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Research advance of Bacillus velezensis:bioinformatics,characteristics,and applications

Food Science and Human Wellness 2024年第4期13卷 1756-1766页

作者： ting su Biao Shen Xingjuan Hu Yue Teng Peifang Weng Zufang Wu Lianliang Liu State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Key Laboratory of Animal Protein Deep Processing Technology of ZhejiangZhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and NutritionSchool of Food and Pharmaceutical SciencesNingbo UniversityNingbo 315000China Zhoushan Customs District Zhoushan 316100China

Bacillus velezensis is a Gram-positive and spore-forming bacterium.It has potent antimicrobial properties that can be used to promote plant growth and as a pesticide by inhibiting pathogens.B.velezensis has the capability to generate a diverse range of enzymes that have potential applications in various fields,such as enzyme production,fermented food,degradation of pollutants,and bioenergy.In addition,B.velezensis is a promising probiotic.It possesses high bile-salt tolerance characteristics and has a high success rate of colonization in the intestinal mucosa.Besides,the strain can also regulate gut microbiota constitute by increasing the number of beneficial microorganisms and decreasing the number of pathogens.Furthermore,based on its special properties,including high-yield protease production and high salt-tolerance,B.velezensis shows potential for use in marine protein fermentation,opening up new avenues for the development of novel food products and bioactive peptides.In addition,B.velezensis can shorten the fermentation time as well as improve the nutritional value and flavor of fermented food.The safety of B.velezensis for food production was evaluated.This review provides valuable insights into the potential uses and benefits of B.velezensis,particularly in the context of fermented foods.

关键词： Bacillus velezensis Bioinformatics Properties Fermentation Bioactive peptides

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Trametinib boosts palbociclib’s efficacy in breast cancer via autophagy inhibition

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Oncology Research 2024年第7期32卷 1197-1207页

作者： ANGUO WU JIAO YAN ting su CHI FENG XIN LONG YIRU PAN RUPEI YE TIAN XIA HANAN LONG JIANMING WU XIULI XIAO Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaKey Laboratory of Medical Electrophysiology of Ministry of EducationSchool of PharmacySouthwest Medical UniversityLuzhou646000China The Department of Pathology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China The Department of Pathology Mianyang Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaMianyang621000China The Department of Pathology Yongchuan Hospital of Chongqing Medical UniversityChongqing402160China School of Basic Medical Sciences Southwest Medical UniversityLuzhou646000China School of Clinical Medical Sciences Southwest Medical UniversityLuzhou646000China

Breast cancer,a predominant global health issue,requires ongoing exploration of new therapeutic strategies.Palbociclib(PAL),a well-known cyclin-dependent kinase(CDK)inhibitor,plays a critical role in breast cancer treatment.While its efﬁcacy is recognized,the interplay between PAL and cellular autophagy,particularly in the context of the RAF/MEK/ERK signaling pathway,remains insufﬁciently explored.This study investigates PAL’s inhibitory effects on breast cancer using both in vitro(MCF7 and MDA-MB-468 cells)and in vivo(tumor-bearing nude mice)models.Aimed at elucidating the impact of PAL on autophagic processes and exploring the potential of combining it with trametinib(TRA),an MEK inhibitor,our research seeks to address the challenge of PAL-induced drug resistance.Ourﬁndings reveal that PAL signiﬁcantly decreases the viability of MCF7 and MDA-MB-468 cells and reduces tumor size in mice while showing minimal cytotoxicity in MCF10A cells.However,PAL also induces protective autophagy,potentially leading to drug resistance via the RAF/MEK/ERK pathway activation.Introducing TRA effectively neutralized this autophagy,enhancing PAL’s anti-tumor efﬁcacy.A combination of PAL and TRA synergistically reduced cell viability and proliferation,and in vivo studies showed notable tumor size reduction.In conclusion,the PAL and TRA combination emerges as a promising strategy for overcoming PAL-induced resistance,offering a new horizon in breast cancer treatment.

关键词： Palbociclib Trametinib Protective autophagy RAF/MEK/ERK MCF7 MDA-MB-468

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Prospects in the application of ultrasensitive chromosomal aneuploidy detection in precancerous lesions of gastric cancer

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World Journal of Gastrointestinal surgery 2024年第1期16卷 6-12页

作者： su-ting Qian Fei-Fei Xie Hao-Yu Zhao Qing-Sheng Liu Dan-Li Cai Department of Digestive Hangzhou Hospital of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina Science and Education Section Hangzhou Hospital of Traditional Chinese MedicineHangzhou 310007Zhejiang ProvinceChina Intensive Care Unit The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 311122Zhejiang ProvinceChina

Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.

关键词： Gastric cancer Precancerous lesions of gastric cancer Molecular typing Ultrasensitive chromosomal aneuploidy detection Adjuvant therapy Application prospects

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Ionizable polymeric nanocarriers for the codelivery of bi-adjuvant and neoantigens in combination tumor immunotherapy

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Bioactive Materials 2023年第8期26卷 169-180页

作者： ting su Xiang Liu Shuibin Lin Furong Cheng Guizhi Zhu Center for Translational Medicine Precision Medicine InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Department of Pharmaceutics and Center for Pharmaceutical Engineering and Sciences Institute for Structural Biology and Drug DiscoverySchool of PharmacyThe Developmental Therapeutics ProgramMassey Cancer CenterVirginia Commonwealth UniversityRichmondVA23298USA

Ionizable lipid nanocarriers have made historical contribution to COVID-19 mRNA vaccines.Here,we report ionizable polymeric nanoparticles that co-deliver bi-adjuvant and neoantigen peptides for cancer immunotherapy in combination with immune checkpoint blockade(ICB).Current cancer ICB benefits only a small subset of patients,largely due to a lack of pre-existing target cells and checkpoint targets for ICB,tumor antigenic heterogeneity,and tumor immunosuppression.Therapeutic vaccines hold the potential to enhance ICB therapeutic efficacy by expanding antitumor cell repertoires,upregulating immune checkpoint levels and hence sensitizing ICB,and reducing tumor immunosuppression.Chemically defined peptide vaccines are attractive,but their current therapeutic efficacy has been limited due to 1)poor vaccine delivery to immunomodulatory lymph nodes(LNs)and antigen(Ag)-presenting cells(APCs),2)poor immunostimulant adjuvant efficacy with restricted target cell subsets in humans,3)limited adjuvant/Ag codelivery to enhance Ag immunogenicity,and 4)limited ability to overcome tumor antigenic heterogeneity.Here,we developed nanovaccines(NVs)using pH-responsive polymeric micellular nanoparticles(NPs)for the codelivery of bi-adjuvant[Toll-like receptor(TLR)7/8 agonist R848 and TLR9 agonist CpG]and peptide neoantigens(neoAgs)to draining LNs for efficient Ag presentation in a broad range of APC subsets.These NVs potentiated the immunogenicity of peptide Ags and elicits robust antitumor T cell responses with memory,and remodeled the tumor immune milium with reduced tumor immunosuppression.As a result,NVs significantly enhanced ICB therapeutic efficacy for murine colorectal tumors and orthotopic glioblastoma multiforme(GBM).These results suggest marked potential of bi-adjuvant/neoAg-codelivering NVs for combination cancer immunotherapy.

关键词： Polymeric nanoparticles Combination adjuvants Cancer neoantigen Nanovaccine codelivery Cancer immunotherapy

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Recent advances in memristors based on two-dimensional ferroelectric materials

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Frontiers of physics 2024年第1期19卷 195-218页

作者： Wenbiao Niu Guanglong Ding Ziqi Jia Xin-Qi Ma JiYu Zhao Kui Zhou su-ting Han Chi-Ching Kuo Ye Zhou Institute for Advanced Study Shenzhen UniversityShenzhen 518060China College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China Institute of Organic and Polymeric Materials Research and Development Center of Smart Textile TechnologyTaipei University of TechnologyTaipei 10608TaiwanChina

In this big data era, the explosive growth of information puts ultra-high demands on the data storage/computing, such as high computing power, low energy consumption, and excellent stability. However, facing this challenge, the traditional von Neumann architecture-based computing system is out of its depth owing to the separated memory and data processing unit architecture. One of the most effective ways to solve this challenge is building brain inspired computing system with in-memory computing and parallel processing ability based on neuromorphic devices. Therefore, there is a research trend toward the memristors, that can be applied to build neuromorphic computing systems due to their large switching ratio, high storage density, low power consumption, and high stability. Two-dimensional (2D) ferroelectric materials, as novel types of functional materials, show great potential in the preparations of memristors because of the atomic scale thickness, high carrier mobility, mechanical flexibility, and thermal stability. 2D ferroelectric materials can realize resistive switching (RS) because of the presence of natural dipoles whose direction can be flipped with the change of the applied electric field thus producing different polarizations, therefore, making them powerful candidates for future data storage and computing. In this review article, we introduce the physical mechanisms, characterizations, and synthetic methods of 2D ferroelectric materials, and then summarize the applications of 2D ferroelectric materials in memristors for memory and synaptic devices. At last, we deliberate the advantages and future challenges of 2D ferroelectric materials in the application of memristors devices.

关键词： two-dimensional ferroelectric materials synthesis strategies memristors artificial synapses

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QBFO-BOMP Based Channel Estimation Algorithm for mmWave Massive MIMO Systems

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Computer Modeling in Engineering & Sciences 2023年第11期137卷 1789-1804页

作者： Xiaoli Jing Xianpeng Wang Xiang Lan ting su State Key Laboratory of Marine Resource Utilization in South China Sea and School of Information and Communication Engineering Hainan UniversityHaikou570228China

At present,the traditional channel estimation algorithms have the disadvantages of over-reliance on initial conditions and high complexity.The bacterial foraging optimization(BFO)-based algorithm has been applied in wireless communication and signal processing because of its simple operation and strong self-organization ability.But the BFO-based algorithm is easy to fall into local optimum.Therefore,this paper proposes the quantum bacterial foraging optimization(QBFO)-binary orthogonal matching pursuit(BOMP)channel estimation algorithm to the problem of local optimization.Firstly,the binary matrix is constructed according to whether atoms are selected or not.And the support set of the sparse signal is recovered according to the BOMP-based algorithm.Then,the QBFO-based algorithm is used to obtain the estimated channel matrix.The optimization function of the least squares method is taken as the fitness function.Based on the communication between the quantum bacteria and the fitness function value,chemotaxis,reproduction and dispersion operations are carried out to update the bacteria position.Simulation results showthat compared with other algorithms,the estimationmechanism based onQBFOBOMP algorithm can effectively improve the channel estimation performance of millimeter wave(mmWave)massive multiple input multiple output(MIMO)systems.Meanwhile,the analysis of the time ratio shows that the quantization of the bacteria does not significantly increase the complexity.

关键词： Channel estimation bacterial foraging optimization quantum bacterial foraging optimization binary orthogonal matching pursuit massive MIMO

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Research advance of Bacillus velezensis: bioinformatics， characteristics， and applications

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Food Science and Human Wellness 2023年

作者： ting su Biao Shen Xingjuan Hu Yue Teng Peifang Weng Zufang Wu Lianliang Liu Zhoushan Customs District State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition School of Food and Pharmaceutical Sciences Ningbo University

Bacillus velezensis is a gram-positive and spore-forming bacterium. It has potent antimicrobial properties that can be used to promote plant growth and as a pesticide by inhibiting pathogens. B. velezensis has the capability to generate a diverse range of enzymes that have potential applications in various fields， such as enzyme production， fermented food， degradation of pollutants， and bioenergy. In addition， B. velezensis is a promising probiotic. It possesses high bile-salt tolerance characteristics and has a high success rate of colonization in the intestinal mucosa. Besides， the strain can also regulate gut microbiota constitute by increasing the number of beneficial microorganisms and decreasing the number of pathogens. Furthermore， based on its special properties， including high-yield protease production and high salt-tolerance， B. velezensis shows potential for use in marine protein fermentation， opening up new avenues for the development of novel food products and bioactive peptides. In addition， B. velezensis can shorten the fermentation time as well as improve the nutritional value and flavor of fermented food. The safety of B. velezensis for food production was evaluated. This review provides valuable insights into the potential uses and benefits of B. velezensis， particularly in the context of fermented foods.

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Automated coverage-driven testing: combining symbolic execution and model checking

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Science China(Information Sciences) 2016年第9期59卷 242-243页

作者： ting su Geguang PU Weikai MIAO Jifeng HE Zhendong su Shanghai Key Laboratory of Trustworthy Computing East China Normal University Department of Computer Science University of California

Software testing is the primary way to ensure software quality,but occupies more than 50%the cost of software development[1].It was estimated that software failures cost the US economy alone about 60 billion each year... 详细信息

关键词： test combining symbolic execution and model checking Automated coverage-driven testing DSE code

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Integrable Variable-coefficient Coupled Cylindrical NLS Equations and Their Explicit Solutions

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Acta Mathematicae Applicatae Sinica 2014年第4期30卷 1017-1024页

作者： ting su Guo-hua DING Jian-yin FANG Department of Mathematical and Physical Science Henan Institute of Engineering

Based on the generalized dressing method, we propose integrable variable coefficient coupled cylin-drical nonlinear SchrSdinger equations and their Lax pairs. As applications, their explicit solutions and their reduct... 详细信息

关键词： variable-coefficient coupled NLS equations the generalized dressing method integrability

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大学校区内体育社团培养学生运动技能的研究

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当代体育科技 2024年第6期14卷 156-159页

作者：苏婷陕西国防工业职业技术学院陕西西安710300

体育社团是学校中一个重要的组织,通过提供丰富多样的体育活动和训练机会,帮助学生全面发展。该研究旨在探讨利用校区内体育社团培养学生运动技能的有效性和可行性。通过对相关文献的综述和实地调查,发现校区内体育社团在培养学生运动... 详细信息

体育社团是学校中一个重要的组织,通过提供丰富多样的体育活动和训练机会,帮助学生全面发展。该研究旨在探讨利用校区内体育社团培养学生运动技能的有效性和可行性。通过对相关文献的综述和实地调查,发现校区内体育社团在培养学生运动技能方面具有巨大潜力,该文将分析校区内体育社团对学生运动技能培养的影响因素,并提出一些建议,以优化校区内体育社团的运作。

关键词：大学校区体育社团大学生运动技能

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