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A two-pronged strategy utilizing exosomes extracted from antigenpresenting cells to combat hepatitis B

Nano Research 2024年第10期17卷 9084-9094页

作者： Fumin Hu Dangyang Wang ting lu Guanghui Ma Hua Yue State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100190China

Chronic hepatitis B(CHB)is consistently challenging to conquer with numerous complications and *** the effectiveness of antiviral therapies in suppressing hepatitis B virus(HBV)replication,there is an urgent need for novel and more effective treatment *** strategies predominantly emphasize immune activation but still face challenges in sufficiently eliciting T cell *** into account the targeted delivery of nanoparticles to the liver and spleen via intravenous injection,we have proposed a dual-pronged therapeutic strategy based on antigen-presenting cells(APCs)-derived ***,exosomes targeted to the spleen can activate specific immune responses,while those targeted to the liver can modulate or reverse the liver’s immunosuppressive *** immunization,exosome formulations exhibit the remarkable ability to effectively activate APCs,thereby triggering the proliferation of CD8^(+)T ***,they also play an immunoregulatory role by converting M2 macrophages into M1 *** two-pronged therapeutic strategy precisely addresses the issues of T cell dysfunction and immune suppression,both characteristic features of CHB *** combined with Aluminum(Alum)-adjuvanted vaccine,these exosome formulations not only demonstrate a high level of cellular immune response but also secrete specific antibodies comparable to those induced by Alum *** combined approach effectively enhances both cellular and humoral immunity,offering a promising avenue for the development of therapeutic hepatitis B vaccines based on exosome formulations.

关键词： chronic hepatitis B antigen-presenting cells(APCs)-derived exosomes immunoregulatory role two-pronged therapeutic strategy

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Two-dimensional bimetallic selenium-containing metal-organic frameworks and their calcinated derivatives as electrocatalysts for overall water splitting

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Frontiers in Energy 2024年第3期18卷 378-389页

作者： Zhao-ting SHANG Tang-ming LI Bing-qian HU Min LIU Wang-ting lu Fan YU Yun ZHENG Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education College of Optoelectronic Materials and TechnologyJianghan UniversityWuhan 430056China Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1Canada

The use of two-dimensional(2D)layered metal-organic frameworks(MOFs)as self-sacrificial templates has been proven to be a successful method to create high-efficiency Selenium(Se)-containing electrocatalysts for overall water ***,two strategies are then utilized to introduce Se element into the Co–Fe MOF,one being the etching of as-prepared MOF by SeO_(2) solution,and the other,the replacing of SCN−with SeCN−as the construction *** electrochemical activity of the pristine 2D MOF and their calcinated derivatives for catalyzing the hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)is evaluated and further *** is found that the effect of introducing Se on improving electrochemical catalytic activity is significant for the HER ***,the calcinated derivative in the replacing method exhibits an overpotential of 235 mV for HER and 270 mV for OER at a current density of 10 mA/*** comparing the two methods of introducing Se element into MOF,similar electrocatalytic activity can be achieved on the their calcinated *** high electrochemical performance of 2D CoFe-MOF derivatives may be resulted from the unique 2D hierarchical porous structure and strong synergistic effect between different components in the material.

关键词： 2D MOF selenium(Se)-containing materials hydrogen evolution reaction(HER) oxygen evolution reaction(OER)

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Incidence of surgical site infection in minimally invasive colorectal surgery

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1121-1129页

作者： lu-ting Ni Ru Zhao Yi-Ru Ye Yi-Ming Ouyang Xin Chen Department of Surgery The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Surgical site infection(SSI)is a common complication of colorectal *** invasive surgery notably reduces the incidence of *** study aimed to compare the incidences of SSI after robot-assisted colorectal surgery(RACS)vs that after laparoscopic assisted colorectal surgery(LACS)and to analyze associated risk factors for SSI in minimally invasive colorectal *** To compare the incidences of SSI after RACS and LACS,and to analyze the risk factors associated with SSI after minimally invasive colorectal *** Clinical data derived from patients who underwent minimally invasive colorectal surgery between October 2020 and October 2022 at the First Affiliated Hospital of Soochow University were *** in clinical characteristics and surgeryrelated information associated with RACS and LACS were compared,and possible risk factors for SSI were *** A total of 246 patients(112 LACS and 134 RACS)were included in the ***(17.5%)developed *** proportions of patients who developed SSI were similar in the two groups(17.9%vs 17.2%,P=0.887).Diabetes mellitus,intraoperative blood loss≥100 mL,and incision length were independent risk factors for *** additional risk factors included neoadjuvant therapy,lesion site,and operation *** There was no difference in SSI incidence in the RACS and LACS *** mellitus,intraoperative blood loss≥100 mL,and incision length were independent risk factors for postoperative SSI.

关键词： Colorectal surgery Minimally invasive surgery Surgical site infection

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Are the Green TBTs a Stimulus or a Trap for Enterprises’Green Technology Development?

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China Finance and Economic Review 2024年第2期13卷 26-45页

作者： ting lu Qiyuan Xu Chinese Academy of Social Sciences(CASS)

Green trade barriers are often seen as a catalyst that promotes exporting countries to develop green ***,by distinguishing the green technology behavior of enterprises into green technology transformation and green technology innovation,this paper finds that although green trade barriers can encourage enterprises in exporting countries to increase investment in green technology transformation in order to obtain rapid market access,they crowd out the resources of green technology innovation of *** other words,green trade barriers will strengthen enterprises’dependence on the introduction of green technologies,weaken their innovation capabilities,and increase the risk of being locked in the middle of the global industrial chain,creating a trap *** the data of enterprises in the heavily polluting industry of A-shares from 2009 to 2021,this paper confirms the existence of the trap *** addition,this paper finds that due to the infl uence of short-sightedness of managers,alleviating corporate financing constraints can enhance the promotion effect of green trade barriers on the green technological transformation of enterprises,but cannot reduce its inhibiting effect on green technology *** study also finds that even if the time window is extended to the medium and long term,green trade barriers cannot have a significant positive impact on enterprises’green technology ***,the government should not overestimate the role of green trade barriers in encouraging green development and green technology innovation,nor should it rely too much on loose financing *** contrast,government should formulate targeted industrial policies to help enterprises overcome green trade barriers through technological innovation.

关键词： green TBTs trap effect green technology innovation reconstruction of GVCs

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Glymphatic function and its influencing factors in different glucose metabolism states

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World Journal of Diabetes 2024年第7期15卷 1537-1550页

作者： Bin Tian Chen Zhao Jia-Li Liang Hui-ting Zhang Yi-Fan Xu Hui-Lei Zheng Jia Zhou Jiang-Nian Gong Shu-ting lu Zi-San Zeng Department of Radiology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Magnetic Resonance Research Collaboration Siemens HealthineersGuangzhou 510620Guangdong ProvinceChina Magnetic Resonance Research Collaboration Siemens Healthineers Ltd.Wuhan 430071Hubei ProvinceChina Department of Health Management The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Dysfunction of the glymphatic system in the brain in different stages of altered glucose metabolism and its influencing factors are not well *** To investigate the function of the glymphatic system and its clinical correlates in patients with different glucose metabolism states,the present study employed diffusion tensor imaging along the perivascular space(DTI-ALPS)*** Sample size was calculated using the pwr package in R *** crosssectional study enrolled 22 patients with normal glucose metabolism(NGM),20 patients with prediabetes,and 22 patients with type 2 diabetes mellitus(T2DM).A 3.0T magnetic resonance imaging was used to evaluate the function of the glymphatic *** mini-mental state examination(MMSE)was used to assess general cognitive *** DTI-ALPS index of bilateral basal ganglia and the mean DTI-ALPS index was ***,the correlation between DTI-ALPS and clinical features was *** The left-side,right-side,and mean DTI-ALPS index in the T2DM group were significantly lower than that in the NGM *** right-side DTI-ALPS and mean DTI-ALPS index in the T2DM group were significantly lower than those in the prediabetes ***-ALPS index lateralization was not *** MMSE score in the T2DM group was significantly lower than that in the NGM and prediabetes *** controlling for sex,the left-side DTI-ALPS and mean DTI-ALPS index in the prediabetes group were positively correlated with 2-hour postprandial blood glucose level;the left-side DTI-ALPS index was negatively correlated with total cholesterol and low-density lipoprotein *** right-side DTI-ALPS and mean DTI-ALPS index were negatively correlated with the glycosylated hemoglobin level and waist-to-hip ratio in the prediabetes *** left-side,right-side,and mean DTI-ALPS index in the T2DM group were positively correlated with *** left-side and mean DTIALPS index in the T2DM group were negatively

关键词： Glymphatic system Prediabetes Type 2 diabetes mellitus Magnetic resonance imaging Diffusion tensor imaging along the perivascular space

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圣俗同构——青藏高原东缘大、小金川流域嘉绒“达尔尕”制度性表演的文化阐释

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中国音乐 2024年第5期 127-137页

作者：卢婷四川音乐学院中华传统音乐研究院

“达尔尕”是青藏高原东缘大、小金川流域嘉绒藏族在人生仪礼、传统年节、法会祭典等特定时空场域下展开的仪式性歌舞。“达尔尕”受制于其赖以生存的人文生态系统,在信仰观念、社会制度、文化规则的影响下维持着极具制度性的表演模式... 详细信息

“达尔尕”是青藏高原东缘大、小金川流域嘉绒藏族在人生仪礼、传统年节、法会祭典等特定时空场域下展开的仪式性歌舞。“达尔尕”受制于其赖以生存的人文生态系统,在信仰观念、社会制度、文化规则的影响下维持着极具制度性的表演模式。其中“信仰观念”是建构“达尔尕”制度性表演的核心要素。日常生活中“达尔尕”虽以“俗”的面相展现,但其精神内核却是超越世俗娱乐的对“圣”的追求。本文对“达尔尕”的制度性表演进行描述,并对其“圣俗同构”的文化属性做深入阐释。

关键词：嘉绒 “达尔尕” 圣俗同构制度性表演

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多模态MRI在终末期肾病合并认知障碍中的研究进展

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磁共振成像 2024年第1期15卷 229-234页

作者：陆婷鲁际三峡大学第一临床医学院宜昌443000 湖北省宜昌市中心人民医院放射科宜昌443000

认知障碍在终末期肾病(end-stage renal disease, ESRD)患者中非常普遍,这种障碍涉及一系列认知领域,包括注意力、记忆力和执行力等,严重降低了患者的生活质量。然而这种神经认知缺陷的确切机制尚不清楚,因此在早期阶段检测和管理这种... 详细信息

认知障碍在终末期肾病(end-stage renal disease, ESRD)患者中非常普遍,这种障碍涉及一系列认知领域,包括注意力、记忆力和执行力等,严重降低了患者的生活质量。然而这种神经认知缺陷的确切机制尚不清楚,因此在早期阶段检测和管理这种认知障碍具有很大的挑战性。近年来多模态磁共振成像在这一领域取得了诸多成果,并有望选择出指导早期筛查及诊断慢性肾脏疾病(chronic kidney disease, CKD)患者认知缺陷的影像学生物标志物。本文将简要阐述多种MRI新兴技术及人工智能在ESRD合并认知障碍患者中的研究进展,尝试揭示ESRD患者脑结构、功能、灌注、代谢及神经血管耦合与认知功能障碍之间的联系,帮助临床了解ESRD患者大脑缺陷的潜在神经元机制,有利于合并认知障碍ESRD患者的早期诊断、治疗及随访。

关键词：终末期肾病认知障碍磁共振成像多模态脑功能成像血液透析脑损伤

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回归“本源”的大学美育路径探析

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黑龙江高教研究 2024年第3期42卷 8-11页

作者：路亭首都师范大学北京100048 南昌工程学院江西南昌330000

随着工具理性主义在美育研究中逐渐盛行,大学美育存在的教师思想固化、学生美育观念狭隘的现象愈发明显。其根源在于美育假设了美相关知识的既定性存在而忽视了这些知识产生的“本源”。基于发生现象学视角,美育并不是教会学生对知识简... 详细信息

随着工具理性主义在美育研究中逐渐盛行,大学美育存在的教师思想固化、学生美育观念狭隘的现象愈发明显。其根源在于美育假设了美相关知识的既定性存在而忽视了这些知识产生的“本源”。基于发生现象学视角,美育并不是教会学生对知识简单的“占有”,而是要唤醒与激活学生心中对于“本源”的体验与理解。因此,我们应在反思中回问美的“本源”,将美理解为“我们如何与世界相处”的人生需要。把对“我们如何与世界相处”的体验贯穿在感受艺术生活、理解艺术本质、亲历艺术实践这条美育路径中,从而真正帮助学生养成“我们如何与世界相处”的意识与能力。

关键词：美育美 “本源” 回问发生现象学

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从自杀意念到自杀尝试:自杀行动转变的理论模型与风险因素

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中国临床心理学杂志 2024年第2期32卷 314-322页

作者：应梦婷江光荣鲁婷王磊武汉体育学院心理学系武汉430079 华中师范大学心理学院武汉430079 湖北大学教育学院心理学系武汉430062

自杀意念是自杀尝试的先决条件,但大多数思考自杀的人并不会进一步采取行动。近十年,学术界基于自杀“意念-行动”框架,关注自杀意念向自杀行动的转变,以自杀人际理论、动机-意志整合模型和三阶段理论为代表的理论模型推动了对自杀风险... 详细信息

自杀意念是自杀尝试的先决条件,但大多数思考自杀的人并不会进一步采取行动。近十年,学术界基于自杀“意念-行动”框架,关注自杀意念向自杀行动的转变,以自杀人际理论、动机-意志整合模型和三阶段理论为代表的理论模型推动了对自杀风险因素的重新探索。在区分自杀意念与自杀尝试方面,自杀能力及其影响因素的研究成果最为丰富,此外还有自杀意念相关因素、精神障碍/症状因素、其他心理社会因素以及认知神经功能因素。基于现有研究进展和存在的问题,文章对未来研究方向进行了展望。

关键词：自杀意念自杀尝试 “意念-行动”框架理论模型风险因素

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社区嵌入式养老机构发展路径探析——基于“场域-行动”分析视角

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湘潭大学学报（哲学社会科学版） 2024年第2期48卷 41-45,94页

作者：卢婷成志刚湖南女子学院社会发展学院湖南长沙410004 湘潭大学公共管理学院湖南湘潭411105

养老机构嵌入社区是推动专业机构向社区延伸,整合社区存量资源,健全社区养老服务供给网络的有效途径。从“场域-行动”分析视角对社区嵌入式养老机构的发展路径展开考察,发现在养老机构嵌入发展的过程中,社区中的“地理场域”“科层场... 详细信息

养老机构嵌入社区是推动专业机构向社区延伸,整合社区存量资源,健全社区养老服务供给网络的有效途径。从“场域-行动”分析视角对社区嵌入式养老机构的发展路径展开考察,发现在养老机构嵌入发展的过程中,社区中的“地理场域”“科层场域”“文化场域”“服务场域”“对象场域”共同构成了养老机构嵌入社区的多维“场域”要素。依据不同场域的特性和规约,养老机构采取了场景式嵌入、自主式嵌入、建构式嵌入、协同化嵌入和精准化嵌入的行动策略,映射出政府、社区、机构、居民之间良性互动和合作共治的可行性。

关键词：场域-行动社区养老服务社区嵌入式养老机构

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