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Text Difficulty Study:Do Machines Behave the Same as Humans Regarding Text Difficulty?

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Machine Intelligence Research 2024年第2期21卷 283-293页

作者： Bowen Chen Xiao Ding Yi Zhao Bo fu tingmao Lin Bing Qin ting Liu Research Center for Social Computing and Information Retrieval Harbin Institute of TechnologyHarbin 150001China fundamental Technology Center China Construction Bank Financial Technology Co.Ltd.Beijing 100033China

With the emergence of pre-trained models,current neural networks are able to give task performance that is comparable to ***,we know little about the fundamental working mechanism of pre-trained models in which we do not know how they approach such performance and how the task is solved by the *** example,given a task,human learns from easy to hard,whereas the model learns ***,difficulty-insensitive learning leads to great success in natural language processing(NLP),but little attention has been paid to the effect of text difficulty in *** propose a human learning matching index(HLM Index)to investigate the effect of text *** results show:1)LSTM gives more human-like learning behavior than ***,UID-SuperLinear gives the best evaluation of text difficulty among four text difficulty *** nine tasks,some tasks’performance is related to text difficulty,whereas others are not.2)Model trained on easy data performs best in both easy and medium test data,whereas trained on hard data only performs well on hard test data.3)Train the model from easy to hard,leading to quicker convergence.

关键词： Cognition inspired natural language processing psycholinguistics explainability text difficulty curriculum learning

Prediction of T cell and B cell epitopes of the 22-, 47-, 56-, and 58-kDa proteins of Orientia tsutsugamushi

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Asian Pacific Journal of Tropical Biomedicine 2019年第10期9卷 443-448页

作者： Li-Na Niu ting-ting fu Man-Ling Chen Yu-Ying Dong Jin-Chun Tu Zi-Hao Wang Si-Qi Wang Xuan Zhao Nai-Xu Hou Qian Chen Qiang Wu Laboratory of Tropical Biomedicine and Biotechnology School of Tropical Medicine and Laboratory MedicineHainan Medical UniversityHaikou Hainan 571199China Department of Laboratory the First Affiliated Hospital of Hainan Medical UniversityHaikou Hainan 570102China Department of Gynecology the First Affiliated Hospital of Hainan Medical UniversityHaikou Hainan 570102China State Key Laboratory of Marine Resource Utilization in South China Sea College of Material science and EngineeringHainan UniversityHaikou Hainan 570228 China 5Department of Pathogen BiologySchool of Basic Medicine and Life ScienceHainan Medical UniversityHainan Medical University-University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou Hainan 571199China Key Laboratory of Emergency and Trauma of Ministry of Education&Research Unit of Island Emergency Medicine of Chinese Academy of Medical Sciences Hainan Medical UniversityHaikou Hainan 571199China

Objective:To predict B cell and T cell epitopes of 22-kDa,47-kDa,56-kDa and 58-kDa ***:The sequences of 22-kDa,47-kDa,56-kDa and 58-kDa proteins which were derived from Orientia tsutsugamushi were analyzed by SOPMA,DNAstar,Bcepred,ABCpred,NetMHC,NetMHCⅡand *** 58-kDa tertiary structure model was built by ***:The 22-kDa B-cell epitopes were located at positions 194-200,20-26 and 143-154,whereas the T-cell epitopes were located at positions 154-174,95-107,17-25 and *** 47-kD a protein B-cell epitopes were at positions 413-434,150-161 and 283-322,whereas the T-cell epitopes were located at positions 129-147,259-267,412-420 and *** 56-kDa protein B-cell epitopes were at positions 167-173,410-419 and 101-108,whereas the T-cell epitopes were located at positions 88-104,429-439,232-240 and *** 58-kDa protein B-cell epitopes were at positions 312-317,540-548 and 35-55,whereas the T-cell epitopes were located at positions 415-434,66-84 and ***:We identified candidate epitopes of 22-kDa,47-kDa,56-kDa and 58-kDa proteins from Orientia *** the case of 58-kDa,the dominant antigen is displayed on tertiary structure by homology *** findings will help target additional recombinant antigens with strong specificity,high sensitivity,and stable expression and will aid in their isolation and purification.

关键词： Orientia tsutsugamushi B cell epitopes T cell epitopes Bioinformatic prediction

Biomarkers for hepatocellular carcinoma based on body fluids and feces

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World Journal of Gastrointestinal Oncology 2021年第5期13卷 351-365页

作者： Ming-Cheng Guan Wei Ouyang Ming-Da Wang Lei Liang Na Li ting-ting fu Feng Shen Wan-Yee Lau Qiu-Ran Xu Dong-Sheng Huang Hong Zhu Tian Yang Department of Medical Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Hepatobiliary Surgery Eastern Hepatobiliary Surgery Hospital(Navy Medical University)Second Military Medical UniversityShanghai 200438China

Novel non-/minimally-invasive and effective approaches are urgently needed to supplement and improve current strategies for diagnosis and management of hepatocellular carcinoma(HCC).Overwhelming evidence from published studies on HCC has documented that multiple molecular biomarkers detected in body fluids and feces can be utilized in early-diagnosis,predicting responses to specific therapies,evaluating prognosis before or after therapy,as well as serving as novel therapeutic *** and analysis of proteins,metabolites,circulating nucleic acids,circulating tumor cells,and extracellular vesicles in body fluids(e.g.,blood and urine)and gut microbiota(e.g.,in feces)have excellent capabilities to improve different aspects of management of *** studies have been devoted in identifying more promising candidate biomarkers and therapeutic targets for diagnosis,treatment,and monitoring responses of HCC to conventional therapies,most of which may improve diagnosis and management of HCC in the *** review aimed to summarize recent advances in utilizing these biomarkers in HCC and discuss their clinical significance.

关键词： Hepatocellular carcinoma Biomarker Blood Urine Feces Gut microbiota

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“新医科”背景下“循证医学”教学改革探索

医学教育研究与实践 2024年第4期32卷 462-467页

作者：袁筱婕张维璐付婷邵中军王安辉吉兆华空军军医大学预防医学系特殊环境危害评估与防治教育部重点实验室/流行病学教研室陕西西安710032

目的探讨“新医科”背景下循证医学的教学改革与教学模式。方法将2023和2022学年本科生分别作为干预组和对照组,采用以问题为基础的教学(Problem-based Learning,PBL)联合翻转课堂和传统PBL两种教学模式进行文献评阅实践课教学,通过比... 详细信息

目的探讨“新医科”背景下循证医学的教学改革与教学模式。方法将2023和2022学年本科生分别作为干预组和对照组,采用以问题为基础的教学(Problem-based Learning,PBL)联合翻转课堂和传统PBL两种教学模式进行文献评阅实践课教学,通过比较学生的循证医学考核成绩判断教学效果,通过问卷调查了解学生对于PBL联合翻转课堂教法的评价。结果2023和2022学年分别纳入472和340名学生,PBL联合翻转课堂教学的考核成绩平均为(81.7±6.9)分,高于常规PBL教学的考核成绩[(80.8±4.8)分,P=0.04]。按照学制和专业细分进行分析,成绩的提高主要为五年制口腔医学专业和五年制医学心理学专业(P<0.01)。并且,PBL联合翻转课堂教学学生的优秀率高于常规PBL教学,差异具有统计学意义。问卷调查结果显示,学生在对“循证医学”教学改革表达肯定的基础上,也提出了一些改进意见。结论PBL联合翻转课堂的教学效果优于传统PBL教学,并且得到了学生们的肯定和支持,值得在“循证医学”教学中推广应用。

关键词：循证医学翻转课堂 PBL

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放疗信息管理系统研发及应用现状

现代医院管理 2024年第2期22卷 114-117页

作者：付廷岩孙亚平孔红秀梁瑞吴晓东庄庆昕宁夏回族自治区人民医院银川市750002 成都纽瑞特医疗科技股份有限公司成都市610200

放疗信息系统(Radiotherapy Information System,RTIS)是放疗科信息化的重要组成部分,目前应用率还不到15%。笔者调查了我国内地地区的放疗需求及放疗信息系统应用现状;介绍并比较了传统放疗信息管理模式和RTIS的优缺点;概述了国内使用... 详细信息

放疗信息系统(Radiotherapy Information System,RTIS)是放疗科信息化的重要组成部分,目前应用率还不到15%。笔者调查了我国内地地区的放疗需求及放疗信息系统应用现状;介绍并比较了传统放疗信息管理模式和RTIS的优缺点;概述了国内使用的主流RTIS以及各医院自主研发的RTIS的特点。希望能为RTIS的建设吸引到IT人才,为各放疗机构选购或者自主研发RTIS提供参考。

关键词：放疗信息系统研发应用

Alternative technique to save ischemic bowel segment in management of neonatal short bowel syndrome: A case report

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World Journal of Clinical Cases 2019年第20期7卷 3353-3357页

作者： Lei Geng Lei Zhou Guo-Jian Ding Xiao-Liang Xu Yu-Mei Wu Ji-Jun Liu ting-Liang fu Department of Pediatric Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina Department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina Department of Neonatology Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina Department of Anorectal Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina

BACKGROUND Congenital short bowel syndrome(SBS)associated with malrotation,gut volvulus and jejuno-ileal atresia is a very rare *** is a severe challenge for surgeons to preserve residual ischemic bowel segment in the management of short bowel syndrome,especially in *** SUMMARY We report a newborn baby with gut malrotation associated with jejuno-ileal atresia,congenital SBS and jejunal *** and abdominal distention were *** laparotomy,malrotation associated with jejuno-ileal atresia,congenital SBS and jenunal volvulus was *** total length of the small bowel was 63 cm with proximal jejunal bowel segment measuring 38 cm,including 18 cm necrotic segment below the Treitz’s ligament and 20 cm severe ischemic *** distal part of the small bowel was 25 cm in length and only about 0.8 cm in ***’s procedure,necrotic segment resection and end-to-back duodeno-ileal anastomosis were *** residual severe ischemic jejunum was preserved with single proximal stoma and distal end *** months later,to restore the continuity of the isolated gut segment,end-to-end duodeno-jejunal and jejuno-ileal anastomosis was *** entire functional small bowel length increased to 80 *** fluid therapy and parenteral nutrition were discontinued on the 10th day *** months later,her body weight was 9.5 *** Isolation of severe ischemic bowel segment and staged anastomosis to restore the gut continuity for infants with SBS are safe and feasible.

关键词： Ischemic bowel segment Short bowel syndrome Bowel isolation technique Staged salvaging procedure Case report

Ocular biometry in the adult population in rural central China: a population-based, cross-sectional study

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 812-817页

作者： ting fu Yin-Wei Song Zhi-Qi Chen Jun-Wen He Kun Qiao Xu-Fang Sun Hong Zhang Jun-Ming Wang Department of Ophthalmology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

·AIM: To describe the distribution and determinants of ocular biometric parameters and to ascertain the relative importance of these determinants in a large population of adults in rural central China.·METHODS: A population-based, cross-sectional study performed in rural central China included 1721 participants aged 40 or more years. Ocular biometrical parameters including axial length(AL), anterior chamber depth(ACD), radius of corneal curvature(K) and horizontal corneal diameter [white-to-white(WTW)distance] were measured using non-contact partial coherence interferometry [intraocular lens(IOL)-Master].·RESULTS: Ocular biometric data on 1721 participants with a average age of 57.0 ±8.7y were analyzed at *** general mean AL, ACD, mean corneal curvature radius(MCR), WTW were 22.80±1.12, 2.96±0.36, 7.56±0.26 and 11.75 ±0.40 mm, respectively. The mean values of each parameter in 40 to 49, 50 to 59, 60 to 69, and 70 to91 years age groups were as follows: AL, 22.77 ±0.87,22.76 ±1.06, 22.89 ±1.41, 22.92 ±0.80 mm; ACD, 3.10 ±0.32,2.98 ±0.34, 2.86 ±0.36, 2.77 ±0.35 mm; MCR, 7.58 ±0.25,7.54 ±0.26, 7.55 ±0.26, 7.49 ±0.28 mm; WTW, 11.79 ±0.38,11.75 ±0.40, 11.72 ±0.41, 11.67 ±0.41 mm. The AL, ACD,MCR and WTW were correlated with age and the AL was correlated with height and weight.·CONCLUSION: Our findings can serve as an important normative reference for multiple purposes and may help to improve the quality of rural eye care.

关键词： epidemiological investigation axial length anterior chamber depth Chinese population

A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy

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Chinese Chemical Letters 2024年第3期35卷 332-336页

作者： Dequan Zeng Zhongkai Ma Xin Zan ting Luo Xiang Wang Xiang Gao Xianghui fu School of Health Management Xihua UniversityChengdu 610039China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China College of StomatologySichuan UniversityChengdu 610041China Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengdu 610041China Breast Disease Center Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China

Oral squamous cell carcinoma(OSCC)is known as one of the most malignant tumors with high recurrence and fatality *** poor tumor-targeting ability of traditional chemotherapeutic drugs has been a grand challenge for anti-OSCC *** that,a large quantity of tumor associated macrophages in OSCC tissues further diminish the anti-tumor effects of these ***,we produced a therapeutic nano drug delivery system(FA-PEG-PLA-JQ1)through encapsulating JQ1[a small-molecule inhibitor of bromodomain containing protein 4(BRD4)]into the folic acid(FA)-modified nanoparticle(PEG-PLA),which could prolong the half-life of JQ1 and target the tumor *** then,JQ1 released from this nanoparticle could prevent OSCC growth inducing tumor cell apoptosis,inhibiting tumor angiogenesis and the polarization of M2 type *** conclusion,our date demonstrated the therapeutic benefits of FA-PEG-PLA-JQ1 against OSCC in vivo or in vitro,which could be a novel treatment strategy for OSCC in coming days.

关键词： Folic acid Nanoparticles JQ1 Oral squamous cell carcinoma Macrophages

Normal sperm head morphometric reference values in fertile Asian males

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Asian Journal of Andrology 2024年第3期26卷 315-320页

作者： Ye-Lin Jia Ying-Bi Wu Lin Yu Yan Zheng ting-ting Yang Yan-Yun Wang Bin Zhou Lin Zhang fu-Ping Li Laboratory of Andrology West China Second University Hospital Human Sperm BankChengdu 610000China Laboratory of Molecular Translational Medicine Center for Translational MedicineChengdu 610061China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610061China NHC Key Laboratory of Chronobiology West China Second University HospitalSichuan UniversityChengdu 610000China

Sperm head morphology is crucial for male factor infertility diagnosis and assessment of male reproductive *** are available to analyze sperm head morphology,but they are limited by poor methodology comparability and *** study aimed to explore comprehensive and new normal morphometric reference values for spermatozoa heads infertile Asian *** automated sperm morphology analysis system captured 23152 stained spermatozoa from confirmed *** these samples,1856 sperm head images were annotated by three experienced laboratory technicians as“normal”.Weemployed 14 novel morphometric features to describe sperm head size(head length,head width,length/width ratio,and girth),shape(ellipse intersection over union,girth intersection over union,short-axis symmetry,and long-axis symmetry),area(head,acrosome,postacrosomal areas,and acrosome area ratio),and degrees of acrosome and nuclear *** straight-forwardmethod for the morphometric analysis of sperm by accurate visual measurements is clinically *** measured parameterspresent valuable information to establish morphometric reference intervals for normal sperm heads in fertile Asian *** detailed measurement data will be valuable for interlaboratory comparisons and technician *** vitro fertilizationand andrology laboratory technicians can use these parameters to perform objective morphology evaluation when assessing malefertilization potential.

关键词： fertile Asian males head morphometric reference value normal spermatozoa