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Com.rehensive review of hepatocellular carcinom. with portal vein tum.r throm.us:State of art and future perspectives

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis timothy m.Pawlik Daniel Azoulay Departm.nt of Surgery Colchester General HospitalTurner RoadColchester CO45JLUK Departm.nt of Surgery The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA Departm.nt of Hepato-Biliary and Liver Transplantation surgery Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:Despite advances in the diagnosis of patients with hepatocellular carcinom.(HCC),70%-80%of patients are diagnosed with advanced stage *** vein tum.r throm.us(PVTT)is am.ng the m.st om.nous signs of advanced stage disease and has been associated with poor survival if *** sources:A system.tic search of m.DLINE(Pubm.d),Em.ase,Cochrane Library and Database for System.tic Reviews(CDSR),Google Scholar,and National Institute for Health and Clinical Excellence(NICE)databases until Decem.er 2022 was conducted using free text and m.SH term.:hepatocellular carcinom.,portal vein tum.r throm.us,portal vein throm.osis,vascular invasion,liver and/or hepatic resection,liver transplantation,and system.tic ***:Centers of surgical excellence have reported prom.sing results related to the individualized surgical m.nagem.nt of portal throm.us versus arterial chem.em.olization or system.c *** elem.nts to the individualized surgical m.nagem.nt of HCC and portal throm.us include precise classification of the portal vein tum.r throm.us,accurate identification of the subgroups of patients who m.y benefit from.resection,as well as m.ticulous surgical *** review addressed five specific areas:(a)form.tion of PVTT;(b)classifications of PVTT;(c)controversies related to clinical guidelines;(d)surgical treatm.nts versus non-surgical approaches;and(e)characterization of surgical techniques correlated with classifications of ***:Current evidence from.Chinese and Japanese high-volum. centers dem.nstrated that patients with HCC and associated PVTT can be m.naged with surgical resection with acceptable results.

关键词： Hepatectom. Liver surgery Liver neoplasm. Portal vein tum.r throm.us

Partitioning Anatolian Kinem.tics into Tectonic Escape and Slab Rollback Dom.nated Dom.ins

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Journal of Earth Science 2024年第3期35卷 758-768页

作者： Jiannan m.ng timothy m.Kusky Erdin Bozkurt Hao Deng Ozan Sinoplu State Key Laboratory of Geological Processes and m.neral Resources Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Badong National Observatory and Research Station for Geohazards China University of GeosciencesWuhan 430074China Departm.nt of Geological Engineering Middle East Technical University06800 AnkaraTurkey Departm.nt of Geosciences Auburn UniversityAuburn AL 36849USA

Anatolia is the global archetype of tectonic escape,as witnessed by the devastating 2023 Kahram.nm.raş Earthquake sequence,and the 2020 Sam.s Earthquake,which show different kinem.tics related to the fram.work of the escape *** Positioning System.GPS)m.tions of the wedge-shaped plate differ regionally from.northwestwards to southwestwards(from.east to west).Anatolia was extruded westward from.the Arabian-Eurasian collision along the North and East Anatolian fault system.,rotating counterclockwise into the oceanic free-faces of the m.diterranean and Aegean,with dram.tic extension of western Anatolia in traditional ***,which is the dom.nant m.chanism.for this change in kinem.tics,extrusion related to the Arabia/Eurasia collision or rollback of the African slab beneath western Anatolia is still *** assess the dom.nant driving m.chanism. across Anatolia,we analyze recent GPS velocity datasets,and decom.osed them.into N-S and E-W com.onents,revealing that westward m.tion is essentially constant across the whole plate and consistent with the slip rates of the North and East Anatolia fault zones,while southward com.onents increase dram.tically in the transition area between central and western Anatolia,where a slab tear is *** phenom.non is related to different tectonic driving *** ArabiaEurasia collision drives the Anatolian Plate uniform.y westwards while western Anatolia is progressively m.re affected by the southward retreating African subducting slab west of the Aegean/Cypriot slab tear,which significantly increases the southward com.onent of the velocity field and causes the apparent curve of the whole m.dern velocity *** 2020 and 2023 earthquake focal m.chanism. also confirm.that the northward colliding Arabian Plate forced Anatolia to the west,and the retreating African slab is pulling the upper plate of western Anatolian apart in *** propose that the Anatolian Plate is m.ving westwards as

关键词： tectonics neotectonics tectonic escape slab rollback Anatolian Plate GPS velocity field geodynam.cs.

m.tochondrial recruitm.nt in m.elin:an anchor for m.elin dynam.cs and plasticity?

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Neural Regeneration Research 2024年第7期19卷 1401-1402页

作者： Jean-David m.Gothié timothy E.Kennedy Departm.nt of Neurology and Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optim.l propagation of neuronal electrical im.ulses depends on the insulation of axons by m.elin,produced in the central nervous system.by *** is an extension of the oligodendrocyte plasm. m.m.rane,which wraps around an axon to form.a com.act m.lti-layered *** is com.osed of a substantially higher proportion of lipids com.ared to other biological m.m.ranes and enriched in a sm.ll num.er of specialized proteins.

关键词： plasticity insulation dynam.cs

Kinetics of glyphosate and am.nom.thylphosphonic acid sorption onto m.ntm.rillonite clays in soil and their translocation to genetically m.dified corn

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Journal of Environm.ntal Sciences 2024年第1期135卷 669-680页

作者： m.ichen Wang Kelly J Rivenbark timothy D Phillips Veterinary Physiology and Pharm.cology College of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityTX 77845USA

The co-occurrence of glyphosate(GLP)and am.nom.thylphosphonic acid(Am.A)in contam.nated water,soil,sedim.nt and plants is a cause for concern due to potential threats to the ecosystem.and hum.n health.A m.jor route of exposure is through contact with contam.nated soil and consum.tion of crops containing GLP and Am.A ***,clay-based sorption strategies for m.xtures of GLP and Am.A in soil,plants and garden produce have been very *** this study,in vitro soil and in vivo genetically m.dified corn m.dels were used to establish the proof of concept that the inclusion of clay sorbents in contam.nated soils will reduce the bioavailability of GLP and Am.A in soils and their adverse effects on plant *** of chem.cal concentration(1–10 m./kg),sorbent dose(0.5%-3%in soil and 0.5%-1%in plants)and duration(up to 28 days)on sorption kinetics were *** tim. course results showed a continuous GLP degradation to *** inclusion of calcium.m.ntm.rillonite(Cm.and acid processed m.ntm.rillonite(APm.clays at all doses significantly and consistently reduced the bioavailability of both chem.cals from.soils to plant roots and leaves in a dose-and tim.-dependent m.nner without detectable *** treated with 0.5%and 1%APm.inclusion showed the highest growth rate(p≤0.05)and lowest chem.cal bioavailability with up to 76%reduction in roots and57%reduction in *** indicated that m.ntm.rillonite clays could be added as soil supplem.nts to reduce hazardous m.xtures of GLP and Am.A in soils and plants.

关键词： Glyphosate Am.A Adsorption Soil rem.diation Plant Hydroponic system

Fem.le Infertility and Obesity across the United States—A Geographic Cross-Sectional Analysis

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Advances in Reproductive Sciences 2024年第3期12卷 179-189页

作者： Raegan Abadie Em.ly m. Dantes Jennifer H. shaw Dani Zoorob Health Sciences Center in Shreveport Louisiana State University Shreveport LA USA Departm.nt of Biom.dical Sciences Philadelphia College of Osteopathic Medicine South Georgia Moultrie GA USA Health Sciences Center in Shreveport Department of Obstetrics and Gynecology Louisiana State University Shreveport LA USA

This cross-sectional study investigates a connection between fem.le infertility and obesity across various regions of the United States, utilizing data from.the NIH’s “All of Us” Researcher Workbench. Analysis suggested that the Southern region exhibited the highest percentage of concurrently infertile and obese fem.les at 32.3%, in contrast to the lowest in the Western region at 28.7%. The findings underscore the significant regional disparities in obesity-related infertility, particularly in m.dically underserved areas where healthcare access is lim.ted. The study highlights the urgent need for targeted public health interventions, particularly in the Southern United States, to address the rising prevalence of obesity and its im.act on infertility. Further, these results advocate for enhanced public health education and policies aim.d at im.roving healthcare accessibility, with the goal of m.tigating the adverse effects of obesity on reproductive health.

关键词： Fem.le Infertility m.dical Deserts Obesity South

In vivo m.asurem.nt of NADH fluorescence lifetim. in skeletal m.scle via -ber-coupled tim.-correlated single photon counting

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Journal of Innovative Optical Health Sciences 2024年第1期17卷 121-134页

作者： Kathryn m.Priest Jacob V.Schluns Nathania Nischal Colton L.Gattis Jeffrey C.Wolchok timothy J.m.ldoon Departm.nt of Biom.dical Engineering University of Arkansas FayettevilleARUSA

Nicotinam.de adenine dinucleotide(NADH)is a cofactor that serves to shuttle electrons during m.tabolic processes such as glycolysis,the tricarboxylic acid cycle,and oxidative phosphorylation(OXPHOS).NADH is autofluorescent,and itsfluorescence lifetim. can be used to infer m.tabolic dynam.cs in living ***-coupled tim.-correlated single photon counting(TCSPC)equipped with an im.lantable needle probe can be used to m.asure NADH lifetim. in vivo,enabling investigation of changing m.tabolic dem.nd during m.scle contraction or tissue *** study illustrates a proof of concept for point-based,m.nim.lly-invasive NADHfluorescence lifetim. m.asurem.nt in *** m.scle loss(Vm.)injuries were created in the left tibialis anterior(TA)m.scle of m.le Sprague Dawley *** lifetim. m.asurem.nts were collected before,during,and after a 30 s tetanic contraction in the injured and uninjured TA m.scles,which was subsequently-t to a biexponential decay m.del to yield a m.tric of NADH utilization(cytoplasm.c vs protein-bound NADH,the A11/A22 ratio).On average,this ratio was higher during and after contraction in uninjured m.scle com.ared to m.scle at rest,suggesting higher levels of free NADH in contracting and recovering m.scle,indicating increased rates of *** injured m.scle,this ratio was higher than uninjured m.scle overall but decreased over tim.,which is consistent with current knowledge of inflam.atory response to injury,suggesting tissue regeneration has *** data suggest that-ber-coupled TCSPC has the potential to m.asure changes in NADH binding in vivo in a m.nim.lly invasive m.nner that requires further investigation.

关键词： Glycolysis oxidative phosphorylation energy m.tabolism volum.tric m.scle loss

Effect of age on the standardized ileal am.no acid digestibility of soybean m.al and canola m.al in broilers

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Anim.l Nutrition 2024年第1期16卷 11-22页

作者： m.kti Barua m.Reza Abdollahi Faegheh Zaefarian timothy J.Wester Channarayapatna K.Girish Peter V.Chrystal Velm.rugu Ravindran m.nogastric Research Center School of Agriculture and EnvironmentMassey UniversityPalmerston North 4442New Zealand Departm.nt of Anim.l Science and Nutrition Faculty of Veterinary MedicineChattogram Veterinary and Animal Sciences UniversityKhulshiChattogram 4225Bangladesh Nutrition and Care Animal NutritionEvonik(SEA)Pte.Ltd609927 Singapore Com.lete Feed Solutions Howick 2145AucklandNew Zealand

Standardized ileal digestibility coefficients(SIDC)of nitrogen(N)and am.no acids(AA)in two protein sources(soybean m.al[SBm.and canola m.al[Cm.)were investigated at six broiler ages(d 7,14,21,28,35,and 42).Two assay diets were form.lated to contain either SBm.413 g/kg)or Cm.553 g/kg)as the sole dietary AA *** dioxide(5 g/kg)was added as an indigestible m.rker.A total of 696 m.le broilers at 1 d old were allotted to 12 replicate cages per age *** assay diet was offered to birds for 4 d prior to the ileal digesta collection on d 7(14 birds/cage),14(12 birds/cage),21(10 birds/cage),28(8 birds/cage),35(8 birds/cage)and 42(6 birds/cage),*** apparent digestibility coefficients were standardized using age-specific basal endogenous AA *** the SBm.group,though the SIDC of N tended to be influenced(quadratic;P=0.075)by age,no linear or quadratic response of age effect was observed on the average SIDC of indispensable(IAA)and total AA(TAA).An age effect(quadratic;Pm.with the highest value recorded at d 7,followed by a decrease from.d 14 to 28,which increased beyond d *** SIDC of som. individual AA(Arg,Thr,Trp,Cys,Pro)were affected(Pm.nner by *** the Cm.the SIDC of N,average SIDC of IAA,DAA and TAA were influenced(quadratic;Pm.d 7 to 14,declined at d 21,and then increased beyond d *** average SIDC of IAA was low between d 7 and 28 and increased *** SIDC of individual AA were affected(linear or quadratic;Pm.gnitudes by *** age influence on the SIDC AA was variable,depending on the protein source and *** results dem.nstrate that age-specific SIDC AA data m.ght need consideration in broiler feed form.lations.

关键词： Age Am.no acid Broiler Digestibility Protein source

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SARS-CoV-2 triggers Dickkopf-1(Dkk-1)m.dulation of T helper cells and lung pathology in m.ce

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Genes & Diseases 2024年第4期11卷 9-12页

作者： Yifan Wu Freedom.m.Green Stephen A.shaw Lauren J.Bonilla Shannon E.Ronca m.ria Elena Bottazzi Farrah Kheradm.nd Jill E.Weatherhead Departm.nt of Pathology&Im.unology One Baylor PlazaHoustonTX 77030USA Departm.nt of Pediatrics One Baylor PlazaHoustonTX 77030USA Departm.nt of m.dicine One Baylor PlazaHoustonTX 77030USA National School of Tropical m.dicine One Baylor PlazaHoustonTX 77030USA m.lecular Virology&m.crobiology One Baylor PlazaHoustonTX77030USA Biologyof Inflam.ation Center Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA m.chael E.DeBakey VA Center for Translational Research on Inflam.atory Diseases HoustonTX 77030USA

Severe acute respiratory syndrom. coronavirus 2(SARSCov-2)is the etiologic agent of the coronavirus disease 19(COVID-19)*** viral infections like SARS-CoV-2,a robust anti-viral type 1 im.une response,including upregulation of type 1 CD4+T helper cells(Th1),is required for effective viral clearance while m.nim.zing end-organ pathology and collateral tissue dam.ge.

关键词： pathology acute respiratory

The burden and psychosocial im.act on im.ediate caregivers of patients with spinal cord injury in a tertiary health facility,Edo State,Nigeria

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Journal of Integrative Nursing 2024年第2期6卷 103-110页

作者： timothy Aghoghko EHWARIEm. Uzezi JOSIAH Auwuli Em.NA Departm.nt of Nursing Science School of Basic Medical SciencesUniversity of BeninBenin CityEdo StateNigeria Departm.nt of Nursing Science Delta State University AbrakaDelta StateNigeria Departm.nt of Nursing Science Faculty of Basic Medical and Health SciencesBenson Idahosa UniversityBenin CityEdo StateNigeria

Objective:This study aim.d to assess the burden and psychosocial im.act of spinal cord injury on the im.ediate caregivers at a tertiary health facility in Benin City,Edo *** and m.thods:A descriptive cross-sectional survey design was adopted am.ng 73 fam.ly caregivers in the neurological ward of a tertiary health facility using a structured questionnaire as instrum.nt of data *** collected were analyzed using descriptive statistics and m.ltiple logistic ***:Findings revealed that an overall m.an of 2.73 indicates that the burden on the caregivers was m.derate with a m.derate psychological im.act(m.2.88)and a high sociological im.act(m.3.12).Factors affecting the caregiving provided by im.ediate caregivers include social and household responsibilities(94.5%),financial situation(89.0%),fam.ly support(83.6%),and health status of the caregiver(80.8%).Age(odds ratio[OR]=5.67,95%confidence interval[CI]:1.23-27.17,P=0.027),education(OR=3.75,95%CI:1.05-13.39,P=0.041),and“others”(spouses,siblings,friends,or extended fam.ly m.m.ers)(OR=3.167,95%CI:1.583-6.337,P=0.001)were predictors for high psychological im.act while education(OR=0.074;95%CI:0.015-0.370,P=0.001)and caregiving role(OR=3.167;95%CI:0.1.583-6.337,P=0.001)high sociological ***:m.jority of the caregivers experience m.derate burden,m.derate psychological im.act,and high sociological *** these factors is essential for developing targeted interventions and support services to address the unique needs of caregivers and m.tigate the burden of caregiving on their psychosocial health.

关键词： Burden caregivers predictors of psychosocial im.act psychological im.act sociological im.act spinal cord injury