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World Journal of Clinical Cases 2022年第20期10卷 7105-7115页

作者： Xi-Wen Zhang Zan-Hui Jia Li-Ping Zhao yi-Shi Wu Man-Hua Cui Yan Jia tian-Min Xu Department of Gynecology The Second Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina

BACKGROUND Lynch syndrome(LS)is an autosomal dominant hereditary disorder because of germline mutations in DNA mismatch repair genes,such as MutL homolog 1(MLH1),PMS1 homolog 2,MutS homolog 2,and MutS homolog *** mutations could make individuals and their families more susceptible to experiencing various malignant *** Chinese,MLH1 germline mutation c.(453+1_454-1)_(545+1_546-1)del-related LS has been infrequently ***,we report a rare LS patient with colorectal and endometrioid adenocarcinoma and describe her pedigree *** SUMMARY A 57-year-old female patient complained of irregular postmenopausal vaginal bleeding for 6 *** was diagnosed with LS,colonic malignancy,endometrioid adenocarcinoma,secondary fallopian tube malignancy,and intermyometrial ***,she was treated by abdominal hysterectomy,bilateral oviduct oophorectomy,and sentinel lymph node *** testing was performed using next-generation sequencing technology to detect the causative genetic ***,all her family members were offered a free genetic test,but no one accepted *** No tumor relapse or metastasis was found in the patient during the 30-mo followup *** genetic panel sequencing showed a novel pathogenic germline mutation in MLH1,c.(453+1_454-1)_(545+1_546-1)del,for ***,cancer genetic counseling and testing are still in the initial development state in China,and maybe face numerous challenges in the further.

关键词： Lynch syndrome Colorectal cancer Endometrial cancer MLH1 gene Gene testing Case report

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油藏地球物理学方法在地质建模中的应用

石油勘探与开发 2000年第5期27卷 61-62页

作者：尹天放中国石油天然气集团公司石油勘探开发科学研究院

构造模型、岩石物性参数模型和流体模型是油藏数值模拟所使用的三维地质模型中最重要的组成部分 ,充分应用油藏地球物理学方法 ,可以提高所建地质模型网络节点参数的准确程度。文中给出一些实例 ,利用地震均方根振幅剖面精细解释断层、... 详细信息

构造模型、岩石物性参数模型和流体模型是油藏数值模拟所使用的三维地质模型中最重要的组成部分 ,充分应用油藏地球物理学方法 ,可以提高所建地质模型网络节点参数的准确程度。文中给出一些实例 ,利用地震均方根振幅剖面精细解释断层、恢复古应力场进行层面曲率分析、计算破裂值的平面分布来判断地质体的破裂程度从而建立构造模型 ;采用三维地震相干切片技术和多参数约束反演技术 ,定量地建立岩石物性参数分布模型 ,并解释单砂体骨架空间分布 ,建立单砂体骨架模型 ;利用地震连井剖面 ,综合测井、地质资料 ,以人工神经网络技术和多元统计分析为基础的模式识别技术 ,对地震属性与油气藏关系进行聚类分析 ,建立流体模型 ,可以确定油、气、水的区域分布。

关键词：油田地质建模油藏地球物理学方法构造模型

Correlation between the warning symptoms and prognosis of cardiac arrest

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World Journal of Clinical Cases 2022年第22期10卷 7738-7748页

作者： Kang Zheng yi Bai Qiang-Rong Zhai Lan-fang Du Hong-Xia Ge Guo-Xing Wang Qing-Bian Ma Department of Emergency Medicine Peking University Third HospitalBeijing 100191China Department of Emergency Medicine Beijing Friendship HospitalBeijing 100050China

BACKGROUND A low survival rate in patients with cardiac arrest is associated with failure to recognize the condition in its initial ***,recognizing the warning symptoms of cardiac arrest in the early stage may play an important role in *** To investigate the warning symptoms of cardiac arrest and to determine the correlation between the symptoms and *** We included all adult patients with all-cause cardiac arrest who visited Peking University Third Hospital or Beijing Friendship Hospital between January 2012 and December *** on population,symptoms,resuscitation parameters,and outcomes were *** Of the 1021 patients in the study,65.9%had symptoms that presented before cardiac arrest,25.2%achieved restoration of spontaneous circulation(ROSC),and 7.2%survived to *** patients with symptoms had higher rates of an initial shockable rhythm(12.2%vs 7.5%,P=0.020),ROSC(29.1%vs 17.5%,P=0.001)and survival(9.2%vs 2.6%,P=0.001)than patients without *** with the out-of-hospital cardiac arrest(OHCA)without symptoms subgroup,the OHCA with symptoms subgroup had a higher rate of calls before arrest(81.6%vs 0.0%,P<0.001),health care provider-witnessed arrest(13.0%vs 1.4%,P=0.001)and bystander cardiopulmonary resuscitation(15.5%vs 4.9%,P=0.002);a shorter no flow time(11.7%vs 2.8%,P=0.002);and a higher ROSC rate(23.8%vs 13.2%,P=0.011).Compared to the in-hospital cardiac arrest(IHCA)without symptoms subgroup,the IHCA with symptoms subgroup had a higher mean age(66.2±15.2 vs 62.5±16.3 years,P=0.005),ROSC(32.0%vs 20.6%,P=0.003),and survival rates(10.6%vs 2.5%,P<0.001).The top five warning symptoms were dyspnea(48.7%),chest pain(18.3%),unconsciousness(15.2%),paralysis(4.3%),and vomiting(4.0%).Chest pain(20.9%vs 12.7%,P=0.011),cardiac etiology(44.3%vs 1.5%,P<0.001)and survival(33.9%vs 16.7%,P=0.001)were more common in males,whereas dyspnea(54.9%vs 45.9%,P=0.029)and a non-cardiac etiology(53.3%vs 41.7%,P=0.003)were mor

关键词： Cardiac arrest Warning symptoms Immediate recognition Etiology Cardiopulmonary resuscitation Prognosis

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用植物酯酶法快速检测蔬菜中的有机磷农药

北京工业大学学报 2006年第12期32卷 1057-1061页

作者：康天放赵华张雁章辛夷北京工业大学环境与能源工程学院北京100022

为了快速检测蔬菜中的有机磷农药残留状况,分别从京9428、京9583、京东8、京2小麦中提取植物酯酶,将这些酶用于有机磷农药的检测,采用分光光度法比较了不同质量浓度的对硫磷对小麦酯酶活力的抑制情况.结果表明,不同品种小麦酯酶对于对... 详细信息

为了快速检测蔬菜中的有机磷农药残留状况,分别从京9428、京9583、京东8、京2小麦中提取植物酯酶,将这些酶用于有机磷农药的检测,采用分光光度法比较了不同质量浓度的对硫磷对小麦酯酶活力的抑制情况.结果表明,不同品种小麦酯酶对于对硫磷的敏感度不同,在所研究的小麦酯酶中,京2酯酶对对硫磷最为敏感,其检测限达到3.0×10-7mg/L.同时对酶促反应的温度、时间和pH值进行了优化,并应用此方法对蔬菜样品中的有机磷农药进行了检测.

关键词：水解酶有机磷农药酶抑制分光光度法

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双回路接地距离保护的分析和整定

电力系统保护与控制 2009年第18期37卷 43-45页

作者：方天宇浙江电力调度通信中心浙江杭州310007

平行线路零序互感的存在,导致接地距离保护不能正确测量线路阻抗。在实际整定工作中,如何整定接地距离的补偿系数和可靠系数,整定规程没有给出具体的方法。分析了线路的实测阻抗,和高压电网在接地故障时电流分布的特点。基于不同系统运... 详细信息

平行线路零序互感的存在,导致接地距离保护不能正确测量线路阻抗。在实际整定工作中,如何整定接地距离的补偿系数和可靠系数,整定规程没有给出具体的方法。分析了线路的实测阻抗,和高压电网在接地故障时电流分布的特点。基于不同系统运行方式,定性和定量地研究了零序互感对接地测量阻抗的影响,进而提出了接地距离保护一个简单实用的整定方法,具有普遍适用性。

关键词：接地距离零序互感整定

高稳定液态D-阿洛酮糖3-差向异构酶制剂研究

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当代化工 2024年第3期53卷 712-716,721页

作者：韩亚宏郭元亨王小艳丁长河周浩冉小力田芳河南工业大学河南郑州450001 中粮营养健康研究院有限公司北京102209 中粮生物科技股份有限公司北京100005 吉林中粮生化有限公司玉米深加工国家工程研究中心吉林长春130033

为解决D-阿洛酮糖3-差向异构酶(DAE)衰减过快、贮运成本高的问题,拟开发一款具有良好存贮稳定性的DEA液态酶制剂。以半衰期为评价依据,通过单因素试验筛选出对半衰期影响显著的4个因素,并进一步利用响应曲面法对酶制剂的配方进行优化。... 详细信息

为解决D-阿洛酮糖3-差向异构酶(DAE)衰减过快、贮运成本高的问题,拟开发一款具有良好存贮稳定性的DEA液态酶制剂。以半衰期为评价依据,通过单因素试验筛选出对半衰期影响显著的4个因素,并进一步利用响应曲面法对酶制剂的配方进行优化。结果表明:稳定DAE酶制剂的最佳配比为0.1mol·L^(-1)CaCl_(2)、3.96%海藻糖、41.68%葡萄糖、29.32%PEG-400。在此条件下,半衰期为292天,与模拟理论值的相对误差仅为0.17%。通过工艺优化,将DAE的储存时间大幅延长,提高了酶制剂的贮运性能。

关键词： D-阿洛酮糖3-差向异构酶高稳定性液态酶制剂

Blended coals for improved coal water slurries

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Journal of China University of Mining and Technology 2008年第1期18卷 50-54页

作者： GU tian-ye WU Guo-guang LI Qi-hui SUN Zhi-qiang ZENG fang WANG Guang-you MENG Xian-liang School of Chemical Engineering and Technology China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

Three coal samples of different ranks were used to study the effect of coal blending on the preparation of Coal Water Slurry (CWS). The results show that by taking advantage of two kinds of coal, the coal concentration in slurry made from hard-to-pulp coal can be effectively improved and increased by 3%–5% generally. DLT coal (DaLiuTa coal mine) is very poor in slurryability and the stability and rheology of the resulting slurry are not very good. When the amount of easily slurried coal is more than 30%, all properties of the CWS improve and the CWS meets the requirements for use as fuel. Coalification, porosity, surface oxygenic functional groups, zeta potential and grindability have a great effect on the performance of blended coal CWS. This leads to some differences in performance between the slurry made from a single coal and slurry made from blended coal.

关键词： low rank coal coal water slurry coal blending slurryability zeta potential

Replication potentials of HIV-1/HSIV in PBMCs from northern pigtailed macaque （Macaca leonina）

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Zoological Research 2014年第3期35卷 186-195页

作者： Ai-Hua LEI Gao-Hong ZHANG Ren-Rong tian Jia-Wu ZHU Hong-yi ZHENG Wei PANG Yong-Tang ZHENG Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Kunming College of Life Sciences University of Chinese Academy of Sciences Kunming Yunnan 650204 China University of Science and Technology of China Hefei 230026 China Kunming Primate Research Center Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China

The northern pig-tailed macaque （Macaca leonina） has been identified as an independent species of Old World monkey, and we previously found that PBMCs from M. leonina were susceptible to human immunodeficiency virus type 1 （HIV-1）, which may be due to the absence of a TRIM5 protein restricting HIV-1 replication. Here we investigated the infection potentials of six laboratory adapted HIV-1 strains and three primary HIV-1 isolates in PBMCs from M. leonina. The results indicate that these strains are characterized by various but low replication levels, and among which, HIV-INL4-3 shows the highest replication ability. Based on the abundant evidence of species-specific interactions between restriction factors APOBEC3 and HIV/SIV-derived Vif protein, we subsequently examined the replication potentials of v/f-substituted HIV-1 （HSIV） in M. leonina PBMCs. Notably, HSIV-vifmac and stHIV-lsv chimeras, two HIV-1Ni.4-3-derived viruses encoding the viral infectivity factor （Vif） protein from SIVmac239, replicated robustly in cells from M. leonina, which suggests that HSIV could effectively antagonize the antiviral activity of APOBEC3 proteins expressed in cells of M. leonina. Therefore, our data demonstrate that M. leonina has the potential to be developed into a promising animal model for human AIDS.

关键词： HIV-1 HSIV Replication PBMC Northern pig-tailed macaque (Macaca leonina)

Comparison of odv-e25 Gene and Three ORFs Genomic Structure from Three Baculovirus

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Wuhan University Journal of Natural Sciences 1999年第4期4卷 491-494页

作者： QI yi peng, LIU De li, JIN tian quan College of Life Sciences, Wuhan University, Wuhan 430072,China Wuhan University College of Life Sciences Wuhan China (GRID:grid.49470.3e) (ISNI:***)

The occulusion derived virus envelope protein gene (odv e25) of Leucania separata nuclear polyhedrosis virus (LsNPV) was identified by the sequencing the pLsx3 fragment, and compared with other three baculovirus... 详细信息

关键词： odv e25 sequencing hydrophobility analysis LsNPV

Insulation effect of air cavity in sand mold using 3D printing technology

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China Foundry 2018年第1期15卷 37-43页

作者： Cheng-yang Deng Jin-wu Kang Hao-long Shangguan Tao Huang Xiao-peng Zhang Yong-yi Hu tian-you Huang School of Materials Science and Engineering Tsinghua University Key Laboratory for Advanced Materials Processing Technology Ministryof Education Beijing China Beijing DRUCK Technology Development Co. Ltd. China

The insulation effect of the air cavity surrounding the riser in a 3D printed sand mold was studied. The influence of the air cavity on heat flux was theoretically analyzed. The results demonstrated that the heat flux of the air cavity in the 3D printed sand mold was significantly less than that of resin-bonded sand. The insulation effect of the air cavity in sand molds for a cylinder casting and a stress-frame casting were simulated using software COMSOL. The results illustrated that the air cavity could be used to insulate the riser and it was more suitable for a lower melting point metal casting. An air cavity with 10-15 mm width and 5-10 mm away from the riser can significantly prolong the solidification of the riser by over 10%. Meanwhile, the sand mold for the stressframe was made by 3D printing technology and poured with aluminum alloy A356 melt. The experiment results showed that the presence of the air cavity led to a 12.5% increase of the solidification time of its riser.

关键词： 3D printing sand mold air cavity insulation effect riser