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肝细胞癌及癌旁组织、远癌肝组织、背景肝组织的超高场强MRI扩散加权成像的对比研究

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中华肝脏病杂志 2024年第8期32卷 726-733页

作者：袁涛谭邦国欧静吴玉平陈天武成都市第五人民医院核医学科成都611130 川北医学院附属医院放射科南充637000 攀枝花市中心医院放射科攀枝花617000 重庆医科大学附属第二医院放射科重庆400010

目的探讨肝细胞癌(HCC)及癌旁组织、远癌肝组织、背景肝组织在超高场强*** MRI扩散加权成像(DWI)多b值表观扩散系数(ADC)及指数化表观扩散系数(eADC)的差异性。方法收集2018年1月-2021年10月经手术病理证实的连续性HCC患者68例,根据有... 详细信息

目的探讨肝细胞癌(HCC)及癌旁组织、远癌肝组织、背景肝组织在超高场强*** MRI扩散加权成像(DWI)多b值表观扩散系数(ADC)及指数化表观扩散系数(eADC)的差异性。方法收集2018年1月-2021年10月经手术病理证实的连续性HCC患者68例,根据有无肝硬化分为肝硬化组(n=39)、非肝硬化组(n=29),并分别在扩散敏感因子(b)取50、100、400、600、1000s/mm^(2)的DWI图像测量癌组织、癌旁组织(包括近侧癌旁组织、远侧癌旁组织)、远癌肝组织、背景肝组织的平均ADC及eADC。采用Kruskal-Wallis H检验及Bonferroni法检验5种组织测量值的差异性,并根据差异有统计学意义的参数行受试者操作特征(ROC)曲线评价其鉴别5种组织的诊断效能。结果5种组织平均ADC及eADC比较显示,肝硬化组、癌组织与近侧癌旁组织、远侧癌旁组织、远癌肝组织、背景肝组织在b值分别为50、100、400、600s/mm^(2)测量的平均ADC、eADC,以及癌组织与近侧癌旁组织在b=1000s/mm^(2)测量的平均ADC,差异有统计学意义(调整后P值均0.005)。而在非肝硬化组,近侧癌旁组织分别与远癌肝组织、背景肝组织b=50s/mm^(2)的平均ADC,以及近侧癌旁组织与远癌肝组织b=100s/mm^(2)的平均ADC及eADC差异均有统计学意义(调整后P值均0.005)。平均ADC及eADC区分5种组织(癌组织与近侧癌旁组织、远侧癌旁组织、远癌肝组织、背景肝组织)的效能显示,在肝硬化组,b=50s/mm^(2)时诊断效能最佳,平均ADC的ROC曲线下面积(AUC)分别为0.815、0.828、0.855、0.855,平均eADC的AUC分别为0.815、0.830、0.856、0.855;在非肝硬化组,在b=100s/mm^(2)时诊断效能最佳,平均ADC的AUC分别为0.787、0.823、0.841、0.821,平均eADC的AUC分别为0.836、0.874、0.893、0.873。在非肝硬化组,b=50s/mm^(2)区分近侧癌旁组织与远癌肝组织,以及近侧癌旁组织与背景肝组织的平均ADC的AUC分别为0.605、0.604;b=100s/mm^(2)区分近侧癌旁组织与远癌肝组织的平均ADC的AUC为0.619,平均eADC的AUC为0.620。结论在肝硬化和非肝硬化患者,多b值测量的平均ADC及eADC有助于区分HCC与近侧癌旁组织、远侧癌旁组织、远癌肝组织、背景肝组织。在非肝硬化患者,b=50s/mm^(2)的平均ADC、100s/mm^(2)的平均ADC与eADC在近侧癌旁组织与远癌肝组织、背景肝组织间存在差异性。

关键词：肝细胞癌磁共振成像扩散加权成像诊断

基于瘤周肝组织DWI列线图模型预测肝切除术后复发性肝细胞癌局部进展研究

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磁共振成像 2024年第2期15卷 63-70页

作者：王晶曾朝强汤梦月许敏张小明陈天武川北医学院附属医院放射科医学影像四川省重点实验室南充637000 川北医学院第二临床医学院·南充市中心医院影像科南充637000 重庆医科大学附属第二医院放射科重庆400010

目的探讨构建基于肝切除术后复发性肝细胞癌(recurrent hepatocellular carcinoma,rHCC)瘤周区域表观扩散系数(apparent diffusion coefficient,ADC)列线图模型预测局部进展的可行性。材料与方法采用回顾性队列研究方法,收集川北医学院... 详细信息

目的探讨构建基于肝切除术后复发性肝细胞癌(recurrent hepatocellular carcinoma,rHCC)瘤周区域表观扩散系数(apparent diffusion coefficient,ADC)列线图模型预测局部进展的可行性。材料与方法采用回顾性队列研究方法,收集川北医学院附属医院2021年1月至2022年12月诊断为肝切除术后rHCC患者的MRI资料及临床特征。基于Firevoxel软件测量rHCC瘤周肝组织ADC平均值(peritumor ADCmean,pADCmean)、最小值(peritumor ADCmin,pADCmin)、最大值(peritumor ADCmax,pADCmax)和肿瘤ADC平均值(tumor ADCmean,tADCmean)、最小值(tumor ADCmin,tADCmin)、最大值(tumor ADCmax,tADCmax),以及背景肝组织ADC平均值(background liver tissue ADCmean,bADCmean)、最小值(background liver tissue ADCmin,bADCmin)、最大值(background liver tissue ADCmax,bADCmax)。计算瘤周与背景肝组织ADCmean比值(ratio of pADCmeanto bADCmean,RPB-ADCmean)、ADCmin比值(ratio of pADCminto bADCmin,RPB-ADCmin)、ADCmax比值(ratio of pADCmaxto bADCmax,RPB-ADCmax),以及肿瘤与背景肝组织ADCmean比值(ratio of tADCmeanto bADCmean,RTB-ADCmean)、ADCmin比值(ratio of tADCminto bADCmin,RTB-ADCmin)、ADCmax比值(ratio of tADCmaxto bADCmax,RTB-ADCmax)。采用Cox回归分析筛选独立危险因素,并构建列线图预测模型,绘制受试者工作特征(receiver operating characteristic,ROC)曲线和决策曲线分析(decision curve analysis,DCA),评价模型预测rHCC局部进展的价值。结果本研究共纳入70例肝切除术后rHCC患者,随访证实肿瘤局部进展率为65.7%(46/70)。多因素Cox回归分析显示,pADCmin、RPB-ADCmean和异常凝血酶原是肝切除术后rHCC局部进展的独立危险因素(P均<0.05)。列线图模型预测肝切除术后rHCC在3个月内、6个月内局部进展的ROC曲线下面积分别为0.834、0.841,DCA显示模型有较好临床净收益。结论pADCmin、RPB-ADCmean和异常凝血酶原是预测肝切除术后rHCC局部进展的独立危险因素,构建的列线图模型可直观地预测rHCC局部进展,且具有较好的效能和临床价值。

关键词：肝细胞癌复发瘤周肝组织磁共振成像扩散加权成像列线图

膝关节前外侧旋转不稳定的诊断与治疗研究进展

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中华创伤骨科杂志 2024年第3期26卷 272-276页

作者：周毅强吴子英万方李宏陈天午戈允申厦门市中医院骨科厦门361009 复旦大学附属华山医院运动医学科上海200040

前交叉韧带、前外侧复合体和外侧半月板共同维持膝关节的前外侧旋转稳定性,控制胫骨内旋。临床上膝关节前外侧旋转不稳定并不少见,其主要损伤机制是非接触性损伤。轴移试验、胫骨内旋试验可提示前外侧旋转不稳定。X线片、CT、磁共振成... 详细信息

前交叉韧带、前外侧复合体和外侧半月板共同维持膝关节的前外侧旋转稳定性,控制胫骨内旋。临床上膝关节前外侧旋转不稳定并不少见,其主要损伤机制是非接触性损伤。轴移试验、胫骨内旋试验可提示前外侧旋转不稳定。X线片、CT、磁共振成像及超声检查可辅助诊断及鉴别诊断。对于急性前外侧旋转不稳定,良好的前交叉韧带重建技术是避免术后残留前外侧旋转不稳定的基础,前外侧韧带重建及关节外腱固定术可酌情选择;而对于慢性前外侧旋转不稳定,采用前外侧韧带重建或关节外腱固定术治疗均有效。本文对膝关节前外侧旋转不稳定的诊断与治疗研究进展进行综述,以期为临床诊治提供参考。

关键词：膝关节关节不稳定性诊断技术和方法治疗

Dopamine multivalent-modified polyaspartic acid for MRI-guided near-infrared photothermal therapy

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Regenerative Biomaterials 2023年第1期10卷 678-689页

作者： Liang Du Wei chen Jie Zhong Shuang Yan chenwu Yang Yu Pu Jiang Zhu tianwu chen Xiaoming Zhang Changqiang Wu Medical Imaging Key Laboratory of Sichuan Province and School of Medical Imaging Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000PR China

Nanophotothermal agents that provide efficient and precise treatment at tumor sites are attracting increasing attention in *** particular,the method combination of nanophotothermal agents and magnetic resonance imaging(MRI)shows great promise for biomedical therapeutic ***,a simple nanophotothermal agent with dopamine multivalent-modified polyaspartic acid chelated superparamagnetic iron oxide(SPIO)and ferric ion(SPIO@PAsp-DAFe/PEG)was developed for MRI-guided near-infrared photothermal therapy(PTT).SPIO@PAsp-DAFe/PEG was random SPIO nanocluster with good water solubility,had a diameter of 57.8±7.8 nm in dynamic light scattering,negatively charged surface(zeta potential=−11 mV),exhibited good stability and outstanding photothermal conversion efficiency(35.4%)and produced superior magnetic resonance enhanced *** the experiment with tumor-bearing mice,the MRI not only monitored the accumulation of SPIO@PAsp-DAFe/PEG nanocomposites enhanced by near-infrared irradiation after intravenous administration but also determined the appropriate time window for *** the use of MRI-guided near-infrared therapy,the SPIO@PAsp-DAFe/PEG nanocomposites provided excellent therapeutic effects,confirming their great potential as effective MRI/PTT therapeutic agents.

关键词： dopamine superparamagnetic iron oxide nanocomposites magnetic resonance imaging photothermal therapy

Gadolinium-hyaluronic acid nanoparticles as an efficient and safe magnetic resonance imaging contrast agent for articular cartilage injury detection

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Bioactive Materials 2020年第4期5卷 758-767页

作者： Rong Lu Yuyang Zhang Hongyue Tao Lu Zhou Huidi Li tianwu chen Peng Zhang Yao Lu Shuang chen Department of Radiology Huashan HospitalFudan UniversityShanghai200040China Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai201203China Department of Sports Medicine Huashan HospitalFudan UniversityShanghai200040China Guangdong Key Lab of Orthopedic Technology and Implant Materials Key Laboratory of Trauma&Tissue Repair of Tropical Area of PLAGuangzhouGuangdong510010China Orthopedic Centre Clinical Research CentreZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong510280China

Accurate detection of cartilage injuries is critical for their proper treatment because these injuries lack the selfhealing ability and lead to joint ***,the low longitudinal T1 relaxivity(r1)and non-specificity of contrast agents(such as gadolinium(III)-diethylenetriamine-pentaacetic acid(Gd-DTPA))significantly limit the efficiency of clinical magnetic resonance imaging(MRI)*** overcome these drawbacks,we integrated hyaluronic acid(HA)with Gd to synthesize a Gd-DTPA-HA composite,which was subsequently freeze-dried to produce nanoparticles(NPs).The resultant Gd-HA NPs demonstrated a greater r1 value(12.51 mM^-1 s^-1)compared with the bulk Gd-DTPA-HA(8.37 mM^-1 s^-1)and clinically used Gd-DTPA(3.88 mM^-1 s^-1).Moreover,the high affinity of HA to the cartilage allowed these NPs to penetrate deeper beyond the cartilage *** a result,Gd-HA NPs considerably increased the quality of cartilage and lesion MR images via their intra-articular injection in ***,2 h after NP administration,the signal-to-noise ratio at the injured cartilage site was 2.3 times greater than the value measured before the *** addition,Gd-HA NPs exhibited good biosafety properties due to the absence of adverse effects in the blood or on the main *** was also showed that Gd NPs were first metabolized by the kidney and liver and then excreted from the body with ***,Gd-HA NPs can potentially serve as an efficient MRI contrast agent for improved detection of cartilage injuries.

关键词： Hyaluronic acid Gadolinium Nanoparticles Magnetic resonance imaging contrast agents Cartilage injury

Stratified-structural hydrogel incorporated with magnesium-ion-modified black phosphorus nanosheets for promoting neuro-vascularized bone regeneration

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Bioactive Materials 2022年第10期7卷 271-284页

作者： Yan Xu Chao Xu Lei He Junjie Zhou tianwu chen Liu Ouyang Xiaodong Guo Yanzhen Qu Zhiqiang Luo Deyu Duan Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430074China College of Life Science and Technology Huazhong University of Science and TechnologyChina Wuhan430022China Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Fudan University Sports Medicine Institute Shanghai200040China

Angiogenesis and neurogenesis play irreplaceable roles in bone *** biomaterial implantation that mimics native skeletal tissue is extensively studied,the nerve-vascular network reconstruction is neglected in the design of *** goal here is to establish a periosteum-simulating bilayer hydrogel and explore the efficiency of bone repair via enhancement of angiogenesis and *** this contribution,we designed a bilayer hydrogel platform incorporated with magnesium-ion-modified black phosphorus(BP)nanosheets for promoting neuro-vascularized bone ***,we incorporated magnesium-ion-modified black phosphorus(BP@Mg)nanosheets into gelatin methacryloyl(GelMA)hydrogel to prepare the upper hydrogel,whereas the bottom hydrogel was designed as a double-network hydrogel system,consisting of two interpenetrating polymer networks composed of GelMA,PEGDA,andβ-TCP *** magnesium ion modification process was developed to enhance BP nanosheet stability and provide a sustained release platform for bioactive *** results demonstrated that the upper layer of hydrogel provided a bionic periosteal structure,which significantly facilitated angiogenesis via induction of endothelial cell migration and presented multiple advantages for the upregulation of nerve-related protein expression in neural stem cells(NSCs).Moreover,the bottom layer of the hydrogel significantly promoted bone marrow mesenchymal stem cells(BMSCs)activity and osteogenic *** next employed the bilayer hydrogel structure to correct rat skull *** on our radiological and histological examinations,the bilayer hydrogel scaffolds markedly enhanced early vascularization and neurogenesis,which prompted eventual bone regeneration and *** current strategy paves way for designing nerve-vascular network biomaterials for bone regeneration.

关键词： Angiogenesis Neurogenesis Bone regeneration Hydrogel Black phosphorus

In situ Observation of Li Deposition-Induced Cracking in Garnet Solid Electrolytes

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Energy & Environmental Materials 2022年第2期5卷 524-532页

作者： Jun Zhao Yongfu Tang Qiushi Dai Congcong Du Yin Zhang Dingchuan Xue tianwu chen Jingzhao chen Bo Wang Jingming Yao Ning Zhao Yanshuai Li Shuman Xia Xiangxin Guo Stephen J.Harris Liqiang Zhang Sulin Zhang Ting Zhu Jianyu Huang Clean Nano Energy Center State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlanta Georgia 30332USA Department of Engineering Science and Mechanics The Pennsylvania State UniversityUniversity Park PA 16802USA Energy Storage Division Lawrence BerkeleyNational LaboratoryBerkeley CA 94720USA College of Physics Qingdao UniversityQingdao 266071China Hebei Key Laboratory of Applied Chemistry School of Environmental and Chemical EngineeringYanshan UniversityQinhuangdao 066004China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China

Lithium(Li)penetration through solid electrolytes(SEs)induces short circuits in Li solid-state batteries(SSBs),which is a critical issue that hinders the development of high energy density *** cracking in ceramic SEs has been often shown to accompany Li penetration,the interplay between Li deposition and cracking remains ***,we constructed a mesoscale SSB inside a focused ion beam-scanning electron microscope(FIB-SEM)for in situ observation of Li deposition-induced cracking in SEs at nanometer *** results revealed that Li propagated predominantly along transgranular cracks in a garnet Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO).Cracks appeared to initiate from the interior of LLZTO beneath the electrode surface and then propagated by curving toward the LLZTO *** resulting bowl-shaped cracks resemble those from hydraulic fracture caused by high fluid pressure on the surface of internal cracks,suggesting that the Li deposition-induced pressure is the major driving force of crack initiation and *** high pressure generated by Li deposition is further supported by in situ observation of the flow of filled Li between the crack flanks,causing crack widening and *** work unveils the dynamic interplay between Li deposition and cracking in SEs and provides insight into the mitigation of Li dendrite penetration in SSBs.

关键词： cracking garnet solid electrolyte in situ observation Li deposition

人工韧带用于前交叉韧带修复重建：目前产品与经验

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中国修复重建外科杂志 2020年第1期34卷 1-9页

作者：陈天午陈世益复旦大学运动医学研究所上海200040 复旦大学附属华山医院运动医学科上海200040

人工韧带产品自20世纪70年代开始用于临床重建前交叉韧带(anterior cruciate ligament,ACL),经历了较为坎坷的发展历程。早期人工韧带产品重建ACL疗效欠佳,大多以失败告终。近20年来随着新人工韧带产品的出现,临床应用其重建ACL逐渐增多... 详细信息

人工韧带产品自20世纪70年代开始用于临床重建前交叉韧带(anterior cruciate ligament,ACL),经历了较为坎坷的发展历程。早期人工韧带产品重建ACL疗效欠佳,大多以失败告终。近20年来随着新人工韧带产品的出现,临床应用其重建ACL逐渐增多,常用人工韧带包括Leeds-Keio TM、LARSTM(Ligament Advanced Reinforcement System)、Trevira HochfestTM,其中LARSTM应用较多。上述人工韧带具有优越的力学性能,累积失败和并发症发生率较早期产品有显著改善,但也有各自不足之处。

关键词：人工韧带前交叉韧带重建

Stretchable,Transparent,and Ultra-Broadband Terahertz Shielding Thin Films Based on Wrinkled MXene Architectures

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Nano-Micro Letters 2024年第9期16卷 110-122页

作者： Shaodian Yang Zhiqiang Lin Ximiao Wang Junhua Huang Rongliang Yang Zibo chen Yi Jia Zhiping Zeng Zhaolong Cao Hongjia Zhu Yougen Hu Enen Li Huanjun chen tianwu Wang Shaozhi Deng Xuchun Gui State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China National Key Laboratory of Materials for Integrated Circuits Shenzhen Institute of Advanced Electronic MaterialsShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Guangdong Province Key Laboratory of Display Material and Technology Guangzhou 510275People’s Republic of China China Academy of Aerospace Science and Innovation Beijing 100176People’s Republic of China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China GBA Branch of Aerospace Information Research Institute Chinese Academy of SciencesGuangzhou 510700People’s Republic of China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049People’s Republic of China Guangdong Provincial Key Laboratory of Terahertz Quantum Electromagnetics Guangzhou 510700People’s Republic of China

With the increasing demand for terahertz(THz)technology in security inspection,medical imaging,and flexible electronics,there is a significant need for stretchable and transparent THz electromagnetic interference(EMI)shielding *** EMI shielding materials,like opaque metals and carbon-based films,face challenges in achieving both high transparency and high shielding efficiency(SE).Here,a wrinkled structure strategy was proposed to construct ultra-thin,stretchable,and transparent terahertz shielding MXene films,which possesses both isotropous wrinkles(height about 50 nm)and periodic wrinkles(height about 500 nm).Compared to flat film,the wrinkled MXene film(8 nm)demonstrates a remarkable 36.5%increase in SE within the THz *** wrinkled MXene film exhibits an EMI SE of 21.1 dB at the thickness of 100 nm,and an average EMI SE/t of 700 dBμm^(−1)over the 0.1-10 *** calculations suggest that the wrinkled structure enhances the film’s conductivity and surface plasmon resonances,resulting in an improved THz wave ***,the wrinkled structure enhances the MXene films’stretchability and *** bending and stretching(at 30%strain)cycles,the average THz transmittance of the wrinkled film is only 0.5%and 2.4%,*** outstanding performances of the wrinkled MXene film make it a promising THz electromagnetic shielding materials for future smart windows and wearable electronics.

关键词： Terahertz Wrinkle structure Electromagnetic interference shielding MXene