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Natural Scie.ce 2021年第6期13卷 194-207页

作者： timothy e. black Me.hat Radi Amanda Some.s Charle. I. Abramson Laboratory of Comparative.Psychology and Be.avioral Biology Psychology Department Oklahoma State University Stillwater USA Pe.t Physiology De.artme.t Plant Protection Research Institute ARC Giza Egypt

Hone. be.s are.an e.tablishe. animal mode. for studying le.rning and me.ory re.ate. be.aviors. In re.e.t ye.rs, hone. be.s have.be.ome.more.common as a mode. for inve.tigations of mole.ular biology, including ge.e.e.pre.sion. Hone. be.s have.be.n use. to e.trapolate.ge.e.ic functions found in othe. inve.te.rate., such as Drosophila melanogaster. The honey bee model has also provided a means for isolating novel genes, including non-coding microRNA fragments. Integrating the study of learning and memory with molecular genetics, the present work examines the effect of learning acquisition and memory consolidation in free-choice paradigms on the expression of a suite of genes of interest. Results suggest that short-term learning acquisition causes differential expression of microRNA fragments, while memory consolidation differentially affects the expression of the serine/threonine protein kinase gene in honey bees. These results corroborate previous findings suggesting the importance of protein kinases in the formation of long term memory, and suggest that microRNA may play a large role in regulation of cytoskeletal scaffolding proteins.

关键词： Hone. Be.s Le.rning Me.ory Ge.e.e.pre.sion microRNA

Mitochondrial re.ruitme.t in mye.in:an anchor for mye.in dynamics and plasticity?

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Ne.ral Re.e.e.ation Re.e.rch 2024年第7期19卷 1401-1402页

作者： Je.n-David M.Gothié timothy e.Ke.ne.y De.artme.t of Ne.rology and Ne.rosurge.y Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optimal propagation of ne.ronal e.e.trical impulse. de.e.ds on the.insulation of axons by mye.in,produce. in the.ce.tral ne.vous syste. by *** is an e.te.sion of the.oligode.drocyte.plasma me.brane.which wraps around an axon to form a compact multi-laye.e. *** is compose. of a substantially highe. proportion of lipids compare. to othe. biological me.brane. and e.riche. in a small numbe. of spe.ialize. prote.ns.

关键词： plasticity insulation dynamics

Compre.e.sive.re.ie. of he.atoce.lular carcinoma with portal ve.n tumor thrombus:State.of art and future.pe.spe.tive.

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He.atobiliary & Pancre.tic Dise.se. Inte.national 2024年第3期23卷 221-227页

作者： Paschalis Gavriilidis timothy M Pawlik Danie. Azoulay De.artme.t of Surge.y Colchester General HospitalTurner RoadColchester CO45JLUK De.artme.t of Surge.y The Ohio State Wexner Medical CenterJames Comprehensive Cancer CenterColumbusOHUSA De.artme.t of He.ato-Biliary and Live. Transplantation surge.y Paul Brousse University HospitalParis-Saclay UniversityVillejuif 94800France

Background:De.pite.advance. in the.diagnosis of patie.ts with he.atoce.lular carcinoma(HCC),70%-80%of patie.ts are.diagnose. with advance. stage.*** ve.n tumor thrombus(PVTT)is among the.most ominous signs of advance. stage.dise.se.and has be.n associate. with poor survival if *** source.:A syste.atic se.rch of Me.LINe.PubMe.),e.base.Cochrane.Library and Database.for Syste.atic Re.ie.s(CDSR),Google.Scholar,and National Institute.for He.lth and Clinical e.ce.le.ce.NICe.database. until De.e.be. 2022 was conducte. using fre. te.t and Me.H te.ms:he.atoce.lular carcinoma,portal ve.n tumor thrombus,portal ve.n thrombosis,vascular invasion,live. and/or he.atic re.e.tion,live. transplantation,and syste.atic ***:Ce.te.s of surgical e.ce.le.ce.have.re.orte. promising re.ults re.ate. to the.individualize. surgical manage.e.t of portal thrombus ve.sus arte.ial che.oe.bolization or syste.ic *** e.e.e.ts to the.individualize. surgical manage.e.t of HCC and portal thrombus include.pre.ise.classification of the.portal ve.n tumor thrombus,accurate.ide.tification of the.subgroups of patie.ts who may be.e.it from re.e.tion,as we.l as me.iculous surgical *** re.ie. addre.se. five.spe.ific are.s:(a)formation of PVTT;(b)classifications of PVTT;(c)controve.sie. re.ate. to clinical guide.ine.;(d)surgical tre.tme.ts ve.sus non-surgical approache.;and(e.characte.ization of surgical te.hnique. corre.ate. with classifications of ***:Curre.t e.ide.ce.from Chine.e.and Japane.e.high-volume.ce.te.s de.onstrate. that patie.ts with HCC and associate. PVTT can be.manage. with surgical re.e.tion with acce.table.re.ults.

关键词： He.ate.tomy Live. surge.y Live. ne.plasms Portal ve.n tumor thrombus

e.aluation of a Wire.e.s Solar Powe.e. Pe.sonal We.the. Station

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Agricultural Scie.ce. 2024年第1期15卷 36-53页

作者： Robe.t J. Lascano timothy S. Goe.e. De.nis C. Gitz III John e. Stout Cropping Syste.s Re.e.rch Laboratory Wind Erosion and Water Conservation Research Unit USDA-ARS Lubbock TX USA

We.are.e.aluating dryland cotton production in Martin County, Te.as, me.suring cotton lint yie.d pe. unit of rainfall. Our goal is to colle.t rainfall data pe. 250 - 400 ha. Upon se.e.tion of a rainfall gauge. we.re.lize. that the.cost of using, for e.ample. a tipping bucke.-type.rain gauge.would be.too e.pe.sive.and thus se.rche. for an alte.native.me.hod. We.se.e.te. an all-in-one.comme.cially available.we.the. station;he.e.fte., re.e.re. to as a Pe.sonal We.the. Station (PWS) that is both wire.e.s and solar powe.e.. Our obje.tive.was to e.aluate.ave.age.me.sure.e.ts of rainfall obtaine. with the.PWS and to compare.the.e.to me.sure.e.ts obtaine. with an automatic we.the. station (AWS). For this purpose. we.installe. four PWS de.loye. within 20 m of the.Plant Stre.s and Wate. Conse.vation Me.e.rological Towe. that was use. as our AWS, locate. at USDA-ARS Cropping Syste.s Re.e.rch Laboratory, Lubbock, TX. In addition, we.me.sure. and compare. hourly ave.age.value. of short-wave.irradiance.(Rg), air te.pe.ature.(Tair) and re.ative.humidity (RH), and wind spe.d (WS), and calculate. value. of de.point te.pe.ature.(Tde.). This comparison was done.ove. a 242-day pe.iod (1 Octobe. 2022-31 May 2023) and re.ults indicate. that the.e.was no statistical diffe.e.ce.in me.sure.e.ts of rainfall be.we.n the.PWS and AWS. Hourly ave.age.value. of Rg me.sure. with the.PWS and AWS agre.d on cle.r days, but PWS me.sure.e.ts we.e.highe. on cloudy days. The.e.was no statistical diffe.e.ce.be.we.n PWS and AWS hourly ave.age.me.sure.e.ts of Tair, RH, and calculate. Tde.. Hourly ave.age.me.sure.e.ts of Rg and WS we.e.more.variable. We.conclude. that the.PWS we.se.e.te. will provide.ade.uate.value. of rainfall and othe. we.the. variable. to me.t our goal of e.aluating dryland cotton lint yie.d pe. unit rainfall.

关键词： Automation Se.sors Citize. We.the. Station Me.one. Rainfall We.the. Variable.

Partitioning Anatolian Kine.atics into Te.tonic e.cape.and Slab Rollback Dominate. Domains

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Journal of e.rth Scie.ce 2024年第3期35卷 758-768页

作者： Jiannan Me.g timothy M.Kusky e.din Bozkurt Hao De.g Ozan Sinoplu State.Ke. Laboratory of Ge.logical Proce.se. and Mine.al Re.ource. Center for Global TectonicsSchool of Earth SciencesChina University of GeosciencesWuhan 430074China Badong National Obse.vatory and Re.e.rch Station for Ge.hazards China University of GeosciencesWuhan 430074China De.artme.t of Ge.logical e.gine.ring Middle East Technical University06800 AnkaraTurkey De.artme.t of Ge.scie.ce. Auburn UniversityAuburn AL 36849USA

Anatolia is the.global arche.ype.of te.tonic e.cape.as witne.se. by the.de.astating 2023 Kahramanmaraş e.rthquake.se.ue.ce.and the.2020 Samos e.rthquake.which show diffe.e.t kine.atics re.ate. to the.frame.ork of the.e.cape.*** Positioning Syste.(GPS)motions of the.we.ge.shape. plate.diffe. re.ionally from northwe.twards to southwe.twards(from e.st to we.t).Anatolia was e.trude. we.tward from the.Arabian-e.rasian collision along the.North and e.st Anatolian fault syste.s,rotating counte.clockwise.into the.oce.nic fre.-face. of the.Me.ite.rane.n and Ae.e.n,with dramatic e.te.sion of we.te.n Anatolia in traditional ***,which is the.dominant me.hanism for this change.in kine.atics,e.trusion re.ate. to the.Arabia/e.rasia collision or rollback of the.African slab be.e.th we.te.n Anatolia is still *** asse.s the.dominant driving me.hanisms across Anatolia,we.analyze.re.e.t GPS ve.ocity datase.s,and de.ompose. the. into N-S and e.W compone.ts,re.e.ling that we.tward motion is e.se.tially constant across the.whole.plate.and consiste.t with the.slip rate. of the.North and e.st Anatolia fault zone.,while.southward compone.ts incre.se.dramatically in the.transition are. be.we.n ce.tral and we.te.n Anatolia,whe.e.a slab te.r is *** phe.ome.on is re.ate. to diffe.e.t te.tonic driving *** Arabiae.rasia collision drive. the.Anatolian Plate.uniformly we.twards while.we.te.n Anatolia is progre.sive.y more.affe.te. by the.southward re.re.ting African subducting slab we.t of the.Ae.e.n/Cypriot slab te.r,which significantly incre.se. the.southward compone.t of the.ve.ocity fie.d and cause. the.appare.t curve.of the.whole.mode.n ve.ocity *** 2020 and 2023 e.rthquake.focal me.hanisms also confirm that the.northward colliding Arabian Plate.force. Anatolia to the.we.t,and the.re.re.ting African slab is pulling the.uppe. plate.of we.te.n Anatolian apart in *** propose.that the.Anatolian Plate.is moving we.twards as

关键词： te.tonics ne.te.tonics te.tonic e.cape slab rollback Anatolian Plate GPS ve.ocity fie.d ge.dynamics.

Half a ce.tury afte. the.r discove.y:Structural insights into e.onucle.se.and anne.lase.prote.ns catalyzing re.ombine.ring

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e.gine.ring Microbiology 2024年第1期4卷 39-54页

作者： Lucy J.Fitsche. timothy P.Ne.ing Nikolas P.Johnston Charle. e.Be.l Gökhan Tolun School of Che.istry and Mole.ular Bioscie.ce and Molecular HorizonsUniversity of WollongongWollongongNSWAustralia The.ARC Training Ce.tre.for Cryo-e.e.tron Microscopy of Me.brane.Prote.ns University of WollongongWollongongNSWAustralia Faculty of Scie.ce University of Technology SydneyUltimoNSW 2007Australia De.artme.t of Biological Che.istry and Pharmacology The Ohio State University College of MedicineColumbusOH 43210

Re.ombine.ring is an e.se.tial tool for mole.ular biologists,allowing for the.facile.and e.ficie.t manipulation of bacte.ial ge.ome. dire.tly in ce.ls without the.ne.d for costly and laborious in vitro manipulations involving re.triction *** main workhorse. be.ind re.ombine.ring are.bacte.iophage.prote.ns that promote.the.single.strand anne.ling(SSA)homologous re.ombination pathway to re.air double.strande. DNA *** the.e.have.be.n se.e.al re.ie.s e.amining re.ombine.ring me.hods and applications,comparative.y fe. have.focuse. on the.me.hanisms of the.prote.ns that are.the.ke. playe.s in the.SSA pathway:a 5′→3′e.onucle.se.and a single.strand anne.ling prote.n(SSAP or“anne.lase.).This re.ie. dive. into the.structure. and functions of the.two SSA re.ombination syste.s that we.e.the.first to be.de.e.ope. for re.ombine.ring in ***:the.Re.e. syste. from *** Rac prophage.and the.�Re. syste. from bacte.iophage..By comparing the.structure. of the.Re.T and Re.𝛽anne.lase.,and the.Re.e.and𝜆e.o e.onucle.se.,we.provide.ne. insights into how the.structure. of the.e.prote.ns dictate.the.r *** the.se.ue.ce.conse.vation of the.�λe.o and Re.e.e.onucle.se. give. more.profound insights into the.r critical functional ***,as re.ombine.ring acce.e.ate. and e.olve. in the.laboratory,a be.te. unde.standing of the.me.hanisms of the.prote.ns be.ind this powe.ful te.hnique.will drive.the.de.e.opme.t of improve. and e.pande. capabilitie. in the.future.

关键词： Re.ombine.ring Re.β λe.o Re.e Re.T Prote.n structure Anne.lase e.onucle.se

Impact of pre. and pe.i-ope.ative.risk factors on le.gth of stay and hospital re.dmission following minimally-invasive.partial ne.hre.tomy

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Asian Journal of Urology 2024年第1期11卷 72-79页

作者： Vane.sa A.Lukas Rahul Dutta Ashok K.He.al Matve. Tsivian timothy e.Crave. Nicholas A.De.be. David D.Thie. Ram Anil Pathak Brigham and Wome.'s Hospital Division of UrologyDepartment of Surgery75 Francis StreetBostonMAUSA Atrium He.lth Wake.Fore.t Baptist Me.ical Ce.te. Department of Urology1 Medical Center BlvdWinston-SalemNCUSA Mayo Clinic Florida Department of Urology4500 San Pablo RoadJacksonvilleFLUSA

Obje.tive.We.conducte. an analysis of the.Ame.ican Colle.e.of Surge.ns National Surgical Quality Improve.e.t Program database.for minimally-invasive.partial ne.hre.tomy case. re.orte. with the.goal to ide.tify pre.and pe.i-ope.ative.variable. associate. with le.gth of stay(LOS)gre.te. than 3 days and re.dmission within 30 ***:Re.ords from 2008 to 2018 for“laparoscopy,surgical;partial ne.hre.tomy”for prolonge. LOS and re.dmission cohorts we.e.*** analysis with Chi-square.t-te.ts,and multivariable.logistic re.re.sion analysis with odds ratios(ORs),p-value.,and 95%confide.ce.inte.vals asse.se. statistical ***:Totally,20306 re.ords for LOS gre.te. than 3 days and 15854 for re.dmission within 30 days we.e.*** and multivariable.analysis e.hibite. similar *** LOS gre.te. than 3 days,unde.going non-e.e.tive.surge.y(OR=5.247),transfusion of gre.te. than four units within 72 h prior to surge.y(OR=5.072),pre.ope.ative.re.al failure.or dialysis(OR=2.941),and poor pre.ope.ative.functional status(OR=2.540)e.hibite. the.stronge.t statistically significant *** hospital re.dmission within 30 days,loss in body we.ght gre.te. than 10%in 6 months prior to surge.y(OR=2.227)and ble.ding disorde.s(OR=2.081)e.hibite. stronge.t statistically significant ***:Multiple.pre.and pe.i-ope.ative.risk factors are.inde.e.de.tly associate. with prolonge. LOS and hospital re.dmission within 30 days of surge.y using the.Ame.ican Colle.e.of Surge.ns National Surgical Quality Improve.e.t Program *** the.risks factors that can pote.tially be.improve. prior to minimally-invasive.partial ne.hre.tomy is crucial to informing patie.t se.e.tion,optimization strate.ie.,and patie.t e.ucation.

关键词： Minimally-invasive.partial ne.hre.tomy The.Ame.ican Colle.e.of Surge.ns National Surgical Quality Improve.e.t Program Le.gthof stay Hospital re.dmission

Bulking Up the.Bay-Position Substitue.ts e.able. e.hance. Se.e.tivity of C_(s)‑Symme.ric Boron Subphthalocyanine.Subnaphthalocyanine.Hybrids

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Pre.ision Che.istry 2024年第4期2卷 161-181页

作者： Nina F.Farac Alan J.Lough timothy P.Be.de. De.artme.t of Che.ical e.gine.ring and Applie. Che.istry University of TorontoTorontoOntario M5S 3E5Canada De.artme.t of Che.istry University of TorontoTorontoOntario M5S 3H6Canada De.artme.t of Mate.ials Scie.ce.and e.gine.ring University of TorontoTorontoOntario M5S 3E4Canada De.artme.t of Me.hanical and Industrial e.gine.ring University of TorontoTorontoOntario M5S 3G8Canada

The.pre.ise.synthe.is of subporphyrinoid hybrids withπ-e.pande. topologie. and unique.mate.ial prope.tie. plays a promising role.in the.de.ign of functional ***,se.e.tive.and controllable.route. to boron subphthalocyanine.subnaphthalocyanine.hybrids,Bsub(Pc_(3‑p)-Nc_(p))s,are.de.irable.for this purpose.ye. synthe.ically challe.ging due.to random mixture. of C_(s-),C_(3v-),and,in some.case.,C_(1)-symme.ric compounds that form during traditional statistical mixe. ***,we.addre.se. this issue.by de.e.oping a ste.ically drive. mixe. cyclotrime.ization with e.hance. se.e.tivity for the.targe.e. C_(s)-symme.ric hybrid and comple.e.suppre.sion of ste.ically crowde. macrocyclic *** proce.s,couple. with a rationally de.igne. pre.ursor be.ring bulky phe.yl substitue.ts,e.able. the.synthe.is and characte.ization of bay-position phe.ylate. Ph_(2)-(R_(p))_(8)Bsub(Pc_(2)-Nc_(1))hybrids with haloge.s(Rp=Cl or F)in the.r pe.iphe.al isoindole.*** se.e.tivity range. be.we.n 59 and 72%with re.arkable.yie.ds,significantly highe. than that of conve.tional mixe. *** findings we.e.augme.te. by the.re.ical calculations on pre.ursor Le.is basicity as guiding principle. into hybrid macrocycle.***,the.incorporation of unfuse. phe.yl groups and haloge. atoms into the.hybrid frame.ork re.ulte. in fine.tune. optical,structural,e.e.tronic,and e.e.troche.ical *** straightforward approach achie.e. improve. se.e.tivity and controlle. narrowing of the.product distribution,affording the.e.ficie.t synthe.is of structurally sophisticate. Bsub(Pc_(2)-Nc_(1))*** the. e.pands the.library of 3-dime.sionalπ-e.te.de. macrocycle. for use.in a range.of applications,such as in optoe.e.tronic de.ice. with pre.ise.y tailore. optical prope.tie..

关键词： subphthalocyanine hybrids low-symme.ry aromatic macrocycle se.e.tive.cyclotrime.ization ste.ically drive. che.istry broad absorption mate.ial prope.tie.

Ace.abular cup size.tre.ds in total hip arthroplasty

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World Journal of Orthope.ics 2024年第1期15卷 39-44页

作者： Danie. Patrick McKe.na Ale. Price.timothy McAle.se.Darre. Dahly Paul McKe.na May Cle.ry De.artme.t of Trauma and Orthopae.ics University Hospital WaterfordWaterford X91 ER8EIreland De.artme.t of e.ide.iology and Public He.lth University College CorkCork T12 XF62Ireland

BACKGROUND Total hip arthroplasty(THA)is a common proce.ure.for e.d stage.*** le.rning curve.for THA is comple. and *** of the.most difficult skills to maste. is ace.abular *** wish to ide.tify if e.pe.ie.ce.in arthroplasty le.ds to pre.e.vation of more.bone.*** To inve.tigate.if incre.sing surge.n e.pe.ie.ce.will pre.ict an e.e. de.re.sing ace.abular cup *** A re.rospe.tive.case.se.ie. of four atte.ding orthopae.ic surge.ns was *** unce.e.te. e.e.tive.total hip arthroplastie. since.appointme.t we.e.se.e.te. for *** size.of ace.abular cup use. was note. and logistic re.re.sion was use. to ide.tify if a tre.d to smalle. cups *** A total of 1614 subje.ts we.e.include. with a me.n age.of 64 *** cups we.e.on ave.age.0.18mm smalle. pe. ye.r(95%confide.ce.inte.val-0.25 to-0.11,Pe.n tre.ds showe. cup size. to de.re.se.0.27 mm/ye.r for surge.n A,0.02 mm/ye.r for surge.n B,0.15 mm/ye.r for surge.n C and 0.29 mm/ye.r for surge.n *** of the.four surge.ns had a more.pronounce. tre.d to smalle. cups for male.subje.ts than the.r fe.ale.*** We.found incre.sing surge.n e.pe.ie.ce.to be.associate. with an e.e.-de.re.sing ace.abular cup *** ace.abular cup size.may act as a surrogate.marke. of surgical proficie.cy by virtue.of de.re.se. ace.abular re.ming.

关键词： Hip Arthroplasty Ace.abulum Cup Le.rning

Cultural e.clusion and the.Transformation of the.Cultural Landscape. The.Origins of Anti-Chine.e.Racism in Canada

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Social Scie.ce. in China 2024年第3期45卷 181-202页

作者： timothy J.Stanle. Faculty of e.ucation University of Ottawa

Anti-Chine.e.racism in Canada is a social structure.of racialize. e.clusion that ove. time.came.to be.built into the.se.tle. colonialism that continue. to shape.the.*** of e.rope.n,and e.pe.ially of British and Fre.ch origins,have.conse.ue.tly cre.te. the.cultural landscape. that constitute.the.country(i.e.,its mate.ial constructions and dominant cultural ove.lays).Whe. re.d against the.e.landscape.,pe.ple.of Chine.e.origins and me.be.s of othe. racialize. groups continue.to be.positione. as alie.s who do not be.ong in the.country in way in which pe.ple.racialize. as white.are.*** on British Columbia(BC),Canada's we.te.nmost province.and the.historical activity of pe.ple.of Chine.e.origins,this pape. trace. the.history of anti-Chine.e.racism and its links to Anglo-Canadian se.tle. *** has long be.n linke. to China,and the.Chine.e.e.te.e. BC at the.same.time.as e.rope.ns be.ore.the.country *** this,Chine.e.pe.ple.have.re.e.te.ly be.n positione. as thre.ts to Anglo-Canadian dominance.and e.pe.ially to control ove. the.land and its *** Canadian re.istance.to racist e.clusions,along with that of othe. groups,has le. to the.e.imination of le.islate. ***,historic e.clusions continue.to shape.cultural landscape. and popular unde.standings of who be.ongs and who doe. *** the.e.landscape. re.uire. an antiracist proje.t of pursuing common proje.ts that cross ove. racialize. diffe.e.ce. to re.ake.the.te.ritory in ways that affirm the.pre.e.ce.of all the.pe.ple. of Canada.

关键词： Chine.e.Canadians cultural e.clusion white.supre.acy racism