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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith tiffany m.zúñiga Forrest L.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

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Trends and seasonality in hospitalizations for acute alcohol-related and biliary pancreatitis in the USA

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 173-181页

作者： Artem Shmelev Anne m Sill tiffany Horrigan Steven C Cunningham Department of Surgery Saint Agnes HealthcareBaltimoreMDUSA

Background:The incidence of acute pancreatitis(AP)is characterized by circannual and geographical *** aim of this study was to describe seasonal variation and trends in hospitalizations for AP in the USA with respect to AP ***:The Nationwide Inpatient Sample data(2000–2016)from the Healthcare Cost and Utilization Project were *** study population included all primary hospitalizations for *** AP(BAP)and alcohol-induced AP(AAP)were distinguished by diagnostic and procedural ICD *** trend decomposition was ***:There was a linear increase in annual incidence(per 100000 population)of AAP in the USA(from 17.0 in 2000 to 22.9 in 2016),while incidence of BAP,equaled 19.9 in 2000,peaked at 22.1 in 2006 and decreased to 17.4 in *** incidence demonstrated 18%annual incidence amplitude with summer peak and winter trough,more prominent in *** 2016,within AAP,the highest incidence(per 100000 population)was noted among African-Americans(up to 50.4),followed by males aged 56–70 years(26.5)and Asians of low income(25.5);within BAP,above the average incidence was observed in Hispanic(up to 25.8)and Asian(up to 25.0)*** most consistent and rapid increase in AP incidence was noted in males aged 56–70 years with an alcoholic etiology(average 6%annual incidence growth).Conclusions:The incidence and annual trends of AP vary significantly among demographic and socioeconomic groups and this knowledge may be useful for the planning of healthcare resources and identification of at-risk populations.

关键词： Pancreatitis Alcoholic pancreatitis Incidence Seasonal variation

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COVID-19 associated liver injury:A general review with special consideration of pregnancy and obstetric outcomes

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World Journal of Gastroenterology 2022年第42期28卷 6017-6033页

作者： Katherine m.Cooper Alessandro Colletta Alison m.Asirwatham tiffany A.moore Simas Deepika Devuni Department of medicine University of Massachusetts Chan Medical SchoolWorcesterMA 01605United States Department of Obstetrics and Gynecology University of Massachusetts Chan Medical SchoolWorcesterMA 01605United States Departments of Pediatrics Psychiatryand Population&Quantitative Health SciencesUniversity of Massachusetts Chan Medical SchoolWorcesterMA 01605United States Division of Gastroenterology and Hepatology University of Massachusetts Chan Medical SchoolWorcesterMA 1605United States

Liver injury is an increasingly recognized extra-pulmonary manifestation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** disease 2019(COVID-19)associated liver injury(COVALI)is a clinical syndrome encompassing all patients with biochemical liver injury identified in the setting of SARS-CoV-2 *** profound clinical implications,its pathophysiology is poorly ***,most information on COVALI is derived from the general population and may not be applicable to individuals under-represented in research,including pregnant *** manuscript reviews:Clinical features of COVALI,leading theories of COVALI,and existing literature on COVALI during pregnancy,a topic not widely explored in the ***,we synthesized data from the general and perinatal populations that demonstrates COVALI to be a hepatocellular transaminitis that is likely induced by systemic inflammation and that is strongly associated with disease severity and poorer clinical outcome,and offered perspective on approaching transaminitis in the potentially COVID-19 positive patient in the obstetric setting.

关键词： COVID-19 liver injury Pregnancy Perinatal liver disease Systemic inflammation Special populations

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Demonstration of the test-retest reliability and sensitivity of the Lower Limb Functional Index-10 as a measure of functional recovery post burn injury:a cross-sectional repeated measures study design

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Burns & Trauma 2016年第2期4卷 153-159页

作者： margaret E.Ryland tiffany L.Grisbrook Fiona m.Wood michael Phillips Dale W.Edgar School of Physiotherapy and Exercise Science Curtin UniversityBentley 6102WAAustralia School of Physiotherapy and Exercise Science Curtin UniversityBentley 6102WAAustralia Fiona Wood Foundation of Western Australia Fiona Stanley Hospital11 Warren DriveMurdoch 6150WAAustralia Fiona Wood Foundation of Western Australia Fiona Stanley Hospital11 Warren DriveMurdoch 6150WAAustralia State Adult Burn Unit Fiona Stanley HospitalLevel 411 Warren Smith DriveMurdoch 6150WAAustralia Burn Injury Research Unit The University of Western AustraliaCrawley 6009WAAustralia Harry Perkins Institute of medical Research The University of Western AustraliaCrawley 6009WAAustralia Fiona Wood Foundation of Western Australia Fiona Stanley Hospital11 Warren DriveMurdoch 6150WAAustralia State Adult Burn Unit Fiona Stanley HospitalLevel 411 Warren Smith DriveMurdoch 6150WAAustralia Burn Injury Research Unit The University of Western AustraliaCrawley 6009WAAustralia Burn Injury Research Node The University of Notre Dame Australia19 Mouat StFremantle 6160WAAustralia

Background:Lower limb burns can significantly delay recovery of *** lower limb functional outcomes is challenging in the unique burn patient population and necessitates the use of reliable and valid *** aims of this study were to examine the test-retest reliability,sensitivity,and internal consistency of Sections 1 and 3 of the Lower Limb Functional Index-10(LLFI-10)questionnaire for measuring functional ability in patients with lower limb burns over ***:Twenty-nine adult patients who had sustained a lower limb burn injury in the previous 12 months completed the test-retest procedure of the *** addition,the minimal detectable change(mDC)was calculated for Section 1 and 3 of the *** 1 is focused on the activity limitations experienced by patients with a lower limb disorder whereas Section 3 involves patients indicating their current percentage of pre-injury ***:Section 1 of the LLFI-10 demonstrated excellent test-retest reliability(intra-class correlation coefficient(ICC)0.98,95%CI 0.96–0.99)whilst Section 3 demonstrated high test-retest reliability(ICC 0.88,95%CI 0.79–0.94).mDC scores for Sections 1 and 3 were 1.27 points and 30.22%,*** consistency was demonstrated with a significant negative association(rs=?0.83)between Sections 1 and 3 of the LLFI-10(pmonstrates that Section 1 and 3 of the LLFI-10 are reliable for measuring functional ability in patients who have sustained lower limb burns in the previous 12 months,and furthermore,Section 1 is sensitive to changes in patient function over time.

关键词： Outcome measure Questionnaire Lower limb function Internal consistency minimal detectable change Burn

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Chemotherapy of ovarian cancer in elderly patients

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Cancer Biology & medicine 2015年第4期12卷 292-301页

作者： tiffany A.Troso-Sandoval Stuart m.Lichtman Department of medicine Memorial Sloan Kettering Cancer CenterNew York

Epithelial ovarian cancer is primarily a disease of older women. Advanced age is risk factor for decreased survival. Optimal surgery and the safe and effective administration of chemotherapy are essential for prolonged progression-free and overall survival(OS). In this article, the available regimens in both the primary treatment and relapsed setting are reviewed.

关键词： Ovarian cancer chemotherapy paclitaxel carboplatin intraperitoneal elderly geriatrics

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An objective measure for the assessment and management of fluid shifts in acute major burns

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Burns & Trauma 2018年第1期6卷 21-32页

作者： Pippa Kenworthy michael Phillips tiffany L.Grisbrook William Gibson Fiona m.Wood Dale W.Edgar Fiona Wood Foundation Fiona Stanley HospitalPerthWestern AustraliaAustralia School of Physiotherapy and Exercise Science Curtin UniversityPerthWestern AustraliaAustralia Burns Service of Western Australia Fiona Stanley HospitalPerthWestern AustraliaAustralia Burn Injury Research Node Notre Dame UniversityFremantleWestern AustraliaAustralia Harry Perkins Institute of medical Research The University of Western AustraliaPerthWestern AustraliaAustralia School of Physiotherapy Notre Dame UniversityFremantleWestern AustraliaAustralia Adult State Burns Service Fiona Stanley HospitalMurdoch DriveMurdochWestern Australia 6150Australia.

Background: major burns are life threatening. Fluid resuscitation is required for survival to maintain intravascular volumes and prevent hypovolemic shock. Bioimpedance spectroscopy (BIS) has been recognised as a potential method of monitoring fluid shifts after burn and in other disease states. The aims of this study were to examine the reliability of BIS across different dressing conditions and electrode positions, establish the influence of Acticoat?on BIS variable measures and determine the validity of whole-body BIS to assess net fluid shift in the presence of moderate to major burns. methods: An observational longitudinal cohort study was conducted from December 2014 to February 2016. Patients with over 15% total body surface area (TBSA) burns and injury less than 48 h were enrolled in the study. BIS triplicate measures were collected in an open wound and with an ActicoatTmdressing (at 5 half hour intervals). Standard and alternate electrode placements were utilised for the reliability analysis and standard placement only for determining the validity of BIS in moderate to major burns. The Impedimde SFB7 was used to collect whole-body and segmental BIS measures. Stata statistical software, release 14 was utilised to analyse all results. Descriptive analyses were performed and were reported using the means and standard deviations (SD). Results: BIS-repeated measures established BIS raw resistance (R), and predicted volume variables were reliable in any condition (intra-class correlation coefficient (ICC) 0.996-0.999, 95% confidence intervals (CI) 0.996-0.999) without a systematic difference. Acticoat?dressings significantly influenced all BIS-predicted volumes (p≤0.01) as determined by multilevel mixed effects (mLmE) linear regression analysis. Validity of BIS was demonstrated by resistance variables significantly decreasing with increasing net ionic fluid shift and increased TBSA (severity of injury) and calculated fluid volumes increasing with increasing net f

关键词： Bioelectrical impedance Oedema Wounds Fluid resuscitation Dressings

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Infection-acquired versus vaccine-acquired immunity in an SIRWS model

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Infectious Disease modelling 2018年第1期3卷 118-135页

作者： tiffany Leung Patricia T.Campbell Barry D.Hughes Federico Frascoli James m.mcCaw School of mathematics and Statistics University of MelbourneParkvilleVictoria 3010Australia Victorian Infectious Diseases Reference Laboratory Epidemiology Unit Peter Doherty Institute for Infection and ImmunityUniversity of Melbourne and Royal Melbourne HospitalParkvilleVictoria 3010Australia Infection and Immunity Research Theme Murdoch Children's Research InstituteRoyal Children's HospitalParkvilleVictoria 3052Australia Department of mathematics Faculty of ScienceEngineering and TechnologySwinburne University of TechnologyHawthornVictoria 3122Australia melbourne School of Population and Global Health University of MelbourneParkvilleVictoria 3010Australia

In some disease systems,the process of waning immunity can be subtle,involving a complex relationship between the duration of immunitydacquired either through natural infection or vaccinationdand subsequent boosting of immunity through asymptomatic *** present and analyse a model of infectious disease transmission where primary and secondary infections are distinguished to examine the interplay between infection and *** we allow the duration of infection-acquired immunity to differ from that of vaccine-acquired immunity to explore the impact on long-term disease patterns and prevalence of infection in the presence of immune *** model demonstrates that vaccination may induce cyclic behaviour,and the ability of vaccinations to reduce primary infections may not lead to decreased *** the boosting of vaccine-acquired immunity delays a primary infection,the driver of transmission largely remains primary *** contrast,if the immune boosting bypasses a primary infection,secondary infections become the main driver of transmission under a sufficiently long duration of *** results show that the epidemiological patterns of an infectious disease may change considerably when the duration of vaccine-acquired immunity differs from that of infection-acquired *** study highlights that for any particular disease and associated vaccine,a detailed understanding of the waning and boosting of immunity and how the duration of protection is influenced by infection prevalence are important as we seek to optimise vaccination strategies.

关键词： Infectious disease modelling Vaccination Waning immunity Immune boosting

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Comparison of Detection of Antibodies with Yeast Lysate Antigens Prepared from Two Isolates of <i>Blastomyces dermatitidis</i>by Two Different methods: Sensitivity and Specificity Evaluations

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Open Journal of medical microbiology 2012年第4期2卷 142-146页

作者： tiffany R. Allison Gene m. Scalarone Department of Biological Sciences Idaho State University Pocatello USA

Blastomycosis, a systemic fungal disease, caused by the dimorphic fungus Blastomyces dermatitidis, has continually presented clinicians with concerns with regard to laboratory diagnosis and prevention. For years researchers have strived to develop antigens with a high degree of sensitivity and specificity. The purpose of this study was to gain a bet- ter understanding of how two novel yeast lysate antigens, prepared from two B. dermatitidis isolates by different meth- ods, would be able to detect antibody responses in immunized rabbits in a specific and sensitive manner. The en- zyme-linked immunosorbent assay (ELISA) was used to evaluate antibody in serum specimens with yeast lysate re- agents prepared after allowing yeast cells to lyse for 1 or 7 days. The results indicated that reactivity was greater with the day 7 antigens, with both the B5896 and 597 B. dermatitidis isolates, when compared to the day 1 antigens;in con- trast the day 1 preparations exhibited less cross reactivity when assayed against anti-Histoplasma capsulatum serum specimens.

关键词： Isoelectric Focusing ELISA Blastomycosis Lysate Antigen Antibody Detection

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Reconstructing landscapes of ungulate parturition and predation using vegetation phenology

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Current zoology 2022年第3期68卷 275-283页

作者： Paige VAN DE VUURST Seth A.mOORE Edmund J.ISAAC Yvette CHENAUX-IBRAHIm tiffany m.WOLF Luis E.ESCOBAR Department of Fish and Wildlife Conservation Virginia TechBlacksburgVA 24061USA Department of Biology and Environment Grand Portage Band of Lake Superior ChippewaGrand PortageMN 55605USA Veterinary Population medicine University of MinnesotaSt PaulMN 55108USA

Enhanced vegetation index(EVI)data can be used to identify and define the space in which ungulates practice parturition and encounter *** study explores the use of EVI data to identify landscapes linked to ungulate parturition and predation events across space,time,and environmental *** a case study,we used the moose population(Alces alces)of northern minnesota in the *** remotely sensed EVI data rasters and global positioning system collar data,we quantified how vegetation phenology and moose movement shaped the births and predation of 52 moose calves from 2013 to 2020 on or adjacent to the Grand Portage Indian *** known sources of predation were American black bears(Ursus americanus,n=22)and gray wolves(Canis lupus,n=28).Satellite-derived data summarizing seasonal landscape features at the local level revealed that landscape heterogeneity use by moose can help to quantitatively identify landscapes of parturition and predation in space and time across large *** phenology proved to be differentiable between adult moose ranges,sites of cow parturition,and sites of calf *** characteristics of each moose group were consistent and tractable based on environment,suggesting that sites of parturition and predation of moose are predictable in space and *** is possible that moose selected specific landscapes for parturition despite risk of increased predation of their calves,which could be an example of an"ecological trap."This analytical framework can be employed to identify areas for future ungulate research on the impacts of landscape on parturition and predation dynamics.

关键词： bear EVI moose parturition predation prey vegetation phenology

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Latent Profiles of Social media Users, STI Knowledge, and Condom Use among African American Young Adults

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Social Networking 2020年第1期9卷 1-10页

作者： Chakema Carmack Lycinda Rodriguez Taylor m. Coleman megan Heath tiffany Ewere Psychological Health & Learning Sciences Department University of Houston Houston TX USA

The abundance of social networking platforms has increased the frequency and the availability for which individuals communicate with one another. The feasibility and accessibility to go online to find sexual partners pose opportunity for contracting sexually transmitted infections (STI) in the absence of safe sexual practices. Low condom use has been reported among young adults who seek sexual partners online. African American young adults have some of the highest rates of infection for certain STIs. In order to mitigate the incidence and prevalence of STIs in at-risk populations, sexually active young adults must use condoms consistently and correctly during sexual activities. The present study sought to uncover the heterogeneity within African American young adults regarding their online networking utilization, STI knowledge, and sexual risk behavior. African American young adults (N = 236), ages 18 - 23, completed private online survey administration. Using latent class analysis, three classes were identified: Social Network Communicators (43%;N = 101), Social Networking Daters (36%;N = 83), and media Sharers (21%;N = 52). Social Networking Daters exhibited the highest probability of using online dating sites daily, low STI knowledge, and a zero probability of consistent condom use. All three groups exhibited relatively low STI knowledge. Furthermore, having a history of STI increased the likelihood of being classified into the Social Networking Daters class relative to the other classes. Findings highlight the need to capitalize upon online platforms for African American young adults who utilize online dating sites and other online environments.

关键词： Social Networking Condom Use Online Dating Sexual Behavior Latent Class Analysis

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