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Multifunctional health-promoting effects of oolong tea and its products

Food Science and Human Wellness 2022年第3期11卷 512-523页

作者： Shuzhen Wang ting zeng Shuang Zhao Yu Zhu Changchun Feng Jianfeng Zhan Shiming Li Chi-Tang Ho Alexander Gosslau Huanggang Normal University College of Life ScienceHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive UtilizationHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie MountainsHubei Zhongke Research Institute of Industrial TechnologyHuanggang 438000China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Department of Food Science Rutgers UniversityNJ 08901USA Department of Science(Biology) City University of New YorkNY 10007USA

Oolong tea,partially fermented from Camellia sinensis leaves,exhibits significant antioxidative,anti-inflammatory,and anti-cancer activities as indicated in several in vitro and in vivo ***,studies on health promoting effects of oolong tea and its characteristic compounds are *** potential efficacy of bioactives derived from oolong tea and their roles as promising anticancer agents,their cardio-protective benefits during hypoxic conditions,effects in treating allergic disorders,potential prebiotic activities,improvement of blood lipid status in human beings,effectivity as oral hypoglycemic agent in the treatment of type 2 diabetes,and their potentials to reduce the risk of obesity have been discussed in this *** promising studies mainly gained from animal studies might broaden the consumption and usage of the phenolic-enriched oolong tea and its products in food and pharmaceutical ***,potential health beneficial effects of oolong tea in humans should be further complemented by large-sized,randomized double-blind and placebo-controlled trials to consolidate potential therapeutic applications.

关键词： Oolong tea Anticancer potential Antioxidative activity Microbiota modulating activities Synergistic effects

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孤独症谱系障碍儿童家庭干预训练模式的临床探讨

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教育生物学杂志 2024年第1期12卷 37-41页

作者：李爱文邓梁琼马丽琴曾婷覃小燕陈玲广州市妇女儿童医疗中心柳州医院柳州545001

目的观察孤独症谱系障碍(autism spectrum disorder,ASD)患儿家长主导实施的家庭干预训练的效果。方法选取2021年1月—2022年1月柳州市妇幼保健院收治的64例ASD患儿作为研究对象,根据家长自愿原则分为观察组(n=34)和对照组(n=30)。观... 详细信息

目的观察孤独症谱系障碍(autism spectrum disorder,ASD)患儿家长主导实施的家庭干预训练的效果。方法选取2021年1月—2022年1月柳州市妇幼保健院收治的64例ASD患儿作为研究对象,根据家长自愿原则分为观察组(n=34)和对照组(n=30)。观察组患儿由经过培训的家长主导实施家庭干预训练;对照组患儿上午在医院由治疗师训练,其他时间由家长在家随时随地训练。2组患儿均采用综合康复训练治疗3个月。比较2组患儿治疗前后孤独症行为量表(autism behavior checklist,ABC)、孤独症治疗评估量表(autism treatment evaluation checklist,ATEC)和简式父母育儿压力问卷(parenting stress index-short form,PSI-SF)评分的差异。结果治疗前和治疗后,ABC、ATEC各项目评分和PSI-SF总评分的组间差异均无统计学意义(P>0.05);与治疗前比较,治疗后2组患儿ABC、ATEC各项目评分和PSI-SF总评分均显著降低,差异有统计学意义(P<0.05)。结论家长主导实施的家庭干预模式与医院为主导的干预模式的短期疗效相当,能明显减轻家长的经济和育儿压力。

关键词：训练模式家庭干预孤独症谱系障碍儿童育儿压力

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Construction of Naphthalenediimide Lanthanide(Ⅲ)-MOFs and Composites Incorporated Electron-Rich Pyrene Derivative as Multifunctional Fluorescence Sensing for Nitro Aromatic Compounds and Aldehydes

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Chinese Journal of Chemistry 2024年第3期42卷 283-293页

作者： Rong Huo ting Zhang Guang zeng Chen Wang Yong Heng Xing Feng Ying Bai College of Chemistry and Chemical Engineering Liaoning Normal UniversityDalianLiaoning116029 China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning116023 China

The development of host-guest MOF luminescent composites has attracted considerable attention. However,it is still a challenge to reasonably design large scale conjugated polycarboxylic acids metal-organic framework (MOF) and modulate donor-acceptor interaction. Herein,a series of isostructural 3D porous lanthanide MOF [Ln_(2)(BINDI)0.5(NO_(3))(DMA)(H_(2)O)]∙DMA∙2.5H_(2)O (Ln = La (1),Ce (2),Pr (3) and Nd (4);H_(4)BINDI (N,N’-bis(5-isophthalic acid)-1,4,5,8-naphthalenediimide) were synthesized. Considering the electron-deficient performances of Ln-BINDI MOFs,D-A type composites Ln-MOFs (1—4@H_(4)TBAPy) were prepared via the incorporation of electron-rich H_(4)TBAPy (1,3,6,8-tetrakis(p-benzoic acid) pyrene),which more improved the luminescence performance of complexes 1—4 and can be used as fluorescence sensors for the detection of nitro compounds and aldehydes. High sensitivity of 1@H_(4)TBAPy towards pNBA,pNA PNP,DNP,and TNP could be achieved through hydrogen bond interactions between MOF and analytes,as well as the π-π interaction between H_(4)TBAPy and the naphthalene ring of BINDI,thus the fluorescence quenching efficiency of 1@H_(4)TBAPy was better than that of the complex 1. In addition,it is found that 1@H_(4)TBAPy has high selectivity and sensitivity to aromatic aldehyde SA,5-Mesal and HMBA. Such strategy to enhance the emission of NDI based Ln-BINDI MOFs,will open up an avenue to obtain more fluorescent MOFs for sensing.

关键词： Ln-MOF Pyrene molecule NACs Aldehydes Fluorescence sensing Carboxylate ligands Charge transfer Donor-acceptor systems

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Intrahepatic cholangiocarcinoma is more complex than we thought:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1469-1474页

作者： Jian-ting zeng Jie-Feng Zhang Yu Wang Zhou Qing Zhen-Hua Luo Yan-Lin Zhang Yi Zhang Xian-ZhangLuo Key Laboratory for Biorheological Science and Technology of Ministry of Education Chongqing UniversityChongqing University Cancer HospitalChongqing 400030China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND Brain metastasis from intrahepatic cholangiocarcinoma is *** the best of our knowledge,only a few cases have been *** biological behavior was complex,and treatment requires further *** SUMMARY A 62-year-old woman complained of left limb *** computed tomography showed a 5.0 cm×5.6 cm lesion in the left lobe of the *** markers were *** analysis indicated absence of hepatitis *** magnetic resonance imaging revealed a 1.0 cm×1.3 cm mass in the right frontal *** cholangiocarcinoma with brain metastasis was diagnosed by our liver cancer multidisciplinary *** sufficient preparation,the patient underwent partial frontal lobotomy and left *** results confirmed that both the lesions were *** cycles of gemcitabine combined with S1 were *** a 39 mo postoperative follow-up,no sign of local recurrence or distant metastasis was *** This case expands our knowledge concerning the complex and heterogeneous nature of tumor metastasis.

关键词： Intrahepatic cholangiocarcinoma Brain metastasis Multidisciplinary team Synchronous brain metastasis Case report

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Influence of lunar regolith compressibility on sampling performance of thick wall spiral drills

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Chinese Journal of Aeronautics 2023年第2期36卷 350-362页

作者： Yong PANG Tao ZHANG Hongyu WEI ting zeng Yinliang ZHANG Guidong MO Kun XU Shen YIN Guoxin WANG Xingwang ZHANG Xiaoming LAI Xilun DING Beijing Spacecrafts China Academy of Space TechnologyBeijing 100094China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China

A 2 m class robotic drill was sent to the Moon and successfully collected and returned regolith samples in late 2020 by *** was a typical thick wall spiral drill(TWSD)with a hollow auger containing a complex coring system to retain subsurface regolith *** the robotic drill was launched,a series of laboratory tests were carried out to investigate and predict the possible drilling loads it may encounter in the lunar *** work presents how the sampling performance of the TWSD is affected by the regolith *** and analysis during the drilling and sampling process in a simulated lunar regolith environment were *** compressibility of a typical lunar regolith simulant(LRS)was measured through unidirectional compression tests to study the relationship between its inner regolith stress and bulk density.A theoretical model was established to elucidate the cutting discharge behavior by auger flights based on the aforementioned *** were conducted with the LRS,and the results show that the sampling performance is greatly affected by the flux of the drilled cuttings into the spiral flight *** work helped in scheduling reasonable drilling parameters to promote the sampling performance of the robotic drill in the Chinese Chang’E 5 mission.

关键词： Drilling mechanics Lunar drilling Lunar regolith compressibility Regolith sampling performance Thick wall spiral drill

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H9亚型禽流感病毒M1蛋白原核表达及免疫效果初步研究

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动物医学进展 2024年第6期45卷 1-6页

作者：李小凤谢芝勋阮志华李孟李丹张民秀谢志勤罗思思韦悠谢丽基曾婷婷张艳芳黄娇玲王盛广西壮族自治区兽医研究所/广西兽医生物技术重点实验室/农业农村部中国(广西)-东盟跨境动物疫病防控重点实验室广西南宁530001

旨在原核表达H9亚型禽流感病毒(AIV)M1蛋白,初步探究其免疫效果,为研制AIV疫苗奠定基础。通过构建重组质粒pET-32a-M1,诱导表达,Western blot验证蛋白表达情况,将重组蛋白免疫接种小鼠,通过测定血清中IgG抗体效价,脾细胞培养上清多细胞... 详细信息

旨在原核表达H9亚型禽流感病毒(AIV)M1蛋白,初步探究其免疫效果,为研制AIV疫苗奠定基础。通过构建重组质粒pET-32a-M1,诱导表达,Western blot验证蛋白表达情况,将重组蛋白免疫接种小鼠,通过测定血清中IgG抗体效价,脾细胞培养上清多细胞因子分泌情况评价其免疫效果。结果显示,M1重组蛋白主要以可溶性蛋白存在,Western blot结果可见特异性条带。免疫接种小鼠后,血清产生IgG抗体,抗体效价为1∶30000。小鼠脾细胞上清液IL-2、IL-4、IL-6与对照组相比较,含量显著增加(P<0.01),而抑制IL-1β、IL-5、IL-13、IL-12p70、IL-18、GM-CMF、IFN-γ、TNF-α分泌。结果表明,M1重组蛋白免疫原性良好,刺激机体产生体液免疫和细胞免疫,为禽流感疫苗深入研究奠定了基础。

关键词：禽流感 M1蛋白原核表达免疫效果

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Anti-viral activity of Staphylococcus aureus lysates against herpes simplex virus type-Ⅰinfection:an in vitro and in vivo study

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International Journal of Ophthalmology(English edition) 2021年第10期14卷 1463-1472页

作者： Tian-Lan Lin Chao Cheng Wei-ting zeng Fang Duan Yin-Hui Pei Xiu-Ping Liu Fu Shang Kai-Li Wu Zhongshan Ophthalmic Center State Key Laboratory of OphthalmologySun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM:To investigate the effect of Staphylococcus aureus(***)lysates(SALs)on herpes simplex virus type-Ⅰ(HSV1)infection in human corneal epithelial(HCE)cells and in a mouse model of HSV1 ***:HCE,Vero,HeLa,and BV2 cells were infected with HSV1[HSV1f strain,HSV1f;HSV-1-H129 with green fluorescent protein(GFP)knock-in,HSV1g].Pre-or post-infection,SAL at various concentrations was added to the culture medium for 24 *** fluorescence in HSV1g or plaque formation by HSV1f were *** effects of heat-treated SAL,precooled acetone-precipitated SAL,and SAL subjected to ultrafiltration(100 kDa)were *** effects of other bacterial components and lysates on HSV1 infection were also tested,including lipoteichoic acid(LTA),peptidoglycan(PGN),staphylococcal protein A(SPA),andα-hemolysin from ***(α-toxin)as well as lysates from a wild-type *** strain,***,and Escherichia coli(W-SAL,SEL,and ECL,respectively).In addition,SAL eye drops were applied topically to BALB/c mice with HSV1 keratitis,followed by in vivo ***:The cytopathic effect,plaque formation(HSV1f),and GFP expression(HSV1g)in infected cells were inhibited by SAL in a dose-dependent *** active component of SAL(≥100 kDa)was heat-sensitive and retained activity after acetone *** HSV1ginfected cells,treatment with LTA-sa,α-toxin,PGN-sa,or SPA did not inhibit GFP ***,W-SAL,and SEL(but not ECL)decreased GFP *** mice with HSV1 keratitis,SAL reduced corneal lesions by 71%.CONCLUSION:The results of this study demonstrate that SAL can be used to inhibit HSV1 infection,particularly *** studies are needed to determine the active components and mechanism underlying the effects of SAL.

关键词： herpes simplex virus type-1 Staphylococcus aureus infection cornea epithelial cells keratitis

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A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy

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Chinese Chemical Letters 2024年第3期35卷 332-336页

作者： Dequan zeng Zhongkai Ma Xin Zan ting Luo Xiang Wang Xiang Gao Xianghui Fu School of Health Management Xihua UniversityChengdu 610039China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China College of StomatologySichuan UniversityChengdu 610041China Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengdu 610041China Breast Disease Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

Oral squamous cell carcinoma(OSCC)is known as one of the most malignant tumors with high recurrence and fatality *** poor tumor-targeting ability of traditional chemotherapeutic drugs has been a grand challenge for anti-OSCC *** that,a large quantity of tumor associated macrophages in OSCC tissues further diminish the anti-tumor effects of these ***,we produced a therapeutic nano drug delivery system(FA-PEG-PLA-JQ1)through encapsulating JQ1[a small-molecule inhibitor of bromodomain containing protein 4(BRD4)]into the folic acid(FA)-modified nanoparticle(PEG-PLA),which could prolong the half-life of JQ1 and target the tumor *** then,JQ1 released from this nanoparticle could prevent OSCC growth inducing tumor cell apoptosis,inhibiting tumor angiogenesis and the polarization of M2 type *** conclusion,our date demonstrated the therapeutic benefits of FA-PEG-PLA-JQ1 against OSCC in vivo or in vitro,which could be a novel treatment strategy for OSCC in coming days.

关键词： Folic acid Nanoparticles JQ1 Oral squamous cell carcinoma Macrophages

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斑马鱼tectb内耳基因敲除品系的构建及其作用机制

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激光生物学报 2024年第2期33卷 143-150,166页

作者：刘玲朱俊伟曾婷谢缤灵陶桂芳朱贤宇谢华平湖南师范大学动物营养与人体健康实验室长沙410081

TECTB基因编码的β-盖膜蛋白(β-tectorin)在人类听觉功能中具有重要的调控作用,是内耳器官中覆盖膜的重要组成成分,在声音转导为神经信号的过程中发挥着关键作用。β-tectorin突变会导致人类非综合征性耳聋的发生,而目前关于听觉障碍... 详细信息

TECTB基因编码的β-盖膜蛋白(β-tectorin)在人类听觉功能中具有重要的调控作用,是内耳器官中覆盖膜的重要组成成分,在声音转导为神经信号的过程中发挥着关键作用。β-tectorin突变会导致人类非综合征性耳聋的发生,而目前关于听觉障碍发生的分子机制仍然有待研究。斑马鱼(Danio rerio)是一种常用的试验动物模型,能够对内耳发育和相关疾病的研究提供重要的价值。为了研究tectb基因在斑马鱼内耳发育中的作用,本研究利用CRISPR/Cas9基因编辑技术,成功构建tectb内耳基因缺失型斑马鱼模型,并对tectb基因缺失的斑马鱼表型进行初步分析。首先,在tectb基因的第三号外显子上设计靶位点以及基因型检测引物,经体外扩增得到向导DNA(sgDNA),再对其进行体外转录,得到向导RNA(sgRNA);然后,将sgRNA与Cas9酶通过显微注射的方式注射到野生型斑马鱼胚胎中,经基因型鉴定筛选出携带突变的嵌合体F0代鱼,培养至性成熟后与野生型斑马鱼杂交得到F1代突变体杂合子;在遗传稳定性鉴定及基因序列测序之后,保留突变类型为移码突变的F1代鱼,培养至成年后,经过自交得到F2代tectb突变体纯合子;最后,通过体式显微镜初步观察及毛细胞染色试验,发现突变体斑马鱼内耳组织结构正常,耳石形态和大小没有明显差异,毛细胞的发育也没有明显缺陷,但是体内器官与组织的发育是否发生变化,需要进行深入研究。这项研究为深入了解内耳发育的分子机制和耳聋等人类疾病提供了有价值的研究模型,借助tectb基因敲除斑马鱼模型,我们可以探究该基因在疾病发生中的具体作用,更好地研究内耳发育中的关键途径,有利于进一步深入研究听力的调控机制。

关键词：斑马鱼 tectb CRISPR/Cas9 内耳发育毛细胞

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Campylobacter enteritis in adult patients with acute diarrhea from 2005 to 2009 in Beijing, China

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Chinese Medical Journal 2011年第10期124卷 1508-1512页

作者： CHEN Jie SUN Xin-ting zeng Zheng YU Yan-yan Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

Background There has been a marked global increase in the incidence of human Campylobacter enteritis in recent years. This study investigated the epidemiological and clinical features of Campylobacter enteritis in adult patients suffering from acute *** This was a retrospective review of Campylobacter enteritis in adult patients with acute diarrhea presenting at Beijing University First Hospital, Beijing, China, in the summer and autumn （April to October） of 2005 to 2009. The data collected included the species of campylobacter identified, and the age, gender, clinical manifestations and results of laboratory test on stool samples collected from the patients. Campylobacter sensitivity tests to various antimicrobial agents were conducted on 80 specimens. Chi-square tests were applied using SPSS13.0 software and a two-sided P value of 〈0.05 was considered statistically *** Campylobacter spp. isolated from the stool specimens of 142 patients with diarrhea represented 14.9% of all the cases examined. C. jejuni was identified in 127 patients （89.4%） and C. coli in 15 others （10.6%）. The infection incidence was highest in the age range of 21-30 years which comprised 21.7% of the total cases examined. Most cases of diarrhea （46 patients） occurred in June. Watery diarrhea （97.2%）, abdominal pain （72.5%） and fever （64.8%） were the most common manifestations of enteric campylobacteriosis. Only four patients （2.8%） had bloody diarrhea. The antimicrobial resistance rates were： cefoperazone （100%）, levofloxacin （61.3%）, gentamicin （12.5%）, erythromycin （6.3%）, and azithromycin （2.5%）.Conclusions Campylobacter was prevalent among adults with acute diarrhea from 2005 to 2009 in Beijing, China. The large number of those afflicted by the disease warrants the commission of a large multicenter study to determine the extent of enteric campylobacteriosis in this region

关键词： Campylobacter enteritis drug resistance signs and symptoms

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