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Drosophila models used to simulate human ATP1A1 gene mutations that cause Charcot-Marie-Tooth type 2 disease and refractory seizures

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Neural Regeneration Research 2025年第1期20卷 265-276页

作者： Yao Yuan Lingqi Yu Xudong Zhuang Dongjing wen Jin He Jingmei Hong Jiayu Xie Shengan Ling Xiaoyue Du wenfeng Chen Xinrui Wang Institute of Life Sciences College of Biological Science and EngineeringFuzhou UniversityFuzhouFujian ProvinceChina NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate(Fujian Maternity and child Health Hospital) FuzhouFujian ProvinceChina Medical Research Center Fujian Maternity and Child Health HospitalCollege of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology and Institute of Neurology of The First Affiliated Hospital Institute of Neuroscienceand Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina

Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory *** develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause *** located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)*** addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive *** these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut *** found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in *** heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal *** Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.

关键词： ATP1A1 Atpα bang-sensitive paralysis Charcot-Marie-Tooth disease type 2 CRISPR/Cas9 homology-directed repair Na^(+)/K^(+)-ATPase point mutation seizures sodium pump

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Integrable nonlocal PT-symmetric generalized so(3,R)-mKdV equations

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Communications in Theoretical Physics 2023年第12期75卷 19-24页

作者： Shou-ting Chen wen-Xiu Ma School of Mathematics and Statistics Xuzhou University of TechnologyXuzhou 221008JiangsuChina Department of Mathematics Zhejiang Normal UniversityJinhua 321004ZhejiangChina Department of Mathematics King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Mathematics and Statistics University of South FloridaTampaFL 33620-5700United States of America School of Mathematical and Statistical Sciences North-West UniversityMafikeng CampusPrivate Bag X2046Mmabatho 2735South Africa

Based on a soliton hierarchy associated with so(3,R),we construct two integrable nonlocal PT-symmetric generalized mKdV *** key step is to formulate two nonlocal reverse-spacetime similarity transformations for the involved spectral matrix,and therefore,integrable nonlocal complex and real reverse-spacetime generalized so(3,R)-mKdV equations of fifth-order are *** resulting reduced nonlocal integrable equations inherit infinitely many commuting symmetries and conservation laws.

关键词： integrable equation lax pair nonlocal reduction PT-symmetry zero curvature equation

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Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1395-1406页

作者： Qiu-Xiao Yu Ping-Ying Fu chi Zhang Li Li wen-ting Huang Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhen 518116Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer and the second most common cause of cancer-related mortality ***-epithelial transition factor(MET)gene participates in multiple tumor biology and shows clinical potential for pharmacological manipulation in tumor *** amplification has been reported in CRC,but data are very *** pathological values of MET in CRC may provide new therapeutic and genetic screening options in future clinical *** To determine the pathological significance of MET amplification in CRC and to propose a feasible screening *** A number of 205 newly diagnosed CRC patients undergoing surgical resection without any preoperative therapy at Shenzhen Cancer Hospital of chinese Academy of Medical Sciences were *** patients were without RAS/RAF mutation or microsatellite *** amplification and c-MET protein expression were analyzed using fluorescence in situ hybridization(FISH)and immunohistochemistry(IHC),*** between MET aberration and pathological features were detected using the chi-squared *** free survival(PFS)during the two-year follow-up was detected using the Kaplan-Meier method and log rank *** results of MET FISH and IHC were com pared using one-way *** Polysomy-induced MET amplification was observed in 14.4%of cases,and focal MET amplification was not ***-induced MET amplification was associated with a higher frequency of lymph node metastasis(LNM)(P<0.001)and higher tumor budding grade(P=0.02).In the survival analysis,significant difference was detected between patients with amplified-and non-amplified MET in a two-year follow-up after the first diagnosis(P=0.001).C-MET scores of 0,1+,2+,and 3+were observed in 1.4%,24.9%,54.7%,and 19.0%of tumors,respectively.C-MET overexpression correlated with higher frequency of LNM(P=0.002),but no significant difference of PFS was dete

关键词： Colorectal cancer MET Amplification Pathological features Prognosis Fluorescence in situ hybridization

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Local intraseasonal air-sea relationship over the North Indian Ocean and western North Pacific during the spring-to-summer transition

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Atmospheric and Oceanic Science Letters 2017年第1期10卷 65-72页

作者： HU wen-ting LI ting State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics（LASG） Institute of Atmospheric PhysicsChinese Academy of Science

This study investigates the local air-sea relationship associated with the two dominant intraseasonal oscillation（ISO） components during the spring-to-summer transition and compares their properties using multiple air-sea variables in the period *** amplitude of percentage variance in SST in periods of 10-20 and 30-60 days are comparable,but the locations of the maxima differ.A strong percentage variance in the 10-20-day SST is evident in the equatorial western Pacific,whereas for the 30-60-day SST the strongest ratio occurs in the North Indian Ocean（NIO）,South china Sea（SCS）,and North *** the NIO,SCS,and Philippine Sea,there are significant correlations between SST and precipitation for both 10-20-day and 30-60-day *** contrast,the correlations between SST and surface heat fluxes cover a broader region and have larger ***,the atmospheric variables and surface heat fluxes show larger variations within the higher frequency ***,the amplitude of the correlation coefficients between SST and surface heat fluxes,and SST and rainfall,is greater in the lower frequency *** corresponding time lags for the different variables reveal that a strong local air-sea interaction is indicated over the NIO,SCS,and western North Pacific,from April to June in both timescales;however,the strength of the air-sea relationship depends on the region and variable.

关键词： Air-sea relationship intraseasonal oscillation spring-to-summer transition North Indian Ocean western North Pacific

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Non-Fourier heat conduction analysis of a 2-D plate with inner cracks at arbitrary direction angles

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chinese Journal of Aeronautics 2022年第3期35卷 537-549页

作者： Zhuoxin wen chi HOU Meiying ZHAO Xiaopeng WAN School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China

This paper investigates the problem of a 2-D plate containing internal cracks at arbitrary angles to the heating surface under thermal *** finite difference method is applied to solve the temperature distribution and a difference scheme of the oblique crack is *** the first time,a non-Fourier heat transfer analysis method of a 2-D plate with inner cracks at arbitrary direction angles is ***,for a strip with an inner crack paralleling to the surface,numerical results are compared with the analytical solutions by rotating the boundary,and perfect agreement is *** experiments are further presented to investigate the influence of crack orientation angle and multi-crack distribution on non-Fourier heat conduction.

关键词： Difference scheme Finite difference method Multi-crack Non-Fourier heat conduction Temperature distribution

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Facile Synthesis of Functional Poly(methyltriazolylcarboxylate)s by Solvent-and Catalyst-free Butynoate-Azide Polycycloaddition

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chinese Journal of Polymer Science 2020年第1期38卷 17-23,I0005页

作者： Wei-wen chi Rong-Yuan Zhang ting Han Jian Du Hong-Kun Li Wei-Jie Zhang Yong-Fang Li Ben Zhong Tang State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Laboratory o f Advanced Optoelectronic MaterialsCollege o f ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Department o f Urology The First AfTiliated Hospital ofSoochow UniversitySuzhou 215006China Department o f Chemistry Hong Kong Branch o f Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University o f Science&TechnologyClear Water BayKowloonHong KongChina

The copper-catalyzed and metal-free azide-alkyne click polymerizations have become efficient tools for polymer synthesis. However,the 1,3-dipolar polycycloadditions between internal alkynes and azides are rarely employed to construct functional polymers. Herein, the polycycloadditions of dibutynoate(1) and tetraphenylethene-containing diazides(2) were carried out at 100 °C for 12 h under solvent-and catalyst-free conditions, producing soluble poly(methyltriazolylcarboxylate)s(PMTCs) with high molecular weights in high yields. The resultant polymers were thermally stable with 5% weight loss temperatures up to 377 °C. The PMTCs showed aggregation-induced emission(AIE)properties. They could work as fluorescent sensors for detecting explosive with high sensitivity, and generate two-dimensional fluorescent photopatterns with high resolution. Furthermore, their triazolium salts could be utilized for cell-imaging applications.

关键词： Solvent-and catalyst-free polycycloaddition Aggregation-induced emission Photopattern Cell imaging

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Drivers of microbial beta-diversity in wastewater treatment plants in china

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Journal of Environmental Sciences 2022年第5期34卷 341-349页

作者： Bing Zhang ting Yang Chenxiang Sun Xianghua wen College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China Environmental Simulation and Pollution Control State Key Joint Laboratory School of EnvironmentTsinghua UniversityBeijing 100084China

As one of the most well-documented biogeographic patterns,the distance-decay relation-ship provides insights into the underlying mechanisms driving biodiversity ***-though wastewater treatment plants(WWTPs)are well-controlled engineered ecosystems,this pattern has been seen among microbial communities in activated sludge(AS).However,little is known about the relative importance of environmental heterogeneity and dispersal limitation in shaping AS microbial community across china;especially they are related to spatial scale and organism ***,we assessed the distance-decay relationship based on different spatial scales and microbial phylogenetic groups by analyzing 132 activated sludge(AS)samples across china comprising 3,379,20016S rRNA *** results in-dicated that the drivers of distance-decay pattern in china were *** biogeographic patterns in WWTPs were mainly driven by dispersal limitation at both local and national *** contrast,conductivity,SRT,and pH played dominant roles in shaping AS microbial community compositions at the regional *** rates and the drivers of beta-diversity also varied with microorganism ***,a quantitative re-lationship between dispersal limitation ratio and AS microbial turnover rate was ***,these results highlighted the importance of considering multiple spatial scales and micro-organism types for understanding microbial biogeography in WWTPs and pro-vided new insights into predicting variations in AS community structure in response to environmental disturbance.

关键词： Wastewater treatment plant Distance-decay pattern Scale-dependent Microbial assembly Dispersal limitation

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克尔凯郭尔与卢卡奇马克思主义哲学观的流变

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武汉大学学报（哲学社会科学版） 2025年第1期78卷 77-85页

作者：温权武汉大学马克思主义学院湖北武汉430072

克尔凯郭尔并非卢卡奇偶然提及的学术注脚,而是其理解马克思的背景支援。卢卡奇在不同时期都对克尔凯郭尔作了选择性评述,并将其接受或重构马克思主义哲学的曲折心路历程逐一呈现:通过质疑克尔凯郭尔在人与世界相统一问题上遭遇的“审... 详细信息

克尔凯郭尔并非卢卡奇偶然提及的学术注脚,而是其理解马克思的背景支援。卢卡奇在不同时期都对克尔凯郭尔作了选择性评述,并将其接受或重构马克思主义哲学的曲折心路历程逐一呈现:通过质疑克尔凯郭尔在人与世界相统一问题上遭遇的“审美—伦理”悖论,青年卢卡奇从心灵掘进到阶级意识,将“主体—总体”辩证图式看作马克思的认识论地平,由此创作出《历史与阶级意识》;之后,为回应该书引起的争议,盛年的卢卡奇以批判克尔凯郭尔的非理性主义为契机,尝试清除“主体—总体”辩证图式中残余的主体形而上学痕迹,开始在方法论维度正视生产实践与经济规律间的有机联系;及至晚年,当卢卡奇立足社会存在,抨击克尔凯郭尔有关主体优先性的宗教幻象时,他又把社会性的“自在—自为”运动内嵌于人性的“主体—总体”辩证图式,并根据超然的悟性,默认马克思主义哲学是将经济规律置于从属地位的劳动本体论,再度退回《历史与阶级意识》的主体形而上学谋划。不难看出,在卢卡奇臧否克尔凯郭尔与马克思的“主体—总体”辩证桥段中,当事人对“人之实然性和应然性的现实统一”问题所秉持的龃龉心态暴露无遗。这也恰好说明,卢卡奇一生都徘徊于正统的马克思主义与人道的马克思主义之间。

关键词： “主体—总体”辩证图式克尔凯郭尔卢卡奇《历史与阶级意识》

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Lump solutions to a generalized Bogoyavlensky-Konopelchenko equation

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Frontiers of Mathematics in china 2018年第3期13卷 525-534页

作者： Shou-ting CHEN wen-Xiu MA School of Mathematics and Physical Science Xuzhou Institute of Technology Xuzhou 221008 China Department of Mathematics and Statistics University of South Florida Tampa FL 33620 USA College of Mathematics and Systems Science Shandong University of Science and Technology Qingdao 266590 China International Institute for Symmetry Analysis and Mathematical Modelling Department of Mathematical Sciences North-West University Mafikeng Campus Mmabatho 2735 South Africa

A （2 ＋ 1）-dimensional generalized Bogoyavlensky-Konopelchenko equation that possesses a Hirota bilinear form is considered. Starting with its Hirota bilinear form, a class of explicit lump solutions is computed through conducting symbolic computations with Maple, and a few plots of a specific presented lump solution are made to shed light on the characteristics of lumps. The result provides a new example of （2 ＋ 1）-dimensional nonlinear partial differential equations which possess lump solutions.

关键词： Symbolic computation lump solution soliton theory

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The Subvariety Lattice of the Join of Two Semigroup Varieties

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Acta Mathematica Sinica,English Series 2009年第6期25卷 971-982页

作者： wen ting ZHANG Yan Feng LUO Department of Mathematics Lanzhou University Lanzhou 730000 P. R. China

The join A ∨ B of two semigroup varieties A and B is investigated. The latrine of subvarieties of A ∨ B is completely described, It is shown that this lattice is finite and non-modular and that all varieties in it a... 详细信息

关键词： semigroups varieties identities lattice

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