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In vitro microglia models:the era of engineered cell microenvironments

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Neural Regeneration Research 2023年第8期18卷 1709-1710页

作者： Ahmed Sharaf Raissa timmerman Jeffrey Bajramovic Angelo Accardo Department of Precision and Microsystems Engineering Delft University of TechnologyDelftthe Netherlands Alternatives Unit Biomedical Primate Research CentreRijswijkthe Netherlands 3Rs Centre Utrecht UniversityUtrechtthe Netherlands

Background:The most widely employed approach by cell biologists to performing in vitro cell culture assays is the one using 2D plastic culture ware systems,which allows reproducibility and ease of ***,this method is ***,in most cases,these flat surfaces lead to the formation of unrealistic 2D cell monolayers,which do not reproduce the complex configuration characteristics of native tissues in terms of dimensionality,rigidity,and *** this reason,a new generation of interdisciplinary scientists,working across microengineering and cell biology has started to develop engineered cell microenvironments(Huang et al.,2017)by employing advanced materials and fabrication approaches(Fan et al.,2019)over the last two *** on the level of resolution of the adopted manufacturing technique,the geometrical features of these structures can reach micrometric or even sub-micrometric dimensions comparable to the ones of cellular somas or cellular filopodia,therefore fostering cell-biomaterial *** developed structures are pivotal for a better investigation of fundamental mechanobiology(Lemma et al.,2019),the optimization of in vitro disease modeling,drug/treatment screening(Gao et al.,2021),and tissue engineering(Mani et al.,2022).

关键词： culture rigidity

Phase Ⅱ Study of Stereotactic Body Radiotherapy in Patients With Medicallylnoperable Stage Ⅰ or Ⅱ Non-Small Cell Lung Cancer

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Phase Ⅱ Study of Stereotactic Body Radiotherapy in Patients...

Selenium’s Utility in Mercury Toxicity: A Mini-Review

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Robert timmerman MD Trial Lead Organizations Radiation Therapy Oncology Group

＜正＞Objectives Primary 1. Determine whether treatment with stereotactic body radiotherapy results in acceptable local control （i.e., ≥ 80%） in patients with medically inoperable stage Ⅰ or Ⅱ non - small cell lung cancer. Secondary 1. Determine treatment - related toxicity in patients treated with this therapy. 2. Determine disease - free survival, overall survival, and patterns of failure in patients treated with this therapy.

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Food and Nutrition Sciences 2021年第2期12卷 124-137页

作者： Roswell timmerman Stanley T. Omaye Department of Nutrition and the Environmental Sciences and Health Graduate Program University of Nevada Reno USA

Purpose: This review of the literature intends to provide readers an understanding of the prophylactic and antidotal usefulness of selenium (Se) for mercury (Hg) toxicity. We will provide an explanation of Hg and Se interactions for potential remediation options to contaminated ecosystems. Design/methodology/approach: In this mini-review, we discuss mechanistic aspects between Hg and Se, the implication for health outcomes, and its usefulness in the ecological recovery of Hg contaminated areas. Findings: Mercury has a strong affinity for Se, resulting in Se-dependent enzymes and proteins’ deactivation with devastating consequences to the host. It is likely that Hg’s toxicity results in Se deficiency. Selenium compounds can have prophylactic or antidotal effects to prevent or reverse the adverse toxicity action of Hg exposure. Current research indicates that the chemical interactions between Hg and Se are unique. The Hg capturing capacity of Se is a million times higher than sulfur compounds and results in inactive complexes. Practical implications: Future work can target engineering methods for technologies that can reduce the toxicity of Hg in the environment. Originality/value: The unique interactions between the elements are that Hg can compromise Se dependent enzymes;howeve

关键词： Mercury Selenium Toxicity Selenoproteins Human Health Oxidative Stress

Toll-Like Receptor Expression in the Peripheral Nerve

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神经损伤与功能重建 2010年第6期5卷 436-444页

作者： SOFIE GOETHALS ELKE YDENS VINCENT timmerman SOPHIE JANSSENS Peripheral Neuropathy Group Department of Molecular GeneticsVIB and University of Antwerp Neurogenetics Laboratory Institute Born-Bunge and University of Antwerp

Toll样受体(TLRs)是由进化上相对保守的蛋白家族构成的一组识别受体,是固有免疫系统的第一道防线。受到微生物配体刺激后,TLRs通过激活各种信号通路引发机体一系列防御反应。TLRs还能被内源性危险信号激活,因此推断神经退行性变也可能通... 详细信息

Toll样受体(TLRs)是由进化上相对保守的蛋白家族构成的一组识别受体,是固有免疫系统的第一道防线。受到微生物配体刺激后,TLRs通过激活各种信号通路引发机体一系列防御反应。TLRs还能被内源性危险信号激活,因此推断神经退行性变也可能通过TLRs激活免疫反应。近来研究发现中枢神经系统表达各种类型的TLRs,但周围神经系统中TLRs的表达形式尚无定论。本研究结果显示,施万细胞上表达大量TLRs,主要为TLR3和TLR4。感觉神经元和运动神经元上几乎没有TLRs表达。对NF-κB信号通路的检测显示,施万细胞上所有的TLRs都是有功能的,可被细菌脂蛋白(TLR1/TLR2配体)激活,产生强烈反应。静息状态下,坐骨神经上TLRs的表达形式与施万细胞相似,主要为TLR3、TLR4和TLR7,可能在免疫监督中扮演重要角色。通过显微外科方式对坐骨神经造成急性神经退行性变后,诱导TLR1大量表达,其它TLRs的表达水平无变化。综上所述,本研究结果显示,施万细胞可能在周围神经中扮演类似中枢神经系统小胶质细胞的角色。急性神经退行性变诱导TLR表达变化,说明在分布于周围神经的TLRs在静息状态和激活状态下具有不同功能。

关键词：施万细胞固有免疫系统神经退行性变 Toll样受体逆转录定量聚合酶链反应

Drought and conflicts at the local level: Establishing a water sharing mechanism for the summer-autumn rice production in Central Vietnam

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International Soil and Water Conservation Research 2019年第4期7卷 362-375页

作者： Chuong Van Huynh Catharien Terwisscha van Scheltinga Ty Huu Pham Non Quoc Duong Phuong Thi Tran Linh Hoang Khanh Nguyen Tung Gia Pham Ngoc Bich Nguyen Jos timmerman Hue University Viet Nam Climate Change and Adaptive Land and Water Management Group Wageningen Environmental ResearchNetherlands University of Agriculture and Forestry Hue UniversityViet Nam

In recent years,water for agricultural production gradually became a significant challenge in the context of climate change in *** solutions are required,which consider the use of resources for both human needs and ecology,and that account for the equitable distribution and the livelihood of the farmers now and in the *** particular,the farmers in the province of Quang Nam faring water shortage in the cultivation of paddy in the summer-autumn *** arise regarding the sharing of the water between the farmers,the drinking water company and the hydropower *** the context of climate change,the water shortage is expected to increase in the *** article presents the results of participatory action research (PAR) approach to develop a local level mechanism for water sharing,in which stakeholders actively *** sharing mechanism was developed,envisioning a sustainable solution for inclusive water *** mechanism was successfully implemented in two cases,one at commune level (Tho stream) and one at the district level (Mo stream).The participatory approach proved to be successful in setting up a broadly acceptable mechanism that will need to be further incorporated in the institutional set-up.

关键词： Adaptation Agriculture Climate change Governance Rice production Water sharing

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热收缩管材

绝缘材料 1978年第Z1期 65-69页

作者： Robert timmerman 孙安根 Essex Group Inc

二十三种不同配方的聚烯烃热收缩绝缘软管在三种剂量下进行了高能辐照并对他们的交联度、可燃性、抗张强度和延伸率以及热稳定性进行试验。测定了组分含量和类型对上述性能的影响。抗氧剂的含量及类型对交联度有很大的影响,敏化剂的含... 详细信息

二十三种不同配方的聚烯烃热收缩绝缘软管在三种剂量下进行了高能辐照并对他们的交联度、可燃性、抗张强度和延伸率以及热稳定性进行试验。测定了组分含量和类型对上述性能的影响。抗氧剂的含量及类型对交联度有很大的影响,敏化剂的含量也有很大的影响,而稳定剂的含量及类型则影响较小。抗张强度和延伸率受组分或者辐照剂量的影响不大。敏化剂和稳定剂的含量提高,耐燃性改善。稳定剂的种类会影响可燃性。一般说来,辐照剂量提高,耐燃性得到改善。改变稳定剂的类型能够改善热稳定性,提高敏化剂含量或者减少抗氧剂的含量将降低热稳定性。

关键词：抗氧剂延伸率功能特性辐照剂量敏化剂交联度聚合物聚烯烃燃烧性能耐燃性热收缩管扯断强度力学强度抗张强度管材

组胺H_3配基:仅是药理学工具或是潜在的治疗药

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国外医学（药学分册） 1991年第2期18卷 79-82页

作者： timmerman H 黄向东

本世纪20年代发现组胺具有生理功能。首先认识到它与变态反应有关,随之出现了一些抗组胺药,如苯海拉明等。60年代提出了存在 H_1和 H_2两种组胺受体的假设,继而获得了这两种受体的选择性配基。对这些化合物的研究导致了一些重要药物的发... 详细信息

本世纪20年代发现组胺具有生理功能。首先认识到它与变态反应有关,随之出现了一些抗组胺药,如苯海拉明等。60年代提出了存在 H_1和 H_2两种组胺受体的假设,继而获得了这两种受体的选择性配基。对这些化合物的研究导致了一些重要药物的发现,主要是受体拮抗剂。

关键词：组胺 H3受体 H3配基

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天光人影共徘徊

设计家 2009年第3期 76-81页

作者： Matthew G Trzebiatowski Bill timmerman 余丹美国Frank Lloyd Wright(弗兰克·赖特)学院美国Collins设计与技术学院 Blank Studio

瑜伽是一种需要静澈内心,以达到人与自然在某种程度上互通的运动。然而随着瑜伽在大都市里的流行和兴盛,瑜伽馆通常开设于商业中心大厦中,被柏油铺设的停车场、非自然装饰的迷你绿化带和其他彼此间几乎没有区别的高楼所包围。本案例中的... 详细信息

瑜伽是一种需要静澈内心,以达到人与自然在某种程度上互通的运动。然而随着瑜伽在大都市里的流行和兴盛,瑜伽馆通常开设于商业中心大厦中,被柏油铺设的停车场、非自然装饰的迷你绿化带和其他彼此间几乎没有区别的高楼所包围。本案例中的Yoga Deva(deva在梵文中是神的意思),设计师希望通过创造一种空间的内在连续来消减人们的紧绷感,其最直接的想法是将人们从对于外部环境的视觉观感中转移过来。这个新的内部空间希望提供一种纯净的单色画效果,与商业大街上纷繁杂乱的现实世界相区别,让人们在此间静静体验自己内心的沉思和冥想。

关键词：瑜伽内部空间练习入口处室内运动转移半透明光线天光

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基于天然药物开发的探索 004