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18q末端缺失综合征伴主动脉瓣关闭不全1例患儿的遗传学分析及文献回顾

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中华医学遗传学杂志 2024年第10期41卷 1259-1263页

作者：崔慧敏张芳尹婷王志伟王鑫顾青青张璟璐谭娟连云港市妇幼保健院连云港222000

摘要目的探讨1例18q末端缺失综合征患儿的遗传学特征。方法选取2023年7月20日于连云港市妇幼保健院就诊的1例18q末端缺失综合征患儿作为研究对象,回顾性分析患儿的临床资料。抽取患儿的外周血样,进行染色体G显带核型分析和染色体微阵列... 详细信息

摘要目的探讨1例18q末端缺失综合征患儿的遗传学特征。方法选取2023年7月20日于连云港市妇幼保健院就诊的1例18q末端缺失综合征患儿作为研究对象,回顾性分析患儿的临床资料。抽取患儿的外周血样,进行染色体G显带核型分析和染色体微阵列分析(CMA),对患儿父母的外周血样进行染色体G显带核型分析。在中国知网、万方数据知识服务平台以及PubMed数据库中以"18q-综合征""18q缺失综合征""18q-syndrome""18q deletion syndrome""18q terminal deletion"为关键词,检索2013年11月1日至2023年11月1日合并心脏发育异常的文献并进行分析。本研究通过江苏省连云港市妇幼保健院医学伦理委员会的审查(伦理号:LYG-MER2021017)。结果患儿为4岁6月龄女性,表现为身材矮小、智力低下、特殊面容、主动脉瓣关闭不全、双侧外耳道闭锁以及脑白质影像学改变。其外周血G显带核型为46,XX,del(18)(q21),CMA检测结果为arr[GRCh37]18q21.33q23(60065821_77317445)×1,患儿父母染色体核型均未见异常。文献回顾共检索到7篇文献,共涉及11个病例,所有病例均存在18q23区域缺失。18q末端缺失综合征心脏发育异常表型多样,以肺动脉狭窄(27.3%,3/11)、房间隔缺损(27.3%,3/11)和室间隔缺损(27.3%,3/11)最为常见。结论18q末端缺失可能是导致患儿生长智力发育迟缓、特殊面容、心脏发育异常、外耳道闭锁以及脑白质发育不良的遗传学病因。

关键词：主动脉瓣关闭不全 18q末端缺失综合征心脏发育异常染色体G显带核型分析染色体微阵列分析

Joint Optimization of Resource Allocation and Trajectory Based on User Trajectory for UAV-Assisted Backscatter Communication System

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China Communications 2024年第2期21卷 197-209页

作者： Peizhong Xie Junjie Jiang ting Li yin Lu School of Communication and Information Engineering Nanjing University of Posts and TelecommunicationsNanjing 210003China Key Lab of Broadband Wireless Communication and Sensor Network Technology(Nanjing University of Posts and Telecommunications) Ministry of EducationNanjing 210003China

The Backscatter communication has gained widespread attention from academia and industry in recent years. In this paper, A method of resource allocation and trajectory optimization is proposed for UAV-assisted backscatter communication based on user trajectory. This paper will establish an optimization problem of jointly optimizing the UAV trajectories, UAV transmission power and BD scheduling based on the large-scale channel state signals estimated in advance of the known user trajectories, taking into account the constraints of BD data and working energy consumption, to maximize the energy efficiency of the system. The problem is a non-convex optimization problem in fractional form, and there is nonlinear coupling between optimization *** iterative algorithm is proposed based on Dinkelbach algorithm, block coordinate descent method and continuous convex optimization technology. First, the objective function is converted into a non-fractional programming problem based on Dinkelbach method,and then the block coordinate descent method is used to decompose the original complex problem into three independent sub-problems. Finally, the successive convex approximation method is used to solve the trajectory optimization sub-problem. The simulation results show that the proposed scheme and algorithm have obvious energy efficiency gains compared with the comparison scheme.

关键词： energy efficiency joint optimization UAV-assisted backscatter communication user trajectory

膳食炎症指数与血清炎症标志物和血脂异常的相关性研究

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宁夏医科大学学报 2024年第2期46卷 176-181页

作者：张亚娣李小霞尹婷杨婵张毓洪赵燚宁夏医科大学公共卫生学院银川750004 宁夏环境因素与慢性病控制重点实验室银川750004 宁夏医科大学护理学院银川750004

目的探讨能量调整的膳食炎症指数(energy-adjusted DII,E-DII)与炎性因子和血脂异常之间的关系。方法数据来自宁夏自然人群队列,按照成组匹配的病例对照研究纳入病例组(血脂异常者)245例和对照组247例。膳食调查采用食物频率法并计算E-... 详细信息

目的探讨能量调整的膳食炎症指数(energy-adjusted DII,E-DII)与炎性因子和血脂异常之间的关系。方法数据来自宁夏自然人群队列,按照成组匹配的病例对照研究纳入病例组(血脂异常者)245例和对照组247例。膳食调查采用食物频率法并计算E-DII。利用Spearman相关和二元Logistic回归模型分别分析E-DII与炎性因子和血脂异常的关系。结果病例组的血脂指标(TC、TG、LDL-C)和炎性因子(IL-2、IL-6、TNF-α)的平均值高于对照组,IL-18低于对照组(P均0.05)。将E-DII按三分位数分组,在中性组IL-6与E-DII呈正相关(r=0.162,P=0.038),在促炎倾向组E-DII与IL-18呈负相关(r=-0.188,P=0.016)。在Logistics回归模型中,经调整混杂因素前后,以及在糖尿病和非糖尿患者群亚组分析中,未发现E-DII和血脂异常的关联,经趋势性检验差异无统计学意义(P均>0.05)。结论E-DII与IL-6和IL-18相关,尚未发现其与血脂异常的关联。

关键词：能量调整的膳食炎症指数血脂异常炎症标志物病例对照研究

N-doped coaxial CNTs@a-Fe_2O_3@C nanofibers as anode material for high performance lithium ion battery

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Journal of Energy Chemistry 2018年第5期27卷 1453-1460页

作者： Peng Huang Wei Tao Haixia Wu Xiaogang Li ting yin Qian Zhang Wen Qi Guo Gao Daxiang Cui Institute of Nano Biomedicine and Engineering. Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument Department of Instrument Science and Engineering. School of Electronic Information and Electrical Engineering. Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China College of Chemistry and Bioengineering Yichun University Yichun 336000 Jiangxi China

N-doped coaxial CNTs@α-Fe_2O_3@C nanofibers have been successfully synthesized according to a facile solvothermal/hydrothermal method. The obtained CNTs@α-Fe_2O_3@C nanofibers composites exhibited spe- cial three-dimensional （3-D） network structure, which endows they promising candidate for anode ma- terials of lithium ion battery. The coaxial property of CNTs@α-Fe_2O_3@C nanofibers could significantly improve the cycling and rate performance owing to the acceleration of charge/electron transfer, improve- ment of conductivity, maintaining of structural integrity and inhibiting the aggregation. The α-Fe_2O_3 nanoparticles with small size and high percentage of N-doped amount could further improve the elec- trochemical performance. As for the CNTs@α-Fe_2O_3@C nanofibers, the capacity presented a high value of 1255.4 mAh/g at 0.1 C, and retained at 1213.4 mAh/g after 60 cycles. Even at high rate of 5 C, the ca- pacity still exhibited as high as 319 mAh/g. The results indicated that the synthesized N-doped coaxial CNTs@α-Fe_2O_3@C nanofibers exhibited high cvcling and rate oerformance.

关键词： N-doped Coaxial nanofibers Lithium batteries α-Fe_2O_3

Structure and photocatalytic properties of TiO_2-Graphene Oxide intercalated composite

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Chinese Science Bulletin 2011年第3期56卷 331-339页

作者： ZHANG Qiong HE YunQiu CHEN XiaoGang HU DongHu LI LinJiang yin ting JI LingLi School of Materials Science and Engineering Tongji University Shanghai 200092 China

TiO2-Graphene Oxide intercalated composite (TiO2-Graphene Oxide) has been successfully prepared at low temperature (80°C) with graphite oxide (GO) and titanium sulfate (Ti(SO4)2) as initial *** was firstly exfoliated by NaOH and formed single and multi-layered graphite oxide mixture which can be defined as graphene oxide,[TiO]2+ induced by the hydrolysis of Ti(SO4)2 diffused into graphene oxide interlayer by electrostatic *** nucleation and growth of TiO2 crystallites took place at low temperature and TiO2-Graphene Oxide composite was successfully ***,the photocatalytic properties of TiO2-Graphene Oxide under the irradiation of UV light were also *** results show that the degradation rate of methyl orange is 1.16 mg min-1 g-1(refer to the efficiency of the initial 15 min).Compared with P25 powder,this kind of intercalation composite owns much better *** the other hand,the reusable properties and stable properties of TiO2-Graphene Oxide intercalated composite are also discussed in this *** last,crystalline structure,interface status,thermal properties and microscopic structure of TiO2-Graphene Oxide were characterized by X-ray diffraction (XRD),X-ray photoelectron spectroscopy (XPS),thermogravimetric analysis (TGA),field emission scanning electron microscopy (FESEM) and high-resolution Transmission Electron Microscopy (HRTEM).Also,we have analyzed major influencing factors and mechanism of the composite structures which evidently improve the photocatalytic properties.

关键词：光催化性能复合氧化物二氧化钛石墨插层晶体结构高分辨透射电子显微镜场发射扫描电子显微镜 Ti(SO4)2

Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity

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Signal Transduction and Targeted Therapy 2023年第10期8卷 5046-5058页

作者： Huangcan Li Xiong Wang Yiran Wang Yichen Li ying Chen yin-ting Wong Jufang He Ming-Liang He Department of Biomedical Sciences City University of Hong KongHong KongChina CityU Shenzhen Research Institute NanshanShenzhenChina Department of Neurosciences City University of Hong KongHong KongChina

variety of ways to antagonize host defense through eliminating IFN-signaling intracellularly for ***,the way by viruses target IFN-signaling extracellularly has not been *** by both coronavirus SARS-CoV-2 and enterovi... 详细信息

关键词： immunity diseases eliminating

基于数据挖掘算法的大学生就业分析——以韩山师范学院统计学专业为例

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韩山师范学院学报 2024年第3期45卷 68-75页

作者：陈烁权钟银婷佘梓润佘梓航韩山师范学院数学与统计学院广东潮州521041 维捷布斯克国立工艺大学经济与工商管理学院维捷布斯克211322

为探讨毕业生的就业情况,使用python软件,对195位毕业生,从大学学业成绩、就业地点、就业薪资等方面进行数据分析.结果表明,生源地与就业地点之间存在一定的关联性,生源地在三、四线城市的学生更倾向于一线城市就业.学业成绩与就业薪资... 详细信息

为探讨毕业生的就业情况,使用python软件,对195位毕业生,从大学学业成绩、就业地点、就业薪资等方面进行数据分析.结果表明,生源地与就业地点之间存在一定的关联性,生源地在三、四线城市的学生更倾向于一线城市就业.学业成绩与就业薪资之间也具有一定的关联性,优秀的成绩往往使毕业生获得更好的就业机会和更高的薪资.此外,不同的单位类型、所属行业、职业类型对毕业生的初次就业薪资也有一定的影响,而初次就业地点、学生毕业去向以及性别对学生就业薪资水平的影响则相对较小.

关键词：随机森林算法关联规则 python 学业成绩薪资

西藏日喀则地区清洁能源集中供暖热源探索研究

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洁净与空调技术 2024年第3期 78-82页

作者：王京南殷婷杨泽洪罗放许艳李姝颖不详

从西藏日喀则地区的资源禀赋出发,分析清洁能源——生物质能、太阳能、地热能、天然气、清洁电能等用于集中供暖的适用性。并在清洁能源分析的基础上,对适用性热源(生物质能、太阳能、地热能、天然气、清洁电能等)进行投资运行经济性分... 详细信息

从西藏日喀则地区的资源禀赋出发,分析清洁能源——生物质能、太阳能、地热能、天然气、清洁电能等用于集中供暖的适用性。并在清洁能源分析的基础上,对适用性热源(生物质能、太阳能、地热能、天然气、清洁电能等)进行投资运行经济性分析,从投资运行经济性角度对西藏日喀则地区清洁能源集中供暖热源进行推荐。

关键词：日喀则集中供暖热源空气源热泵

USP19 Stabilizes TAK1 to Regulate High Glucose/Free Fatty Acid-induced Dysfunction in HK-2 Cells

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Current Medical Science 2024年第4期44卷 707-717页

作者： Xiao-hui YAN yin-na ZHU Yan-ting ZHU Kidney Disease and Dialysis Center Shaanxi Provincial People's HospitalXi'an 710068China Department of Nephrology The Third Affiliated Hospital of Xi'an Medical UniversityXi'an 710000China Nephrology and Hemodialysis Center Shaanxi Provincial People's HospitalXi'an 710068China

Objective Obesity-induced kidney injury contributes to the development of diabetic nephropathy(DN).Here,we identified the functions of ubiquitin-specific peptidase 19(USP19)in HK-2 cells exposed to a combination of high glucose(HG)and free fatty acid(FFA)and determined its association with TGF-beta-activated kinase 1(TAK1).Methods HK-2 cells were exposed to a combination of HG and ***19 mRNA expression was detected by quantitative RT-PCR(qRT-PCR),and protein analysis was performed by immunoblotting(IB).Cell growth was assessed by Cell Counting Kit-8(CCK-8)viability and 5-ethynyl-2′-deoxyuridine(EdU)proliferation *** cycle distribution and apoptosis were detected by flow *** USP19/TAK1 interaction and ubiquitinated TAK1 levels were assayed by coimmunoprecipitation(Co-IP)assays and *** In HG+FFA-challenged HK-2 cells,USP19 was highly ***19 knockdown attenuated HG+FFA-triggered growth inhibition and apoptosis promotion in HK-2 ***,USP19 knockdown alleviated HG+FFA-mediated PTEN-induced putative kinase 1(PINK1)/Parkin pathway inactivation and increased mitochondrial reactive oxygen species(ROS)generation in HK-2 ***,USP19 stabilized the TAK1 protein through ***,increased TAK1 expression reversed the USP19 knockdown-mediated phenotypic changes and PINK1/Parkin pathway activation in HG+FFA-challenged HK-2 *** The findings revealed that USP19 plays a crucial role in promoting HK-2 cell dysfunction induced by combined stimulation with HG and FFAs by stabilizing TAK1,providing a potential therapeutic strategy for combating DN.

关键词： HK-2 cells high glucose free fatty acid dysfunction USP19 deubiquitination