检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

人血浆中氯雷他定浓度的LC-MS测定

光谱实验室 2005年第6期22卷 1337-1340页

作者：江婷程传格苑金鹏陈立宗山东省分析测试中心济南市经十路东科院路19号250014

建立了LC-MS法测定人血浆中氯雷他定浓度的方法。血浆在碱性条件下用乙醚-二氯甲烷(2.5∶1,V/V)提取,以罗哌卡因为内标,采用ZORBAX Eclipse XDB-C8柱,API-ES质谱检测器,正离子模式,采集方式为SIM。流动相为乙腈-水(0.2%NH4Ac,0.1%HAc)... 详细信息

建立了LC-MS法测定人血浆中氯雷他定浓度的方法。血浆在碱性条件下用乙醚-二氯甲烷(2.5∶1,V/V)提取,以罗哌卡因为内标,采用ZORBAX Eclipse XDB-C8柱,API-ES质谱检测器,正离子模式,采集方式为SIM。流动相为乙腈-水(0.2%NH4Ac,0.1%HAc)。氯雷他定在0.2—50ng/mL范围内线性关系良好,相对回收率为88.0%—98.6%,RSD小于10%,定量下限为0.2ng/mL。

关键词：氯雷他定罗哌卡因液相色谱-质谱血药浓度

Selective flotation of smithsonite, quartz and calcite using alkyl diamine ether as collector

在线全文

学校读者我要写书评

暂无评论

Transactions of Nonferrous Metals Society of China 2018年第1期28卷 163-168页

作者： Hai-ling ZHU Wen-qing QIN chen chen Li-yuan CHAI Lai-shun LI San-jun LIU ting ZHANG School of Metallurgy and Environment Central South University Changsha 410083 China School of Minerals Processing and Bioengineering Central South University Changsha 410083 China

The flotation separation of smithsonite from calcite and quartz using a alkyl diamine ether(ge-609)as the collector was investigated through micro-flotation experiments and the real ore flotation *** results show that ge-609exhibits good collecting capability to three minerals without *** presence of sodium sulfide enhances the flotation of smithsonite and calcite while inhibits ***,both sodium silicate and sodium hexametaphosphate exhibit good selective inhibition to *** real ore test results show that a zinc concentrate containing23.51%Zn with the recovery of71.02%is obtained in the closed-circuit *** understand the adsorption of ge-609on smithsonite surface,zeta potential measurement and FTIR analysis were carried out,and the results indicate that the collector ge-609can adsorb on smithsonite surface through both electrostatic adsorption and chemical adsorption,and the presence of sodium sulfide enhances the adsorption of ge-609.

关键词： smithsonite quartz calcite alkyl diamine ether sodium sulfide sulphidization flotation

Management of regional citrate anticoagulation for continuous renal replacement therapy:guideline recommendations from Chinese emergency medical doctor consensus

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2023年第6期10卷 733-750页

作者： Shu-Yuan Liu Sheng-Yong Xu Lu Yin ting Yang Kui Jin Qiu-Bin Zhang Feng Sun Ding-Yu Tan Tian-Yu Xin Yu-Guo chen Xiao-Dong Zhao Xue-Zhong Yu jun Xu Emergency Medical Doctor Branch of the Chinese Medical Doctor Association Emergency Department The Sixth Medical CenterChinese PLA General HospitalBeijing 100048China State Key Laboratory of Complex Severe and Rare Diseases Emergency DepartmentPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Emergency Department Peking University Shenzhen HospitalShenzhen 518000China Emergency Department The First Affiliated Hospital of Kunming Medical UniversityKunming 650000China Emergency Department The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001China Emergency Department The Second Affiliated Hospital of Hainan Medical CollegeHaikou 570100China Emergency Department The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Emergency Depart‑ment Northern Jiangsu People’s HospitalClinical Medical College of Yang‑zhou UniversityYangzhou 225001China Emergency Department and Chest Pain Center Qilu Hospital of Shandong UniversityJinan 100005China Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Jinan 100005China Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Qilu Hospital of Shandong UniversityJinan 100005China Emergency Department The Fourth Medical CenterChinese PLA General HospitalBeijing 100048China Jiangxi Provincial People’s Hospital Nanchang330046China The Second Affiliated Hospital of Shenzhen University ShenzhenGuangdong 518035China The First Hos‑pital of Tsinghua University Beijing100016China The Affiliated Hospital and Medical School of Nantong University NantongJiangsu 226001China The First People’s Hospital of Lianyungang LianyungangJiangsu 222000China Shaanxi People’s Hospital Xi’an 710068China Renmin Hospital of Wuhan University Wuhan 430060China Shenzhen Hospital of South‑ern Medical University ShenzhenGuangdong 518000China The Second People’s Hospital of Huai’an Huai’anJiangsu 223002China The Affiliated Suqian Hospital of Xuzhou Medical Univers

Continuous renal replacement therapy(CRRT)is widely used for treating critically-ill patients in the emergency department in *** therapy is needed to prevent clotting in the extracorporeal circulation during *** citrate anticoagulation(RCA)has been shown to potentially be safer and more effective,and is now recommended as the preferred anticoagulant method for ***,there is still a lack of unified standards for RCA management in the world,and there are many problems in using this method in clinical *** Emergency Medical Doctor Branch of the Chinese Medical Doctor Association(CMDA)organized a panel of domestic emergency medicine experts and international experts of CRRT to discuss RCA-related issues,including the advantages and disadvantages of RCA in CRRT anticoagulation,the principle of RCA,parameter settings for RCA,monitoring of RCA(mainly metabolic acid-base disorders),and special issues during *** on the latest available research evidence as well as the paneled experts'clinical experience,considering the generalizability,suitability,and potential resource utilization,while also balancing clinical advantages and disadvantages,a total of 16 guideline recommendations were formed from the experts'consensus.

关键词： Continuous renal replacement therapy Emergency Anticoagulation Citrate Guideline Expert consensus

明胶基多孔碳球电极材料的制备及电化学性能研究

在线全文

学校读者我要写书评

暂无评论

无机化学学报 2007年第2期23卷 365-368页

作者：慈颖葛军王小峰陈文浩郭燕川陈丽娟中国科学院理化技术研究所

超级电容器是一种新型的储能器件．它既能与二次电池、燃料电池组成混合动力系统．也可以单独作为储能器件，其应用范围正在不断的扩大。碳材料因其低廉的价格、高比表面积和实用性而成为最热门的电极材料。碳材料电极电容器的电容主要... 详细信息

超级电容器是一种新型的储能器件．它既能与二次电池、燃料电池组成混合动力系统．也可以单独作为储能器件，其应用范围正在不断的扩大。碳材料因其低廉的价格、高比表面积和实用性而成为最热门的电极材料。碳材料电极电容器的电容主要来源于界面的双电层。从某种程度上说．碳材料的比表面积、孔径大小、孔密度等物化性质直接影响着电容器的比容量。而碳材料的这些物化性质受到很多制备因素的影响。虽然容量密度的大小主要取决于碳基电极材料的比表面积。但是材料比表面积的大小并不与其容量密度成正比关系．这主要是由于碳基材料中小于2nm的微孔的存在．使得电解液不能够有效浸入而形成微电容，导致该部分微孔和比表面积不能形成有效电容。因而，如何改善孔径分布及活化材料表面，成为提高碳基材料容量密度的主要途径。

关键词：明胶基多孔碳球活化温度超级电容器性能

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2021年第10期6卷 3142-3154页

作者： Jiejie geng Liang chen Yufeng Yuan Ke Wang Youchun Wang chuan Qin Guizhen Wu Ruo chen Zheng Zhang Ding Wei Peng Du jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan chen National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi'an 710032China School of Medicine Shanghai UniversityShanghai 200444China Zhongnan Hospital of Wuhan University Wuhan 430071China Division of HIV/AIDS and Sex-transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)and WHO Collaborating Center for Standardization and Evaluation of BiologicalsBeijing 102629China Institute of Laboratory Animals Science Chinese Academy of Medical SciencesBeijing 100071China NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 100871China Beijing Institute of Biotechnology Beijing 100871China Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'an 710032China Beijing Institute of Microbiology and Epidemiology Beijing 100071China School of Basic Medicine Fourth Military Medical UniversityXi'an 710032China Jiangsu Pacific Meinuoke Biopharmceutical Co.Ltd Changzhou 213022China

SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing *** in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 ***,we identified CD147 as a universal receptor for SARS-CoV-2 and its ***,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,***,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and *** infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling ***,we proposed that severe COVID-19-related cytokine storm is induced by a"spike protein-CD147-CyPA signaling axis":Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK ***,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine ***,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its ***,our findings provided a new perspective for severe COVID-19-related ***,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment.

关键词： CD147 cytokine storm

用后向SBS压缩电光调Q Cr∶LiSAF激光脉冲宽度的研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国激光 2001年第4期28卷 304-306页

作者：葛传文张为俊陈长水王沛陶德杰苏红中国科学院安徽光机所激光光谱学开放实验室合肥230031

在抽运能量一定的条件下 ,采用强聚焦短焦距透镜提高焦点处的光功率密度 ,将Cr∶LiSAF电光调Q激光器的输出脉冲聚焦于装有CS2 介质的受激布里渊散射 (SBS)池中 ,实现了宽线宽、多横模Cr∶LiSAF激光脉冲的后向SBS ,并观察到对激光脉宽的... 详细信息

在抽运能量一定的条件下 ,采用强聚焦短焦距透镜提高焦点处的光功率密度 ,将Cr∶LiSAF电光调Q激光器的输出脉冲聚焦于装有CS2 介质的受激布里渊散射 (SBS)池中 ,实现了宽线宽、多横模Cr∶LiSAF激光脉冲的后向SBS ,并观察到对激光脉宽的有效压缩。

关键词： Cr:LiSAF激光受激布里渊散射脉宽压缩压缩电光调Q 脉冲宽度

Surface rupture and hazard characteristics of the Wenchuan Ms 8.0 earthquake, Sichuan, China

在线全文

学校读者我要写书评

暂无评论

Natural Science 2010年第3期2卷 160-174页

作者： Rong-jun Zhou Yong Li Liang Yan Jian-cheng Lei Yi Zhang Yu-Lin He Long-Shen chen Xiao-Gang Li Shi-Yuan Wang You-Qing Ye Yu-Fa Liu chuan-chuan Kang Tian-Yong ge Qiang He Wei Huang 不详

Longmen Shan is located the special joint be-tween Tibetan Plateau inland in the west and Yangtze craton in the east. Consisting of a se-ries of parallel imbricated thrust, it develops, from the west to the east, the Maoxian- Wenchuan, Beichuan-Yingxiu and Pengxian- ﹡This research was supported by China National Natural Science Foundation grant 40841010, 40972083 and China National Science and Technology supporting Plan Foundation grant 2006BAC13B02-07, 2006BAC13B01-604. Guanxian faults. The Wenchuan earthquake is a thrust with strike-slip type, and thre surface ruptures are located on the Beichuan-Yingxiu fault zone and Pengxian-Guanxian fault zone. The surface rupture on the Beichuan-Yingxiu fault shows the thrust and dextral slip charac-teristic. The maximum vertical displacement of the surface rupture is about 10.3 m and the maxi-mum right-lateral displacement is about 5.85m. Though the vertical displacements and the hori-zontal displacements in the different segments have certain differences, as a whole, the ratio of the vertical displacement and the horizontal dis-placement is close to 1:1. The surface rupture on the Pengxian-Guanxian fault shows thrust and dextral characteristic. The rates of vertical dis-placements and the horizontal displacements ones on the most other segments are between 1:3 and 1:2. So the Beichuan- Yingxiu fault is a dextral-slip and thrust fault and the average ver-tical displacement is equal to the average hori-zontal displacement, while the Pengxian- Guan xian fault is thrust fault with a little dextral-slip component. The total intensity area above Ⅵ de-gree of the Wenchuan earthquake is about 333000 km2. The high earthquake intensity line stretches to N40-50°E along Longmen Shan tectonic belt. The rate of the long axis and the minor is betw- een 8:1 and 10:1. Three Ⅺ intensity regions are isolated in distribution. It presents a multipoint instantaneous characteristic of the rupture.

关键词： Wenchuan earthquake Longmen Shan Surface rupture Hazard Sichuan China

草酸青霉菌Penicillium oxalicum IM-3对氯代吡啶烟碱类杀虫剂的代谢作用

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生态与农村环境学报 2010年第3期26卷 246-250页

作者：姬微微陈婷桑琪戴亦军葛峰袁生南京师范大学生命科学学院江苏南京210046 环境保护部南京环境科学研究所江苏南京210042

从土壤中分离出1株可降解氯代吡啶烟碱类杀虫剂啶虫脒(AAP)的丝状真菌菌株IM-3,经形态观察和18S rDNA序列比对,IM-3菌株被鉴定为草酸青霉菌(Penicillium oxalicum)。培养14 d,***-3在矿物盐培养基中可降解41.6%的啶虫脒、14.1%的吡虫啉(... 详细信息

从土壤中分离出1株可降解氯代吡啶烟碱类杀虫剂啶虫脒(AAP)的丝状真菌菌株IM-3,经形态观察和18S rDNA序列比对,IM-3菌株被鉴定为草酸青霉菌(Penicillium oxalicum)。培养14 d,***-3在矿物盐培养基中可降解41.6%的啶虫脒、14.1%的吡虫啉(IMI),但不降解噻虫啉(THI)和烯啶虫胺(NIT)。HPLC和LC-MS/MS分析显示,啶虫脒降解途径为N-脱甲基生成IM2-1和氧化断裂氰基亚胺基生成IM1-3。

关键词：草酸青霉菌(Penicillium oxalicum) 氯代吡啶烟碱类杀虫剂生物降解代谢途径

甲壳型液晶高分子的分子形状和相结构调控:从片状分子到柱状分子和从层状相到柱状相

在线全文

学校读者我要写书评

暂无评论

高分子学报 2023年第9期54卷 1343-1354页

作者：郑军峰葛云翀程晓帆吴雅婷徐鹏陈尔强南京林业大学化学工程学院应用化学系南京210037 北京大学化学与分子工程学院高分子科学与工程系北京100871

为调控甲壳型液晶高分子(MJLCPs)的分子形状和相结构,以“苯-苄酯-苯”为柔性连接基团设计了一个新的MJCLP 1P,为对比研究,又设计了一个化学结构相似但含有“苯-酯-苯”刚性连接基团的MJLCP 2P.研究结果表明,参考聚合物2P呈现稳定的层... 详细信息

为调控甲壳型液晶高分子(MJLCPs)的分子形状和相结构,以“苯-苄酯-苯”为柔性连接基团设计了一个新的MJCLP 1P,为对比研究,又设计了一个化学结构相似但含有“苯-酯-苯”刚性连接基团的MJLCP 2P.研究结果表明,参考聚合物2P呈现稳定的层状液晶相,其分子形状应为片状构象;目标聚合物1P低温时形成层状液晶相,高温则为柱状液晶相,其分子形状应分别为片状和棒状.本研究提出了1P的分子形状和相转变的机理:低温时,“苯-苄酯-苯”采取反式构象,侧链类似于棒状液晶基元,整个分子为片状,进而形成层状液晶相;高温时,“苯-苄酯-苯”采取旁氏构象,侧链对主链的甲壳效应增加,驱动整个分子为棒状,进而形成柱状液晶相.通过在MJLCPs的侧链中引入“苯-苄酯-苯”柔性连接基团,实现了MJLCPs的分子形状和相结构调控.

关键词：甲壳型液晶高分子层状液晶相柱状液晶相片状分子柱状分子