检索结果-南通市图书馆

中国中医药图书情报杂志 2024年第3期48卷 174-177页

作者：张天慧李荣慧龙凤娇刘婷雷晓明张国民湖南中医药大学中西医结合学院湖南长沙410208

本文介绍张崇泉教授从肾论治老年常见皮肤病,以带状疱疹、湿疹、银屑病为例,阐述张教授诊疗思路及用药经验,附验案一则,以期为临床应用补肾法治疗常见皮肤病提供新思路。

关键词：张崇泉从肾论治皮肤病名医经验

A superconducting wireless energiser based on electromechanical energy conversion

在线全文

学校读者我要写书评

暂无评论

Superconductivity 2023年第3期7卷 53-64页

作者： Hongye zhang tianhui Yang Francesco Grilli Wenxin Li Paul M.Tuohy Ying Xin Department of Electrical and Electronic Engineering The University of ManchesterManchester M139PLUnited Kingdom School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China Institute for Technical Physics Karlsruhe Institute of TechnologyKarlsruhe 76131Germany

A superconducting magnet(SM)can produce high magnetic fields up to a dozen times stronger than those generated by an electromagnet made of normal conductors or a permanent magnet(PM),and thus has attracted increasing research efforts in many domains including medical devices,large scientific equipment,transport,energy storage,power systems,and electric machines.Wireless energisers,e.g.,high temperature superconducting(HTS)flux pumps,can eliminate the thermal load from current leads and arc erosion of slip rings,and are thus considered a promising energisation tool for SMs.However,the time‐averaged DC output voltage in existing HTS flux pumps is generated by dynamic resistance:the dynamic loss is unavoidable,and the total AC loss will become significant at high frequencies.This study introduces a highly efficient superconducting wireless energizer(SWE)designed specifically for SMs.The SWE takes advantage of the inherent properties of a superconducting loop,including flux conservation and zero DC resistivity.Extensive theoretical analysis,numerical modelling exploiting the H‐ϕformulation,and experimental measurements were conducted to demonstrate the efficiency and efficacy of the novel SWE design.The electromechanical performance and loss characteristics of the SWE system have also been investigated.Compared to conventional HTS flux pumps,the proposed SWE has lower excitation loss,in the order of 10−1 mW,and thus can achieve a high system efficiency of no less than 95%.Furthermore,it has a simpler structure with higher reliability,considered ready for further industrial development.In addition to deepening the understating of the intricate electromechanical dynamics between magnetic dipoles and superconducting circuits,this article provides a novel wireless energisation technique for SMs and opens the way to step changes in future electric transport and energy sectors.

关键词： Wireless energisation Superconducting magnet High temperature superconductor Electromechanical energy conversion Electric transport

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

乳癌与微生物菌群失调相关性研究进展

青岛大学学报（医学版） 2024年第1期60卷 155-158页

作者：王炳东王慧哲孙雷苏天慧张正福邹晓青岛大学附属青岛市中心医院乳腺外科山东青岛266042

乳癌作为全球最常见的癌症,严重威胁着女性的健康。微生物菌群失调与抑郁症、肥胖症、糖尿病、癌症等疾病密切相关。人体微生物菌群失调与恶性肿瘤的关系已成为临床研究的热点。越来越多的研究表明,肠道和乳腺组织微生物菌群失调与乳癌... 详细信息

乳癌作为全球最常见的癌症,严重威胁着女性的健康。微生物菌群失调与抑郁症、肥胖症、糖尿病、癌症等疾病密切相关。人体微生物菌群失调与恶性肿瘤的关系已成为临床研究的热点。越来越多的研究表明,肠道和乳腺组织微生物菌群失调与乳癌发生和发展相关。本文对微生物菌群失调与乳癌发生和发展相关性研究进展进行综述,以期为乳癌的防治提供理论支持。

关键词：乳腺肿瘤微生物群生态失调综述

Six-dimensional potential energy surface of the dissociative chemisorption of HCl on Au(111) using neural networks

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2014年第1期57卷 147-155页

作者： LIU tianhui FU BiNa zhang Dong H State Key Laboratory of Molecular Reaction Dynamics and Center for Theoretical Computational Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences

We constructed a six-dimensional potential energy surface(PES)for the dissociative chemisorption of HCl on Au(111)using the neural networks method based on roughly 70000 energies obtained from extensive density functional theory(DFT)calculations.The resulting PES is accurate and smooth,based on the small fitting errors and good agreement between the fitted PES and the direct DFT calculations.Time-dependent wave packet calculations show that the potential energy surface is very well converged with respect to the number of DFT data points,as well as to the fitting process.The dissociation probabilities of HCl initially in the ground rovibrational state from six-dimensional quantum dynamical calculations are quite diferent from the four-dimensional fixed-site calculations,indicating it is essential to perform full-dimensional quantum dynamical studies for the title molecule-surface interaction system.

关键词： potential energy surface,DFT calculations,neural networks,wave packet,six-dimensional

Efficacy and safety of ixekizumab in Chinese patients with plaque psoriasis

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2023年第3期136卷 360-361页

作者： He Huang Min Chen Wenjuan Wu tianhui Yang Hao Liu Zhengwei Zhu Wenjun Wang Sen Yang Xian Ding Hui Wang Yujun Sheng Yaohua zhang Min Li Xuejun zhang Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230031China Ferry Institute of Dermatology HefeiAnhui 230000China Boao Super Hospital Dermatology Center QionghaiHainan 571437China Department of Dermatology Dushu Lake Hospital Affiliated to Soochow University(Medical Center of Soochow UniversitySuzhou Dushu Lake Hospital)SuzhouJiangsu 215125China Department of Dermatology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006China Department of Dermatology Institute of DermatologyHuashan HospitalFudan UniversityShanghai 200040China

To the Editor:Psoriasis is a common,chronic papulosquamous skin disease occurring worldwide,presenting at any age,and leading to a substantial burden for individuals and society.Interleukin(IL)-17A is considered the key effector cytokine inducing psoriatic inflammation and tissue damage.[1]Ixekizumab is a humanized monoclonal immunoglobulin G specifically binding to and inhibiting IL-17A.The efficacy and safety of ixekizumab in patients with psoriasis have been clearly demonstrated in several randomized clinical trials,namely UNCOVER-1,UNCOVER-2,UNCOVER-3,and UNCOVER-J.[2,3]However,the clinical research data on ixekizumab in Chinese psoriasis patients remain limited.

关键词： patients psoriasis clinical

Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第3期12卷 1213-1224页

作者： Meiyue Song Jiaxin Wang Youliang Sun Junling Pang Xiaona Li Yuan Liu Yitian Zhou Peiran Yang tianhui Fan Ying Liu Zhaoguo Li Xianmei Qi Baicun Li Xinri zhang Jing Wang Chen Wang State Key Laboratory of Medical Molecular Biology Department of PhysiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100730China Tsinghua-Peking Center for Life Sciences Department of BiologyCollege of MedicineTsinghua UniversityBeijing 100084China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China National Clinical Research Center for Respiratory Diseases Beijing 100029China Peking Union Medical College Chinese Academy of Medical SciencesBeijing 100730China Peking Union Medical College MD ProgramBeijing 100730China Department of Respiratory the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Pulmonary and Critical Care Medicine the First Hospital of Shanxi Medical UniversityTaiyuan 030001China

Silicosis is a leading cause of occupational disease-related morbidity and mortality worldwide,but the molecular basis underlying its development remains unclear.An accumulating body of evidence supports gasdermin D(GSDMD)-mediated pyroptosis as a key component in the development of various pulmonary diseases.However,there is little experimental evidence connecting silicosis and GSDMD-driven pyroptosis.In this work,we investigated the role of GSDMD-mediated pyroptosis in silicosis.Single-cell RNA sequencing of healthy and silicosis human and murine lung tissues indicated that GSDMD-induced pyroptosis in macrophages was relevant to silicosis progression.Through microscopy we then observed morphological alterations of pyroptosis in macrophages treated with silica.Measurement of interleukin-1βrelease,lactic dehydrogenase activity,and real-time propidium iodide staining further revealed that silica induced pyroptosis of macrophages.Additionally,we verified that both canonical(caspase-1-mediated)and non-canonical(caspase-4/5/11-mediated)signaling pathways mediated silica-induced pyroptosis activation,in vivo and in vitro.Notably,Gsdmd knockout mice exhibited dramatically alleviated silicosis phenotypes,which highlighted the pivotal role of pyroptosis in this disease.Taken together,our results demonstrated that macrophages underwent GSDMD-dependent pyroptosis in silicosis and inhibition of this process could serve as a viable clinical strategy for mitigating silicosis.

关键词： Silicosis Gasdermin D Pyroptosis Macrophage Pulmonary fibrosis

Impact of Household Endowments on Response Capacity of Farming Households to Natural Disasters

在线全文

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2012年第4期3卷 218-226页

作者： Haixia zhang tianhui Zhuang Weizhong Zeng College of Economics and Management Sichuan Agricultural University Chengdu 611130 China

This article investigates the impact of household endowments on household’s ability to cope with natural disaster risks and the determining factors of disaster coping capacity. We present results of a research based on household survey. The data were analyzed with an ordered Probit model regression. The project surveyed 923 rural households in 2009 and 2010 in 39 national-level poverty-stricken counties of Sichuan, Yunnan, and Guizhou Provinces and Chongqing Municipality. This research determined that the economic strength of households is the most important factor affecting their disaster coping capacity. The ability of farming households to cope with disasters is also significantly impacted by family members’ experiences and their economic context at the village level. Ethnic minority areas in southwestern China are the poorest in the country and are often the main disasteraffected areas. Since household endowments significantly affect the ability of farming households to cope with disasters, integration of disaster risk management and poverty reduction is a viable way of enhancing coping capacity of farming households to natural disasters.

关键词： disaster Impact Chongqing

Dopamine hydrochloride and carboxymethyl chitosan coatings for multifilament surgical suture and their influence on friction during sliding contact with skin substitute

在线全文

学校读者我要写书评

暂无评论

Friction 2020年第1期8卷 58-69页

作者： Gangqiang zhang Ganlin ZHENG tianhui REN Xiangqiong ZENG Emile van der HEIDE Advanced Lubricating Materials Laboratory Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Institute of Functional Textiles and Advanced Materials Colloge of Textlies&ClothingQingdao UniversityQingdao 266000China School of Chemistry and Chemical Engineering Key Laboratory of Thin Film and Microfabrication Technology(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Laboratory for Surface Technology and Tribology University of TwenteEnschede 7500AEThe Netherlands TU Delft Faculty of Civil Engineering and GeosciencesStevinweg 1Delft 2628 CNThe Netherlands Soete Laboratory Ghent UniversityZwijnaarde B-9052Belgiu

In order to reduce the damage to tissue and fill the interstices between fibers,multifilament sutures are frequently treated with certain coating materials.The objective of this study was to create and characterize dopamine hydrochloride(DA)and carboxymethyl chitosan(CMCS)coatings on surgical sutures and investigate their effects on the frictional performance of the surgical sutures during sliding through a skin substitute.The effects of the treatment on the physical and chemical characteristics of the surgical sutures were evaluated.The friction force of the surgical sutures during sliding through the skin substitute was experimentally determined using a penetration friction apparatus.The coefficient of friction(COF)was calculated using a linear elastic model and was used to estimate the frictional behavior of the surgical suture‐skin interactions.The results showed that the DA coating could evenly deposit on the surface of the etched multifilament surgical suture surfaces in a weakly alkaline buffer solution.The CMCS coating material could form a uniform film on the surface of the sutures.Minor changes in the surface roughness of the multifilament surgical sutures with different treatments occurred in this study.The friction force and the COF of the multifilament surgical sutures with DA and CMCS coating showed little change when compared with untreated multifilament surgical sutures.

关键词： friction surgical suture coating Biomaterials skin substitute

天牖穴龙虎交战针法治疗交感型颈椎病的临床观察

在线全文

学校读者我要写书评

暂无评论

中国中医急症 2024年第3期33卷 503-506页

作者：张继玉王鼎皓陈蓉吉学东邓学娟贺成彪李天慧程鹏重庆市九龙坡区中医院重庆400050 重庆市九龙坡区九龙社区卫生服务中心重庆400050

目的观察天牖穴“龙虎交战”针法治疗交感型颈椎病的临床疗效并探讨其治疗机制。方法将100例交感型颈椎病患者随机分为治疗组与对照组各50例,治疗组行天牖穴“龙虎交战”针法,对照组行普通针刺,每日1次,治疗7次后休息1 d,治疗14次为1个... 详细信息

目的观察天牖穴“龙虎交战”针法治疗交感型颈椎病的临床疗效并探讨其治疗机制。方法将100例交感型颈椎病患者随机分为治疗组与对照组各50例,治疗组行天牖穴“龙虎交战”针法,对照组行普通针刺,每日1次,治疗7次后休息1 d,治疗14次为1个疗程,分别记录两组患者治疗前后VAS评分、颈交感神经症状评分、经颅多普勒超声(TCD)、脑干听觉诱发电位(BAEP)及尿去甲肾上腺素(NA)的变化。结果治疗组治疗后VAS评分、颈交感神经症状评分、TCD、BAEP及尿NA的改善优于对照组,两组比较差异具有统计学意义(P<0.05)。结论天牖穴“龙虎交战”针法是治疗交感型颈椎病的一种有效方法。

关键词：交感神经型颈椎病针刺天牖穴龙虎交战针法

汉防己乙素衍生物LYY-47对三阴性乳腺癌细胞及其多倍体巨瘤细胞增殖、凋亡的作用和机制

在线全文

学校读者我要写书评

暂无评论

贵州医科大学学报 2024年第3期49卷 313-328页

作者：余晓静张望明贺天辉刘小花艾海锋安丽君杨留启潘卫东刘杰麟贵州医科大学基础医学院免疫学教研室贵州贵阳550025 九江学院附属医院检验科江西九江332000 德江县民族中医院检验科贵州铜仁565200 贵州大学药学院贵州贵阳550025 贵州医科大学省部共建药用植物功效与利用国家重点实验室贵州贵阳550014

目的探讨汉防己乙素衍生物LYY-47对三阴性乳腺癌(TNBC)细胞及其多倍体巨瘤细胞(PGCCs)增殖、凋亡的作用和机制。方法取TNBC MDA-MB-231细胞和MDA-MB-436细胞培养至对数生长期,诱导形成PGCCs,培养35 d,采用苏木素-伊红(H&E)染色观察不同... 详细信息

目的探讨汉防己乙素衍生物LYY-47对三阴性乳腺癌(TNBC)细胞及其多倍体巨瘤细胞(PGCCs)增殖、凋亡的作用和机制。方法取TNBC MDA-MB-231细胞和MDA-MB-436细胞培养至对数生长期,诱导形成PGCCs,培养35 d,采用苏木素-伊红(H&E)染色观察不同培养时间时2种细胞的PGCCs形态学特征并进行计数;收集MDA-MB-231细胞、PGCCs及其子代细胞,采用流式细胞仪检测分析细胞周期,采用Western blot检测周期相关蛋白[细胞周期蛋白依赖性激酶1(CDK1)和细胞周期蛋白B1(CyclinB1)]、干性相关蛋白[乙醛脱氢酶1A1(ALDH1A1)、白细胞分化抗原44(CD44)及白细胞分化抗原133(CD133)]、DNA损伤修复相关蛋白[布卢姆(BLM)、Rad51及乳腺癌易感基因1(BRCA1)]及凋亡相关蛋白[BCL2-相关X蛋白(Bax)、B淋巴细胞瘤蛋白-2(Bcl-2)、裂解凋亡蛋白酶-3(cleaved Caspase-3)及裂解凋亡蛋白酶-8(cleaved Caspase-8)]的表达,采用噻唑蓝(MTT)法和克隆形成实验检测细胞活力和细胞集落数,采用细胞免疫荧光实验检测磷酸化组蛋白2AX(γ-H2AX)的表达;采用荧光偏振实验检测BLM DNA解旋酶的活性;收集对数生长期MDA-MB-231细胞,分为对照组(同等体积的完全培养基)、紫杉醇(PTX)组(500 nmol/L PTX)、3-CF 3,4-F-苯基类似物(ML216)组(3μmol/L ML216)及ML216+PTX组(500 nmol/L PTX和3μmol/L ML216),采用Image J软件计数各组细胞数;收集对数生长期MDA-MB-231细胞及其PGCCs子代细胞,分为对照组(0.00μmol/L)、LYY-47给药组(2.50μmol/L、5.00μmol/L及6.50μmol/L),采用流式细胞仪检测上述各组细胞的凋亡情况;6周龄雌性无特定病原体(SPF)级无胸腺BALB/c裸鼠12只,皮下分别注射5×10^(6)个MDA-MB-231细胞及其PGCCs子代细胞,每隔3天测量1次肿瘤体积,连续29 d,处死裸鼠剥离肿瘤、称重,取肿瘤组织制作切片,采用H&E染色和免疫组织化学染色观察细胞形态和检测BLM、Ki-67的表达。结果与TNBC MDA-MB-231和MDA-MB-436细胞相比,PTX诱导的PGCCs出现增大的细胞核和细胞质区域,通过不对称分裂产生子代细胞;与MDA-MB-231细胞相比,PGCCs中S期和G2/M期细胞增加、CDK1和CyclinB1蛋白表达下调(P<0.05或P<0.01),其子代细胞中S期细胞增加、G2/M期细胞减少且CDK1、CyclinB1蛋白表达上调(P<0.05或P<0.01),PGCCs及其子代细胞中ALDH1A1、CD44及CD133蛋白表达上调(P<0.05),PGCCs子代细胞的增殖和克隆形成能力增强(P<0.05),γ-H2AX、BLM、BRCA1及Rad51蛋白表达上调(P<0.05);与PTX组相比,ML216+PTX组PGCCs形成的数量明显减少(P<0.01);PGCCs子代细胞体内成瘤的生长速度、肿瘤的体积和重量均大于MDA-MB-231细胞(P<0.01),瘤体中BLM与Ki-67均呈高表达(P<0.01);与对照组相比,LYY-47给药组BLM 642-1290 DNA解旋酶的ATPase、dsDNA解链活性以及DNA结合活性均下调(P<0.05),MDA-MB-231细胞及其PGCCs子代细胞中BLM、Rad51及BRCA1蛋白表达也均下调(P<0.05);与对照组相比,LYY-47给药组和ML216给药组MDA-MB-231及其PGCCs子代细胞增殖和克隆形成能力降低(P<0.05),LYY-47给药组能够引起MDA-MB-231及其PGCCs子代细胞G2/M期细胞增加(P<0.05)、S期细胞减少(P<0.05)、细胞内周期相关蛋白CDK1与CyclinB1的表达下调(P<0.05),ML216给药组MDA-MB-231及其PGCCs子代细胞G1期细胞增多、S期细胞减少(P<0.05);与对照组比较,LYY-47给药组MDA-MB-231细胞及其PGCCs子代细胞的总凋亡比例增加、Bcl-2表达下调及Bax、cleaved Caspase-3、cleaved Caspase-8蛋白表达上调(P<0.05)。结论LYY-47和ML216可影响TNBC及其PGCCs子代细胞的增殖,其机制可能与抑制BLM DNA解旋酶诱导细胞凋亡和阻滞细胞周期有关。

关键词：乳腺肿瘤 DNA解旋酶类细胞增殖细胞凋亡汉防己乙素衍生物多倍体巨瘤细胞 BLM DNA解旋酶