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碱性成纤维细胞生长因子反义寡核苷酸抑制胶质瘤细胞增殖的体外试验

2011中华医学会神经外科学学术会议

作者： Lin Sun1 Bin Wang1 Tong Liu1 Jianning Zhang1 Rongcai Jiang1 1.Department of Neurosurgery, tianjin Medical University General Hospital tianjin neurological institute

Background Endothelial progenitor cells (EPCs), as a biomarker of angiogenesis, were shown to have angiogenic potential contributing to neovascularization in brain injury. This study aimed at revealing the relationshi... 详细信息

关键词： Traumatic brain injury Diffuse axonal injury Traumatic intracerebral hemorrhage Endothelial progenitor cells

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中华实验外科杂志 1998年第6期15卷 571-572页

作者：王金环浦佩玉王春艳王广秀天津医科大学神经病研究所脑肿瘤室 300052

目的探讨碱性成纤维细胞生长因子(bFGF)反义寡核苷酸抑制胶质瘤细胞生长的作用。方法以脂质体介导将硫代磷酸修饰的bFGF反义寡核苷酸转染人脑胶质瘤细胞系TJ905,采用原位杂交和MTT对bFGF mRNA表达水平及细胞存活率进行检测。结果经bFGF... 详细信息

目的探讨碱性成纤维细胞生长因子(bFGF)反义寡核苷酸抑制胶质瘤细胞生长的作用。方法以脂质体介导将硫代磷酸修饰的bFGF反义寡核苷酸转染人脑胶质瘤细胞系TJ905,采用原位杂交和MTT对bFGF mRNA表达水平及细胞存活率进行检测。结果经bFGF反义寡核苷酸转染,TJ905细胞bFGF mRNA表达水平显著降低,细胞存活率明显下降。结论 bFGF反义寡核苷酸可抑制胶质瘤细胞增殖。可进一步研究将bFGF基因作为反义治疗的目的基因。

关键词：胶质瘤细胞增殖反义寡核苷酸 bFGF

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Notch信号通路异常和肿瘤的生成

透析与人工器官 2008年第2期19卷 32-36页

作者：裘明哲浦佩玉天津医科大学总医院神经外科天津市神经病学研究所神经肿瘤实验室天津300052

近年研究表明,Notch信号通路与肿瘤发生有关,但Notch对肿瘤的发生、发展可以起着截然相反的作用。在某些组织中Notch单个或多个成员具有显性癌基因作用,而在另一些组织量则发挥着抑癌基因的功能。本文就Notch在肿瘤研究中的研究进展作... 详细信息

近年研究表明,Notch信号通路与肿瘤发生有关,但Notch对肿瘤的发生、发展可以起着截然相反的作用。在某些组织中Notch单个或多个成员具有显性癌基因作用,而在另一些组织量则发挥着抑癌基因的功能。本文就Notch在肿瘤研究中的研究进展作以综述。

关键词：信号通路肿瘤

Dynamic Changes and Significance of Circulating EPCs、VWF and TM in Patients with Traumatic Brain Injury

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Dynamic Changes and Significance of Circulating EPCs、VWF an...

The Method of Single Peak Fourier Analysis of Measuring the Size of Mosaic Block and Microstrain by X-ray Diffraction

2011中华医学会神经外科学学术会议

作者： Liang Wang1 ,2 Dong Wang2 ,3 Rongcai Jiang2 ,3 Jing-fei Dong4 Jiang-ning Zhang2 ,3 1.Department of Neurosurgery,tianjin 5 th center hospital 2.tianjin neurological institute 3.Department of Neurosurgery, tianjin Medical University 4.Department of Medicine, Baylor College of Medicine, Houston, TX7 7 03 0, USA

Background Traumatic brain injury(TBI)has high mortality and morbidity rates, but is short of a reliable marker to predict its prognosis. Both von Willebrand factor (VWF) and thrombomodulin (TM) are markers for endoth... 详细信息

关键词： Traumatic brain injury von Willebrand factor Thrombomodulin Endothelial progenitor cells

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Journal of Materials Science & Technology 2000年第1期16卷 67-70页

作者： Ming CHANG (tianjin institute of Technology, tianjin 300191, China) tianjin institute of Technology Tianjin 300191 China

The values of mosaic block size and microstrain measured by the method of Voigt function are sometimes largely erroneous and difficult to be revised. In this paper, the causes of the 'hook effect' which inevitably exists in the method of Fourier analysis are explained; then the method for resolving this effect is put forward; and finally the method of hypothetical function is used to simplify the method of the Fourier analysis from multi-peak to single-peak. By introducing the parameter m, this method can not only indicate the degree of errors, but also revise them as well, it is simple, clear and able to accomplish the intricate pattern calculation quickly by the aid of computer. In the end, we argue the identity between method of the approximate function and the Fourier analysis, and give a more accurate proportional coefficient k.

关键词： Measurement theory

γ-PHASE IN WC-Co CEMENTED CARBIDES

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中国有色金属学会会刊：英文版 1993年第2期3卷 51-57页

作者： Liu,Shourong tianjin institute of Hard Alloy,tianjin 300222,China

The allotropic transformation process of the γ-phase in WC-Co cemented carbides has been *** of γ-grain and the γ-domain have been proposed forward:The γ-domain is the residual FCC-typeβ-Co grain that failed to transform when cooling alloy sample and γ-base is the HCP-type x-Co transformedmainly by means of diffusion,the outline of the γ-grain is consistent with the newly fromed β-Co grain formedat high *** quantity and distribution of γ-grain domain are related to the cooling rate after sinter-ing and influence the alloys properties.

关键词： WC-Co cemented carbides γ-grain γ-domain

Experimental Research on the Erosion Pattern and Protection Using the Extended Modelling Method

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China Ocean Engineering 1997年第4期12卷 441-448页

作者： Liu Shunkuan Senior Engineer, tianjin Port Engineering institute, tianjin 300222 tianjin Port Engineering institute Tianjin 300222 China

In the paper the extended modelling method with serial sands is used in an experimental research on the erosion patterns at the discharge outlet of a beach Hua-Neng power plant. The theoretical basis for the extended modelling method with serial sands is systematically presented in the paper and the method has been successfully employed in the sediment experiment of coastal works. According to the Froude Law, the model is designed to be a normal one with movable bed, the geometric scale lambda(L) = lambda(H) = 15, and three scales of sediment grain size are chosen, i.e., lambda(d1) = 0.207; lambda(d2) = 0.393; and lambda(d3) = 0.656. The median particle diameter of sea beach prototype sand d(50p) = 0.059 mm and the dis-changed water flow of the power plant is 21.7 m(3) / s. Three types of natural sea sands have been chosen as the serial modelling sands to extend the simulation of the prototype, thus replacing the conventional test in which artificial lightweight sands are used. As a result, this method can not only reduce the cost significantly, but also it is an advanced technique easy to use. Upon a series of tests, satisfactory results have been obtained.

关键词： extended modelling method discharge outlet erosion pattern beach protection

Consensus of Chinese experts on glioma multidisciplinary team management(2nd edition)

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Chinese Medical Journal 2024年第11期137卷 1267-1270页

作者： Jinsong Wu Zhirui Zhou Zanyi Wu Zhiwei Tang Ming Li Siyuan Yin Xufei Luo Ling Wang Yaolong Chen Guoguang Zhao Tao Jiang Ying Mao The National Glioma MDT Alliance of National Center for neurological Diseases Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Department of Radiation Oncology Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Neurosurgery Department The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Neurosurgery Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan 463599China State Key Laboratory of Pharmaceutical Biotechnology Institute for Brain SciencesAdvanced Institute for Life SciencesSchool of Life SciencesNanjing UniversityNanjingJiangsu 210023China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouGansu 730000China School of Public Health Lanzhou UniversityLanzhouGansu 730000China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China 不详

To increase the consistency of glioma multidisciplinary team(MDT)management across different regions and hospitals at varying levels,we have updated the Expert Consensus on MDT of Glioma in China based on the currently available *** version has revised and updated the process-management rules and quality-control standards for a glioma MDT,providing reference and guidance for relevant clinical disciplines and *** members of the Consensus Expert Group,abstract,background,and prospects can be seen in supplementaryle,http://***/CM9/B999.

关键词： glioma MDT Expert

β→α Transformation of γ-Phase in Sintered WC-Co Cemented Carbides

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Journal of Materials Science & Technology 1996年第5期12卷 398-400页

作者： Shourong LIU (tianjin institute of Hard Alloy tianjin 300222, China)Yi LIU (Shandong University Jinan 250100, China) tianjin institute of Hard Alloy Tianjin 300222 China Shandong University Jinan 250100 China

Varying the morphology and the structure of γ-phase (Co-base Co-W-C solid solution) by means of altering the cooling rate and the preparing method of liquid sintered WC-Co cemented carbides samples, the mechanism of fcc→hcp transformation of γ-phase in WC-Co alloy has been explored. The results show that, the cooling rate is an important affecting factor on fcc→hcp transformation of γ-phase and the fcc→hcp transformation is mainly a diffusive type when cooling WC-Co samples above room temperature

关键词： WC Co Phase in Sintered WC-Co Cemented Carbides Transformation of