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Improvement of hepatic fibrosis after tenofovir disoproxil fumarate switching to tenofovir alafenamide for three years

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World Journal of Hepatology 2024年第7期16卷 1009-1017页

作者： Tung Huynh Delana MyAn Bui tina Xiwen Zhou Ke-Qin Hu Department of Pharmacy University of California Irvine Medical CenterOrangeCA 92868United States University of Houston HoustonTX 77204United States Chicago Medical School at rosalind Franklin University North ChicagoIL 60064United States Division of Gastroenterology and Hepatology University of California IrvineSchool of MedicineOrangeCA 92868United States

BACKGrOUND Both tenofovir alafenamide(TAF)and tenofovir disoproxil fumarate(TDF)are the first-line treatments for chronic hepatitis B(CHB).We have showed switching from TDF to TAF for 96 weeks resulted in further alanine aminotransferase(AlT)improvement,but data remain lacking on the long-term benefits of TDF switching to TAF on hepatic *** To assess the benefits of TDF switching to TAF for 3 years on AlT,aspartate aminotransferase(AST),and hepatic fibrosis improvement in patients with *** A single center retrospective study on 53 patients with CHB who were initially treated with TDF,then switched to TAF to determine dynamic patterns of AlT,AST,AST to platelet ratio index(APrI),fibrosis-4(FIB-4)scores,and shear wave elastography(SWE)reading improvement at switching week 144,and the associated *** The mean age was 55(28-80);45.3%,males;15.1%,clinical cirrhosis;mean baseline AlT,24.8;AST,25.7 U/l;APrI,0.37;and FIB-4,*** 144 weeks TDF switching to TAF,mean AlT and AST were reduced to 19.7 and 21,*** baseline to switching week 144,the rates of AlT and ASTle)/25(female)andle)/19(female)were persistently increased;hepatic fibrosis was also improved by APrIrom 79.2%to 96.2%;FIB-4rom 52.8%to 58.5%,respectively;mean APrI was reduced to 0.27;FIB-4,to 1.38;and mean SWE reading,from 7.05 to 6.30 kPa after a mean of 109 weeks *** renal function was stable and the frequency of patients with glomerular filtration rate>60 ml/min was increased from 86.5%at baseline to 88.2%at switching week *** Our data confirmed that switching from TDF to TAF for 3 years results in not only persistent AlT/AST improvement,but also hepatic fibrosis improvement by APrI,FIB-4 scores,as well as SWE reading,the important clinical benefits of long-term hepatitis B virus antiviral treatment with TAF.

关键词： Tenofovir alafenamide Tenofovir disoproxil fumarate Switching Hepatic fibrosis improvement Aspartate aminotransferase to platelet ratio index Fibrosis-4 Shear wave elastography

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Exercise training improves long-term memory in obese mice

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life Metabolism 2024年第1期3卷 37-50页

作者： Oliver K.Fuller Casey l.Egan tina l.r.binson Nimna Perera Heidy K.latchman lauren V.Terry Emma D.Mclennan Carolina Chavez Emma l.Burrows John W.Scott robyn M.Murphy Henriette van Praag Martin Whitham Mark A.Febbraio Monash Institute of Pharmaceutical Sciences Monash UniversityMelbourneVictoria3052Australia la Trobe Institute for Molecular Science La Trobe UniversityMelbourneVictoria3086Australia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoria3052Australia Department of Biomedical Sciences Charles E.Schmidt College of Medicineand Stiles-Nicholson Brain InstituteFlorida Atlantic UniversityJupiterFL 33458United States College of life and Environmental Sciences University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom

Obesity has been linked to a range of pathologies,including *** contrast,regular physical activity is associated with the prevention or reduced progression of ***,physical activity can improve memory and spatial cognition,reduce age-related cognitive decline,and preserve brain volume,but the mechanisms are not fully ***,we investigated whether any detrimental effects of high-fat diet(HFD)-induced obesity on cognition,motor behavior,adult hippocampal neurogenesis,and brain-derived neurotrophic factor(BDNF)could be mitigated by voluntary exercise training in male C57Bl/6 ***-induced impairment of motor function was not reversed by ***,voluntary wheel running improved long-term memory and increased hippocampal neurogenesis,suggesting that regular physical activity may prevent cognitive decline in obesity.

关键词： obesity exercise cognition

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Obstetric Emergencies at the Kara University Hospital Maternity Ward: Sociodemographic, Etiological and Prognostic Aspects

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Open Journal of Obstetrics and Gynecology 2024年第1期14卷 69-76页

作者： logbo-Akey Kossi Edem Bassowa Akila Ketevi tina Kambote Yendoubé Patchidi Kibandou Amewouho Kofi Ajavon Dédé régina Aboubakari Abdoul-Samadou Service de Gynécologie-Obstétrique CHU Kara Université de Kara Kara Togo Service de Gynécologie-Obstétrique CHU Campus Université de Lomé Lomé Togo Service de Gynécologie-Obstétrique CHU Sylvanus Olympio Université de Lomé Togo Faculté des sciences de la santé Université de Lomé Lomé Togo Service de Gynécologie-Obstétrique CHR Tomdé Université de Kara Togo

Introduction: Obstetric emergencies are common throughout the world and more particularly in developing countries where they are responsible for high maternal-fetal mortality and morbidity. Objective: Study obstetric emergencies in the maternity ward of Kara University Hospital. Method: retrospective and descriptive study from April 1, 2022 to March 30, 2023, carried out in the Obstetrics and Gynecology Department of Kara University Hospital. results: Eight hundred and thirty-five (835) obstetric emergencies were recorded out of 2215 admissions, i.e. a frequency of 37.7%. The average age of the patients was 26.7 with a range of 14 and 45 years. They were primigravidas (36.7%) and nulliparous (38.7%), referred (84.7%) and came from rural areas (72%). Emergencies occurred in the 3rd trimester in 74.1% and in parturients (54.1%). Preeclampsia (27%), cessation of progression of labor due to feto-pelvic disproportion (12.4%), postpartum hemorrhage (7.5%) constituted the main obstetric emergencies. In 44.8%, the delivery was carried out vaginally. Magnesium sulfate was the most used drug, i.e. 30.1%;followed by antihypertensive medications in 28.1%. Blood transfusion was performed in 24.3%. The evolution was simple in 90.9%. The maternal fatality rate was 1.6%. The perinatal case fatality rate was 12.3%. Conclusion: Obstetric emergencies are common, dominated by preeclampsia, stopping progress of labor and postpartum hemorrhages. They are responsible for high morbidity and mortality.

关键词： Obstetric Emergency Kara University Hospital

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Obstetric references in Disadvantaged Environments: Case of references to the University Hospital Center of Kara, in Northern Togo

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Open Journal of Obstetrics and Gynecology 2024年第2期14卷 267-277页

作者： Kossi Edem logbo-Akey Bassowa Akila Kofi Mawoulé Améwouho Ketevi tina Yendoubé Pierre Kambote Dédé régine Diane Ajavon Baguilane Djoauguibe Abdoul-Samadou Aboubakari Koffi Akpadza Service de Gynécologie-Obstétrique CHU Kara Togo Service de Gynécologie-Obstétrique CHU Campus Lomé Togo Service de Gynécologie-Obstétrique CHU Sylvanus Olympio Lomé Togo Service de Gynécologie-Obstétrique CHR Tomdé Kara Togo

Introduction: references are frequent and most often carried out in emergency situations. The objective of this study was to describe the epidemiological and clinical profile of obstetric referrals to the CHU-Kara. Methodology: This was a retrospective cross-sectional descriptive study conducted from September 1, 2022, to February 28, 2023, at CHU-Kara, focusing on obstetric referrals to the Gynecology-Obstetrics department. result: 828 patients were referred for obstetric reasons out of 1295 admissions, representing a frequency of 63.9%. The average age was 25.04 years. They were primigravida (38.3%), unemployed (62.7%). Motorcycles were the main means of transportation, accounting for 53.1% of cases. The average distance to reach the referral center was 31.6 km, covered in an average of 71 minutes. In 40.7% of cases, patients had less than 4 prenatal consultations and were referred in peripartum (56.6%) for pre-eclampsia (14%), post-term pregnancy (11.8%), dystocia (10.5%). Eighty-six point nine percent (86.9%) of the referred patients were able to deliver during their stay in the department, of which 61.7% had vaginal deliveries. The maternal and perinatal mortality rates were 0.7% and 14.9%, respectively. Conclusion: Obstetric referrals to Kara University Hospital are frequent during the perpartum period and are often carried out by motorbike.

关键词： Obstetric referral Epidemiology Prognosis CHU-Kara

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Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth runzhe Chen Yang liu Junya Fujimoto lingzhi Hong Alexandre reuben Susan Varghese Carmen Behrens tina McDowell luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning le Natalie I Vokes Chao Cheng John V.Heymach Don l.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TrACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSClC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and rNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KrAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

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Neuroprotective potential of traditional Ayurvedic Kadha:age-related neurological disorders:a comprehensive literature review

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Traditional Medicine research 2024年第9期9卷 51-77页

作者： Sarvin Sadreddini Mohammad Javad Emami Kazemabad Sogand Sheikholeslami Kosar Chitzan-Zadeh Mohammad Taha Kouchaki Midia rashidi Amir Abbas Ghayerin Shahin Sabaghi Ghazal Tavakoli Sepehr Nanbakhsh tina Mansourian Arefeh Tabashiri Fariba Arbab Mojeni Mohammed Namiq Amin Zahra Taheri Seyed Esmaeil Sedighi Taraneh Tarkashvand Parham Amirazodi Mobina Fathi Shirin Yaghoobpoor Niloofar Deravi School of Medicine Tabriz University of Medical SciencesTabriz ***Iran School of Medicine Qom University of Medical SciencesQom ***Iran School of Medicine Hamadan University of Medical SciencesHamadan ***Iran School of Medicine Ahvaz Jundishapur University of Medical SciencesAhvaz ***Iran Faculty of Medicine Tabriz University of Medical SciencesTabriz ***Iran School of Medicine Iran University of Medical SciencesTehran ***Iran School of Medicine Shahid Beheshti University of Medical SciencesTehran ***Iran School of Medicine Mazandaran University of Medical SciencesSari ***Iran School of Medicine Kermanshah University of Medical SciencesKermanshah ***Iran Faculty of Pharmacy Pharmaceutical Sciences BranchIslamic Azad UniversityTehran ***Iran Department of Biology Faculty of SciencePayamNoor UniversityTehran ***Iran Faculty of Medicine Islamic Azad University of Medical ScienceTehran 193951495Iran International Campus Shahid Sadoughi University of Medical SciencesYazd ***Iran

Despite modern medicine’s advancements,age-related neurological diseases like Alzheimer’s disease and Parkinson’s disease remain challenging due to high costs,side effects,and limited ***,a traditional Indian medicine system,offers Kadha tea as a potential herbal *** review explores Kadha’s components(basil(Ocimum basilicum l.),black pepper(Piper nigrum l.),Cinnamon(Cinnamomum verum ***),ginger(Zingiber officinale roscoe),and raisin(Vitis vinifera l.))and their interaction with various neurological *** suggest Kadha exhibits anti-inflammatory,antioxidant,and antiviral properties,potentially impacting Alzheimer’s disease,Parkinson’s disease,neurotoxicity,neuroinflammation,and brain *** focusing on specific disease mechanisms and Kadha’s intergrade effects,this review aims to elucidate its potential role in managing age-related neurological disorders.

关键词： Ayurveda Kadha neuroprotective neurological disorders traditional medicine

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Approaches for handling high-dimensional cluster expansions of ionic systems

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npj Computational Materials 2022年第1期8卷 1254-1264页

作者： Julia H.Yang tina Chen luis Barroso-luque Zinab Jadidi Gerbrand Ceder Department of Materials Science and Engineering BerkeleyCA94720USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA

Disordered multicomponent systems attract great interest due to their engineering design flexibility and subsequent rich space of ***,detailed characterization of the structure and atomic correlations remains challenging and hinders full navigation of these complex spaces.A lattice cluster expansion is one tool to obtain configurational and energetic *** in theory a cluster expansion can be applied to any system of any dimensionality,the method has primarily been used in binary systems or ternary *** we apply cluster expansions in high-component ionic systems,setting up the largest cluster expansion ever attempted to our *** doing so,we address and discuss challenges specific to high-component ionic systems,namely charge state assignments,structural relaxations,and rank-deficient *** introduce practical procedures to make the fitting and analysis of complex systems tractable,providing guidance for future computational studies of disordered ionic systems.

关键词： properties cluster ionic

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Children are not little adults:blood transfusion in children with burn injury

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Burns & Trauma 2017年第3期5卷 158-163页

作者： tina l. Palmieri Shriners Hospital for Children Northern California and the University of California Davis 2425 Stockton Blvd Suite 718 Sacramento CA 95817 USA

Blood transfusion in burns larger than 20%total body surface area (TBSA) are frequent due to operative procedures, blood sampling, and physiologic response to burn injury. Optimizing the use of blood transfusions requires an understanding of the physiology of burn injury, the risks and benefits of blood transfusion, and the indications for transfusion. Age also plays a role in determining blood transfusion requirements. Children in particular have a different physiology than adults, which needs to be considered prior to transfusing blood and blood products. This article describes the physiologic differences between children and adults in general and after burn injury and describes how these differences impact blood transfusion practices in children.

关键词： Blood transfusion Pediatric Burn injury

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An Accurate Dynamic Forecast of Photovoltaic Energy Generation

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Fluid Dynamics & Materials Processing 2022年第6期18卷 1683-1698页

作者： Anoir Souissi Imen Guidara Maher Chaabene Giuseppe Marco tina Moez Bouchouicha Signal Image et Maîtrise de l’Energie(SIME Laboratory)Tunis1008Tunisia Dipartimento di Ingegneria Elettrica Elettronica e InformaticaCatania95125Italy laboratoire lIS-Equipe SIIM Département GMP IUT Toulon83041France

The accurate forecast of the photovoltaic generation(PVG)process is essential to develop optimum installation sizing and pragmatic energy planning and *** paper proposes a PVG forecast model for a PVG/Battery *** forecasting strategy is built on a Medium-Term Energy Forecasting(MTEF)approach refined dynamically every hour(Dynamic Medium-Term Energy Forecasting(DMTEF))and adjusted by means of a Short-Term Energy Forecasting(STEF)*** MTEF predicts the generated energy for a day ahead based on the PVG of the last 15 *** for STEF,it is a combination between PVG Short-Term(ST)forecasting and DMTEF methods obtained by selecting the least inaccurate PVG estimation every 15 *** algorithm results are validated by measures taken on a 3 KWp standalone PVG/Battery *** proposed approaches have been integrated into a management algorithm in order to make a pragmatic decision to ensure load supply considering relevant constraints and priorities and guarantee the battery *** results show that STEF provides accurate results compared to measures in stable and perturbed *** NMBE(Normalized Mean Bias Error)is equal to-0.58%in stable days and 26.10%in perturbed days.

关键词： Energy Forecasting MTEF DMTEF STEF ArIMA model photovoltaic energy

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Considerations for pediatric burn sedation and analgesia

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Burns & Trauma 2017年第4期5卷 218-228页

作者： Alice Fagin tina l. Palmieri Arkansas Children's Hospital 1 Children's Way Little Rock AR 72202 USA Shriners Hospitals for Children Northern California and University of California Davis 2425 Stockton Blvd Suite 718 Sacramento CA USA

Burn patients experience anxiety and pain in the course of their injury, treatment, and recovery. Hence, treatment of anxiety and pain is paramount after burn injury. Children, in particular, pose challenges in anxiety and pain management due to their unique physiologic, psychologic, and anatomic status. Burn injuries further complicate pain management and sedation as such injuries can have effects on medication response and elimination. Burn injuries further complicate pain management and sedation as such injuries can have effects on medication response and elimination. The purpose of this review is to describe the challenges associated with management of anxiety, pain, and sedation in burned children and to describe the different options for treatment of anxiety and pain in burned children.

关键词： Pediatric Sedation Burns

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