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Role of novel biomarkers in diabetic cardiomyopathy

World Journal of Diabetes 2021年第6期12卷 685-705页

作者： Marko Kumric tina ticinovic kurir Josip A Borovac Josko Bozic Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia Emergency Medicine Institute of Emergency Medicine of Split-Dalmatia CountySplit 21000Croatia

Diabetic cardiomyopathy(DCM)is commonly defined as cardiomyopathy in patients with diabetes mellitus in the absence of coronary artery disease and *** DCM is now recognized as a cause of substantial morbidity and mortality among patients with diabetes mellitus and clinical diagnosis is still inappropriate,various expert groups struggled to identify a suitable biomarker that will help in the recognition and management of DCM,with little success so ***,we thought it important to address the role of biomarkers that have shown potential in either human or animal studies and which could eventually result in mitigating the poor outcomes of *** the array of biomarkers we thoroughly analyzed,long noncoding ribonucleic acids,soluble form of suppression of tumorigenicity 2 and galectin-3 seem to be most beneficial for DCM detection,as their plasma/serum levels accurately correlate with the early stages of *** combination of relatively inexpensive and accurate speckle tracking echocardiography with some of the highlighted biomarkers may be a promising screening method for newly diagnosed diabetes mellitus type 2 *** purpose of the screening test would be to direct affected patients to more specific confirmation *** perspective is in concordance with current guidelines that accentuate the importance of an interdisciplinary team-based approach.

关键词： Diabetic cardiomyopathy Heart failure Biomarkers Diabetes mellitus Cardiomyopathy

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Impact of the COVID-19 pandemic on inflammatory bowel disease patients:A review of the current evidence

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World Journal of Gastroenterology 2021年第25期27卷 3748-3761页

作者： Marko Kumric tina ticinovic kurir Dinko Martinovic Piero Marin Zivkovic Josko Bozic Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia Department of Gastroenterology University Hospital of SplitSplit 21000Croatia

Since the initial coronavirus disease 2019(COVID-19)outbreak in China in December 2019,the infection has now become the biggest medical issue of modern *** major contributors that amplified the impact of the disease and subsequently increased the burden on health care systems were high mortality among patients with multiple co-morbidities and overcapacity of intensive care *** the gastroenterology-related community,particular concern was raised with respect to patients with inflammatory bowel disease(IBD),as those patients are prone to opportunistic infections mainly owing to their immunosuppressive-based ***,we sought to summarize current knowledge regarding COVID-19 infection in patients with ***,it seems that IBD is not a comorbidity that poses an increased risk for COVID-19 acquisition,except in patients treated with ***,outcomes of the infected patients are largely dependent on therapeutic modality by which they are treated,as some worsen the clinical course of COVID-19 infection,whereas others seem to dampen the detrimental effects of ***,we discussed the present and the future impact of COVID-19 pandemic and concomitantly increased health care burden on IBD-management.

关键词： COVID-19 SARS-CoV-2 Inflammatory bowel disease Crohn’s disease Ulcerative colitis

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Role of endoscopic ultrasound in anticancer therapy:Current evidence and future perspectives

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1863-1879页

作者： Andre Bratanic Dorotea Bozic Antonio Mestrovic Dinko Martinovic Marko Kumric tina ticinovic kurir Josko Bozic Department of Gastroenterology and Hepatology University Hospital of SplitSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia

The digestive system is one of the most common sites of malignancies in *** gastrointestinal tumors represent a massive global health burden both in terms of morbidity and health care expenditures,scientists continuously develop novel diagnostic and therapeutic methods to ameliorate the detrimental effects of this group of *** from the well-established role of the endoscopic ultrasound(EUS)in the diagnostic course of gastrointestinal and hepatobiliary malignancies,we have recently become acquainted with a vast array of its therapeutic possibilities.A multitude of previously established,evidence-based methods that might now be guided by the EUS emerged:Radiofrequency ablation,brachytherapy,fine needle injection,celiac plexus neurolysis,and endoscopic submucosal *** this review we endeavored to provide a comprehensive overview of the role of these methods in different malignancies of the digestive system,primarily in the treatment and symptom control in pancreatic cancer,and additionally in the management of hepatic,gastrointestinal tumors,and pancreatic cysts.

关键词： Pancreatic cancer Endoscopic ultrasound Endoscopic ultrasound-guided fine needle injection Pancreatic cyst Gastrointestinal tumor Portal vein

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Adherence to Mediterranean diet and advanced glycation endproducts in patients with diabetes

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World Journal of Diabetes 2021年第11期12卷 1942-1956页

作者： Marko Grahovac Marko Kumric Marino Vilovic Dinko Martinovic Ante Kreso tina ticinovic kurir Josip Vrdoljak Karlo Prizmic Joško Božić Department of Pharmacology University of Split School of MedicineSplit 21000Croatia Department of Pathophysiology University of Split School of MedicineSplit 21000Croatia Department of Endocrinology University Hospital of SplitSplit 21000Croatia

BACKGROUND In recent years,American Diabetes Association started to strongly advocate the Mediterranean diet(MD)over other diets in patients with diabetes mellitus(DM)because of its beneficial effects on glycemic control and cardiovascular(CV)risk *** levels of advanced glycation endproducts(AGEs)emerged as an indicator of CV risk in *** biopsy being invasive,the use of AGE Reader has been shown to reflect tissue AGEs *** To examine the association between adherence to MD and AGEs in patients with DM type *** This cross-sectional study was conducted on 273 patients with DM type II.A survey questionnaire was composed of 3 separate *** first part of the questionnaire included general data and the habits of the *** second part aimed to assess the basic parameters of participants’diseases and associated *** third part of the questionnaire was the Croatian version of the 14-item MD service score(MDSS).AGEs levels and associated CV risk were measured using AGE Reader(DiagnOptics Technologies BV,Groningen,The Netherlands).RESULTS A total of 27(9.9%)patients fulfilled criteria for adherence to MD,with a median score of 8.0(6.0-10.0).Patients with none/limited CV risk had significantly higher percentage of MD adherence in comparison to patients with increased/definite CV risk(15.2%vs 6.9%,P=0.028),as well as better adherence to guidelines for nuts(23.2%vs 12.6%,P=0.023)and legumes(40.4%vs 25.9%,P=0.013)*** number of patients with glycated hemoglobin(HbA1c)7%(14.9%vs 7.3%,P=0.045).Moreover,those patients followed the MDSS guidelines for eggs(33.0%vs 46.8%,P=0.025)and wine(15.6%vs 29.8%,P=0.006)consumption more *** score had significant positive correlation with disease duration(r=0.179,P=0.003)and negative correlation with body mass index(BMI)values(r=-0.159,P=0.008).In the multiple linear regression model,BMI(β±SE,-0.09±0.04,P=0.037

关键词： Mediterranean diet Cardiovascular disease Diabetes mellitus Advanced glycation endproducts Dietary habits Atherosclerosis

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