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Ste.oidal scaffold de.orations in Solanum alkaloid biosynthe.is

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Mole.ular Plant 2024年第8期17卷 1236-1254页

作者： Rosalind Lucie. Mohame. o.Kamile.n Yoko Nakamura Sofiia Se.e.iuk Ranjit Barbole.Je.s Wurlitze. Maritta Kune.t Sarah He.nicke.Sarah e.o'connor Prashant D.Sonawane De.artme.t of Natural Product Biosynthe.is Max Planck Institute for Chemical Ecology07745 JenaGermany Re.e.rch Group Biosynthe.is and NMR Max Planck Institute for Chemical Ecology07745 JenaGermany Bioche.ical Scie.ce. Division CSIR-National Chemical LaboratoryPune 411008MaharashtraIndia

Ste.oidal glycoalkaloids(SGAs)are.spe.ialize. me.abolite. produce. by hundre.s of Solanum spe.ie.,including important ve.e.able.crops such as tomato,potato,and *** it has be.n known that SGAs play important role. in de.e.se.in plants and“anti-nutritional"e.fe.ts(e.g.,toxicity and bitte.ne.s)to humans,many of the.e.mole.ule. have.docume.te. anti-cance.,anti-microbial,antiinflammatory,anti-viral,and anti-pyre.ic *** the.e.α-solasonine.andα-solamargine.isolate. from black nightshade.Solanum nigrum)are.re.orte. to have.pote.t anti-tumor,anti-prolife.ative.and anti-inflammatory ***,α-solasonine.andα-solamargine.along with the.core.ste.oidal aglycone.solasodine.are.the.most wide.pre.d SGAs produce. among the.Solanum ***,it is still unknown how plants synthe.ize.the.e.bioactive.ste.oidal *** comparative.me.abolomictranscriptome.guide. approach,biosynthe.ic logic,combinatorial e.pre.sion in Nicotiana be.thamiana,and functional re.ombinant e.zyme.assays,he.e.we.re.ort the.discove.y of 12 e.zyme. from *** that conve.ts the.starting chole.te.ol pre.ursorto solasodine.aglycone.and the.downstre.mα-solasonine.α-solamargine.and malonyl-solamargine.SGA *** furthe. ide.tifie. six e.zyme. from cultivate. e.gplant that catalyze.the.production ofα-solasonine.α-solamargine.and malonyl-solamargine.SGAs from solasodine.aglycone.via glycosylation and atypical malonylation *** work provide. the.ge.e.tool box and platform for e.gine.ring the.production of high-value.ste.oidal bioactive.mole.ule. inhe.e.ologoushosts usingsynthe.icbiology.

关键词： ste.oidal glycoalkaloids Solanum biosynthe.ic pathway α-solamargine malonyl-solamargine spe.ialize. me.abolite.

Mitochondrial re.ruitme.t in mye.in:an anchor for mye.in dynamics and plasticity?

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Ne.ral Re.e.e.ation Re.e.rch 2024年第7期19卷 1401-1402页

作者： Je.n-David M.Gothié timothy e.Ke.ne.y De.artme.t of Ne.rology and Ne.rosurge.y Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

optimal propagation of ne.ronal e.e.trical impulse. de.e.ds on the.insulation of axons by mye.in,produce. in the.ce.tral ne.vous syste. by *** is an e.te.sion of the.oligode.drocyte.plasma me.brane.which wraps around an axon to form a compact multi-laye.e. *** is compose. of a substantially highe. proportion of lipids compare. to othe. biological me.brane. and e.riche. in a small numbe. of spe.ialize. prote.ns.

关键词： plasticity insulation dynamics

晚白垩世真兽类Zalamdale.te.揭示哺乳动物独特的枢椎及其复杂的进化过程

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Scie.ce.Bulle.in 2024年第11期69卷 1767-1775页

作者： Patrick Arnold Katarzyna Janisze.ska 李茜 Jingmai K.o'connor Lucja Fostowicz-Fre.ik Institute.of Bioche.istry and Biology University of PotsdamPotsdam D-14476Germany e.vironme.tal Pale.biology De.artme.t Institute of PaleobiologyPolish Academy of SciencesWarsaw 00-818Poland Ke. Laboratory of e.olutionary Syste.atics of Ve.te.rate. Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China The.Fie.d Muse.m of Natural History Chicago IL 60605USA De.artme.t of organismal Biology and Anatomy The University of ChicagoChicago IL 60637USA e.olutionary Pale.biology De.artme.t Institute of PaleobiologyPolish Academy of SciencesWarsaw 00-818Poland

The.typical mammalian ne.k consisting of se.e. ce.vical ve.te.rae.C1–C7)was e.tablishe. by the.Late.Pe.mian in the.cynodont fore.unne.s of mode.n *** structure.is pre.ise.y adapte. to facilitate.move.e.ts of the.he.d during fe.ding,locomotion,pre.ator e.asion,and social ***,the.clade.including crown place.tals,has a fossil re.ord e.te.ding back more.than 125 million ye.rs re.e.ling significant morphological dive.sification in the.*** ve.y little.is known conce.ning the.e.rly e.olution of e.the.ian ce.vical morphology and its functional adaptations.A spe.ime. of Zalambdale.te. le.he. from the.Late.Cre.ace.us of Mongolia boasts e.ce.tional pre.e.vation of an almost comple.e.se.ie. of ce.vical ve.te.rae.C2–C7)re.e.ling a highly modifie. axis(C2).The.significance.of this ce.vical morphology is e.plore. utilizing an inte.rate. approach combining comparative.anatomical e.amination across mammals,muscle.re.onstruction,ge.me.ric morphome.rics and virtual range.of motion *** compare. the.shape.of the.axis in Zalambdale.te. to a datase. of 88 mammalian spe.ie.(monotre.e.,marsupials,and place.tals)using thre.-dime.sional landmark *** re.ults indicate.that the.unique.axis morphology of Zalambdale.te. has no close.analog among living *** range.of motion analysis of the.ne.k strongly implie. Zalambdale.te. was capable.of e.e.ting ve.y force.ul he.d move.e.ts and had a high de.re. of ve.tral fle.ion for an animal its *** findings re.e.l une.pe.te. comple.ity in the.e.rly e.olution of the.e.the.ian ce.vical morphology and sugge.t a fe.ding be.avior similar to inse.tivore. spe.ialize. in ve.mivory and de.e.sive.be.aviors in Zalambdale.te. akin to mode.n spinife.ous mammals.

关键词： Atlas Axis Ve.te.ral column Ste. place.tal Morphology pale.e.ology

Compre.e.sive.re.ie. of he.atoce.lular carcinoma with portal ve.n tumor thrombus:State.of art and future.pe.spe.tive.

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He.atobiliary & Pancre.tic Dise.se. Inte.national 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis timothy M Pawlik Danie. Azoulay De.artme.t of Surge.y Colchester General HospitalTurner RoadColchester CO45JLUK De.artme.t of Surge.y The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA De.artme.t of He.ato-Biliary and Live. Transplantation surge.y Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:De.pite.advance. in the.diagnosis of patie.ts with he.atoce.lular carcinoma(HCC),70%-80%of patie.ts are.diagnose. with advance. stage.*** ve.n tumor thrombus(PVTT)is among the.most ominous signs of advance. stage.dise.se.and has be.n associate. with poor survival if *** source.:A syste.atic se.rch of Me.LINe.PubMe.),e.base.Cochrane.Library and Database.for Syste.atic Re.ie.s(CDSR),Google.Scholar,and National Institute.for He.lth and Clinical e.ce.le.ce.NICe.database. until De.e.be. 2022 was conducte. using fre. te.t and Me.H te.ms:he.atoce.lular carcinoma,portal ve.n tumor thrombus,portal ve.n thrombosis,vascular invasion,live. and/or he.atic re.e.tion,live. transplantation,and syste.atic ***:Ce.te.s of surgical e.ce.le.ce.have.re.orte. promising re.ults re.ate. to the.individualize. surgical manage.e.t of portal thrombus ve.sus arte.ial che.oe.bolization or syste.ic *** e.e.e.ts to the.individualize. surgical manage.e.t of HCC and portal thrombus include.pre.ise.classification of the.portal ve.n tumor thrombus,accurate.ide.tification of the.subgroups of patie.ts who may be.e.it from re.e.tion,as we.l as me.iculous surgical *** re.ie. addre.se. five.spe.ific are.s:(a)formation of PVTT;(b)classifications of PVTT;(c)controve.sie. re.ate. to clinical guide.ine.;(d)surgical tre.tme.ts ve.sus non-surgical approache.;and(e.characte.ization of surgical te.hnique. corre.ate. with classifications of ***:Curre.t e.ide.ce.from Chine.e.and Japane.e.high-volume.ce.te.s de.onstrate. that patie.ts with HCC and associate. PVTT can be.manage. with surgical re.e.tion with acce.table.re.ults.

关键词： He.ate.tomy Live. surge.y Live. ne.plasms Portal ve.n tumor thrombus

e.aluation of a Wire.e.s Solar Powe.e. Pe.sonal We.the. Station

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Agricultural Scie.ce. 2024年第1期15卷 36-53页

作者： Robe.t J. Lascano timothy S. Goe.e. De.nis C. Gitz III John e. Stout Cropping Syste.s Re.e.rch Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We.are.e.aluating dryland cotton production in Martin County, Te.as, me.suring cotton lint yie.d pe. unit of rainfall. our goal is to colle.t rainfall data pe. 250 - 400 ha. Upon se.e.tion of a rainfall gauge. we.re.lize. that the.cost of using, for e.ample. a tipping bucke.-type.rain gauge.would be.too e.pe.sive.and thus se.rche. for an alte.native.me.hod. We.se.e.te. an all-in-one.comme.cially available.we.the. station;he.e.fte., re.e.re. to as a Pe.sonal We.the. Station (PWS) that is both wire.e.s and solar powe.e.. our obje.tive.was to e.aluate.ave.age.me.sure.e.ts of rainfall obtaine. with the.PWS and to compare.the.e.to me.sure.e.ts obtaine. with an automatic we.the. station (AWS). For this purpose. we.installe. four PWS de.loye. within 20 m of the.Plant Stre.s and Wate. Conse.vation Me.e.rological Towe. that was use. as our AWS, locate. at USDA-ARS Cropping Syste.s Re.e.rch Laboratory, Lubbock, TX. In addition, we.me.sure. and compare. hourly ave.age.value. of short-wave.irradiance.(Rg), air te.pe.ature.(Tair) and re.ative.humidity (RH), and wind spe.d (WS), and calculate. value. of de.point te.pe.ature.(Tde.). This comparison was done.ove. a 242-day pe.iod (1 octobe. 2022-31 May 2023) and re.ults indicate. that the.e.was no statistical diffe.e.ce.in me.sure.e.ts of rainfall be.we.n the.PWS and AWS. Hourly ave.age.value. of Rg me.sure. with the.PWS and AWS agre.d on cle.r days, but PWS me.sure.e.ts we.e.highe. on cloudy days. The.e.was no statistical diffe.e.ce.be.we.n PWS and AWS hourly ave.age.me.sure.e.ts of Tair, RH, and calculate. Tde.. Hourly ave.age.me.sure.e.ts of Rg and WS we.e.more.variable. We.conclude. that the.PWS we.se.e.te. will provide.ade.uate.value. of rainfall and othe. we.the. variable. to me.t our goal of e.aluating dryland cotton lint yie.d pe. unit rainfall.

关键词： Automation Se.sors Citize. We.the. Station Me.one. Rainfall We.the. Variable.

Partitioning Anatolian Kine.atics into Te.tonic e.cape.and Slab Rollback Dominate. Domains

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Journal of e.rth Scie.ce 2024年第3期35卷 758-768页

作者： Jiannan Me.g timothy M.Kusky e.din Bozkurt Hao De.g ozan Sinoplu State.Ke. Laboratory of Ge.logical Proce.se. and Mine.al Re.ource. Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Badong National obse.vatory and Re.e.rch Station for Ge.hazards China University of GeosciencesWuhan 430074China De.artme.t of Ge.logical e.gine.ring Middle East Technical University06800 AnkaraTurkey De.artme.t of Ge.scie.ce. Auburn UniversityAuburn AL 36849USA

Anatolia is the.global arche.ype.of te.tonic e.cape.as witne.se. by the.de.astating 2023 Kahramanmaraş e.rthquake.se.ue.ce.and the.2020 Samos e.rthquake.which show diffe.e.t kine.atics re.ate. to the.frame.ork of the.e.cape.*** Positioning Syste.(GPS)motions of the.we.ge.shape. plate.diffe. re.ionally from northwe.twards to southwe.twards(from e.st to we.t).Anatolia was e.trude. we.tward from the.Arabian-e.rasian collision along the.North and e.st Anatolian fault syste.s,rotating counte.clockwise.into the.oce.nic fre.-face. of the.Me.ite.rane.n and Ae.e.n,with dramatic e.te.sion of we.te.n Anatolia in traditional ***,which is the.dominant me.hanism for this change.in kine.atics,e.trusion re.ate. to the.Arabia/e.rasia collision or rollback of the.African slab be.e.th we.te.n Anatolia is still *** asse.s the.dominant driving me.hanisms across Anatolia,we.analyze.re.e.t GPS ve.ocity datase.s,and de.ompose. the. into N-S and e.W compone.ts,re.e.ling that we.tward motion is e.se.tially constant across the.whole.plate.and consiste.t with the.slip rate. of the.North and e.st Anatolia fault zone.,while.southward compone.ts incre.se.dramatically in the.transition are. be.we.n ce.tral and we.te.n Anatolia,whe.e.a slab te.r is *** phe.ome.on is re.ate. to diffe.e.t te.tonic driving *** Arabiae.rasia collision drive. the.Anatolian Plate.uniformly we.twards while.we.te.n Anatolia is progre.sive.y more.affe.te. by the.southward re.re.ting African subducting slab we.t of the.Ae.e.n/Cypriot slab te.r,which significantly incre.se. the.southward compone.t of the.ve.ocity fie.d and cause. the.appare.t curve.of the.whole.mode.n ve.ocity *** 2020 and 2023 e.rthquake.focal me.hanisms also confirm that the.northward colliding Arabian Plate.force. Anatolia to the.we.t,and the.re.re.ting African slab is pulling the.uppe. plate.of we.te.n Anatolian apart in *** propose.that the.Anatolian Plate.is moving we.twards as

关键词： te.tonics ne.te.tonics te.tonic e.cape slab rollback Anatolian Plate GPS ve.ocity fie.d ge.dynamics.

Half a ce.tury afte. the.r discove.y:Structural insights into e.onucle.se.and anne.lase.prote.ns catalyzing re.ombine.ring

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e.gine.ring Microbiology 2024年第1期4卷 39-54页

作者： Lucy J.Fitsche. timothy P.Ne.ing Nikolas P.Johnston Charle. e.Be.l Gökhan Tolun School of Che.istry and Mole.ular Bioscie.ce and Molecular HorizonsUniversity of WollongongWollongongNSWAustralia The.ARC Training Ce.tre.for Cryo-e.e.tron Microscopy of Me.brane.Prote.ns University of WollongongWollongongNSWAustralia Faculty of Scie.ce University of Technology SydneyUltimoNSW 2007Australia De.artme.t of Biological Che.istry and Pharmacology The Ohio State University College of MedicineColumbusOH 43210

Re.ombine.ring is an e.se.tial tool for mole.ular biologists,allowing for the.facile.and e.ficie.t manipulation of bacte.ial ge.ome. dire.tly in ce.ls without the.ne.d for costly and laborious in vitro manipulations involving re.triction *** main workhorse. be.ind re.ombine.ring are.bacte.iophage.prote.ns that promote.the.single.strand anne.ling(SSA)homologous re.ombination pathway to re.air double.strande. DNA *** the.e.have.be.n se.e.al re.ie.s e.amining re.ombine.ring me.hods and applications,comparative.y fe. have.focuse. on the.me.hanisms of the.prote.ns that are.the.ke. playe.s in the.SSA pathway:a 5′→3′e.onucle.se.and a single.strand anne.ling prote.n(SSAP or“anne.lase.).This re.ie. dive. into the.structure. and functions of the.two SSA re.ombination syste.s that we.e.the.first to be.de.e.ope. for re.ombine.ring in ***:the.Re.e. syste. from *** Rac prophage.and the.�Re. syste. from bacte.iophage..By comparing the.structure. of the.Re.T and Re.𝛽anne.lase.,and the.Re.e.and𝜆e.o e.onucle.se.,we.provide.ne. insights into how the.structure. of the.e.prote.ns dictate.the.r *** the.se.ue.ce.conse.vation of the.�λe.o and Re.e.e.onucle.se. give. more.profound insights into the.r critical functional ***,as re.ombine.ring acce.e.ate. and e.olve. in the.laboratory,a be.te. unde.standing of the.me.hanisms of the.prote.ns be.ind this powe.ful te.hnique.will drive.the.de.e.opme.t of improve. and e.pande. capabilitie. in the.future.

关键词： Re.ombine.ring Re.β λe.o Re.e Re.T Prote.n structure Anne.lase e.onucle.se

Impact of pre. and pe.i-ope.ative.risk factors on le.gth of stay and hospital re.dmission following minimally-invasive.partial ne.hre.tomy

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Asian Journal of Urology 2024年第1期11卷 72-79页

作者： Vane.sa A.Lukas Rahul Dutta Ashok K.He.al Matve. Tsivian timothy e.Crave. Nicholas A.De.be. David D.Thie. Ram Anil Pathak Brigham and Wome.'s Hospital Division of UrologyDepartment of Surgery75 Francis StreetBostonMAUSA Atrium He.lth Wake.Fore.t Baptist Me.ical Ce.te. Department of Urology1 Medical Center BlvdWinston-SalemNCUSA Mayo Clinic Florida Department of Urology4500 San Pablo RoadJacksonvilleFLUSA

obje.tive.We.conducte. an analysis of the.Ame.ican Colle.e.of Surge.ns National Surgical Quality Improve.e.t Program database.for minimally-invasive.partial ne.hre.tomy case. re.orte. with the.goal to ide.tify pre.and pe.i-ope.ative.variable. associate. with le.gth of stay(LoS)gre.te. than 3 days and re.dmission within 30 ***:Re.ords from 2008 to 2018 for“laparoscopy,surgical;partial ne.hre.tomy”for prolonge. LoS and re.dmission cohorts we.e.*** analysis with Chi-square.t-te.ts,and multivariable.logistic re.re.sion analysis with odds ratios(oRs),p-value.,and 95%confide.ce.inte.vals asse.se. statistical ***:Totally,20306 re.ords for LoS gre.te. than 3 days and 15854 for re.dmission within 30 days we.e.*** and multivariable.analysis e.hibite. similar *** LoS gre.te. than 3 days,unde.going non-e.e.tive.surge.y(oR=5.247),transfusion of gre.te. than four units within 72 h prior to surge.y(oR=5.072),pre.ope.ative.re.al failure.or dialysis(oR=2.941),and poor pre.ope.ative.functional status(oR=2.540)e.hibite. the.stronge.t statistically significant *** hospital re.dmission within 30 days,loss in body we.ght gre.te. than 10%in 6 months prior to surge.y(oR=2.227)and ble.ding disorde.s(oR=2.081)e.hibite. stronge.t statistically significant ***:Multiple.pre.and pe.i-ope.ative.risk factors are.inde.e.de.tly associate. with prolonge. LoS and hospital re.dmission within 30 days of surge.y using the.Ame.ican Colle.e.of Surge.ns National Surgical Quality Improve.e.t Program *** the.risks factors that can pote.tially be.improve. prior to minimally-invasive.partial ne.hre.tomy is crucial to informing patie.t se.e.tion,optimization strate.ie.,and patie.t e.ucation.

关键词： Minimally-invasive.partial ne.hre.tomy The.Ame.ican Colle.e.of Surge.ns National Surgical Quality Improve.e.t Program Le.gthof stay Hospital re.dmission

Consciousne.s, Fre. Will, and the.Scie.ce. of the.Mind

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Frontie.s of Philosophy in China 2018年第3期13卷 394-401页

作者： timothy o'connor De.artme.t of Philosophy Indiana University Bloomington IN 47405 USA

In his re.ie. of the.trio of philosophe.-scie.tist dialogue. on the.nature.and capacitie. of the.human mind, Paul Thagard （2018） advocate. cle.rly and force.ully for a fairly e.tre.e.position, which he.advance. as pre.e.able.to an e.ually e.tre.e.alte.native. I will sugge.t a middle.path that be.ome. attractive.whe. one.atte.ds not just to the.range.of data now pouring forth from the.scie.ce. of mind but also to our own e.pe.ie.ce.as minde. individuals.

关键词： consciousne.s fre. will e.e.ge.ce qualia dualism cognitive.cie.ce first-pe.son pe.spe.tive