检索结果-南通市图书馆

Strategies that regulate LSD1 for novel therapeutics

Acta Pharmaceutica Sinica B 2024年第4期14卷 1494-1507页

作者： Meng Li Mengge Dai Bing Cheng Shaotong Li Enhui Guo Junwei Fu ting Ma Bin yu School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China Pingyuan Laboratory State Key Laboratory of Antiviral DrugsHenan Normal UniversityXinxiang 453007China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Histone methylation plays crucial roles in regulating chromatin structure and gene transcrip-tion in epigenetic ***-specific demethylase 1(LSD1),the first identified histone de-methylase,is universally overexpressed in various ***1 dysregulation is closely associated with cancer,viral infections,and neurodegenerative diseases,etc.,making it a promising therapeutic *** LSD1 inhibitors and two small-molecule degraders(UM171 and BEA-17)have entered the clinical ***1 can remove methyl groups from histone 3 at lysine 4 or lysine 9(H3K4 or H3K9),resulting in either transcription repression or *** the roles of LSD1 in transcrip-tional regulation are well-established,studies have revealed that LSDl can also be dynamically regulated by other *** example,the expression or activity of LSD1 can be regulated by many proteins that form transcriptional corepressor complexes with ***,some post-transcriptional modifica-tions and cellular metabolites can also regulate LSD1 expression or its demethylase ***,in this review,we will systematically summarize how proteins involved in the transcriptional corepressor complex,various post-translational modifications,and metabolites act as regulatory factors for LSD1 ac-tivity.

关键词： LSD1 regulation Transcription repression Transcription activation the Corepressor complex Post-transcriptional modifications Metabolites

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bipolar hip arthroplasty using conjoined tendon preserving posterior lateral approach in treatment of displaced femoral neck fractures

引用

World Journal of Clinical Cases 2024年第6期12卷 1076-1083页

作者： ting-Xin Yan Sheng-Jie Dong Bo Ning yu-Chi Zhao Department of Joint Surgery Yantaishan HospitalYantai 264003Shandong ProvinceChina Department of Joint Surgery Dongying People's HospitalDongying 257091Shandong ProvinceChina

BACKGROUND Hip fractures account for 23.8%of all fractures in patients over the age of 75 *** than half of these patients are older than 80 *** hemiarthroplasty(BHA)was established as an effective management option for these *** approaches can be used for the BHA ***,there is a high risk of postoperative *** conjoined tendon-preserving posterior(CPP)lateral approach was introduced to reduce postoperative dislocation *** To evaluate the effectiveness and safety of the CPP lateral approach for BHA in elderly *** We retrospectively analyzed medical data from 80 patients with displaced femoral neck fractures who underwent *** patients were followed up for at least 1 *** the 80 patients,57(71.3%)were *** time to operation averaged 2.3 d(range:1-5 d).The mean age was 80.5 years(range:67-90 years),and the mean body mass index was 24.9 kg/m^(2)(range:17-36 kg/m^(2)).According to the Garden classification,42.5%of patients were typeⅢand 57.5%of patients were typeⅣ.Uncemented bipolar hip prostheses were used for all *** conjoined tendons,dislocations,and adverse complications during and after surgery were *** The mean postoperative follow-up time was 15.3 months(range:12-18 months).The average surgery time was 52 min(range:40-70 min)with an average blood loss of 120 mL(range:80-320 mL).The transfusion rate was 10%(8 of 80 patients).The gemellus inferior was torn in 4 patients(5%),while it was difficult to identify in 2 patients(2.5%)during *** posterior capsule was punctured by the fractured femoral neck in 3 patients,but the conjoined tendon and the piriformis tendon remained *** patients had stem varus greater than 3 degrees or femoral *** were no patients with stem subsidence more than 5 mm at the last *** postoperative dislocations were observed throughout the follow-up *** significance was found between preoperative an

关键词： Conjoined tendon preserving Bipolar hip arthroplasty Femoral neck fractures Postoperative dislocation Posterolateral approach

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characteristics of the crack tip field in high-speed railway tunnel linings under train-induced aerodynamic shockwaves

引用

Underground Space 2024年第5期18卷 199-217页

作者： Yi-Kang Liu yu-Ling Wang E Deng Yi-Qing Ni Wei-chao Yang Wai-Kei Ao School of Civil Engineering Central South UniversityChangsha 410075China National Rail Transit Electrification and Automation Engineering Technology Research Center(Hong Kong Branch) The Hong Kong Polytechnic UniversityHong Kong 999077China Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057China National Engineering Research Center of High-speed Railway Construction Technology Changsha 410075China

High-speed railway tunnels in various countries have continuously reported accidents of vault falling concrete *** the concrete block falling occurs,serious consequences follow,and traffic safety may be *** aerodynamic shockwave evolves from the initial compression wave may be an important inducement causing the tunnel lining cracks to grow and form falling concrete blocks.A joint calculation framework is established based on ANSYS Fluent,ABAQUS,and FRANC3D for calculating the crack tip field under the aerodynamic *** intensification effect of aerodynamic shockwaves in the crack is revealed,and the evolution characteristics of the crack tip field and the influence factors of stress intensity factor(SIF)are *** show that(1)the aerodynamic shockwave intensifies after entering the crack,resulting in more significant pressure in the crack than the input *** maximum pressure of the inclined and longitudinal cracks is higher than the corresponding values of the circumferential crack,respectively.(2)The maximum SIF of the circumferential,inclined,and longitudinal crack appears at 0.5,0.68,and 0.78 times the crack front *** maximum SIF of the circumferential crack is higher than that of the inclined and longitudinal *** possibility of crack growth of the circumferential crack is the highest under aerodynamic shockwaves.(3)The influence of train speed on the SIF of the circumferential crack is more than 40%.When the train speed,crack depth,and crack length change,the change of pressure in the crack is the direct cause of the change of SIF.

关键词： Falling concrete blocks Tunnel lining cracks Aerodynamic shockwave Intensification effect Crack tip field Stress intensity factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nitrogen-doped carbon dots as photocatalysts for organic synthesis:Effect of nitrogen content on catalytic activity

引用

Nano Research 2024年第6期17卷 4825-4833页

作者： Kai-Kai Niu chao-Qun Ma Rui-Zhi Dong Hui Liu Sheng-Sheng yu Ling-Bao Xing School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000China

Regulating the doping of carbon dots(CDs)and the generation of reactive oxygen species(ROS)is essential to selectively control their application in photocatalytic organic *** study successfully synthesized five newly developed nitrogen-doped carbon dots(CDs 1-5)with varying nitrogen content,which have the ability to generate ROS when exposed to light radiation,specifically superoxide anion radicals(O_(2)•-)and singlet oxygen(^(1)O_(2)).The utilization of the aforementioned nitrogen-doped CDs as photocatalysts enables the realization of their potential in facilitating efficient photocatalytic organic ***,it was observed that the photocatalytic efficiency exhibited a gradual decrease when the nitrogen content in the CDs *** order to provide more evidence for this claim,we employed a set of five CDs in the context of photocatalytic dehalogenation ofα-bromoacetophenone,photocatalytic oxidative coupling reaction of amines to imines,photooxidation reaction of sulfides to sulfoxides,and cross-dehydrogenation coupling(CDC)reaction,in which it was further observed that there was a steady decrease in the yields of photocatalytic organic reactions as the nitrogen content in CDs ***,CDs 1 exhibited the best photocatalytic efficiency,thereby reinforcing the hypothesis that a higher nitrogen content corresponds to a decreased catalytic *** study not only investigates the impact of the nitrogen content on the catalytic performance of CDs,but also offers valuable insights for the future utilization of CDs for photocatalytic organic reactions in water.

关键词： carbon dots nitrogen-doped reactive oxygen species photocatalysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Urinary metabolic profiles during Helicobacter pylori eradication in chronic gastritis

引用

World Journal of Clinical Cases 2024年第5期12卷 951-965页

作者： Wen-ting An yu-Xia Hao Hong-Xia Li Xing-Kang Wu Department of Pharmacy Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Department of Gastroenterology Shanxi Provincial People's HospitalTaiyuan 030012Shanxi ProvinceChina Department of Oncology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina Modern Research Center for Traditional Chinese Medicine Shanxi UniversityTaiyuan 030006Shanxi ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is a major risk factor for chronic gastritis,affecting approximately half of the global *** eradication is a popular treatment method for ***-positive chronic gastritis,but its mecha-nism remains *** metabolomics has been used to elucidate the mechanisms of gastric disease ***,no clinical study has been conducted on urinary metabolomics of chronic *** To elucidate the urinary metabolic profiles during *** eradication in patients with chronic *** We applied LC–MS-based metabolomics and network pharmacology to in-vestigate the relationships between urinary metabolites and ***-positive chronic gastritis via a clinical follow-up *** Our study revealed the different urinary metabolic profiles of ***-positive chronic gastritis before and after *** *** metabolites regulated by *** eradication therapy include cis-aconitic acid,isocitric acid,citric acid,L-tyrosine,L-phenylalanine,L-tryptophan,and hippuric acid,which were involved in four metabolic pathways:(1)Phenylalanine metabolism;(2)phenylalanine,tyrosine,and tryptophan biosynthesis;(3)citrate cycle;and(4)glyoxylate and dicarboxylate *** metabolomics and network pharmacology revealed that MPO,COMT,TPO,TH,EPX,CMA1,DDC,TPH1,and LPO were the key proteins involved in the biological progress of *** eradication in chronic *** Our research provides a new perspective for exploring the significance of urinary metabolites in evaluating the treatment and prognosis of ***-positive chronic gastritis patients.

关键词： LC-MS metabolomics chronic gastritis Helicobacter pylori urinary metabolites

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Di-and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair

引用

Science China(Life Sciences) 2024年第6期67卷 1089-1105页

作者： Runfa Chen Meng-Jie Zhao yu-Min Li Ao-Hui Liu Ru-Xin Wang yu-chao Mei Xuefeng Chen Hai-Ning Du Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismHubei Clinical Research Center of Emergency and ResuscitationEmergency Center of Zhongnan HospitalWuhan UniversityWuhan 430072China Hubei Key Laboratory of Cell Homeostasis College of Life SciencesTaiKang Center for Life and Medical SciencesFrontier Science Center for Immunology and MetabolismWuhan UniversityWuhan 430072China

Histone H3 Lys36(H3K36)methylation and its associated modifiers are crucial for DNA double-strand break(DSB)repair,but the mechanism governing whether and how different H3K36 methylation forms impact repair pathways is ***,we unveil the distinct roles of H3K36 dimethylation(H3K36me2)and H3K36 trimethylation(H3K36me3)in DSB repair via non-homologous end joining(NHEJ)or homologous recombination(HR).Yeast cells lacking H3K36me2 or H3K36me3 exhibit reduced NHEJ or HR efficiency.y Ku70 and Rfa1 bind H3K36me2-or H3K36me3-modified peptides and chromatin,*** these interactions impairs y Ku70 and Rfa1 recruitment to damaged H3K36me2-or H3K36me3-rich loci,increasing DNA damage sensitivity and decreasing repair ***,H3K36me2-enriched intergenic regions and H3K36me3-enriched gene bodies independently recruit y Ku70 or Rfa1 under DSB ***,human KU70 and RPA1,the homologs of y Ku70 and Rfa1,exclusively associate with H3K36me2 and H3K36me3 in a conserved *** findings provide valuable insights into how H3K36me2 and H3K36me3 regulate distinct DSB repair pathways,highlighting H3K36 methylation as a critical element in the choice of DSB repair pathway.

关键词： histone H3K36 methylation Ku70 RPA non-homologous end joining homologous recombination

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highly efficient nitrogen fixation over S-scheme heterojunction photocatalysts with enhanced active hydrogen supply

引用

National Science Review 2024年第5期11卷 315-325页

作者： Tong Bao Yamin Xi chaoqi Zhang Peiyang Du Yitong Xiang Jiaxin Li Ling yuan Chengzhong yu chao Liu School of Chemistry and Molecular Engineering East China Normal University Australian Institute for Bioengineering and Nanotechnology The University of Queensland

Photocatalytic N2fixation is a promising strategy for ammonia（NH3） synthesis;however,it suffers from relatively low ammonia yield due to the difficulty in the design of photocatalysts with both high charge transfer efficiency and desirable N2adsorption/activation ***,an S-scheme CoSx/ZnS heterojunction with dual active sites is designed as an efficient N2fixation *** CoSx/ZnS heterojunction exhibits a unique pocket-like nanostructure with small ZnS nanocrystals adhered on a single-hole CoSxhollow *** the heterojunction,the ele ctronic interaction between ZnS and CoSxcreates electron-deficient Zn sites with enhanced N2chemisorption and electron-sufficient Co sites with active hydrogen supply for N2hydrogenation,cooperatively reducing the energy barrier for *** combination with the promoted photogenerated electron-hole separation of the S-scheme heterojunction and facilitated mass transfer by the pocket-like nanostructure,an excellent N2fixation performance with a high NH3yield of 1175.37 μmol g-1h-1is *** study provides new insights into the design of hetero junction photocatalysts for N2fixation.

关键词： photocatalysis nitrogen fixation S-scheme heterojunction active hydrogen ammonia

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Black phosphorus quantum dots induce myocardial inflammatory responses and metabolic disorders in mice

引用

Journal of Environmental Sciences 2024年第3期137卷 53-64页

作者： chao Shen Xiaoyan Ding Jinpeng Ruan Fengkai Ruan Weiping Hu Jiyi Huang Chengyong He Yi yu Zhenghong Zuo Department of Nephrology State Key Laboratory of Cellular Stress BiologySchool of Life SciencesFaculty of Medicine and Life SciencesFujian Clinical Research Center for Chronic Glomerular DiseaseThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361102China

As an ultrasmall derivative of black phosphorus(BP)sheets,BP quantum dots(BP-QDs)have been effectively used in many ***,information on the cardiotoxicity induced by BP-QDs remains *** aimed to evaluate BP-QD-induced cardiac toxicity in *** examination of heart tissue sections was *** sequencing,real-time quantitative PCR(RT–qPCR),western blotting,and enzyme-linked immunosorbent assay(ELISA)assays were used to detect the m RNA and/or protein expression of proinfammatory cytokines,nuclear factor kappa B(NF-κB),phosphatidylinositol3 kinase-protein kinase B(PI3K-AKT),peroxisome proliferator-activated receptor gamma(PPARγ),and glucose/lipid metabolism pathway-related *** found that heart weight and heart/body weight index(HBI)were significantly reduced in mice after intragastric administration of 0.1 or 1 mg/kg BP-QDs for 28 *** addition,obvious infammatory cell infiltration and increased cardiomyocyte diameter were observed in the BP-QD-treated *** expression of proinfammatory cytokines and genes related to the NF-κB signaling pathway further confirmed that BP-QD exposure induced infammatory *** addition,BP-QD treatment also affected the PI3K-AKT,PPARγ,thermogenesis,oxidative phosphorylation,and cardiac muscle contraction signaling *** expression of genes related to glucose/lipid metabolism signaling pathways was dramatically affected by BP-QD exposure,and the effect was primarily mediated by the PPAR signaling *** study provides new insights into the toxicity of BP-QDs to human health.

关键词： BP-QDs Cardiac toxicity Infammatory responses NF-κB signaling pathway PPARγsignaling pathway Glucose/lipid metabolism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In Situ Raman Monitoring of Trace Antibiotics in Different Harsh Water Environments

引用

Energy & Environmental Materials 2024年第1期7卷 284-293页

作者： Chundong Liu Fengcai Lei Maogang Gong Xiaoming Zhou Xiaofei Zhao Zhen Li chao Zhang Baoyuan Man Jing yu School of Physics and Electronics Institute of Materials and Clean EnergyShandong Normal UniversityJinan 250014China College of Chemistry Chemical Engineering and Materials ScienceInstitute of Biomedical SciencesShandong Normal UniversityJinan 250014China Department of Physics and Astronomy University of KansasLawrenceKansas 66045USA Shandong Provincial Hospital Shandong First Medical UniversityJinan 250021China

In situ surface-enhanced Raman scattering(SERS)is a widely used operando analytical technique,while facing numerous complex factors in applications under aqueous environment,such as low detection sensitivity,poor anti-interference capability,etc.,resulting in unreliable *** address these issues,herein a new hydrophobic SERS strategy has been *** comprehensively designing and researching a SERS-active structure of superhydrophobic ZnO/Ag nanowires,we demonstrate that hydrophobicity can not only draw analytes from water onto substrate,but also adjust"hottest spot"from the bottom of the nanowires to the *** a result,the structure can simultaneously concentrate the dispersed molecules in water and the enhanced electric field in structure into a same zone,while perfecting its own anti-interference *** underwater in situ analytical enhancement factor of this platform is as high as 1.67×10^(11),and the operando limited of detection for metronidazole(MNZ)reaches to 10^(-9)*** importantly,we also successfully generalized this structure to various real in situ detection scenarios,including on-site detection of MNZ in corrosive urine,real-time warning of wrong dose of MNZ during intravenous therapy,in situ monitoring of MNZ in flowing wastewater with particulate interference,etc.,demonstrating the great application potential of this hydrophobic *** work realizes a synergistic promotion for in situ SERS performance under aqueous environment,and also provides a novel view for improving other in situ analytical techniques.

关键词： antibiotic detection hydrophobic structure In situ Raman metronidazole wettability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Efficacyand Safetyof Huashi Baidu Granules in Treating Patients with SARS-CoV-2Omicron Variant: A Single-Center Retrospective Cohort Study

引用

Chinese Journal of Integrative Medicine 2024年第2期30卷 107-114页

作者： CHEN Cai-yu ZHANG Wen XU Xiang-ru PU yu-ting TU Ya-dan PENG Wei YAO Xuan ZHOU Shuang FANG Bang-jiang Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai(200032)China Department of Classical Traditional Chinese Medicine Chongqing Hospital of Traditional Chinese MedicineChongqing(400021)China Acupuncture and Massage College Shanghai University of Traditional Chinese MedicineShanghai(201203)China Institute of Emergency and Critical Care Medicine Shanghai University of Traditional Chinese MedicineShanghai(200032)China

Objective:To evaluate the efficacy and safety of Huashi Baidu Granules(HSBD)in treating patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron ***:A single-center retrospective cohort study was conducted during COVID-19 Omicron epidemic in the Mobile Cabin Hospital of Shanghai New International Expo Center from April 1st to May 23rd,*** COVID-19 patients with asymptomatic or mild infection were assigned to the treatment group(HSBD users)and the control group(non-HSBD users).After propensity score matching in a 1:1 ratio,496 HSBD users of treatment group were matched by propensity score to 496 non-HSBD *** in the treatment group were administrated HSBD(5 g/bag)orally for 1 bag twice a day for 7 consecutive *** in the control group received standard care and routine *** primary outcomes were the negative conversion time of nucleic acid and negative conversion rate at day *** outcomes included the hospitalized days,the time of the first nucleic acid negative conversion,and new-onset symptoms in asymptomatic *** events(AEs)that occurred during the study were *** subgroup analysis was conducted in vaccinated(378 HSBD users and 390 non-HSBD users)and unvaccinated patients(118 HSBD users and 106 non-HSBD users).Results:The median negative conversion time of nucleic acid in the treatment group was significantly shortened than the control group[3 days(IQR:2-5 days)vs.5 days(IQR:4-6 days);P<0.01].The negative conversion rate of nucleic acid in the treatment group were significantly higher than those in the control group at day 7(91.73%vs.86.90%,P=0.014).Compared with the control group,the hospitalized days in the treatment group were significantly reduced[10 days(IQR:8-11 days)vs.11 days(IQR:10.25-12 days);P<0.01].The time of the first nucleic acid negative conversion had significant differences between the treatment and control groups[3 days(IQR:2-4 days)vs.5 days(IQR:

关键词： Huashi Baidu Granule severe acute respiratory syndrome coronavirus 2 Omicron variant retrospective cohort trial Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：