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澳大利亚人乳头状瘤病毒疫苗计划实施5年对年轻人群生殖器疣患病情况的影响：国家调查数据分析

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英国医学杂志中文版 2013年第4期16卷 237-237页

作者： Hammad Ali,lecturer Basil Donovan, professor HandanWand,senior lecturer tim R H Read, sexual health physician David G Regan,senior lecturer Andrew E Grulich, professor Christopher K FaMey, professor Rebecca j Guy, associate professor 尹婕(译) 潘凌亚(校) The Kirby Institute University of NewSouth Wales SydneyNSW 2052 Australia Sydney Sexual HealthCentre SydneyHospital SydneyNSW 2000 Australia Melbourne SexualHealth Centre Carlton VIC 3053Australia School of PopulationHealth University ofMelbourne ParkvilleVIC 3010 Australia 北京协和医院妇产科

目的评估2007年中开始的澳大利亚人乳头状瘤病毒（HPV）疫苗计划对生殖器疣患病情况的影响。设计国家调查数据趋势分析。数据来源数据收集于2004--2011年度澳大利亚8所性健康服务机构；其中2所最大的临床中心收集了自我报告的本中心200... 详细信息

目的评估2007年中开始的澳大利亚人乳头状瘤病毒（HPV）疫苗计划对生殖器疣患病情况的影响。设计国家调查数据趋势分析。数据来源数据收集于2004--2011年度澳大利亚8所性健康服务机构；其中2所最大的临床中心收集了自我报告的本中心2009年度HPV疫苗现状。研究对象2004--2011年度首次就诊的85770名澳大利亚出生的国民；其中7686（9．0％）名患生殖器疣。主要结局测量比较前疫苗时期（2004—2007年中）和疫苗时期（2007年中-2001年末）不同人群生殖器疣新发病率变化趋势。结果疫苗时期21岁以下和21～30岁女性诊断患有生殖器疣的比例明显下降，发病率分别从2007年度的11．5％和11．3％下降至2011年度的0．85％和3．1％，P均〈0．001。在30岁以上的女性中未发现发病率的明显下降。在21岁以下和21～30岁异性恋男性人群中疫苗时期生殖器疣的发病率较前疫苗时期明显下降，分别由2007年度12．1％和18．2％下降至2011年度2．2％和8．9％，P均〈0．001。30岁以上的异性恋男性人群中发病率无明显下降。2011年235名21岁以下女性在使用HPV疫苗后无新发生殖器疣病例。结论年轻女性生殖器疣发病率的显著下降和2011年度部分年轻女性使用疫苗后的零发病率，说明HPV疫苗获得实验室外的良好功效。异性恋男性生殖器疣发病率的显著下降可能是由于群体免疫所致。

关键词：男性生殖器疣人乳头状瘤病毒疫苗计划澳大利亚数据收集男性人群患病情况年轻

MLC1在调节星形胶质细胞-突触相互作用中的新角色

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神经损伤与功能重建 2023年第5期18卷 F0003-F0003页

作者： Mandy S j Kater Katharina F Baumgart Aina Badia-Soteras tim S Heistek Karen E Carney A jacob timmerman jan R T vanWeering August B Smit Marjo S van der Knaap Huibert D Mansvelder Mark H G Verheijen Rogier Min Department of Molecular and Cellular Neurobiology Center for Neurogenomics and Cognitive ResearchAmsterdam NeuroscienceVrije Universiteit AmsterdamThe Netherlands Department of Child Neurology Amsterdam Leukodystrophy CenterEmma Children's HospitalAmsterdam University Medical CentersAmsterdam NeuroscienceAmsterdamThe Netherlands Department of Integrative Neurophysiology Center for Neurogenomics and Cognitive ResearchAmsterdam NeuroscienceVrije Universiteit AmsterdamAmsterdamThe Netherlands Department of Human Genetics Center for Neurogenomics and Cognitive ResearchAmsterdam University Medical CentersAmsterdam NeuroscienceVrije Universiteit AmsterdamAmsterdamThe Netherlands

星形胶质细胞膜蛋白MLC1的功能丧失是伴皮质下囊肿的巨脑性白质脑病(MLC)的主要遗传原因,这一罕见病的特征是脑内离子和水稳态失衡。MLC1蛋白主要分布于大脑中的液体屏障周围,例如在星形胶质细胞接触血管的终足和接触脑膜的突起中。该... 详细信息

星形胶质细胞膜蛋白MLC1的功能丧失是伴皮质下囊肿的巨脑性白质脑病(MLC)的主要遗传原因,这一罕见病的特征是脑内离子和水稳态失衡。MLC1蛋白主要分布于大脑中的液体屏障周围,例如在星形胶质细胞接触血管的终足和接触脑膜的突起中。该蛋白是否在其他星形胶质细胞结构域中发挥作用尚不清楚。本研究表明MLC1存在于星形胶质细胞远端突起中,也称为突触周围星形胶质细胞突起(PAP)或星形胶质细胞小叶;在海马CA1区域它们与兴奋性突触密切相互作用。我们发现在Mlc1缺失小鼠中,向兴奋性突触延伸的PAP末端缩短。这一改变会影响谷氨酸能突触传递,导致自发释放事件的速率降低,并在具有挑战性的条件下减慢谷氨酸的再摄取。此外,虽然野生型小鼠中的PAP在恐惧调节过程从突触回缩,但我们发现在Mlc1缺失小鼠中,这种结构可塑性在本已更短的PAP出现障碍。最后,Mlc1缺失小鼠显示情境恐惧记忆减少。总之,本研究揭示了星形胶质细胞蛋白MLC1在调节PAP结构方面的意想不到的作用。MLC1的缺失会改变兴奋性突触传递,阻止恐惧调节诱导的正常PAP重塑,并破坏情境恐惧记忆表达。因此,MLC1是调节星形胶质细胞-突触相互作用的新参与者。

关键词： MLC1 星形胶质细胞恐惧调节突触周围星形胶质细胞突起突触传递

光损害皮肤在二氧化碳激光表面重建后引发的结缔组织重塑

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 35-36页

作者： Orringer j.S. Kang S. johnson T.M. 牛新武 Department of D ermatology Univ. of Michigan Health Systems 1910 Taubman Center 1500 E Medical Center Dr Ann Arbor MI 48109- 0314 United States Dr.

Objective: To quantitatively examine the dynamics of molecular alterations in volved in dermal remodeling after carbon dioxide (CO2) laser resurfacing of phot odamaged human skin. Design: Serial in vivo biochemical analyses after laser therapy. Setting: Academic referral center, Department of Dermatology, University of Mich igan, Ann Arbor. Subjects: Volunteer sample of 28 adults, 48 to 76 years old, wi th clinically evident photodamage of the forearms. Intervention: Focal CO2 laser resurfacing of photodamaged forearms and serial biopsies at baseline and variou s times after treatment. Main Outcome Measures: Reverse transcriptase real-tim e polymerase chain reaction technology and immunohistochemistry were used to ass ess levels of type I and type III procollagens; matrix metalloproteinases (MMPs) 1, 3, 9, and 13; tropoelastin; fibrillin; primary cytokines interleukin 1β an d tumor necrosis factor α ; and profibrotic cytokine transforming growth factor β 1. Results: Production of type I procollagen and type III procollagen messen ger RNA peaked at 7.5 and 8.9 times baseline levels, respectively, 21 days after treatment and remained elevated for at least 6 months. Increases in messenger R NA levels of several cytokines (interleukin 1β , tumor necrosis factor a, and t ransforming growth factor β 1) preceded and/or accompanied changes in collagen levels. Marked increases in messenger RNA levels of MMP- 1 (39 130- fold), MMP - 3 (1041- fold), MMP- 9 (75- fold) , andMMP- 13 (767- fold)were noted. Le vels of fibrillin and tropoelastin rose in a delayed fashion several weeks after treatment. Conclusions: The biochemical changes seen after CO2 laser resurfacin g proceed through a well-organized and highly reproducible wound healing respo nse that results in marked alterations in dermal structure. These quantitative c hanges may serve as a means for comparison as other therapeutic modalitiesmeant to improve the appearance of photodamaged skin are evaluated.

关键词：二氧化碳激光表面重建细胞因子转化生长因子肿瘤坏死因子α 基质金属蛋白酶原胶原主要检测指标弹性蛋白原纤维蛋白

治疗脉络膜黑色素瘤的COMS试验参与者发生第二原发性肿瘤:COMS第25次报道

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 27-28页

作者： Diener-West M . Reynolds S.M . Agugliaro D.j. 杨秀梅 COMS CoordinatingCenter Wilmer Clinical Trials and Biometry550 N Broadw ayBal-timoreMD 21205U nited States Dr

Objective:To reportsitesofsecond prim ary cancerand thetim e to firstdiagnosis during routine follow-up after treat-m ent for choroidal m elanom ***:Prospective longi-tudinalfollow-up ofpatients enrolled in 2random ized trialsconducted by the Collaborative Ocular M elanom a Study(COM S)Group.M ethods:Baseline and annual or sem i-annualsystem ic and laboratory evaluations were perform edaccording to a standard protocolfor 2320patients enrolledin the COM S without evidence of m elanom a m etastasis orother prim ary cancer *** were coded by am ortality coding com m ***:Subsequentto treat-m entfor choroidalm elanom a,a totalof222patients werediagnosed with a second prim ary cancerotherthan basalorsquam ous cellskin cancer (5-yearrate of7.7% 犤95%confidence interval,6.6% -9.0%犦).The m ostcom m onsites were prostate (23% of reported cases)and breast(17%);12ofthese 222patients were diagnosed sim ulta-neously with second prim ary cancers in 2orm ore *** 222patients,113died;37 (33%)were coded asdead with m elanom am etastasis,33(29%)as deadwith a-m alignant tum or other than m etastatic m elanom a,and 13(11% )as dead with a m alignancy of uncertain *** therapy did not significantly increase the develop-m ent of second prim ary *** rate of diagnosis ofsecond prim ary cancer did not differ significantly bysm oking status,although the rate in form er sm okers wasincreased vs that observed in either current sm okers orthose who never sm ***:Routine m edicalsurveillance for developm entofsecond prim ary cancers a-m ong patients treated for choroidalm elanom a is im portant,especially forthose with a history ofsm oking,regardless ofthe size ofchoroidalm elanom a atthe tim e oftreatm ent.

关键词：脉络膜黑色素瘤 COMS 第二原发性肿瘤鳞状细胞转移性黑色素瘤原发癌死亡疾病协作研究诊断率标准化方案

青光眼视神经病变而自动视野计检查正常的患者身心和结构损害的检测

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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 19-20页

作者： Bagga H. Feuer W. j. Greenfield D. S. 王大江(译) 不详 BascomPalmer Eye Institute 7108 Fairway Dr Palm Beach Gardens FL 33418 United States

Objective: To compare the prevalence of structural and psychophysical abnormalities in normal eyes and eyes with glaucomatous optic neuropathy (GON) and normal standard automated perimetry (SAP). Methods: Complete examination,SAP,short-wavelength automated perimetry (SWAP),frequency doubling technology (FDT),scanning laser polarimetry (GDx-VCC),and optical coherence tomography (OCT) of the peripapillary retinal nerve fiber layer (RNFL),optic disc,and macula were performed. Glaucomatous optic neuropathy was defined as cup-disc asymmetry between fellow eyes of greater than 0.2,rim thinning,notching,excavation,or RNFL defect. All eyes had normal SAP. Abnormal measurements on OCT,GDx-VCC,SWAP,and FDT were defined as those outside 95% normal limits. Eyes were stratified into 3 groups based on the OCT-generated vertical cup-disc ratio: mild,moderate,and advanced cupping (cup-disc ratio of 0.7,respectively). Receiver operating characteristic curves were developed to assess sensitivity and specificity of structural and functional assessments. Results: Forty-seven eyes of 47patients (25 with GON and 22 normal) were enrolled (mean± SD age,58± 16 years; range,25-83 years). Compared with normal eyes,eyes with GON had significantly worse mean deviation and pattern standard deviation by means of SWAP and FDT (P=.02-.05); OCT-derived mean and superior and inferior RNFL thickness (P=.008,< .001,and .05,respectively); mean macular thickness (P=.01),rim volume,rim area,cup-disc ratio,and cup area (all P< .001); and GDx-VCC nerve fiber indicator and inferior average (P=.03). There was a significantly (P=.008,.002,.003,and .01,respectively) greater prevalence of abnormalities identified by SWAP,FDT,OCT and GDx-VCC in eyes with advanced cupping (43% ,43% ,57% ,and 57% ,respectively) compared with mild cupping (0% ) and moderate cupping (9% ,5% ,19% ,and 33% ,respectively). Conclusions: Eyes with GON and normal results of SAP have significantly greater structural and p

关键词：青光眼性视神经病变自动视野检查自动视野计结构损害患者受试者操作特征曲线视网膜神经纤维层视乳头周围检测平均年龄

Nightlife in the city: drivers of the occurrence and vocal activity of a tropical owl

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Avian Research 2020年第2期11卷 92-105页

作者： Oscar Humberto Marín‑Gómez Michelle García‑Arroyo Camilo ESánchez‑Sarria jRoberto Sosa‑López Diego Santiago‑Alarcon Ian MacGregor‑Fors Red de Ambiente y Sustentabilidad Instituto de Ecología A.C.Carretera antigua a Coatepec 351El Haya91073 XalapaVeracruzMexico Departamento de Ciencias Naturales y Matemáticas Pontificia Universidad Javeriana Cali760044 CaliColombia Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Oaxaca(CIIDIR) Instituto Politécnico NacionalOaxacaMexico Dirección de Cátedras Consejo Nacional de Ciencia y Tecnología(CONACYT)Mexico CityMexico Red de Biología y Conservación de Vertebrados Instituto de Ecología A.C91073 XalapaVeracruzMexico

Background:Cities differ from non-urban environments by the intensity,scale,and extent of anthropogenic pres-sures,which can drive the occurrence,physiology,and behavior of the organisms thriving in these *** as green cover often predict the occurrence patterns of bird species in urban ***,anthropogenic noise and artificial light at night(ALAN)could also limit the presence and disrupt the behavior of ***,there is still a dearth of knowledge about the influence of urbanization through noise and light pollution on nocturnal bird species *** this study,we assessed the role of green cover,noise,and light pollution on the occurrence and vocal activity of the Mottled Owl(Ciccaba virgata)in the city of Xalapa(Mexico).Methods:We obtained soundscape recordings in 61 independent sites scattered across the city of Xalapa using autonomous recording *** performed a semi-automated acoustic analysis of the recordings,corroborating all Mottled Owl *** calculated two measures of anthropogenic noise at each study site:daily noise(during 24 h)and masking noise(mean noise amplitude at night per site that could mask the owl’s vocalizations).We further performed generalized linear models to relate green cover,ALAN,daily noise,and masking noise in relation to the owl’s occurrence(i.e.,detected,undetected).We also ran linear models to assess relationships among the beginning and ending of vocal activity with ALAN,and with the anthropogenic and masking noise levels at the moment of which vocalizations were ***,we explored variations of the vocal activity of the Mottled Owl measured as vocalization rate across ***:The presence of Mottled Owls increased with the size of green cover and decreased with increases in both artificial light at night and noise *** the temporal scale,green cover was positively related with the ending of the owl’s vocal activity,while daily noise and ALAN levels were not related to the tim

关键词： Anthropogenic noise Acoustic monitoring Nighttime ecology Urban ecology Urbanization Vocal activity

图雷特综合征患儿成年期的抽搐和强制性障碍症状严重程度的转归

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世界核心医学期刊文摘（儿科学分册） 2006年第5期2卷 25-26页

作者： Bloch M.H. Peterson B.S. Scahill L. j.F. Leckman 朱新菊 Child Study Center Yale University School of Medicine PO Box 207900 New Haven CT 06520-790 0 United States.Dr

Background: Tourette syndrome (TS) is a childhood-onset neuropsychiatric diso rder that is characterized by both motor and phonic tics. One half to two thirds of children with TS experience a reduction or complete resolution of tic sympto ms during adolescence. At least one third of adults with TS have comorbid obsess ive-compulsive disorder (OCD). Objectives: To clarify the clinical course of ti c and OCD symptoms in children with TS and determine if baseline clinical measurements in childhood are associated with future symptom severity in late adolesce nce and early adulthood. Design: Prospective cohort study. Setting: Yale Child Study Center tic and OCD outpatient specialty clinic. Participants: Forty-six children with TS who received a structured clinical evaluation prior to age 14 years. Main Outcome Measures: Expert-rated tic and OCD symptom sever ity at follow-up interview an average of 7.6 years later (range, 3.8-12.8 year s). Results: Eighty-five percent of subjects reported a reduction in tic sympto ms during adolescence. Only increased tic severity in childhood was associated w ith increased tic severity at follow-up. The average age at worst-ever tic sev erity was 10.6 years. Forty-one percent of patients with TS reported at one tim e experiencing at least moderate OCD symptoms. Worst-ever OCD symptoms occurred approximately 2 years later than worst-ever tic symptoms. Increased childhood IQ was strongly associated with increased OCD severity at followup. Conclusion: Obsessive-compulsive disorder symptoms in children with TS became more severe a t a later age and were more likely to persist than tic symptoms.

关键词：症状严重程度图雷特综合征成年期抽搐患儿强制性转归障碍神经精神疾病完全缓解

Importance of measurement of rare-earth elements from the Soil Information and Monitoring System:A normalization method for detection of chromium contamination in soils

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Chinese journal Of Geochemistry 2006年第B8期25卷 195-195页

作者： Szegvi j sef Prokisch Per Marth Ba Kov s Zolt Gyi Plant and Soil Protection Service of Hajd Bihar County DebrecenHungary University of Debrecen Department of Food Science and Quality Assurance DebrecenHungary Plant and Soil Protection Central Service BudapestHungary

功能性消化不良患者酸反流的患病率及其伴随症状

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 31-31页

作者： Tack j Caenepeel P Arts j. 纪泛扑 Department of Internal Medicine Division of GastroenterologyUniversity Hospital Gasthuisberg Herestraat 4 9 B-3000 Leuven BelgiumDr.

Aim: A subset of functional dyspepsia patients respond to acid suppressive therapy, but the prevalence of non-erosive reflux disease in functional dyspepsia and its relevance to symptoms have never been established. The aim of the presen t study was to study 24 hour pH monitoring in consecutive functional dyspepsia p atients. Methods: A total of 247 patients with dyspeptic symptoms (166 women, me an age 44 (SEM1) year), with a negative upper gastrointestinal endoscopy and wit hout dominant symptoms of heartburn participated in the study. In all patients, the severity of dyspeptic symptoms and the presence of heartburn was assessed by a questionnaire and a 24 hour oesophageal pH monitoring study was performed. Al l patients underwent a gastric emptying breath test and in 113 a gastric barosta t study was performed. Results: Abnormal pH monitoring (acid exposure >5%of tim e) was found in 58 patients (23%). Of 21 patients with a positive heartburn que stionnaire, 76%had pathological pH monitoring, while this was the case in only 18.5%of patients with a negative heartburn questionnaire. Demographic character istics and the prevalence of other pathophysiological mechanisms did not differ between heartburn negative patients with normal or abnormal acid exposure. Patho logical acid exposure in heartburn negative patients was associated with the pre sence of epigastric pain (65 v 84%, p < 0.005) and of moderate or severe pain ( 48 v 69%, p = 0.005) . Conclusion: Pathological oesophageal acid exposure is on ly present in a subset of heartburn negative functional dyspepsia patients, whic h are characterised by a higher prevalence of epigastric pain.

关键词：酸反流胃灼热非糜烂性反流病抑酸治疗胃肠镜检查呼气试验上消化道胃排空病理生理学腹部疼