAO,and 24 with ***,age,and systemic diseases were *** routine,lipids,hemorheology,carotid and brachial artery doppler ultrasound,and echocardiography were *** optic disc area,cup area,and cup-to-disc ratio(C/D)of the unaffected eye in the NAION and CRAO group and the right eye in the hypertension group were ***:The carotid artery intimal medial thickness(C-IMT)of the affected side of the CRAO group was thicker(P=0.039)and its flow-mediated dilation(FMD)was lower(P=0.049)than the NAION *** with hypertension patients,NAION patients had higher whole blood reduced viscosity low-shear(WBRV-L)and erythrocyte aggregation index(EAI;P=0.045,0.037),and CRAO patients had higher index of rigidity of erythrocyte(IR)and erythrocyte deformation index(EDI;P=0.004,0.001).The optic cup and the C/D of the NAION group were smaller than the other two groups(P<0.0001).The diagnostic prediction model showed high diagnostic specificity(83.7%)and sensitivity(85.6%),which was highly related to hypertension,the C-IMT of the affected side,FMD,platelet(PLT),EAI,and C/***:CRAO patients show thicker C-IMT and worse endothelial function than *** and CRAO may be related to abnormal hemorheology.A small cup and small C/D may be involved in *** diagnostic nomogram can be used to preliminarily identify NAION and CRAO.

关键词： non-arteritic anterior ischaemic optic neuropathy central retinal artery occlusion risk factors diagnostic prediction model nomogram

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Hybrid Dextran-gadolinium Nano-suitcases as High-relaxivity MRI Contrast Agents

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Chinese Journal of Polymer Science 2018年第3期36卷 391-398页

作者： Hao Wang ting-ting dai Bo-Lun Lu Sheng-Li Li Qing Lu Vincent Mukwaya Hong-Jing Dou The State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Plastic and Reconstructive Surgery Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Tissue EngineeringShanghai 200011China Department of Radiology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127 China

Dextran-poly（glycidyl methacrylate）（Dex-PGMA） nano-suitcases were synthesized efficiently via a graft copolymerization induced self-assembly （GISA） approach. On this basis, the Dex-PGMA nano-suitcases were modified with hydrazide, and the attachment of multiple chelated Gd（III） ions to the interior of the nano-suitcases affords nanoscale MRI contrast agents with high relaxivity values. The highly fenestrated dextran shell of the nano-suitcases assures water exchange which readily occurs between the surrounding environment and the Gd（III） ions encapsulated within the hybrid nano-suitcases. The complexation between the hydrophilic hydrazide interior of the nano-suitcases and Gd（III） ions results in an impressive Gd payload at 22.6 wt% in the hybrid nano-suitcases. The longitudinal relaxivity （rl） of the hybrid nano-suitcases is reported as 44.4 L/（mmol-s）, which is 9-14 folds of that of commercial Gd-DTPA agents. In vivo MRI studies demonstrate that the hybrid nano-suitcases accumulated in the lymph node of the rat due to their nanoscale dimensions and displayed strong signals in vivo. The results indicated that the hybrid nano-suitcases provide a promising platform for the diagnosis of lymph node related diseases.

关键词： Crosslinked polymer nanoparticles Gadolinium(llI) MRI contrast agents Lymph node imaging

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Influence of Gd doping on the absolute quantum efficiency and lifetime of Eu_xGd_(1-x)(TTA)_3 phens

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Chinese Chemical Letters 2014年第6期25卷 892-896页

作者： ting-ting dai Lei Liu Dong-Liang Tao Shi-Gang Li HongZhang Yu-Min Cui Yong-Zhong Wang Ji-Tang Chen Kun Zhang Wen-Zhong Sun Xiao-Yun Zhao gel Liu College of Chemistry and Chemical Industry Fuyang Normal College Fuyang 236041 China Anhui Provincial Key Laboratory for Degradation and Monitoring of Pollution of the Environment Fuyang 236041 China School of Physics and Electronic Science Fuyang Normal College Fuyang 236041 China

Absolute quantum yield （Ф） is one of the most important parameters to evaluate the potential of novel materials. Lanthanide complexes EuxGd1-x（TTA）3phens are synthesized with the ratio of Gd3＋ dopant concentration ranging from 10% to 90% to improve the absolute quantum yield. EuxGd1-x（TTA）3phens possess similar infrared and ultraviolet spectra, showing that they have similar molecular structures. The absolute emission quantum yields of EuxGd1-x（TTA）3phens are determined using a fluoromax-4 spectrofluorometer equipped with an integrating sphere. The fluorescence lifetimes of the EuxGd1-x（TTA）3phens are measured in the same experiment. It was found that both absolute quantum yields and fluorescence lifetimes of EuxGd1-x（TTA）3phens are of quasi-periodic variation with the change of the Gd3. dopant concentrations. The absolute quantum efficiency and fluorescence lifetime vary with respect to the Gd content in an opposite fashion, indicating that the rate of energy absorption by the EuxGd1-x（TTA）3phens and the conversion to light energy is critical for the absolute quantum efficiency. The radiative rate constant Kr and non-radiative rate constant Knr are calculated. The dependence of Kr and Knr on the Gd3＋ dopant concentrations is very similar to that of absolute quantum efficiency. The radiation rate constant Kr and absolute quantum efficiency have a linear relationship.

关键词： JEuropium complexes Gd doping Absolute quantum yield Fluorescent lifetime

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由自组装构筑蛋白酶响应性近红外/磁共振双显影微球

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高分子学报 2018年第8期28卷 1127-1140页

作者：郭和泽宋晟戴婷婷李圣利窦红静上海交通大学材料科学与工程学院金属基复合材料国家重点实验室上海200240 上海交通大学医学院附属第九人民医院上海市组织工程重点实验室上海200011

由分子侧链上修饰近红外荧光分子的聚赖氨酸及表面聚丙烯酸修饰的磁共振显影磁性纳米颗粒为组装单元,采用自组装法构筑了在近红外、磁共振双重显影中均具有蛋白酶响应性的纳米尺度自组装微球.微球形成的组装驱动力为聚赖氨酸侧链氨基与... 详细信息

由分子侧链上修饰近红外荧光分子的聚赖氨酸及表面聚丙烯酸修饰的磁共振显影磁性纳米颗粒为组装单元,采用自组装法构筑了在近红外、磁共振双重显影中均具有蛋白酶响应性的纳米尺度自组装微球.微球形成的组装驱动力为聚赖氨酸侧链氨基与磁性纳米颗粒表面羧基在水相中的静电相互作用,两类组装前驱体在静电力作用下组装为纳米尺度团聚体,再通过戊二醛对氨基的适度交联来构筑胰蛋白酶响应的双显影复合微球.该复合微球处于自组装聚集状态时,微球内近红外荧光分子间的距离减小从而发生荧光共振能量转移,导致荧光分子的自淬灭;而在胰蛋白酶活化后的解组装状态,微球内聚赖氨酸重复单元间的酰胺键被胰蛋白酶切断,荧光分子间距扩大,共振能量转移现象消失,从而导致复合微球在胰蛋白酶存在下释放荧光,荧光释放强度/淬灭强度的比值最高可达18.此外,自组装微球的磁共振显影同样具有胰蛋白酶敏感性,这与组装—解组装过程导致微球内磁性纳米颗粒的局部浓度及聚集状态发生变化有关.细胞和动物实验研究表明,复合微球呈现低细胞毒性,并可特异性地对胰蛋白酶阳性的细胞和组织进行近红外/磁共振双显影,在胰蛋白酶的生物影像学检测中具有潜在的应用前景.

关键词：聚赖氨酸蛋白酶响应性磁性纳米颗粒自组装近红外荧光/磁共振双显影

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大蒜精油对屎肠球菌和粪肠球菌产苯乙胺和酪胺的影响

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现代食品科技 2016年第11期32卷 117-122,84页

作者：张雅晴卢士玲黄发添郑婷婷代娜娜李彬彬石河子大学食品学院新疆石河子832000

本试验采用双倍试管稀释法,测定大蒜精油分别对高产苯乙胺和酪胺的***和***的最低抑菌浓度(MIC)和最低杀菌浓度(MBC);并利用高效液相色谱法测定不同浓度的大蒜精油对两株高产苯乙胺和酪胺菌株的影响,从而明确大蒜精油对其产生物胺能力... 详细信息

本试验采用双倍试管稀释法,测定大蒜精油分别对高产苯乙胺和酪胺的***和***的最低抑菌浓度(MIC)和最低杀菌浓度(MBC);并利用高效液相色谱法测定不同浓度的大蒜精油对两株高产苯乙胺和酪胺菌株的影响,从而明确大蒜精油对其产生物胺能力的抑制作用。结果表明:大蒜精油对供试菌株都具有较强的抑菌活性,大蒜精油对***的最大抑制率可达48.20%,对***的最大抑制率为52.41%,且抑菌效果随大蒜精油浓度的增大而逐渐增强;在大蒜精油的添加量为1/2 MIC时,大蒜精油对***和***的生长具有抑制作用;当大蒜精油浓度为0.025%时,能够显著(p<0.05)降低供试菌株产苯乙胺和酪胺的含量,苯乙胺含量与空白组相比降低了26.61%,酪胺的降低了15.54%。说明大蒜精油对高产酪胺和苯乙胺的菌株具有显著(p<0.05)抑制效果,从而减少了酪胺和苯乙胺的生成。

关键词：屎肠球菌粪肠球菌苯乙胺酪胺大蒜精油抑菌活性

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Influence of bubble-particle distance on the dynamic behaviors of a cavitation bubble near a particle

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Journal of Hydrodynamics 2023年第5期35卷 913-922页

作者： Yun dai Hui Zhang ting Chen School of Optical Information and Energy Engineering Wuhan Institute of TechnologyWuhan430205China

Cavitation and silt-erosion often co-exist, causing severe damage on fluid machinery. In this paper, the dynamic behavior of a cavitation bubble near a fixed spherical particle is numerically studied, with the focus on the influence of the stand-off distance γ on the bubble collapse morphology, micro-jet velocities and pressure on the particle. With the increase in the value of γ, the bubble profile in the collapse stage exhibits three distinct characteristics: Mushroom-shaped, pear-shaped and spherical-shaped, and the corresponding micro-jets are identified as contact jet, non-contact jet, and long-distance jet. All studied distances can be categorized into three ranges, and the typical cases in each range are demonstrated. The maximum jet velocity Vmax and the maximum pressure difference between the upper and the bottom of the particle Δpmax show the highest peak at γ = 0.9, with Vmax up to 180 m/s and Δpmax up to 10.8 MPa.

关键词： Cavitation bubble bubble-particle distance fixed particle micro-jet

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Adaptive strategy of Nitraria sibirica to transient salt,alkali and osmotic stresses via the alteration of Na+/K+fluxes around root tips

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Journal of Forestry Research 2023年第2期34卷 425-432页

作者： Xindi Mei ting dai Yingbai Shen Xinjiang Key Laboratory of Biological Resources and Genetic Engineering College of Life Science and TechnologyXinjiang UniversityUrumqi 830046People’s Republic of China National Engineering Laboratory for Tree Breeding Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental PlantsMinistry of EducationThe Tree and Ornamental Plant Breeding and Biotechnology Laboratory of National Forestry and Grassland AdministrationCollege of Biological Sciences and BiotechnologyBeijing Forestry UniversityBeijing 100083People’s Republic of China

Nitraria sibirica *** an important shrub with a strong salt-alkali tolerance,but the mechanism underlying this tolerance remains *** this study,***,with salt-sensitive Vigna radiata(Linn.)Wilczek as the control,was subjected to transient salt stress(100 mM NaCl),alkali stress(50 mM Na_(2)CO_(3)),and osmotic stress(175 mM mannitol).The ionic fluxes of Na^(+)and K^(+)in the root apical region were *** show that,under salt and alkali stress,*** roots exhibited higher capacities to limit Na+influx and reduce K+efflux,thereby resulting in lower Na^(+)/K^(+)ratios compared with *** *** stress induced stronger Na^(+)influx and K+efflux in the root salt stress treatment;Na^(+)influx was mainly observed in the root cap,while K^(+)efflux was mainly observed in the elongation *** under osmotic stress,*** roots showed stronger Na+efflux and weaker K+efflux than *** ***+efflux was mainly observed in the root elongation zone,while K+efflux was in the root *** results reveal the ionic strategy of *** in response to transient salt,alkali,and osmotic stresses through the regulation of Na+/K+flux homeostasis.

关键词： Nirtaria sibirica Na^(+)/K^(+)fl uxes Na^(+)/K^(+)ratios Salt stress Alkali stress Osmotic stress

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Plasmid-based generation of neural cells from human fibroblasts using non-integrating episomal vectors

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Neural Regeneration Research 2019年第3期14卷 501-505页

作者： Shao-Bing dai ting Shen ting-ting Zheng Jia-Li Pu Xin-Zhong Chen Department of Anesthesiology Women's Hospital School of Medicine Zhejiang University Department of Neurology Second Affiliated Hospital College of Medicine Zhejiang University

Differentiation of human fibroblasts into functional neurons depends on the introduction of viral-mediated transcription factors, which present risks of viral gene integration and tumorigenicity. In recent years, although some studies have been successful in directly inducing neurons through sustained expression of small molecule compounds, they have only been shown to be effective on mouse-derived cells. Thus, herein we delivered vectors containing Epstein-Barr virus-derived oriP/Epstein-Barr nuclear antigen 1 encoding the neuronal transcription factor, Ascl1, the neuron-specific microRNA, miR124, and a small hairpin directed against p53, into human fibroblasts. Cells were incubated in a neuron-inducing culture medium. Immunofluorescence staining was used to detect Tuj-1, microtubule-associated protein 2, neuron-specific nucleoprotein NeuN and nerve cell adhesion molecules in the induced cells. The proportion of Tuj1-positive cells was up to 36.7% after induction for 11 days. From day 21, these induced neurons showed neuron-specific expression patterns of microtubule-associated protein 2, NeuN and neural cell adhesion molecule. Our approach is a simple, plasmid-based process that enables direct reprogramming of human fibroblasts into neurons, and provides alternative avenues for disease modeling and neurodegenerative medicine.

关键词： nerve regeneration induced neurons plasmid-based human fibroblasts nucleofection Ascl1 miR124 p53 reprogramming neural regeneration

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Regulation of apoptosis by the papillomavirus E6 oncogene

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World Journal of Gastroenterology 2005年第7期11卷 931-937页

作者： ting-tingLi Li-NaZhao YingHan dai-MingFan InstituteofGastroenterology XijingHospitalFourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina InstituteofGastroenterology XijingHospitalFourthMilitaryMedicalUniversityXi'an710032ShaanxiProvinceChina

Infection with human papillomaviruses is strongly associated with the development of multiple cancers including esophageal squarnous cell carcinoma. The HPV E6 gene is essential for the oncogenic potential of HPV. The regulation of apoptosis by oncogene has been related to carcinogenesis closely; therefore, the modulation of E6 on cellular apoptosis has become a hot research topic recently. Inactivation of the pro-apoptotic tumor suppressor p53 by E6 is an important mechanism by which E6 promotes cell growth; it is expected that inactivation of p53 by E6 should lead to a reduction in cellular apoptosis, numerous studies showed that E6 could in fact sensitize cells to apoptosis. The molecular basis for apoptosis modulation by E6 is poorly understood. In this article, we will present an overview of observations and current understanding of molecular basis for E6-induced apoptosis.

关键词： HPV E6 Apoptosis Esophageal squamous cell carcinoma

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Researching and implementation of reconfigurable Hash chip based on FPGA

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Journal of Systems Engineering and Electronics 2007年第1期18卷 183-187页

作者： Yang Xiaohui dai Zibin Liu Yuanfeng Wang ting Inst. of Electronic Technology the E L. A. Information Engineering Univ Zhengzhou 450004 ER. China

The reconfigurable cryptographic chip is an integrated circuit that is designed by means of the method of reconfigurable architecture, and is used for encryption and decryption. Many different cipher algorithms can be flexibly implemented with the aid of a reconfigurable cryptographic chip and can be used in many fields. This article takes an example for the SHA-1/224/256 algorithms, and then designs a reconfigurable cryptographic chip based on the thought and method of the reconfigurable architecture. Finally, this paper gives the implementation result based on the FPGA of the family of Stratix II of Altera Corporation, and presents a good research trend for resolving the storage in hardware implementation using FPGAs.

关键词： Reconfigurable cryptographic chip FPGA

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