检索结果-南通市图书馆

Physiological roles of NAADP-mediated Ca^(2+) signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2011年第8期54卷 725-732页

作者： Antony GALIONE John PARRINGTON tim FUNNELL Department of Pharmacology University of Oxford

Nicotinic acid dinucleotide phosphate(NAADP) is unique amongst Ca2+ mobilizing messengers in that its principal function is to mobilize Ca2+ from acidic *** studies indicated that it was likely that NAADP activates a novel Ca2+ release channel distinct from the well characterized Ca2+ release channels on the(sarco) -endoplasmic reticulum(ER) ,inositol trisphosphate and ryanodine *** this review,we discuss the emergence of a novel family of endolysosomal channels,the two-pore channels(TPCs) ,as likely targets for NAADP,and how molecular and pharmacological manipulation of these channels is enhancing our understanding of the physiological roles of NAADP as an intracellular Ca2+ mobilizing messenger.

关键词：生理作用钙动员 ryanodine受体钙释放通道三磷酸肌醇介导信号二核苷酸

Immunobiology and immunotherapy of HCC:spotlight on innate and innate-like immune cells

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第1期18卷 112-127页

作者： Benjamin Ruf Bernd Heinrich tim F.Greten Gastrointestinal Malignancy Section Thoracic and Gastrointestinal Malignancies BranchCentre for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA NCI CCR Liver Cancer Program National Institutes of HealthBethesdaMD 20892USA

Immune-based therapies such as immune checkpoint inhibitors have revolutionized the systemic treatment of various cancer *** therapeutic application of monoclonal antibodies targeting inhibitory pathways such as programmed cell death-1(PD-1)/programmed cell death ligand 1(PD-L1)and CTLA-4 to cells of the adaptive immune system has recently been shown to generate meaningful improvement in the clinical outcome of hepatocellular carcinoma(HCC).Nevertheless,current immunotherapeutic approaches induce durable responses in only a subset of HCC *** immunologic mechanisms such as chronic inflammation due to chronic viral hepatitis or alcoholic and nonalcoholic fatty liver disease play a crucial role in the initiation,development,and progression of HCC,it is important to understand the underlying mechanisms shaping the unique tumor microenvironment of liver *** liver is an immunologic organ with large populations of innate and innate-like immune cells and is exposed to bacterial,viral,and fungal antigens through the gut-liver ***,we summarize and highlight the role of these cells in liver cancer and propose strategies to therapeutically target *** also discuss current immunotherapeutic strategies in HCC and outline recent advances in our understanding of how the therapeutic potential of these agents might be enhanced.

关键词： HCC immunotherapy innate immunity tumor microenvironment

Improved MPEG-4 High-Efficiency AAC With Variable-Length Soft-Decision Decoding of the Quantized Spectral Coefficients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2019年第10期16卷 65-82页

作者： Sai Han Hongbing Ma Ping Zhang tim Fingscheidt China United Network Communications Group Company Limited Beijing 100033China Beijing University of Posts and Telecommunications Beijing 100876China Institute for Communications Technology Technische Universitat BraunschweigBraunschweig 38106Germany

MPEG-4 High-Efficiency Advanced Audio Coding (HE-AAC) is designed for low bit rate applications, such as audio streaming in mobile communications. The HE-AAC audio codec offers a better coding efficiency since variable-length codes (VLCs) are adopted. However, HE-AAC has originally been designed for storage and error-free transmission conditions. For the transmission over bit error-prone channels, error propagation is a serious problem for the VLCs. Therefore, a robust HE-AAC decoder is desired, especially for mobile communications. In contrast to traditional hard-decision decoding, utilizing bit-wise channel reliability information, softdecision (SD) decoding has been known to offer better audio quality. In HE-AAC, the global gain parameter is coded with fixedlength codes (FLCs), while the scale factors and quantized spectral coefficients are coded with VLCs. In this work, we apply FL/SD decoding to the global gain parameter, VL/SD decoding to the parameters scale factors and quantized spectral coefficients. Especially, in order to apply VL/SD decoding to the quantized spectral coefficients, a new modified trellis representation in VL/SD decoding is proposed. An improved HE-AAC performance is clearly observed, with the support of both instrumental measurements and a subjective listening test.

关键词： variable-length soft-decision decoding HE-AAC trellis representation quantization spectral coefficients

Upgrading Pathways of Intelligent Manufacturing in China:Transitioning across Technological Paradigms

在线全文

学校读者我要写书评

暂无评论

Engineering 2019年第4期5卷 691-701页

作者： Yuan Zhou Jiyuan Zang Zhongzhen Miao tim Minshall School of Public Policy and Management Tsinghua UniversityBeijing 100084China Center for Strategic Studies Chinese Academy of EngineeringBeijing 100088China Institute for Manufacturing University of CambridgeCambridge CB3 0FSUK

Intelligent technologies are leading to the next wave of industrial revolution in *** developed economies,firms are embracing these advanced technologies following a sequential upgrading strategy-from digital manufacturing to smart manufacturing(digital-networked),and then to newgeneration intelligent manufacturing ***,Chinese firms face a different *** the one hand,they have diverse technological bases that vary from low-end electrified machinery to leading-edge digital-network technologies;thus,they may not follow an identical upgrading *** the other hand,Chinese firms aim to rapidly catch up and transition from technology followers to probable frontrunners;thus,the turbulences in the transitioning phase may trigger a precious opportunity for leapfrogging,if Chinese manufacturers can swiftly acquire domain expertise through the adoption of intelligent manufacturing *** study addresses the following question by conducting multiple case studies:Can Chinese firms upgrade intelligent manufacturing through different pathways than the sequential one followed in developed economies?The data sources include semistructured interviews and archival *** study finds that Chinese manufacturing firms have a variety of pathways to transition across the three technological paradigms of intelligent manufacturing in nonconsecutive *** finding implies that Chinese firms may strategize their own upgrading pathways toward intelligent manufacturing according to their capabilities and industrial specifics;furthermore,this finding can be extended to other catching-up *** paper provides a strategic roadmap as an explanatory guide to manufacturing firms,policymakers,and investors.

关键词： Intelligent manufacturing Upgrading pathways China’s manufacturing Digitalization Networkization New-generation intelligent manufacturing

Impacts of the Diurnal Cycle of Radiation on Tropical Cyclone Intensification and Structure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2014年第6期31卷 1377-1385页

作者： GE Xuyang MA Yue ZHOU Shunwu tim LI Earth System Modeling Center Nanjing University of Information Science and Technology College of Atmospheric Science Nanjing University of Information Science and Technology Key laboratory of Meteorological Disaster Nanjing University of Information Science and Technology International Pacific Research Center University of Hawaii Honolulu HI 96822 USA

To investigate the impacts of the diurnal cycle on tropical cyclones （TCs）,a set of idealized simulations were conducted by specifying different radiation （i.e.,nighttime-only,daytime-only,full diurnal cycle）.It was found that,for an initially weak storm,it developed faster during nighttime than *** impacts of radiation were not only on TC intensification,but also on TC structure and *** nighttime storm tended to have a larger size than its daytime *** nighttime,the radiative cooling steepened the lapse rate and thus reduced the static stability in cloudy regions,enhancing *** heating associated with outer convection induced boundary layer inflows,which led to outward expansion of tangential winds and thus increased the storm size.

关键词： solar shortwave radiation tropical cyclone structure intensification diurnal cycle

Estimating above-ground biomass by fusion of LiDAR and multispectral data in subtropical woody plant communities in topographically complex terrain in North-eastern Australia

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2014年第4期25卷 761-771页

作者： Sisira Ediriweera Sumith Pathirana tim Danaher Doland Nichols School of Environment Science and Engineering Southern Cross University Lismore NSW 2480 Australia Office of Environment and Heritage Alstonville NSW 2477 Australia

We investigated a strategy to improve predicting capacity of plot-scale above-ground biomass （AGB） by fusion of LiDAR and Land- sat5 TM derived biophysical variables for subtropical rainforest and eucalypts dominated forest in topographically complex landscapes in North-eastern Australia. Investigation was carried out in two study areas separately and in combination. From each plot of both study areas, LiDAR derived structural parameters of vegetation and reflectance of all Landsat bands, vegetation indices were employed. The regression analysis was carded out separately for LiDAR and Landsat derived variables indi- vidually and in combination. Strong relationships were found with LiDAR alone for eucalypts dominated forest and combined sites compared to the accuracy of AGB estimates by Landsat data. Fusing LiDAR with Landsat5 TM derived variables increased overall performance for the eucalypt forest and combined sites data by describing extra variation （3% for eucalypt forest and 2% combined sites） of field estimated plot-scale above-ground biomass. In contrast, separate LiDAR and imagery data, andfusion of LiDAR and Landsat data performed poorly across structurally complex closed canopy subtropical minforest. These findings reinforced that obtaining accurate estimates of above ground biomass using remotely sensed data is a function of the complexity of horizontal and vertical structural diversity of vegetation.

关键词： Fusion above-ground biomass LiDAR, multispectral data subtropical plant communities

Factors controlling northward and north-eastward moving tropical cyclones near the coast of East Asia

在线全文

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2019年第4期13卷 778-790页

作者： Qiao LIU Weican ZHOU Melinda PENG tim LI Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Meteorological Disaster Ministry of Education Nanjing University of Information Science and TechnologyNanjing 210044China Joint International Research Laboratory of Climate and Environmental Change Nanjing University of Information Science and TechnologyNanjing 210044China University of Colorado at Colorado University of Colorado at Colorado Spring Colorado SpringCO 80918USA International Pacific Research Center and Department of Atmospheric Sciences School of Ocean and Earth Science and TechnologyUniversity of Hawaii at ManoaHonoluluHI 96822USA

The impacts of multi-time-scale flows on northward and north-eastward moving tropical cyclones(TCs)near the east coast of China in August and September are investigated using reanalysis data from 1982 to *** of interest are under the influence of the subtropical high-pressure system in the western North Pacific(WNP).In August when the subtropical highpressure system is strong and close to the coast line,most TCs in the region move northward,while more TCs move north-eastward in September when the subtropical highpressure system retreats to the *** investigate the influence from different time-scales,the environmental flow is divided intofour components,the synoptic flow,the intraseasonal flow,the interannual flow and the climatological background *** of steering flows between 25°N and 30°N indicates that the meridional steering vectors from all time-scales point to the north,dominated by the intraseasonal *** deciding factor on whether a TC moves to the north or north-east between 25°N and 30°N is the zonal steering *** the northward moving group,the sum of the zonal steering from all time-scales is very *** the other hand,the north-east moving group has a net eastward zonal component mainly contributed by the climatological mean *** individual cases that stood out from the majority of the group are *** those cases,the intraseasonal flow plays an important role in affecting the movement of the TCs mainly through the wave train,in which a cyclonic circulation is located to the north-west(north)and an anticyclonic circulation to the south-east(east)of *** analysis of the steering vectors indicates the importance of all components with different timescales to the movement of TCs.

关键词： northward moving TC north-eastward moving TC steering flow

High-resolution peat records for Holocene monsoon history in the eastern Tibetan Plateau

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2006年第6期49卷 615-621页

作者： Lars G. Franzen A.J.tim Jull Department of Earth Sciences Goteborg University P.O. Box 460 SE-405 30 Goteborg Sweden NSF-AMS Facility University of Arizona Arizona AZ85721 USA

The variations of summer and winter monsoons during the Holocene in theeastern Tibetan Plateau are shown to follow two basic models based on the reliable dating andhigh-resolution monsoon proxies determinations, one being a synchronous model in that both summerand winter monsoons are strengthening or decreasing, and the other to form a complementary *** two different patterns evenly interact with each other on different time scales and togethercompose a complicated monsoon climatic model in this region. The climatic condition integrated bywinter and summer monsoons is synchronous to the global pattern, which also shows the instability ofthe Holocene climate on centennial-millennial timescale. The abrupt monsoon event in about 6.2 kacat. BP is much more severe than that in ca. 8.0 ka cal. BP, which indicates the regional characterof the Asian monsoon and that the Asian monsoon climate is indeed a window on the global climatesystem.

关键词： eastern Tibetan Plateau, Holocene, winter and summer monsoons, asynchronous, peat, climate instability.

在线全文

学校读者我要写书评

暂无评论

原来一切都是五彩斑斓的黑

人与自然 2024年第4期 10-37页

作者：李敏任惠云蒂姆·弗拉克(摄影) 不详

每一种都有独特的羽毛色彩,常见的颜色有蓝色、红色、绿色、黄色、灰色、黑色和色等,它们可以散发出锦缎一样的光彩,亦可变化出多种美轮美免的图案。为什么不同鸟种的羽毛会差别如此之大呢?科学家早已给出了答案,现生鸟类所具有的颜色... 详细信息

每一种都有独特的羽毛色彩,常见的颜色有蓝色、红色、绿色、黄色、灰色、黑色和色等,它们可以散发出锦缎一样的光彩,亦可变化出多种美轮美免的图案。为什么不同鸟种的羽毛会差别如此之大呢?科学家早已给出了答案,现生鸟类所具有的颜色和色彩主要取决于羽毛具有的色素体以及羽毛内部的结构。

关键词：五彩斑斓羽毛颜色色彩