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Roles of nanoparticles in arsenic mobility and microbial community composition in arsenic-enriched soils

Journal of Environmental Sciences 2024年第4期138卷 301-311页

作者： ting luo Qining Zheng Jie Yu Weihao Liang Yan Sun Guixiang Quan Feng Zhou School of Environmental Science and Engineering Yancheng Institute of TechnologyYancheng 224051China Jiangsu Provincial Key Laboratory of Coastal Ecology and Pollution Control Yancheng 224051China School ofEnvironment and Civil Engineering Jiangnan UniversityWuxi 214122China

Environmental effects of nano remediation engineering of arsenic(As)pollution need to be considered.In this study,the roles of Fe_(2)O_(3)and TiO_(2)nanoparticles(NPs)on the microbial mediated As mobilization from As contaminated soil were investigated.The addition of Fe_(2)O_(3)and TiO_(2)NPs restrained As(V)release,and stimulated As(Ⅲ)release.As(V)concentration decreased by 94% and 93% after Fe_(2)O_(3)addition,and decreased by 89% and 45% after Ti O_(2)addition compared to the Biotic and Biotic+Acetate(amended with sodium acetate)controls,respectively.The maximum values of As(Ⅲ)were 20.5 and 27.1μg/L at 48 d after Fe_(2)O_(3)and TiO_(2)NPs addition,respectively,and were higher than that in Biotic+Acetate control(12.9μg/L).The released As co-precipitated with Fe in soils in the presence of Fe_(2)O_(3)NPs,but adsorbed on TiO_(2)NPs in the presence of TiO_(2)NPs.Moreover,the addition of NPs amended with sodium acetate as the electron donor clearly promoted As(V)reduction induced by microbes.The NPs addition changed the relative abundance of soil bacterial community,while Proteobacteria(42.8%-70.4%),Planctomycetes(2.6%-14.3%),and Firmicutes(3.5%-25.4%)were the dominant microorganisms in soils.Several potential As/Fe reducing bacteria were related to Pseudomonas,Geobacter,Desulfuromonas,and Thiobacillus.The addition of Fe_(2)O_(3)and TiO_(2)NPs induced to the decrease of arr A gene.The results indicated that the addition of NPs had a negative impact on soil microbial population in a long term.The findings offer a relatively comprehensive assessment of Fe_(2)O_(3)and TiO_(2)NPs effects on As mobilization and soil bacterial communities.

关键词： Fe_(2)O_(3)and TiO_(2)nanoparticles Arsenic reduction Mobilization Functional gene Microbial community

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A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy

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Chinese Chemical Letters 2024年第3期35卷 332-336页

作者： Dequan Zeng Zhongkai Ma Xin Zan ting luo Xiang Wang Xiang Gao Xianghui Fu School of Health Management Xihua UniversityChengdu 610039China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China College of StomatologySichuan UniversityChengdu 610041China Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengdu 610041China Breast Disease Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

Oral squamous cell carcinoma(OSCC)is known as one of the most malignant tumors with high recurrence and fatality rate.The poor tumor-targeting ability of traditional chemotherapeutic drugs has been a grand challenge for anti-OSCC therapy.Beyond that,a large quantity of tumor associated macrophages in OSCC tissues further diminish the anti-tumor effects of these drugs.Therefore,we produced a therapeutic nano drug delivery system(FA-PEG-PLA-JQ1)through encapsulating JQ1[a small-molecule inhibitor of bromodomain containing protein 4(BRD4)]into the folic acid(FA)-modified nanoparticle(PEG-PLA),which could prolong the half-life of JQ1 and target the tumor tissues.And then,JQ1 released from this nanoparticle could prevent OSCC growth inducing tumor cell apoptosis,inhibiting tumor angiogenesis and the polarization of M2 type macrophages.In conclusion,our date demonstrated the therapeutic benefits of FA-PEG-PLA-JQ1 against OSCC in vivo or in vitro,which could be a novel treatment strategy for OSCC in coming days.

关键词： Folic acid Nanoparticles JQ1 Oral squamous cell carcinoma Macrophages

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Pyrotinib and chrysin synergistically potentiate autophagy in HER2-positive breast cancer

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Signal Transduction and Targeted Therapy 2024年第1期9卷 295-307页

作者： Xiaoxiao Liu Xing Zhang Zhiying Shao Xiaorong Zhong Xin Ding Liang Wu Jie Chen Ping He Yan Cheng Kunrui Zhu Dan Zheng Jing Jing ting luo Institute for Breast Health Medicine Cancer CenterBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Department of Radiation Oncology Cancer CenterAffiliated Hospital of Xuzhou Medical UniversityJiangsu Center for the Collaboration and Innovation of Cancer BiotherapyCancer InstituteXuzhou Medical University221000 XuzhouChina Department of Orthopedics Trauma and Reconstructive SurgeryUniversity Hospital RWTH AachenAachen 52074Germany Cancer Institute Xuzhou Medical University221000 XuzhouJiangsuChina Division of Nephrology and Transplantation Department of Internal MedicineUniversity Medical Center Rotterdam Erasmus MCRotterdam 3015 GDThe Netherlands Institute for Breast Health Medicine Department of General SurgeryBreast CenterWest China HospitalSichuan University610041 ChengduSichuanChina Institute for Breast Health Medicine West China HospitalSichuan University610041 ChengduSichuanChina

Human epidermal growth factor receptor 2(HER2)-positive breast cancer(BC)has been the most challenging subtype of BC,consisting of 20%of BC with an apparent correlation with poor prognosis.Despite that pyrotinib,a new HER2 inhibitor,has led to dramatic improvements in prognosis,the efficacy of pyrotinib monotherapy remains largely restricted due to its acquired resistance.Therefore,identifying a new potential antitumor drug in combination with pyrotinib to amplify therapeutic efficacy is a pressing necessity.Here,we reported a novel combination of pyrotinib with chrysin and explored its antitumor efficacy and the underlying mechanism in HER2-positive BC.We determined that pyrotinib combined with chrysin yielded a potent synergistic effect to induce more evident cell cycle arrest,inhibit the proliferation of BT-474 and SK-BR-3 BC cells,and repress in vivo tumor growth in xenograft mice models.This may be attributed to enhanced autophagy induced by endoplasmic reticulum stress.Furthermore,the combined treatment of pyrotinib and chrysin induced ubiquitination and glucose-6-phosphate dehydrogenase(G6PD)degradation by upregulating zinc finger and BTB/POZ domain-containing family protein 16(ZBTB16)in tumorigenesis of BC.Mechanistically,we identified that miR-16-5p was a potential upstream regulator of ZBTB16,and it showed a significant inverse correlation with ZBTB16.Inhibition of miR-16-5p overexpression by restoring ZBTB16 significantly potentiated the overall antitumor efficacy of pyrotinib combined with chrysin against HER2-positive BC.Together,these findings demonstrate that the combined treatment of pyrotinib and chrysin enhances autophagy in HER2-positive BC through an unrecognized miR-16-5p/ZBTB16/G6PD axis.

关键词： HER2 synergistic Together

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KSKV:Key-Strategy for Key-Value Data Collection with Local Differential Privacy

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3063-3083页

作者： Dan Zhao Yang You Chuanwen luo ting Chen Yang Liu Artificial Intelligence Development Research Center Institute of Scientific and Technical Information of ChinaBeijing100038China Industry Development Department NSFOCUS Inc.BeijingChina School of Information Science and Technology Beijing Forestry UniversityBeijing100083China School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu610054China Institute of Computing Technology China Academy of Railway Sciences Corporation LimitedBeijing10081China

In recent years,the research field of data collection under local differential privacy(LDP)has expanded its focus fromelementary data types to includemore complex structural data,such as set-value and graph data.However,our comprehensive review of existing literature reveals that there needs to be more studies that engage with key-value data collection.Such studies would simultaneously collect the frequencies of keys and the mean of values associated with each key.Additionally,the allocation of the privacy budget between the frequencies of keys and the means of values for each key does not yield an optimal utility tradeoff.Recognizing the importance of obtaining accurate key frequencies and mean estimations for key-value data collection,this paper presents a novel framework:the Key-Strategy Framework forKey-ValueDataCollection under LDP.Initially,theKey-StrategyUnary Encoding(KS-UE)strategy is proposed within non-interactive frameworks for the purpose of privacy budget allocation to achieve precise key frequencies;subsequently,the Key-Strategy Generalized Randomized Response(KS-GRR)strategy is introduced for interactive frameworks to enhance the efficiency of collecting frequent keys through group-anditeration methods.Both strategies are adapted for scenarios in which users possess either a single or multiple key-value pairs.Theoretically,we demonstrate that the variance of KS-UE is lower than that of existing methods.These claims are substantiated through extensive experimental evaluation on real-world datasets,confirming the effectiveness and efficiency of the KS-UE and KS-GRR strategies.

关键词： Key-value local differential privacy frequency estimation mean estimation data perturbation

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Stability of the Rarefaction Wave for a Non-isentropic Navier-Stokes/Allen-Cahn System

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Chinese Annals of Mathematics,Series B 2022年第2期43卷 233-252页

作者： ting luo School of Information Management Jiangxi University of Finance and EconomicsNanchang 330032China

This paper is concerned with the large time behavior of solutions to the Cauchy problem for a one-dimensional compressible non-isentropic Navier-Stokes/Allen-Cahn system which is a combination of the classical Navier-Stokes system with an Allen-Cahn phase field description.Motivated by the relationship between Navier-Stokes/Allen-Cahn and Navier-Stokes,the author can prove that the solutions to the one dimensional compressible non-isentropic Navier-Stokes/Allen-Cahn system tend time-asymptotically to the rarefaction wave,where the strength of the rarefaction wave is not required to be small.The proof is mainly based on a basic energy method.

关键词： Navier-Stokes/Allen-Cahn system Rarefaction wave Stability

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A Combined Genomics and Phenomics Approach is Needed to Boost Breeding in Sugarcane

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Plant Phenomics 2023年第3期5卷 395-398页

作者： ting luo Xiaoyan Liu Prakash Lakshmanan Key Laboratory of Sugarcane Biotechnology and Genetic Improvement(Guangxi) Ministry of Agriculture and Rural AffairsSugarcane Research InstituteGuangxi Academy of Agricultural SciencesGuangxi Key Laboratory of Sugarcane Genetic ImprovementGuangxi Academy of Agricultural SciencesNanning 530007China Interdisciplinary Research Center for Agriculture Green Development in Yangtze River Basin College of Resources and EnvironmentSouthwest UniversityChongqing 400716China Queensland Alliance for Agriculture and Food Innovation University of QueenslandSt Lucia 4067QLDAustralia

Sugarcane is a major food and bioenergy crop globally.It pro-duces~80%of sugar consumed worldwide,with Brazil and India together accounting for 61%of world sugarcane produc-tion in 2021[1].Globally,sugarcane is the 5th largest crop by production value and acreage,and it is also the second largest bioenergy crop[1,2].Modern sugarcane is an interspecific hybrid(Saccharum species hybrid)of wild progenitor species Saccharum officinarum(2n=80;x=10)andSaccharumspon-taneum(2n=40 to 130;x=8)[3].This genetically complex polyploid crop with varied chromosome numbers(100 to 130)has one of the largest genomes(~10 kb)among plants,making sugarcane breeding considerably slow and challenging.

关键词： breeding sugar globally

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Deformable Catalytic Material Derived from Mechanical Flexibility for Hydrogen Evolution Reaction

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Nano-Micro Letters 2024年第2期16卷 287-311页

作者： Fengshun Wang Lingbin Xie Ning Sun ting Zhi Mengyang Zhang Yang Liu Zhongzhong luo Lanhua Yi Qiang Zhao Longlu Wang College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NJUPT)9 WenyuanNanjing 210023People’s Republic of China Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education School of ChemistryXiangtan UniversityXiangtan 411105People’s Republic of China State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)&Institute of Flexible Electronics(Future Technology)Nanjing University of Posts&Telecommunications9 WenyuanNanjing 210023People’s Republic of China

Deformable catalytic material with excellent flexible structure is a new type of catalyst that has been applied in various chemical reactions,especially electrocatalytic hydrogen evolution reaction(HER).In recent years,deformable catalysts for HER have made great progress and would become a research hotspot.The catalytic activities of deformable catalysts could be adjustable by the strain engineering and surface reconfiguration.The surface curvature of flexible catalytic materials is closely related to the electrocatalytic HER properties.Here,firstly,we systematically summarized self-adaptive catalytic performance of deformable catalysts and various micro–nanostructures evolution in catalytic HER process.Secondly,a series of strategies to design highly active catalysts based on the mechanical flexibility of lowdimensional nanomaterials were summarized.Last but not least,we presented the challenges and prospects of the study of flexible and deformable micro–nanostructures of electrocatalysts,which would further deepen the understanding of catalytic mechanisms of deformable HER catalyst.

关键词： Deformable catalytic material Micro-nanostructures evolution Mechanical flexibility Hydrogen evolution reaction

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Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids

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Genes & Diseases 2024年第2期11卷 1066-1081页

作者： Junyan Yan Lu Xiao Di Feng Baolin Chen ting Yang Bei Tong Ruifang luo Yuting Wang Jie Chen Children Nutrition Research Center Children's Hospital of Chongqing Medical UniversityChongqing Key Laboratory of Child Nutrition and HealthMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing 401122China Department of Gastroenterology Children's Hospital of Chongqing Medical UniversityChongqing 401122China

Vitamin A (VA) plays an essential role in modulating both the gut microbiota and gut barrier function.Short-chain fatty acids (SCFAs),as metabolites of the gut microbiota,protect the physiological intestinal barrier;however,they are compromised when VA is deficient.Thus,there is an urgent need to understand how and which SCFAs modulate colonic epithelial barrier integrity in VA deficiency (VAD).Herein,compared with normal VA rats (VAN),at the beginning of pregnancy,we confirmed that the colonic desmosome junction was impaired in the VAD group,and the amounts of acetate,propionate,and butyrate declined because of the decreased abundance of SCFA-producing bacteria (Romboutsia ,Collinsella ,and Allobaculum ).The differentially expressed genes correlated with the gut barrier and the histone deacetylase complex between the VAD and VAN groups were enriched by RNA sequencing.In the VAD group,the expression levels of colonic CEA cell adhesion molecule 1 (CEACAM1) were down-regulated,and the levels of histone deacetylase 1 (HDAC1) and HDAC3 were up-regulated.Intriguingly,the above changes in the VAD groups were rescued by VA supplementation in the early postnatal period.Further study indicated that in Caco-2 cells,butyrate treatment significantly repressed the enrichment of HDAC3 on the promoter of the CEACAM1 gene to induce its expression.Our findings support that butyrate intervention can alleviate the impairment of colonic barrier function caused by VAD,and timely postnatal VA intervention may reverse the damage caused by VAD on gut barrier integrity during pregnancy.

关键词： CEACAM1 Colonic epithelial barrier HDAC3 Short-chain fatty acids Vitamin A deficiency

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What is the Role of Gravity, Turbulence and Magnetic Fields in High-mass Star Formation Clouds?

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Research in Astronomy and Astrophysics 2024年第6期24卷 23-29页

作者： An-Xu luo Hong-Li Liu Guang-Xing Li Sirong Pan Dong-ting Yang School of Physics and Astronomy Yunnan University South-Western Institute for Astronomy Research Yunnan University

To explore the potential role of gravity,turbulence and magnetic fields in high-mass star formation in molecular clouds,this study revisits the velocity dispersion–size （σ–L） and density–size （ρ–L） scalings and the associated turbulent energy spectrum using an extensive data sample.The sample includes various hierarchical density structures in high-mass star formation clouds,across scales of 0.01–100 pc.We observe σ∝L0.26and ρ∝L-1.54scalings,converging toward a virial equilibrium state.A nearly flat virial parameter–mass (αvir-M) distribution is seen across all density scales,with αvirvalues centered around unity,suggesting a global equilibrium maintained by the interplay between gravity and turbulence across multiple scales.Our turbulent energy spectrum (E（k）)analysis,based on theσ–L andρ–L scalings,yields a characteristic E（k）∝k-1.52.These findings indicate the potential significance of gravity,turbulence,and possibly magnetic fields in regulating dynamics of molecular clouds and high-mass star formation therein.

关键词： ISM: clouds stars: formation stars: kinematics and dynamics

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Impact of continuous care on cardiac function in patients with lung cancer complicated by coronary heart disease

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World Journal of Clinical Cases 2024年第2期12卷 314-321页

作者： ting Gao Jin-Lan luo Pan Guo Xi-Wen Hu Xiao-Yan Wei Yan Hu Division of Cardiovascular First Ward Department of Internal MedicineLiyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077Hubei ProvinceChina Department of Cardiovascular Medicine Wuhan Wuchang HospitalWuhan 430063Hubei ProvinceChina Cardiovascular Clinical Medical Center Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077Hubei ProvinceChina Department of Second Thoracic Surgery Hubei Cancer HospitalWuhan 430079Hubei ProvinceChina

BACKGROUND Despite sharing similar pathogenic factors,cancer and coronary heart disease(CHD)occur in comparable populations at similar ages and possess similar susceptibility factors.Consequently,it is increasingly commonplace for patients to experience the simultaneous occurrence of cancer and CHD,a trend that is steadily rising.AIM To determine the impacts of continuing care on lung cancer patients with CHD following percutaneous coronary intervention(PCI).METHODS There were 94 lung cancer patients with CHD following PCI who were randomly assigned to the intervention group(n=38)and the control group(n=41).In the intervention group,continuing care was provided,while in the control group,routine care was provided.An evaluation of cardiac and pulmonary function,medication compliance,a 6-min walk test,and patient quality of life was performed.RESULTS Differences between the two groups were significant in left ventricular ejection fraction,6-min walk test,oxygen uptake,quality of life and medication compliance(P<0.05).In comparison with the control group,the enhancement in the intervention group was more significant.The intervention group had more patients with high medication compliance than the control group,with a statistically significant difference(P<0.05).CONCLUSION After undergoing PCI,lung patients with CHD could benefit from continued care in terms of cardiac and pulmonary function,medications compliance,and quality of life.

关键词： Lung cancer Continuing care Coronary heart disease Percutaneous coronary intervention

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