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An implantable,wireless,battery-free system for tactile pressure sensing

Microsystems & Nanoengineering 2023年第5期9卷 309-320页

作者： Lin Du han hao Yixiao Ding Andrew Gabros Thomas C.E.Mier Jan Van der Spiegel timothy h.lucas.firooz aflatouni Andrew G.Richardson Mark G.Allen Department of Electrical and Systems Engineering School of Engineering and Applied ScienceUniversity of PennsylvaniaPhiladelphiaPAUSA Department of Neurosurgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Departments of Neurosurgery and Biomedical Engineering Ohio State UniversityColumbusOHUSA

The sense of touch is critical to dexterous use of the hands and thus an essential component of efforts to restore hand function after amputation or *** systems have addressed this goal with wearable tactile ***,such wearable sensors are suboptimal for neuroprosthetic systems designed to reanimate a patient’s own paralyzed ***,we developed an implantable tactile sensing system intended for subdermal *** system is composed of a microfabricated capacitive pressure sensor,a custom integrated circuit supporting wireless powering and data transmission,and a laser-fused hermetic silica *** miniature device was validated through simulations,benchtop assessment,and testing in a primate *** sensor implanted in the fingertip accurately measured applied skin forces with a resolution of 4.3 *** output from this novel sensor could be encoded in the brain with microstimulation to provide tactile *** broadly,the materials,system design,and fabrication approach establish new foundational capabilities for various applications of implantable sensing systems.

关键词： system battery fused

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highly stable integration of graphene hall sensors on a microfluidic platform for magnetic sensing in whole blood

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微系统与纳米工程(英文) 2023年第3期9卷 115-127页

作者： Nishal Shah Vasant Iyer Zhiping Zhang Zhaoli Gao Juhwan Park Venkata Yelleswarapu firooz aflatouni A.T.Charlie Johnson David Issadore Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Biomedical Engineering Chinese University of Hong KongShatinHong Kong Department of Physics and Astronomy University of PennsylvaniaPhiladelphiaPA 19104USA Department of Chemical and Biomolecular University of PennsylvaniaPhiladelphiaPA 19104USA

The detection and analysis of rare cells in complex media such as blood is increasingly important in biomedical research and clinical ***-hall detectors(μhD)for magnetic detection in blood have previously demonstrated ultrahigh sensitivity to rare *** sensitivity originates from the minimal magnetic background in blood,obviating cumbersome and detrimental sample ***,the translation of this technology to clinical applications has been limited by inherently low throughput(h),susceptibility to clogging,and incompatibility with commercial CMOS foundry *** help overcome these challenges,we have developed CMOS-compatible graphene hall sensors for integration with PDMS microfluidics for magnetic sensing in *** demonstrate that these grapheneμhDs can match the performance of the best publishedμhDs,can be passivated for robust use with whole blood,and can be integrated with microfluidics and sensing electronics for in-flow detection of magnetic *** show a proof-of-concept validation of our system on a silicon substrate and detect magnetic agarose beads,as a model for cells,demonstrating promise for future integration in clinical applications with a custom CMOS chip.

关键词： integration magnetic fluid

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