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Physicochemical characterization of Dendrobium officinale polysaccharides and regulation of immunometabolic homeostasis in Sub-health mice based on the CD4-Th17/Treg immunity axis

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Food Science and Human Wellness 2024年

作者： Bo Li Ze-hua Zhang Hao-Ru Guan Xing-Li-Shang He Ning wang Ying-Jie Dong Mei Rong Jiu-Jie Jia ting-ting Chen Zhi-Yuan Li Gui-Yuan Lv Lin-Nan Zhang Su-Hong Chen Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals， Zhejiang University of Technology Zhejiang Provincial Key Laboratory of TCM for Innovative R & D and Digital Intelligent Manufacturing of TCM Great Health Products.Huzhou College of Pharmaceutical Science， Zhejiang Chinese Medical University

The aim of this study was to investigate the role of DOPS and DOPS100 in attenuating immune dysfunction in subfertile mice. The results of the study revealed several noteworthy findings. First， DOPS and DOPS100 treatments led to significant improvement in weight gain and reversal of fatigue-related behaviors compared to the normal group. Second， both DOPS and DOPS100 showed effectiveness in reducing immune organ swelling， modulating immunoglobulin （IgA and IgM） levels， and restoring complement （C3c and C4） levels. In addition， they demonstrated a significant ability to enhance the integrity of the intestinal mechanical barrier by differentially upregulating the tight junction proteins Occludin and ZO-1. In addition， it was found that DOPS100 specifically enhanced the CD4+-Th17/Treg immune axis in the gut， as evidenced by increased expression of Foxp3 as well as decreased expression of RORγt， and further modulation of IL-10， IL-22， and IL-17A expression levels of inflammatory factors. These findings collectively suggest that DOPS100 holds significant potential in improving sub-healthy status by repairing the intestinal barrier， restoring local immune homeostasis， and activating the intestinal immune regulatory network. The study's outcomes provide valuable insights into the therapeutic implications of DOPS and DOPS100 in addressing immune dysfunction in sub-healthy conditions.

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基于推进器偏置的半潜式平台动力定位模型试验研究

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船舶力学 2024年第10期28卷 1526-1540页

作者：唐利纲王磊贺华成王一听上海交通大学海洋工程国家重点实验室上海交通大学三亚崖州湾深海科技研究院

半潜式平台在进行动力定位作业时，由于其水线面面积较小而初稳性高较低，其垂向运动（横摇、纵摇、垂荡）易受到推进器法向力作用的影响。基于此，提出一种基于推进器偏置的推力分配模式，旨在合理利用推进器的法向力抑制平台垂向运动... 详细信息

半潜式平台在进行动力定位作业时，由于其水线面面积较小而初稳性高较低，其垂向运动（横摇、纵摇、垂荡）易受到推进器法向力作用的影响。基于此，提出一种基于推进器偏置的推力分配模式，旨在合理利用推进器的法向力抑制平台垂向运动，而不影响平台水平面定位功能。在海洋工程水池开展半潜式平台的动力定位模型试验，对比和分析不同载荷工况及推进器偏置模式下平台的六自由度运动响应。结果表明，推进器偏置策略能够基本保证水平面定位精度，并显著减小平台垂向运动在其固有频率附近的响应幅值，在该试验工况下，功率谱密度（PSD）峰值减小高达54.7%，对波频区间的运动影响则较小。该研究结果可为半潜平台垂向运动抑制提供新思路。

关键词：推进器偏置动力定位半潜式平台模型试验垂向运动

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Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception

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National Science Review 2024年第07期 106-125页

作者： Yan-Nong Dou Yuan Liu Wen-Qun Ding Qing Li hua Zhou Ling Li Meng-ting Zhao Zheng-Yi-Qi Li Jing Yuan Xiao-Fei wang wang-Yuan Zou Anan Li Yan-Gang Sun Institute of Neuroscience Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology CAS Center for Excellence in Brain Science&Intelligence Technology Chinese Academy of Sciences Department of Biology School of Life Science and TechnologyShanghaiTech University Lingang Laboratory University of Chinese Academy of Sciences Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsMoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Department of Anesthesiology Xiangya HospitalCentral South University HUST-Suzhou Institute for Brainsmatics JITRI

Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain, but its underlying circuit mechanism remains largely unknown. Here, we showed that endogenous opioid antinociception required the activation of mu-opioid receptors（MORs） in GABAergic neurons of the central amygdala nucleus（CEA） in a persistent-hyperalgesia mouse model. Pharmacogenetic suppression of these CEAMORneurons, which mimics the effect of MOR activation, alleviated the persistent ***, single-neuron projection analysis revealed multiple projectome-based subtypes of CEAMORneurons, each innervating distinct target brain regions. We found that the suppression of axon branches projecting to the parabrachial nucleus（PB） of one subtype of CEAMORneurons alleviated persistent hyperalgesia, indicating a subtype-and axonal-branch-specific mechanism of action. Further electrophysiological analysis revealed that suppression of a distinct CEA-PB disinhibitory circuit controlled endogenous opioid antinociception. Thus, this study identified the central neural circuit that underlies endogenous opioid antinociception, providing new insight into the endogenous pain modulatory mechanisms.

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Do the offspring of cerebral hypoxia-ischemia rats manifest dysfunction in learning and memory abilities?

Do the offspring of cerebral hypoxia-ischemia rats manifest ...

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中国解剖学会2019年年会

作者： Lu-Lu Xue Jia Liu Yuan Jin Zheng Ma Ya-Xin Tan Ya-Jiang Qing-Jie Xia ting-hua wang Liu-Lin Xiong Institute of Neuroscience Kunming Medical University Institute of Neurological Disease Department of AnesthesiologyTranslational Neuroscience CenterWest China HospitalSichuan University Department of Anesthesiology Affiliated Traditional Chinese Medicine HospitalSouthwest Medical University School of Pharmacy and Medical Sciences Sansom InstituteDivision of Health SciencesUniversity of South Australia

＜正＞To explore whether the offspring of adult model rats with neonatal brain hypoxia and ischemia （HIE） have spatial learning and memory dysfunction,we established HI rat model and found cerebral liquefaction and the motor and cognitive abilities of HI rats were severely damaged compared to sham *** for F2 HI rats,the results of MRI had no significant difference

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偶板造波机生成的内波振幅—理论与实验的比较

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水动力学研究与进展（A辑） 1989年第4期4卷 89-95页

作者：徐肇廷方欣华汪一明青岛海洋大学

本文在线性分层条件下应用二维分层流方程导得了偶板造波机生成内波的理论振幅公式,即a_(2m)=2Ak_(2m)[1-(-1)~m]l_(2m)^(-1)(πm)^(-2),此公式表明偶模态即m为奇数时,对应的内波模态为生成模态。它改进了[1]的理论公式。当A、N及ω不变... 详细信息

本文在线性分层条件下应用二维分层流方程导得了偶板造波机生成内波的理论振幅公式,即a_(2m)=2Ak_(2m)[1-(-1)~m]l_(2m)^(-1)(πm)^(-2),此公式表明偶模态即m为奇数时,对应的内波模态为生成模态。它改进了[1]的理论公式。当A、N及ω不变时,相邻生成模的振幅比为a_(2m)/a_(2(m+2))=(m+2)~2/m^2。在自制的小型内波实验水槽中,用1、2模态联合造波机验证了上述公式,结果表明理论和实验基本吻合。理论公式的不足之处是尚不能预报当m为偶数时的偶模态内波振幅。

关键词：偶板造波机内波振动分层流

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加强对心力衰竭早期防治的认识

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中华全科医师杂志 2024年第1期23卷 3-6页

作者：王华王婷杨杰孚北京医院心内科、国家老年医学中心、中国医学科学院老年医学研究院北京100730

心力衰竭(心衰)是各类心血管疾病进展导致的严重临床综合征,对公共卫生系统造成的负担极大。心衰可防、可治,早期发现及干预对改善患者预后、降低医疗成本至关重要。随着我国分级诊疗政策的不断推进,全科医师和心血管医师在心衰早期筛... 详细信息

心力衰竭(心衰)是各类心血管疾病进展导致的严重临床综合征,对公共卫生系统造成的负担极大。心衰可防、可治,早期发现及干预对改善患者预后、降低医疗成本至关重要。随着我国分级诊疗政策的不断推进,全科医师和心血管医师在心衰早期筛查和预防中均肩负着重要责任。该文结合《中华全科医师杂志》2024年第1期发表的《心力衰竭早期筛查与一级预防中国专家共识(2024年)》对心衰早期筛查与预防的重要性及相关内容作了进一步阐述。

关键词：心力衰竭筛查一级预防

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High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

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Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： Bi-Ang Kang hua-Ming Li Ya-ting Chen Meng-Jie Deng Yan Li Yue-Ming Peng Jian-Jun Gao Zhi-Wei Mo Jia-Guo Zhou Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

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Diagnose and treatment for Type D congenital esophageal atresia with tracheoesophageal fistula

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Pediatric Investigation 2024年第1期8卷 37-43页

作者： Dingding wang Yong Zhao Yanan Zhang Kaiyun hua Yichao Gu Shuangshuang Li Junmin Liao Shen Yang ting Yang Jiawei Zhao Jinshi huang Department of Neonatal Surgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:Type D esophageal atresia(EA)with tracheoesophageal fistula(TEF)is characterized by EA with both proximal and distal *** is a rare congenital anomaly with a very low ***:To investigate diagnostic and treatment strategies for this rare ***:We retrospectively reviewed the clinicopathological features of patients with EA/TEF treated at our institution between January 2007 and September ***:Among 386 patients with EA/TEF,14(3.6%)had type D EA/*** two patients were diagnosed with proximal TEF *** patients were diagnosed *** patients were missed for diagnosis during the initial surgery but was later confirmed by *** the neonatal period,seven patients underwent a one-stage repair of proximal and distal TEF via thoracoscopy or *** to missed diagnosis and other reasons,the other 7 patients underwent two-stage surgery for repair of the proximal TEF,including cervical incision and *** of the 14 patients experienced postoperative complications including anastomotic leakage,pneumothorax,esophageal stricture,and *** who underwent one-stage repair of distal and proximal TEF during the neonatal period showed a higher incidence of anastomotic leak(4/7).In contrast,only one of seven patients with two-stage repair of the proximal TEF developed an anastomotic ***:Type D EA/TEF is a rare condition,and proximal TEFs are easily *** may aim to diagnose and determine the correct surgical approach.A cervical approach may be more suitable for repairing the proximal TEF.

关键词： Diagnosis Therapy Tracheoesophageal fistula Type D congenital esophageal atresia

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悬浮填料对大型污水处理厂运行的实际强化效果

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中国给水排水 2024年第9期40卷 77-83页

作者：王丽花王坤周传庭周振上海城投污水处理有限公司上海201203 上海电力大学环境与化学工程学院上海201306 上海市城市建设设计研究总院<集团>有限公司上海200125

以两座大型污水处理厂为研究对象,分析了悬浮填料对生物处理系统的强化效果。结果表明,投加悬浮填料对有机物的削减能力影响不大,但提高了系统的抗冲击性能。投加填料促进了硝化菌的富集,但菌属类型受投加位置影响,填料位于好氧池前段... 详细信息

以两座大型污水处理厂为研究对象,分析了悬浮填料对生物处理系统的强化效果。结果表明,投加悬浮填料对有机物的削减能力影响不大,但提高了系统的抗冲击性能。投加填料促进了硝化菌的富集,但菌属类型受投加位置影响,填料位于好氧池前段有利于氨氧化菌(norank_f__JG30-KF-CM45和Ellin6067)的富集,位于后段则利于亚硝酸盐氧化菌(Nitrospira)的富集。悬浮填料提高了系统中反硝化菌的种类和丰度,并富集了好氧反硝化菌(Hyphomicrobium、Flavobacterium和Dokdonella),一定程度上提高了工艺的脱氮性能。值得注意的是,悬浮填料易于实现反硝化聚磷菌(DPB)的富集,可使DPB在聚磷菌(PAOs)中的占比达71.3%及以上。

关键词：悬浮填料污水处理厂硝化反硝化聚磷菌

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荷电可调性碳化聚合物点的合成、性能及其对槲皮素的响应研究

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光谱学与光谱分析 2024年第9期44卷 2523-2530页

作者：翁文婷季泉彤王亚庭陈桦杰陈少云泉州师范学院化工与材料学院制药工程系福建泉州362000

以海藻酸钠(SA)为碳源,引入邻苯二胺(oPDA)为助剂,采用一步水热合成法制备新型的氮掺杂碳化聚合物点SA-oPDA CPDs。该CPDs溶液在352nm波长激发下,于462nm处有蓝绿色荧光发射信号,stokes shift可达到110nm,并显示出良好的光稳定性和激发... 详细信息

以海藻酸钠(SA)为碳源,引入邻苯二胺(oPDA)为助剂,采用一步水热合成法制备新型的氮掺杂碳化聚合物点SA-oPDA CPDs。该CPDs溶液在352nm波长激发下,于462nm处有蓝绿色荧光发射信号,stokes shift可达到110nm,并显示出良好的光稳定性和激发波长不依赖性,荧光量子产率为16.9%。碳化聚合物点保留有海藻酸钠聚合链的特征,通过静电吸附组装技术,与壳聚糖形成复合发光薄膜,具有发光器件可应用潜力。该碳点水溶液对pH值极具敏感性,随着溶液环境由酸性变化到碱性,荧光强度增加的同时伴随着荧光发射峰位置从465nm蓝移突变至425nm,相应碳点的表面荷电状态由正电荷变化为负电荷。结构和形貌表征,在高温碳化过程中,该碳点内部形成碳化发光中心,外层表面共存来源于邻苯二胺和海藻酸钠的胺基和羧基。在溶液环境中,碳点的带电状态随溶液pH值的变化而变化,出现类似两性电解质的荷电性质,并在pH 6~7存在等电点。这可能是由于碳点表面羧基的解离和胺基的质子化的共同作用,并导致溶液表现出发光可调性。CPDs在pH 6.80的溶液环境下与铅离子结合后,溶液发射的荧光从蓝色变化为蓝绿色,可实现对一定浓度铅离子的明显可视化响应。研究表明还原性的药物对该碳点荧光信号有明显的猝灭效应。槲皮素对碳点的荧光猝灭程度在7.9×10^(-6)~7.7×10^(-5)mol·L^(-1)浓度范围内,可呈现方程为I0/I=0.8788+1.6897×10^(-6)cQue的线性响应,相关系数r^(2)=0.9748,检出限LOD=1.7×10^(-6)mol·L^(-1)。

关键词：碳化聚合物点荷电可调性槲皮素响应发光薄膜

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