检索结果-南通市图书馆

Clinical and genetic characterization of a large cohort of patients with Wilson’s disease in China

Translational Neurodegeneration 2022年第1期11卷 763-773页

作者： Shijie Zhang Wenming Yang Xiang Li Pei Pei ting dong Yue Yang Jing Zhang Experimental Center of Clinical Research The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031China Department of Neurology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031China Key Laboratory of Xin’An Medicine Anhui University of Chinese MedicineHefei 230031China

Background: Wilson’s disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B (encoding a copper-transporting P-type ATPase) variants that shows various characteristics according to race and geographical region. This study was aimed to provide a comprehensive analysis of ATP7B variants in China and to investigate a plausible role of common variants in WD manifestations. Methods: A total of 1366 patients (1302 index patients and 64 siblings) clinically diagnosed with WD (Leipzig score ≥ 4) were recruited. They underwent ATP7B gene sequencing and information of age and symptoms at onset was collected. The genotype-phenotype correlation was assessed in the index patients who were examined with two pathogenic variants and onset with hepatic (n = 276) or neurologic (n = 665) symptoms. Results: We identified 294 potentially pathogenic ATP7B variants (112 truncating, 174 missense, 8 in-frame) in the 1302 index patients, including 116 novel variants. The most frequent variant was c.2333G>T (R778L, allele fre-quency: 28.96%), followed by c.2975C>T (P992L, 13.82%), c.2621C>T (A874V, 5.99%), c.2755C>G (R919G, 2.46%), and c.3646G>A (V1216M, 1.92%). In 1167 patients, both pathogentic variants were identified, of which 532 differ-ent variant combinations were found. By binary logistic regression analysis, the factor associated with neurological presentation was high age-at-onset, but not sex, protein-truncating variant (PTV), or the common missense variants (R778L, P992L, and A874V). In the neurological group, low age-at-onset was a factor associated with dystonia, gait abnormality, and salivation;high age-at-onset was a factor associated with tremor;and the sex, low age-at-onset and A874V were independent factors associated with dysarthria. In addition, PTV, R778L, and P992L were predominant in early-onset patients, whereas A874V was predominant in late-onset patients, and patients with R778L/A874V geno-type displayed a higher age-at-onset than patien

关键词： Wilson’s disease Chinese ATP7B Genotype-phenotype correlation Large cohort study

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于UHPLC-Q-Orbitrap-MS技术分析肝豆扶木汤中化学成分

引用

中华中医药杂志 2024年第4期39卷 2001-2009页

作者：杨玉龙杨文明魏涛华杨悦郝文杰尚展鹏董婷韩燕全安徽中医药大学第一附属医院合肥230031 新安医学教育部重点实验室合肥230012 北京大学药学院北京100191

目的:采用超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法(UHPLC-Q-Orbitrap-MS)对肝豆扶木汤(GDFMD)中化学成分进行快速鉴定和归属。方法:选择Thermo Fisher Vanquish UHPLC仪器,Aglient SB C_(18)色谱柱(2.1 mm×150 mm,1.8μm),流动相为0.1%甲酸水(A)和乙腈(B),洗脱梯度:0—2 min,3%B;2—7 min,3%~15%B;7—15 min,15%B;15—20 min,15%~40%B;20—22 min,40%~100%B;22—24 min,100%B;流速:0.4 mL/min;柱温:50℃;进样量:2μL。通过正、负离子模式采集质谱数据,根据精确相对分子质量、二级质谱裂解碎片等信息,结合对照品及相关文献信息比对,对GDFMD中化学成分进行鉴定,并对这些化合物的药材来源进行归属。结果:共鉴别了82个化合物,包括26个酚类、25个生物碱、18个皂苷、5个倍半萜、4个游离酚和4个有机酸;其中归属制何首乌8个、枸杞子24个、白芍15个、柴胡4个、三七粉14个、土茯苓16个、郁金6个。结论:采用UHPLC-Q-Orbitrap-MS可实现对GDFMD中化学成分的快速、准确鉴定,基本涵盖了组方中各药材的成分信息,可为完善该复方的质量评价体系和阐明其药效机制奠定基础。

关键词：肝豆扶木汤超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法酚类生物碱皂苷倍半萜游离酚有机酸

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The bacterial small RNAs: The new biomarkers of oral microbiotaassociated cancers and diseases

引用

BIOCELL 2023年第10期47卷 2187-2193页

作者： MENGYING MAO ting dong YANJING LIANG KEYONG YUAN QIAOQIAO JIN PENGFEI ZHANG ZHENGWEI HUANG Department of Endodontics Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Oral Diseases ShanghaiChina Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology ShanghaiChina Department of Nursing Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

The oral microbiota is a vital part of the human microbiota that functions in various physiological processes and ishighly relevant to cancers and other diseases. With the alterations of host immune competence, the homeostatic balanceexisting between the oral microbiota and host may be disturbed and result in the development of diseases. Numerousobservations have suggested that small RNAs are key regulators of bacterial pathogenesis and bacteria-host ***, bacterial small RNAs are considered to be promising biomarkers for the development of novel, and efficacioustherapies for oral dysbiosis. Mechanistic insights into how oral pathogens communicate with other bacteria or host cellsin oral cancers via small RNAs are hot topics of research. Current studies also have begun to elucidate the key role oforal microbiota in the development of systemic diseases. This article discusses existing findings and nascent mechanismsgoverning the small RNA-based interactions between oral microbiota and associated diseases. The knowledge of suchinteractions is key in planning approaches to reverse dysbiosis to achieve health.

关键词： Oral microbiota Biomarkers sRNAs OSCC Oral diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strength and ductility optimization of HPDC AlSi8MgCuZn2 alloys by modifying pre-aging treatment

引用

China Foundry 2024年第4期21卷 343-351页

作者： Yuan-hang Jiang Hui-ting Zheng Fei Liu Hai-dong Zhao National Engineering Research Center of Near-net Shape Forming for Metallic Materials South China University of TechnologyGuangzhou 510641China

Considering the components produced by high pressure die casting(HPDC)process usually with ultra-large sizes and complex morphologies,high temperature solid solution treatment is not a suitable method to further improve their mechanical *** this study,two-stage aging treatment with different pre-aging times was designed and employed to further improve the mechanical properties of HPDC Al8SiMgCuZn *** characteristics of precipitates were evaluated by a transmission electron microscope(TEM),and the precipitation strengthening mechanism was *** results reveal that the strengthening is mainly contributed by the precipitation ofβ″phase after two-stage aging,and the number density and size of the precipitates are significantly depended on the pre-aging *** number density of precipitates is increased with the pre-aging time prolonged from 0 h to 4 h,and then decreases with the further increase of pre-aging time from 4 h to 6 *** precipitates with the highest density and smallest size are observed after pre-aging for 4 *** pre-aged at 100℃for 4 h and then artificial aged at 200℃for 30 min,the yield strength of 207 MPa,ultimate tensile strength of 325 MPa and elongation of 7.6%are achieved.

关键词： high pressure die cast aluminum alloy microstructural heterogeneity mechanical properties precipitation strengthening two-stage aging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

跨学科交叉研究现状与思考——以中南大学湘雅医院为例

引用

中国研究型医院 2024年第4期11卷 8-14页

作者：王少辉胡佩武董婷喻丹何玥唐琨中南大学湘雅医院学科建设办公室中南大学医院管理研究所长沙410008 中南大学湘雅医院科研部长沙410008

目的通过对中南大学湘雅医院近10年发表的科学引文索引(SCI)论文研究领域、合作机构进行统计分析,探索本院医学与多学科交叉研究现状,为医院跨学科交叉研究的深入开展提供参考。方法本研究采用文献计量分析法,基于Web of Science(WOS)... 详细信息

目的通过对中南大学湘雅医院近10年发表的科学引文索引(SCI)论文研究领域、合作机构进行统计分析,探索本院医学与多学科交叉研究现状,为医院跨学科交叉研究的深入开展提供参考。方法本研究采用文献计量分析法,基于Web of Science(WOS)数据库及医院科研管理系统,获取2013—2022年以中南大学湘雅医院为第一或通信单位署名的SCI论文;同时以WOS入藏号为检索条件,获取论文的发表年度、作者地址、学科规范化引文影响力等数据。利用Incites数据平台分析Citation Topics学科引文主题。结果2013—2022年,本院发表的以第一或通信单位署名的SCI论文9523篇,涵盖十大Citation Topics学科引文主题中的200个中观主题、889个微观主题。医学与生命科学领域论文占总发文量的89.6%(8536/9523),包括127个中观主题、707个微观主题;该领域与国内其他单位合作论文占比最高、为36.7%(3130/8536),其次为医院单独署名论文占比26.8%(2293/8536)。非医学与生命科学相关论文占比10.4%(987/9523),包括73个中观主题、182个微观主题;该领域医院单独署名论文占比最高、为35.5%(350/987),其次为与国内其他单位合作论文占比29.4%(290/987)。非医学与生命科学研究领域主要以化学,农业、环境和生态学,工程和材料科学为主。结论校内医学学科之间的交叉融合是医院科学研究的显著特点,跨院系、跨学科的交叉合作需要进一步深化,跨单位、跨地区的交流合作是医院科研活动的重要组成部分。

关键词：科技论文交叉学科附属医院

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SnO_(2)的光催化性能及参杂改性研究

引用

辽宁化工 2024年第9期53卷 1328-1331页

作者：赵丽杨文龙陈其虎董婷徐珮珮酒泉职业技术学院甘肃酒泉735000 甘肃省太阳能发电系统工程重点实验室甘肃酒泉735000 青岛西海岸新区中德应用技术学校山东青岛266000

近年全球工业化进程加快,基于环境保护考虑,半导体光催化技术因无毒、无害、降解有机污染物彻底且速度快等优点而成为解决污染问题的有效途径之一。SnO_(2)理论上能够产生具有强氧化性和还原性的活性基团,但该材料在常规尺寸下量子产率... 详细信息

近年全球工业化进程加快,基于环境保护考虑,半导体光催化技术因无毒、无害、降解有机污染物彻底且速度快等优点而成为解决污染问题的有效途径之一。SnO_(2)理论上能够产生具有强氧化性和还原性的活性基团,但该材料在常规尺寸下量子产率低且活性位点少,主要简述了离子参杂改性SnO_(2)光催化性质的研究进展。

关键词：光催化改性参杂

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

‘红颜’草莓的假植栽培

引用

北方果树 2024年第4期 49-50,66页

作者：杨远杰陈晓旭马廷东王应玲丹东市圣野浆果专业合作社辽宁丹东118300

在辽宁省丹东市,有一种传统的草莓栽培模式——假植栽培。相比较于常规栽培,假植栽培能提前10~15 d上市,且盛果期相对较集中;与冷藏栽培模式比,假植栽培虽然上市时间没有优势,但是假植栽培能做到整个生产周期不断茬。根据多年的栽培管... 详细信息

在辽宁省丹东市,有一种传统的草莓栽培模式——假植栽培。相比较于常规栽培,假植栽培能提前10~15 d上市,且盛果期相对较集中;与冷藏栽培模式比,假植栽培虽然上市时间没有优势,但是假植栽培能做到整个生产周期不断茬。根据多年的栽培管理经验,现将这个栽培模式总结出来,希望能为广大种植者带来技术上的帮助。

关键词： ‘红颜’草莓假植栽培假植苗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

体表子宫肌电监测技术在控释地诺前列酮栓促宫颈成熟中的临床探索

引用

生殖医学杂志 2024年第7期33卷 913-918页

作者：程丹玲杨金英周冰倩潘秀玉董婷婷刘慧姝深圳市龙岗区妇幼保健院(汕头大学医学院龙岗妇幼临床学院) 深圳518000 广州医科大学广州市妇女儿童医疗中心广州510623

目的应用体表子宫肌电监测技术探讨控释地诺前列酮栓促宫颈成熟时子宫肌电活动及其与临床结局的关系。方法选择2020年1月至2023年1月在广州市妇女儿童医疗中心促宫颈成熟的单胎、头位孕妇89例,观察放置控释地诺前列酮栓后子宫肌电活... 详细信息

目的应用体表子宫肌电监测技术探讨控释地诺前列酮栓促宫颈成熟时子宫肌电活动及其与临床结局的关系。方法选择2020年1月至2023年1月在广州市妇女儿童医疗中心促宫颈成熟的单胎、头位孕妇89例,观察放置控释地诺前列酮栓后子宫肌电活动情况,并比较放置控释地诺前列酮栓不同时间出现子宫肌电爆发波的孕妇间临床结局的差异。结果 (1)控释地诺前列酮栓放置后肌电爆发波出现时间与促宫颈成熟耗时、临产间隔、放置至分娩用时呈正相关(P0.05)。结论放置控释地诺前列酮栓较早出现子宫肌电活动的孕妇促宫颈成熟时间更短、24 h阴道分娩率更高,但需重视产后出血发生风险。

关键词：控释地诺前列酮栓引产体表子宫肌电监测技术促宫颈成熟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Immune regulation of the gut-brain axis and lung-brain axis involved in ischemic stroke

引用

Neural Regeneration Research 2024年第3期19卷 519-528页

作者： Xiaodi Xie Lei Wang Shanshan dong ShanChun Ge ting Zhu Institute of Neuroregeneration&Neurorehabilitation Department of PathophysiologySchool of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjingJiangsu ProvinceChina Department of Rehabilitation Medicine The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Local ischemia often causes a series of inflammatory reactions when both brain immune cells and the peripheral immune response are *** the human body,the gut and lung are regarded as the key reactional targets that are initiated by brain ischemic *** microorganisms play an important role in immune regulation and metabolism and affect blood-brain barrier *** addition to the relationship between peripheral organs and central areas and the intestine and lung also interact among each ***,we review the molecular and cellular immune mechanisms involved in the pathways of inflammation across the gut-brain axis and lung-brain *** found that abnormal intestinal flora,the intestinal microenvironment,lung infection,chronic diseases,and mechanical ventilation can worsen the outcome of ischemic *** review also introduces the influence of the brain on the gut and lungs after stroke,highlighting the bidirectional feedback effect among the gut,lungs,and brain.

关键词： enteric glia cells gut microbiota gut-brain axis immune response inflammation ischemic stroke lung-brain axis microglia

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tunable Supercontinuum Generated in a Yb^3＋-Doped Microstructure Fiber Pumped by Ti：Sapphire Femtosecond Laser

引用

Chinese Physics Letters 2018年第10期35卷 31-35页

作者： Wei Wang Fan-Chao Meng Vuan Qing Shi Qiu ting-ting dong Wei-Zhen Zhu Yu-ting Zuo Ying nan Chao Wang Yue-Feng Qi Lan-Tian Hou School of Information Science and Engineering Yanshan University Qinhuangdao 066004 Jiangsu Key Laboratory of Meteorological Observation and Information Processing Nanjing University of Information Science and Technology Nanjing 210000 Key Laboratory for Special Fiber and Fiber Sensor of Hebei Province Qinhuangdao 066004 Intelligence and Information Engineering college Tangshan University Tangshan 063000

We experimentally demonstrate that a tunable supercontinuum（SC） can be generated in a Yb3＋-doped microstructure fiber by the concept of wavelength conversion with a Ti：sapphire femtosecond（fs） laser as the *** results show that an emission light around 1040 nm in an anomalous dispersion region is first generated and amplified by fs pulses in the normal dispersion region. Then, SC spectra from 1100 to 1380 nm and 630 to 840 nm can be achieved by combined effects of higher-order soliton fission and Raman soliton self-frequency shift in the anomalous dispersion region and self-phase modulation, dispersive wave, and four-wave mixing in the normal dispersion region. It is also demonstrated that the 20 nm change of pump results in a 280 nm broadband shift of soliton and the further red-shift of soliton is limited by OH-absorption at 1380 nm.

关键词： Tunable Supercontinuum Generated in a Yb length MSF SC Doped Microstructure Fiber Pumped by Ti:Sapphire Femtosecond Laser Ti

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：