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Prospective evaluation of ^(18)F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 539-554页

作者： tim Akhurst Mithat Gönen Raymond e.Baser Lawrence H.Schwartz Scott Tuorto Lynn A.Brody Anne Covey Karen T.Brown Steven M.Larson Yuman Fong department of Radiology Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA Peter MacCallum Cancer Centre VictoriaAustralia department of epidemiology and Biostatistics Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA department of Surgery Memorial Sloan-Kettering Cancer CenterNew YorkNYUSA

Background:despite considerable advances in preoperative imaging,up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahepatic ***:The current study is a prospective,blinded study comparing utility of[18F]2-fluoro-2-deoxyglucose positron emission tomography(18F-FDG-PeT)to computed tomography(CT)and CT arterial portography(CTAP)as preoperative ***:The 125 planned subjects were *** seen on FDG-PeT alone changed therapy for 23 of 125 patients(18%).FDG-PeT confirmed other radiologic findings in 16 cases(13%),for an overall influence on therapy in 39 cases(31%).FDG-PeT was the most sensitive diagnostic imaging test for extrahepatic cancer;it was 80-90%sensitive for extrahepatic cancer and 70-90%*** the 28 cases of unresectable disease due to extrahepatic disease,FDG-PeT findings solely changed therapies in 16 cases(57%)and influenced therapy in seven other cases(25%).Of the 21 unresectable cases due to extent of intrahepatic disease,FDG-PeT did not solely change therapy in ***,FDG-PeT had the lowest sensitivity for hepatic sites compared with CT or *** particular,small(er tumors were particularly poorly detected by *** area under the receiver operating characteristic(ROC)curve for small tumors was 0.58 and for patients on chemotherapy it was 0.66,a modest improvement over no ***:FDG-PeT is an important test for preoperative staging of patients with hepatic colorectal metastases,affecting treatment decisions in nearly one-third of *** high yield is due mainly to detection of extrahepatic *** is therefore recommended in patients with extrahepatic lesions suspected to be disseminated cancer or those with high risk for extrahepatic *** is not a good test for identification of small tumors in the liver.

关键词： Positron emission tomography(PeT) computed tomography(CT) colorectal hepatic metastases surgery

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***:A Platform for Mainstreaming Citizen Science and Open Science in europe

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Data Intelligence 2021年第1期3卷 136-149页

作者： Katherin Wagenknecht tim Woods Francisco García Sanz Margaret Gold Anne Bowser Simone Rüfenacht Luigi Ceccaroni Jaume Piera Technische Hochschule Wildau Hochschulring 115745 WildauGermany european Citizen Science Association Invalidenstraße 41Berlin 10115Germany Ibercivis Foundation Campus Río EbroC/Mariano Esquillor s/n Edificio I+DZaragoza 50018Spain Leiden University Rapenburg 702311 EZ LeidenThe Netherlands Woodrow Wilson International Center for Scholars 1300 Pennsylvania Ave.WashingtonDCDistrict of Columbia 20004United States earthwatch Mayfield House256 Banbury RoadOxfordOxfordshire OX27DEUK Institut de Ciències del Mar Consejo Superior de Investigaciones CientíficasPasseig Marítim de la Barceloneta37-49Barcelona 08003Spain

Citizen Science(CS)is a prominent field of application for Open Science(OS),and the two have strong synergies,such as:advocating for the data and metadata generated through science to be made publicly available[1];supporting more equitable collaboration between different types of scientists and citizens;and facilitating knowledge transfer to a wider range of audiences[2].While primarily targeted at CS,the *** platform can also support *** of its key functions is to act as a knowledge hub to aggregate,disseminate and promote experience and know-how;for example,by profiling CS projects and collecting tools,resources and training materials relevant to both *** do this,the platform has developed an information architecture that incorporates the public participation in scientific research(PPSR)-Common Conceptual Model.This model consists of the Project Metadata Model,the Dataset Metadata Model and the Observation Data Model,which were specifically developed for CS *** implementing these,the platform will strengthen the interoperating arrangements that exist between other,similar platforms(e.g.,BioCollect and SciStarter)to ensure that CS and OS continue to grow globally in terms of participants,impact and fields of application.

关键词： Citizen Science Metadata Open Science Public participation in scientific research(PPSR)

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development of a CO_2 Tolerant Fischer-Tropsch Catalyst:from Laboratory to Commercial-Sca1e demonstration in Alaska

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Journal of Natural Gas Chemistry 2004年第1期13卷 1-9页

作者： Joep J H M Font Freide tim D Gamlin J Richard Hensman Barry Nay Christopher Sharp BP exploration Operating Company Chertsey RoadSunbury on ThamesMiddlesexTWl6 7LNEnglandDavy Process Technology Lid 20 Eastbourne TerraceLondon W2 6LEEnglandDavy Process Technology Lid 20 Eastbourne TerraceLondon W2 6LEEnglandBP Chemicals LtdChertsey RoadSunbury on ThamesMiddlesexTW16 7LLEnglandBP Chemicals LtdChertsey RoadSunbury on ThamesMiddlesexTW16 7LLEngland

This article describes the development of BP's Fischer-Tropsch catalyst, used for the conversion of carbon monoxide and hydrogen into liquid hydrocarbons. It covers the 18 year period from the early eighties, when laboratory scale preparations and micro-reactors were heavily used, right through to the present day with the commercial scale manufacture and proving of the finished catalyst in BP's new ＄86 million gas to liquids demonstration facility in Nikiski, Alaska. extensive performance testing and scale-up experiments have been successfully carried out, all proof that a laboratory preparation can indeed be translated into a commercial manufacturing process. In addition, the resulting catalyst does not only meet the process design targets, but also exhibits enhanced stability and is tolerant to carbon dioxide. Above all, a commercial scale, fixed bed Fischer-Tropsch catalyst is now available and ready for licensing. Manufacturing procedures and quality control have all been successfully detailed and transferred to the commercial manufacturer.

关键词： carbon dioxide Fisher-Tropsch development syngas commercial catalyst

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热带夏季风场与对流场季节内振荡传播模比较

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应用气象学报 2010年第5期21卷 545-557页

作者：林爱兰 Li tim 李春晖中国气象局广州热带海洋气象研究所/热带季风重点开放实验室广州510080 IPRC and department of Meteorology University of Hawaii

利用1979-2007年卫星观测日平均OLR资料以及NCeP/DOe第2套再分析资料中的风场资料,采用有限区域波一频分析、合成分析等方法,分析对比对流层高、低层风场与对流场所表征的热带北半球夏季季节内振荡(BSISO)各种传播模态谱分布气候特征及... 详细信息

利用1979-2007年卫星观测日平均OLR资料以及NCeP/DOe第2套再分析资料中的风场资料,采用有限区域波一频分析、合成分析等方法,分析对比对流层高、低层风场与对流场所表征的热带北半球夏季季节内振荡(BSISO)各种传播模态谱分布气候特征及其年际异常。结果表明:各要素反映的BSISO各种模态的气候特征及其年际变化存在一定差异,总体而言对流层低层风(850hPa纬向风或经向风)与对流比较一致。850hPa经向风(纬向风)所反映的纬向(经向)传播BSISO谱分布气候特征与对流情况最相似。在eNSO发展年,850hPa经向风反映的赤道东传波加强趋势与对流较为一致;850hPa纬向风、经向风反映的北传波变化趋势都与对流相似。在eNSO衰减年,850hPa纬向风(经向风)反映的赤道东传波(赤道外西传波)减弱趋势与对流较为一致;对流以及850hPa经向风、200hPa纬向风和200hPa经向风4种要素都能体现南海及周边地区北传波明显减弱这一特征。对流和850hPa纬向风所反映的北传波与印度洋偶极子模态之间关系一致。

关键词：热带北半球夏季季节内振荡(BSISO) 各种传播模态气候特征及年际异常风场与对流场

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Shifting Private timberland Ownership in South Carolina: Implications for Management Intensity

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Open Journal of Forestry 2012年第4期2卷 279-285页

作者： John e. Hatcher Jr. Thomas J. Straka Richard A. Harper tim O. Adams Forest Inventory and Analysis USDA Forest Service Southern Research Station Clemson USA School of Agricultural Forest and Environmental Sciences Clemson University Clemson USA South Carolina Forestry Commission Columbia USA School of Agricultural Forest and Environmental Sciences Clemson University Clemson USA

Beginning in the late 1970’s forest industry timberland gained the eye of financial investors. Diamond International and Crown Zellerbach were early firms that were purchased for the “break-up value” of their timberland. timberland was perceived as undervalued by investors and made forest industry firms attractive takeover targets. This started a process where forest industry divested of its timberland. Some firms formed separate entities for its timberland base. Acquisitions and mergers became popular in the industry. Some forest industry companies converted to real estate investment trusts, for tax and defensive reasons. Large institutional investors became interested in timberland as means to diversify their portfolios and increase financial performance. timber management investment organizations developed to manage and procure timberland for these institutional investors. Today little of the forest industry timberland remains with vertically-integrated forest products companies. South Carolina’s forest industry timberland decreased by about 800,000 ha since 1993 (or nearly 90%). This has implications for the state’s timber supply. Forest industry timberlands were some of the most productive and intensively managed forests in the state. We address how forest management might change on this timberland and how long-term timber supply might be impacted in the state.

关键词： Industrial timberland timber Investment Management Organization Real estate Investment Trust timber Supply Forestry Investment

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Long-term results of olecranon fractures treated using the XS nail? system

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中华创伤杂志(英文版) 2022年第6期25卷 336-344页

作者： H?chtl-Lee Leonard Spalteholz Matthias Raven tim Friedrich Moghaddam Arash Friedl Wilhelm Aschaffenburg Trauma and Orthopaedic Research Group Center for Orthopaedics Trauma Surgery and Sports Medicine Hospital Aschaffenburg-Alzenau GGmbH Am Hasenkopf 1 Aschaffenburg Germany Center for Orthopaedics and Trauma Surgery Leipzig Division of Orthopaedics and Trauma Surgery Rotkreuzklinik Wertheim GGmbH Wertheim Am Main

Purpose: Olecranon fractures are particularly vulnerable to distraction and subsequent fracture dislocation due to the high tensile forces. Surgical treatment aims at reducing the fracture and restoring the anatomical joint surface condition, as well as neutralizing the strain inhibiting fracture healing. The XS nail? (Intercus GmbH, Bad Blankenberg, Germany), an intramedullary implant exerting compression across the entire fracture surface, unlike plates, leaves a minimal extra-cortical profile, and can be secured with threaded locking wires, thereby retaining the anatomical reduction without displacement or steps within the articular surface, which was often found in tension band wiring. After encouraging initial results, the long-term outcome was assessed. Methods: This retrospective study evaluated the long-term outcome of patients surgically treated at our trauma center between January 2002 and december 2005 using the XS nail?. Patients over the age of 18 years eligible for the study must have undergone surgery for isolated, recent (less than 14 days) traumatic olecranon fractures, without concomitant injuries to the ipsilateral elbow and forearm. Further exclusion criteria were pseudarthrosis, re-fractures and osteotomy for distal humerus surgery, as well as polytraumatized patients unable to aid in their own recovery. Data were retrospectively gathered by standardised questionnaire and patient records, as well as surgery and anesthesiology reports. Data analysis was performed using Microsoft Office excel? 2016. Results: There were 32 patients, 13 males (mean age 49.0 years) and 19 females (mean age 68.9 years) with 11 Schatzkers type D, 7 each type A and C, 5 type B and 2 type e at an average of 55.2 months, all showing complete consolidation. Of them, 6 patients had a loss of range of motion with more than 10° in the sagittal plane, and only 1 patient exceeded 10° reduction of supina

关键词： Olecranon fracture Intramedullary nail Treatment DASH XS nail

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美国加州活动断层探测及其成果应用

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城市与减灾 2018年第1期 72-76页

作者：陈睿 tim e.Dawson tim P.McCrink 美国加州地质调查局

引言本文简要介绍美国,特别是加利福尼亚州,活动断层探测填图及其成果在抗震减灾中的应用。为避免由地震产生的地表破裂对建筑物造成的直接破坏,加州州政府在1972年颁布了《AlquistPriolo地震断层区划法》（以下简称＂AP法＂）。此后开... 详细信息

引言本文简要介绍美国,特别是加利福尼亚州,活动断层探测填图及其成果在抗震减灾中的应用。为避免由地震产生的地表破裂对建筑物造成的直接破坏,加州州政府在1972年颁布了《AlquistPriolo地震断层区划法》（以下简称＂AP法＂）。此后开始对活动断层系统探测并填制大比例尺活动断层分布图。

关键词：断层探测美国加州成果应用加利福尼亚州地震断层抗震减灾地表破裂活动断层

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低剩余采食量的猪需要低能量维持

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饲料研究 2011年第2期34卷 76-76,79页

作者： tim Lundeen 程宗佳(摘译) 美国大豆协会国际项目北京办事处不详

生猪企业一直高度关注饲料效率问题,尤其是在低利润率和高饲料成本的阶段。Nick Boddicker,Nicholas K Gabler,Michael e Spurlock,Dan Nettleton和Jack C M dekkers介绍,剩余采食量（RFI）是一种计算饲料利用率的方法,即根据猪的增质... 详细信息

生猪企业一直高度关注饲料效率问题,尤其是在低利润率和高饲料成本的阶段。Nick Boddicker,Nicholas K Gabler,Michael e Spurlock,Dan Nettleton和Jack C M dekkers介绍,剩余采食量（RFI）是一种计算饲料利用率的方法,即根据猪的增质量和背膘，计算实际采食量与预计采食量之差。

关键词：采食量生猪剩余低能量 Michael 饲料成本饲料利用率效率问题

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耦合模式FGOALS_s模拟的亚澳季风年际变率及eNSO

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大气科学 2009年第2期33卷 285-299页

作者：吴波周天军 tim Li 包庆中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室北京100029 中国科学院研究生院北京100049 IPRC and department of Meteorology University of Hawaii2525 Correa Rd.HonoluluHI 96822USA

本文评估了中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室(LASG/IAP)新一代耦合气候模式FGOALS_s对亚澳季风和eNSO的模拟。结果表明,FGOALS_s可以模拟出亚澳季风的主要气候态特征。FGOALS_s模拟的eNSO事件振... 详细信息

本文评估了中国科学院大气物理研究所大气科学和地球流体力学数值模拟国家重点实验室(LASG/IAP)新一代耦合气候模式FGOALS_s对亚澳季风和eNSO的模拟。结果表明,FGOALS_s可以模拟出亚澳季风的主要气候态特征。FGOALS_s模拟的eNSO事件振幅为观测值的70%,同时它合理再现了eNSO周期的非规则性。FGOALS_s可以定性模拟出eNSO的主要空间特征。当赤道东太平洋SST升高时,印度洋和西太平洋海表面气压升高,而东太平洋海表面气压降低。FGOALS_s的主要缺陷在于模拟的eNSO峰值多出现在春季和夏季。与eNSO振幅偏小相反,FGOALS_s模拟的亚澳季风年际变率振幅大于观测。但是观测中亚澳季风年际变率与eNSO暖位相的显著负相关关系,在模式中没有得到合理再现,原因部分可归之于耦合模式在eNSO锁相模拟上的缺陷。由于模式模拟的eNSO峰值出现在北半球春季和夏季,Walker环流异常下沉支移动到西北太平洋,其激发出的异常反气旋位置较之观测要偏东,导致印度季风降水和el Nio的负相关关系不显著;在北半球冬季,由于模式中的赤道东太平洋SST暖异常较弱,亚澳季风响应也偏弱。此外,由于赤道东太平洋SST异常向西伸展,观测中位于澳洲季风区的辐散中心向西偏移,最终导致模式中澳洲季风降水与eNSO的负相关同样不显著。

关键词：气候系统模式亚澳季风 eNSO

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Recombinant human zona pellucida proteins ZP1, ZP2 and ZP3 co-expressed in a human cell line

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Asian Journal of Andrology 2004年第1期6卷 3-13页

作者： MirjanaMartic ericK.Moses time.Adams deYiLiu debraA.Gook ClaireGarrett Marjoriee.Dunlop GordonH.W.Baker departmentofObstetricsandGynaecology，UniversityofMelbourne departmentofMedicine UniversityofMelbourne PregnancyResearchCenterRoyalWomen''sHospital ReproductiveServices RoyalWomen''sHospitalandMelbourneIVE CSIRODivisionofHealthScienceandNutrition MelbourneAustralia

Aim: To produce biologically active recombinant human (rh) ZP proteins in a human cell for use in sperm function tests. Methods: The human embryonic kidney cell line 293T was employed to produce rhZP1, rhZP2 and rhZP3 proteins individually and together by co-expression. Presence of these proteins in the culture medium and cell lysate was assessed by Western blotting analysis. The effect of the recombinant proteins on the human AR was assessed. Results: RhZP2 and rhZP3 were secreted into the culture medium, whereas rhZPl was found only in the cell lysate. Interestingly, when all zona pellucida proteins were co-expressed in the same cells, rhZPl was also secreted into the culture medium. However, despite the presence of all three ZP proteins in sufficient concentration and evidence of heavy glycosylation on gel electrophoresis, biological activity to induce the AR was not observed. Conclusion: RhZP1, rhZP2 and rhZP3 were successfully expressed in the human embryonic kidney cell line 293T. It appears that an interaction amongst these proteins may be required for release of rhZPl from the cell. Although this approach is not satisfactory for producing active human ZP proteins, it makes a significant contribution to the understanding of the structural and functional characteristics of the ZP proteins.

关键词： acrosome reaction glycosylation human cell line recombinant proteins zona pellucida

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