检索结果-南通市图书馆

Targeted anti-cancer therapy: Co-delivery of VEGF siRNA and Phenethyl isothiocyanate (PEITC) via cRGD-modified lipid nanoparticles for enhanced anti-angiogenic efficacy

引用

Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 170-187页

作者： Bao Li Haoran Niu Xiaoyun Zhao Xiaoyu Huang Yu Ding Ke Dang tianzhi yang Yongfeng Chen Jizhuang Ma Xiaohong Liu Keda Zhang Huichao Xie Pingtian Ding School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical University Shenyang 110016 China Department of Basic Pharmaceutical Sciences School of Pharmacy Husson University Bangor ME 04401USA College of Pharmacy Shenzhen Technology UniversityShenzhen 518118China

Anti-tumor angiogenesis therapy, targeting the suppression of blood vessel growth in tumors, presents a potent approach in the battle against cancer. Traditional therapies have primarily concentrated on single-target techniques, with a specific emphasis on targeting the vascular endothelial growth factor, but have not reached ideal therapeutic efficacy. In response to this issue, our study introduced a novel nanoparticle system known as CS-siRNA/PEITC&L-cRGD NPs. These chitosan-based nanoparticles have been recognized for their excellent biocompatibility and ability to deliver genes. To enhance their targeted delivery capability, they were combined with a cyclic RGD peptide (cRGD). Targeted co-delivery of gene and chemotherapeutic agents was achieved through the use of a negatively charged lipid shell and cRGD, which possesses high affinity for integrin αvβ3 overexpressed in tumor cells and neovasculature. In this multifaceted approach, co-delivery of VEGF siRNA and phenethyl isothiocyanate (PEITC) was employed to target both tumor vascular endothelial cells and tumor cells simultaneously. The co-delivery of VEGF siRNA and PEITC could achieve precise silencing of VEGF, inhibit the accumulation of HIF-1α under hypoxic conditions, and induce apoptosis in tumor cells. In summary, we have successfully developed a nanoparticle delivery platform that utilizes a dual mechanism of action of anti-tumor angiogenesis and pro-tumor apoptosis, which provides a robust and potent strategy for the delivery of anti-cancer therapeutics.

关键词： Anti-angiogenesis Tumor apoptosis Nanoparticles VEGF siRNA Hypoxia inducible factor(HIF)-1 protein Phenethyl isothi ocyanate(PEITC)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced vibration suppression and energy harvesting in fluid-conveying pipes

引用

Applied Mathematics and Mechanics(English Edition) 2023年第9期44卷 1487-1496页

作者： yang JIN tianzhi yang Tianjin Key Laboratory for Civil Aircraft Airworthiness and Maintenance Civil Aviation University of ChinaTianjin 300300China School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China

A novel vibration absorber is designed to suppress vibrations in fluidconveying pipes subject to varying fluid *** proposed absorber combines the fundamental principles of nonlinear energy sinks(NESs)and nonlinear energy harvesters(NEHs).The governing equation is derived,and a second-order discrete system is used to assess the performance of the developed *** results demonstrate that the proposed absorber achieves significantly enhanced energy dissipation efficiency,reaching up to 95%,over a wider frequency ***,it successfully harvests additional electric *** research establishes a promising avenue for the development of new nonlinear devices aimed at suppressing fluid-conveying pipe vibrations across a broad frequency spectrum.

关键词： fuid-conveying pipe vibration suppression nonlinear energy sink(NES) electromagnetic energy harvesting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Geometrically nonlinear inerter for vibration suppression

引用

Applied Mathematics and Mechanics(English Edition) 2023年第11期44卷 1871-1886页

作者： Yuyang SONG Liqun CHEN tianzhi yang School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy EngineeringShanghai Frontier Science Center of MechanoinformaticsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China

A two-degree-of-freedom(2DOF)vibration isolation structure with an integrated geometric nonlinear inerter(NI)device is *** device is integrated into an inertial nonlinear energy sink(INES),and its vibration suppression performance is examined by the Runge-Kutta(RK)method and verified by the harmonic balance method(HBM).The new isolator is compared with a traditional vibration *** results show a significant improvement in the vibration suppression *** investigate the effects of the excitation amplitude and initial condition on the dynamics of the system,a series of transmissibility-frequency response analyses are performed based on the displacement *** energy flow of the system is analyzed,and numerous calculations reveal a series of ideal values for the energy sink in the NI-INES *** study provides new insights for the design of vibration isolators.

关键词： inerter nonlinear dynamic isolator energy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Direct Multiscale Analysis of Stability of an Axially Moving Functionally Graded Beam with Time-Dependent Velocity

引用

Acta Mechanica Solida Sinica 2020年第2期33卷 150-163页

作者： Ting Yan tianzhi yang Liqun Chen Shanghai Institute of Applied Mathematics and Mechanics Shanghai UniversityShanghai 200072China Department of Mechanics Shanghai UniversityShanghai 200444China Department of Mechanics Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Nonlinear Dynamics and Control Tianjin 300072China

In this study,the transverse vibration of a traveling beam made of functionally graded material was *** material gradation was assumed to vary continuously along the thickness direction of the beam in the form of power law *** effect of the longitudinally varying tension due to axial acceleration was highlighted,and the dependence of the tension on the finite support rigidity was also considered.A complex governing equation of the functionally graded beam was derived by the Hamilton principle,in which the geometric nonlinearity,material properties and axial load were *** direct multiscale method was applied to the analysis process of an axially moving functionally graded beam with timedependent velocity,and the natural frequency and solvability conditions were *** on the conditions,the stability boundaries of subharmonic resonance and combination resonance were *** was found that the dynamic behavior of axial moving beams could be tuned by using the distribution law of the functional gradient parameters.

关键词： Axial motion Functionally graded beam Direct multiscale method Support rigidity Stability boundary

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Natural dynamic characteristics of a circular cylindrical Timoshenko tube made of three-directional functionally graded material

引用

Applied Mathematics and Mechanics(English Edition) 2022年第4期43卷 479-496页

作者： Ye TANG Jiye XU tianzhi yang School of Mechanical Engineering Anhui Polytechnic UniversityWuhu 241000Anhui ProvinceChina Department of Mechanics Tianjin UniversityTianjin 300350China School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China

The natural dynamic characteristics of a circular cylindrical tube made of three-directional(3 D)functional graded material(FGM)based on the Timoshenko beam theory are ***’s principle is utilized to derive the novel motion equations of the tube,considering the interactions among the longitudinal,transverse,and rotation *** dint of the differential quadrature method(DQM),the governing equations are discretized to conduct the analysis of natural dynamic *** Ritz method,in conjunction with the finite element method(FEM),is introduced to verify the present *** is found that the asymmetric modes in the tube are controlled by the 3 D FGM,which exhibit more complicated shapes compared with the unidirectional(1 D)and bi-directional(2 D)FGM *** examples illustrate the effects of the axial,radial,and circumferential FGM indexes as well as the supported edges on the natural dynamic characteristics in *** is notable that the obtained results are beneficial for accurate design of smart structures composed from multi-directional FGM.

关键词： circular cylindrical tube three-directional(3D)functionally graded material(FGM) asymmetric mode natural dynamic characteristic differential quadrature method(DQM)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Merging phononic crystals and acoustic black holes

引用

Applied Mathematics and Mechanics(English Edition) 2020年第2期41卷 279-288页

作者： Xiaofei LYU Qian DING tianzhi yang Department of Mechanics Tianjin UniversityTianjin 300350China Tianjin Key Laboratory of Nonlinear Dynamics and Control Tianjin 300350China

Phononic crystals(PCs) have recently been developed as effective components for vibration suppression and sound absorption. As a typical design of PCs, wave attenuation occurs in the so-called stop-band. However, the structural response is still significantly large in the pass-band. In this paper, we combine PCs and acoustic black holes(ABHs) in a unique device, achieving a versatile device that can attenuate vibration in the stop-band, while suppress vibration in the pass-band. This approach provides a versatile platform for controlling vibration in a multiband with a simple design.

关键词： acoustic black hole(ABH) phononic crystal(PC) transfer matrix method(TMM)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DYNAMIC STABILITY OF A BEAM-MODEL VISCOELASTIC PIPE FOR CONVEYING PULSATIVE FLUID

引用

Acta Mechanica Solida Sinica 2007年第4期20卷 350-356页

作者： Xiaodong yang tianzhi yang Jiduo Jin Department of Engineering Mechnics Shenyang Institute of Aeronautical Engineering Shenyang 110136 China

The dynamic stability in transverse vibration of a viscoelastic pipe for conveying puisative fluid is investigated for the simply-supported case. The material property of the beammodel pipe is described by the Kelvin-type viscoelastic constitutive relation. The axial fluid speed is characterized as simple harmonic variation about a constant mean speed. The method of multiple scales is applied directly to the governing partial differential equation without discretization when the viscoelastic damping and the periodical excitation are considered small. The stability conditions are presented in the case of subharmonic and combination resonance. Numerical results show the effect of viscosity and mass ratio on instability regions.

关键词： parametric resonance fluid conveying pipes multiple scale method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cascaded quasi-zero stiffness nonlinear low-frequency vibration isolator inspired by human spine

引用

Applied Mathematics and Mechanics(English Edition) 2022年第6期43卷 813-824页

作者： Guoxin JIN Zhenghao WANG tianzhi yang Spine Department Shengjing Hospital of China Medical UniversityShenyang 110004China School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China

Human motion induced vibration has very low frequency,ranging from 2 Hz to 5 *** vibration isolators are not effective in low-frequency regions due to the trade-off between the low natural frequency and the high load *** this paper,inspired by the human spine,we propose a novel bionic human spine inspired quasi-zero stiffness(QZS)vibration isolator which consists of a cascaded multi-stage negative stiffness *** force and stiffness characteristics are investigated first,the dynamic model is established by Newton’s second law,and the isolation performance is analyzed by the harmonic balance method(HBM).Numerical results show that the bionic isolator can obtain better low-frequency isolation performance by increasing the number of negative structure stages,and reducing the damping values and external force values can obtain better low-frequency isolation *** comparison with the linear structure and existing traditional QZS isolator,the bionic spine isolator has better vibration isolation performance in low-frequency *** paves the way for the design of bionic ultra-low-frequency isolators and shows potential in many engineering applications.

关键词： bionic spine inspired vibration isolator harmonic balance method(HBM) quasi-zero stiffness(QZS) ultra-low frequency vibration isolation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fractional Dynamics of Fluid-Conveying Pipes Made of Polymer-Like Materials

引用

Acta Mechanica Solida Sinica 2018年第2期31卷 243-258页

作者： Ye Tang tianzhi yang Bo Fang School of Mechanical and Automotive Engineering Anhui Polytechnic University School of Aerospace Engineering Shenyang Aerospace University Department of Mechanics Tianjin University School of Astronautics Harbin Institute of Technology

The fluid-conveying pipes made of polymer-like materials are widely applied in engineering fields. However, the fractional dynamics of fluid-solid interaction remain unknown. In this work, the fractional dynamics of the pipes subjected to the excitation of supporting foun- dation are studied. A new nonlinear, fractional-order dynamic model is presented. The method of multiple scales is adopted directly to solve the model for the case of primary resonances. Numerical results are presented to show the effects of fractional order, foundation vibration, and other physical parameters on the steady-state response and stability.

关键词： Fluid-conveying pipes Fractional dynamics Method of multiple scales Polymer- like materials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In-plane dynamics of a fluid-conveying corrugated pipe supported at both ends

引用

Applied Mathematics and Mechanics(English Edition) 2019年第8期40卷 1119-1134页

作者： Yingjie WANG Qichang ZHANG Wei WANG tianzhi yang Tianjin Key Laboratory of Nonlinear Dynamics and Control Department of MechanicsSchool of Mechanical EngineeringTianjin University

The dynamics and stability of fluid-conveying corrugated pipes are investigated. The flow velocity is assumed to harmonically vary along the pipe rather than with time. The dimensionless equation is discretized with the differential quadrature method (DQM). Subsequently, the effects of the mean flow velocity and two key parameters of the corrugated pipe, i.e., the amplitude of the corrugations and the total number of the corrugations, are studied. The results show that the corrugated pipe will lose stability by flutter even if it has been supported at both ends. When the total number of the corrugations is sufficient, this flutter instability occurs at a micro flow velocity. These phenomena are verified via the Runge-Kutta method. The critical flow velocity of divergence is analyzed in detail. Compared with uniform pipes, the critical velocity will be reduced due to the corrugations, thus accelerating the divergence instability. Specifically, the critical flow velocity decreases if the amplitude of the corrugations increases. However, the critical flow velocity cannot be monotonously reduced with the increase in the total number of the corrugations. An extreme point appears, which can be used to realize the parameter optimization of corrugated pipes in practical applications.

关键词： fluid-structure interaction fluid-conveying corrugated pipe differential quadrature method (DQM) bifurcation flutter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：