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Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural regeneration research 2025年第2期20卷 481-482页

作者： Khaled Alok timothy G.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Machine Learning Techniques in Predicting Hot Deformation Behavior of Metallic Materials

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 713-732页

作者： Petr Opela Josef Walek Jaromír Kopecek Department of Metallurgical Technologies Faculty of Materials Science and TechnologyVSB–Technical University of OstravaOstrava70800Czech Republic FZU—Institute of Physics of the Czech Academy of Sciences Prague18200Czech Republic

In engineering practice,it is often necessary to determine functional relationships between dependent and independent *** relationships can be highly nonlinear,and classical regression approaches cannot always provide sufficiently reliable ***,Machine Learning(ML)techniques,which offer advanced regression tools to address complicated engineering issues,have been developed and widely *** study investigates the selected ML techniques to evaluate their suitability for application in the hot deformation behavior of metallic *** ML-based regression methods of Artificial Neural Networks(ANNs),Support Vector Machine(SVM),Decision Tree regression(DTr),and Gaussian Process regression(GPr)are applied to mathematically describe hot flow stress curve datasets acquired experimentally for a medium-carbon *** the GPr method has not been used for such a regression task before,the results showed that its performance is the most favorable and practically unrivaled;neither the ANN method nor the other studied ML techniques provide such precise results of the solved regression analysis.

关键词： Machine learning Gaussian process regression artificial neural networks support vector machine hot deformation behavior

Laser Stimulation of the Chloroplast/Endoplasmic reticulum Nexus in Tobacco Transiently Produces Protein Aggregates （Boluses） within the Endoplasmic reticulum and Stimulates Local Er remodeling

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Molecular Plant 2011年第5期4卷 886-895页

作者： Lawrence r. Griffing1 3258 TAMU Biology Department Texas A＆M University College Station Texas 77843 USA

Does the Er subdomain that associates with the chloroplast in vivo, hereafter referred to as the chloroplast/Er nexus, play a role in protein flow within the Er？ In studies of tobacco cells either constitutively or transiently expressing Er-retained luminal, GFP-HDEL, or trans-membrane, YFP-rHD3, fluorescent fusion proteins, brief 405-nm （3-6-mW） laser stimulation of the nexus causes a qualitative difference in the movement and behavior of proteins in the Er. Photostimulating the nexus produces fluorescent protein punctate aggregates （boluses） within the lumen and membrane of the Er. The aggregation propagates through the membrane network throughout the cell, but within minutes can revert to normal, with disaggregation propagating back toward the originally photostimulated nexus. In the meantime, the Er grows and anastomoses around the chloroplast, forming a dense cisternal and tubular network. If this network is again photostimulated, bolus formation does not recur and, if the photostimulation results in photobleaching, fluorescence recovery after photobleaching occurs as it would typically in areas away from the nexus. Bolus propagation is not mediated by the actin cytoskeleton, but can be reversed by pre-conditioning the cells for 30 min with high, 40-45℃, temperature （heat stress）. Because it is not reversed with heat stress, the reorganization of the Er at the nexus following photostimulation is a separate event.

关键词： Er-chloroplast transport Er movement actin heat stress fluorescence recovery after photobleaching blue light reception.

Occurrence mechanism of silicate and aluminosilicate minerals in Sarcheshmeh copper flotation concentrate

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International Journal of Minerals,Metallurgy and Materials 2009年第5期16卷 494-499页

作者： H.r.Barkhordar.1 E.Jorjani1 A.Eslami M.Noaparast Mining Engineering Department Science and Research BranchIslamic Azad UniversityPoonakHesarakTehranIran r&D Division-Sarcheshmeh Copper Complex RafsanjanIran School of Mining Engineering University College of EngineeringUniversity of TehranTehranIran

The Sarcheshmeh copper flotation circuit is producing 5× 10^4 t copper concentrate per month with an averaging grade of 28% Cu in rougher, cleaner and recleaner stages. In recent years, with the increase in the open pit depth, the content of aluminosilicate minerals increased in plant feed and subsequently in flotation concentrate. It can motivate some problems, such as unwanted consumption of reagents, decreasing of the copper concentrate grade, increasing of Al2O3 and SiO2 in the copper concentrate, and needing a higher temperature in the smelting process. The evaluation of the composite samples related to the most critical working period of the plant shows that quartz, illite, biotite, chlorite, orthoclase, albeit, muscovite, and kaolinite are the major Al2O3 and SiO2 beating minerals that accompany chalcopyrite, chalcocite, and covellite minerals in the plant feed. The severe alteration to clay minerals was a general rule in all thin sections that were prepared from the plant feed. Sieve analysis of the flotation concentrate shows that Al2O3 and SiO2 bearing minerals in the flotation concentrate can be decreased by promoting the size reduction from 53 to 38 μm. Interlocking of the Al2O3 and SiO2 bearing minerals with chalcopyrite and chalcocite is the occurrence mechanism of silicate and aluminosilicate minerals in the flotation concentrate. The dispersed form of interlocking is predominant.

关键词： copper aluminosilicate silicate flotation

Modified strip saturated models for two equal collinear cracks with coalesced zones in piezoelectric media

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Applied Mathematics and Mechanics(English Edition) 2019年第8期40卷 1097-1118页

作者： S.SINGH1 K.SHArMA r.r.BHArGAVA Department of Sciences and Humanities National Institute of Technology Uttarakhand Srinagar 246174India Department of Mathematics Indian Institute of Technology Roorkee Roorkee 247667India

Two equal collinear cracks with coalesced interior electric saturation zones are analytically studied for two-dimensional (2D) arbitrary polarized semipermeable piezo- electric media based on a modified strip saturated model. The strip saturated model is modified here by varying the strip saturated constant electric displacement condition to the polynomially varying electric displacement conditions. Based on the linear, quadratic, and cubic electric displacement conditions on the inner and outer saturated zones, dif- ferent modified strip saturated models are proposed and studied for two equal collinear cracks. With the Stroh formalism and the complex variable technique, these fracture problems are reduced into different types of non-homogeneous riemann Hilbert problems in unknown generalized complex potential functions. These mathematical problems are then solved with the riemann-Hilbert approach to obtain the stress and electric displace- ment components at any point of the domain. The explicit expressions for the outer saturated zone length, the crack opening potential (COP), the crack opening displace- ment (COD), and the local intensity factors (LIFs) are derived. A numerical study is presented for the modified strip saturated model in 2D arbitrary polarized semiperme- able PZT-4 material. The obtained results are compared with those of the strip saturated model, and the effects of the polynomially varying saturation condition on the saturated zones and the applied electrical loadings are presented.

关键词： complex variable coalesced zone piezoelectric riemann-Hilbert problem strip saturated model

Organization of future training in bariatric gastroenterology

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World Journal of Gastroenterology 2017年第35期23卷 6371-6378页

作者： timothy r Koch timothy r Shope Christopher J Gostout Center for Advanced Laparoscopic General and Bariatric Surgery Med Star Washington Hospital Center and Georgetown University School of Medicine Division of Gastroenterology and Hepatology Mayo Clinic

A world-wide rise in the prevalence of obesity continues. This rise increases the occurrence of, risks of, and costs of treating obesity-related medical conditions. Diet and activity programs are largely inadequate for the long-term treatment of medically-complicated obesity. Physicians who deliver gastrointestinal care after completing traditional training programs, including gastroenterologists and general surgeons, are not uniformly trained in or familiar with available bariatric care. It is certain that gastrointestinal physicians will incorporate new endoscopic methods into their practice for the treatment of individuals with medically-complicated obesity, although the longterm impact of these endoscopic techniques remains under investigation. It is presently unclear whether gastrointestinal physicians will be able to provide or coordinate important allied services in bariatric surgery, endocrinology, nutrition, psychological evaluation and support, and social work. Obtaining longitudinal results examining the effectiveness of this ad hoc approach will likely be difficult, based on prior experience with other endoscopic measures, such as the adenoma detection rates from screening colonoscopy. As a longterm approach, development of a specific curriculum incorporating one year of subspecialty training in bariatrics to the present training of gastrointestinal fellows needs to be reconsidered. This approach should be facilitated by gastrointestinal trainees' prior residency training in subspecialties that provide care for individuals with medical complications of obesity, including endocrinology, cardiology, nephrology, and neurology. Such training could incorporate additional rotations with collaborating providers in bariatric surgery, nutrition, and psychiatry. Since such training would be provided in accredited programs, longitudinal studies could be developed to examine the potential impact on accepted measures of care, such as complication rates, outcomes, and

关键词： Obesity Bariatrics Bariatric surgery Intragastric balloon Endoscopic sleeve gastroplasty Nutrition Endoscopy Training

Ending the Use of Human Antimicrobials in Food Production:The Good,the Bad,and the Ugly

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Engineering 2022年第8期8卷 9-10页

作者： timothy r.Walsh Department of Zoology University of OxfordOxford OX13SZUK Ineos Oxford Institute for Antimicrobial research(IOI) University of OxfordOxford OX13REUK

reducing the inappropriate use of antimicrobial drugs in food systems is a key priority for the Global Leaders Group on Antimicrobial resistance(GLG)[1].Although access to high-quality antimicrobials is important for animal and plant welfare,global leaders recognize that preventing the existential threat of antimicrobial resistance(AMr)will not be possible without reducing the use of human antimicrobials used in food systems[1].

关键词： Human drugs threat

A Preliminary Study of the Noninvasive remote Control System for rat Bio-robot

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Journal of Bionic Engineering 2010年第4期7卷 375-381页

作者： Xitian Pi~(1,2),Shuangshuang Li~1,Lin Xu~1,Hongying Liu~1,Shenshan Zhou~1,Kang Wei~1,Zhenyu Wang~1,Ziru Jia,Xiaolin Zheng~(1,2),Zhiyu Wen~2 1.Bioengineering College,Chongqing University,Chongqing 400030,P.r.China 2.Key Laboratories for National Defense Science and Technology of Innovative Micro-Nano Devices and System Technology,Chongqing University,Chongqing 400030,P.r.China [a] Bioengineering College Chongqing University Chongqing 400030 P. R. China [b] Key Laboratories for National Defense Science Technology of Innovative Micro-Nano Devices System Technology Chongqing University Chongqing 400030 P. R. China

A system is described here that can noninvasively control the navigation of freely behaving rat via ultrasonic,epidermaland LED photic stimulators on the *** system receives commands from a remote host computer to deliver specifiedelectrical stimulations to the hearing,pain and visual senses of the rat *** results demonstrate that the three stimuliwork in groups for the rat *** can control the rat to proceed and make right and left turns with great *** verified that the rat was able to reach a setting destination in the way of cable with the help of a person through theappropriate coordination of the three *** telemetry video camera mounted on the head of the rat also achieveddistant image acquisition and helped to adjust its navigation path over a distance of 300 *** a word,the non-invasive motioncontrol navigation system is a good,stable and reliable bio-robot.

关键词： rat navigation bio-robot ultrasonic stimulator epidermal stimulator LED photic stimulator

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural regeneration research 2025年第9期20卷 2591-2593页

作者： Alena Salasova Anders Nykjær Danish research Institute of Translational Neuroscience DANDrITE-Nordic EMBL Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2