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CCS Chemistry 2024年第1期6卷 177-195页

作者： Lang Zhao shao-Hua Zhuo tian-Yang Wang Jun-Jun Wu jing-Yun Su Wen-Hao Li Bo-Dou Zhang Yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 Beijing Institute for Brain Disorders Beijing 100069 Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084

Cyclic dinucleotides(CDNs)are natural agonists of the stimulator of interferon genes(STING),which is an attractive immunotherapy ***,CDNs and their derivatives are being investigated ***,the poor bioavailability of exogenous CDNs has limited their application in *** nanocarriers are widely used for cytosolic delivery of CDNs,their loading capacity is insufficient,and their complicated composition and purification process raises bio-compatibility ***,we report a super-simplified CDN self-assembly strategy for carrier-free delivery of *** the presence of excess K^(+),CDNs form oligomers which further self-assemble with divalent metal ions(such as Mn^(2+))to form nanoparticles(NPs)in aqueous *** demonstrate that the self-assembled CDN NPs promote cellular uptake of CDNs and enhance tumor immunogenicity by remodeling the tumor microenvironment,inducing immunogenic tumor cell death and increasing tumorinfiltrating lymphocytes,which is conducive to the generation of tumor neoantigen-specific T-cell *** also demonstrate that the use of CDN NPs alone or in combination with immune checkpoint blockades inhibits tumor growth,highlighting the fact that CDN NPs are a potent platform for cancer immunotherapy.

关键词： cyclic dinucleotide STING carrierfree delivery tumor immunogenicity cancer immunotherapy

Sandwich structures with tapered tubes as core:A quasi-static investigation

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Defence Technology（防务技术） 2024年第3期33卷 447-462页

作者： Xinmei Xiang Dehua shao Xin Zhang Umer Sharif Ngoc San Ha Li Xiang jing Zhang Jiang Yi School of Civil Engineering Guangzhou UniversityGuangzhouChina Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhenGuangdongChina School of Engineering Centre for Innovative Structures and MaterialsRMIT UniversityMelbourneAustralia China Southern Airlines Co. LtdShenzhen BranchShenzhen518000China

In this article,the experimental and finite element analysis is utilized to investigate the quasi-static compression features of sandwich constructions built with tapered tubes.3D printing technology was utilized to create the hollow centers of the tapering tubes,with and without *** results demonstrate that the energy absorption(EA)and specific energy absorption(SEA)of the single corrugated tapered tube sandwich are 51.6% and 19.8% higher,respectively,than those of the conical tube ***,the results demonstrate that energy absorbers can benefit from corrugation in order to increase their ***,the tapered corrugated tubes'resistance to oblique impacts was *** to a straight tube,the tapered tube is more resistant to oblique loads and has a lower initial peak crushing force(PCF),according to numerical *** conducting a parametric study,it was discovered that the energy absorption performance of the sandwich construction is significantly affected by the amplitude,number of corrugations,and wall *** and SEA of DTS with corrugation number of 8 increased by 17.4%and 29.6%,respectively,while PCF decreased by 9.2% compared to DTS with corrugation number of 10.

关键词： Sandwich structure Corrugated tube Tapered tube Quasi-static Energy absorption

Two-dimensional silica enhanced solid polymer electrolyte for lithium metal batteries

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Particuology 2024年第2期85卷 146-154页

作者： Zhihong Luo Weiyong Li Chong Guo Ya Song Mingxia Zhou Yan Shi jing Xu Long Li Bin Shi Quansheng Ouyang Jiao-jing shao Guangmin Zhou School of Materials and Metallurgy Guizhou UniversityGuiyang550025China State Key Laboratory of Advanced Chemical Power Sources Zunyi563003China Graphene Materials Engineering Research Center of Guizhou Colleges and Universities Guiyang550025China Tsinghua-Berkeley Shenzhen Institute&Tsinghua Shenzhen International Graduate Schoo Tsinghua UniversityShenzhen518055China

Solid polymer electrolytes(SPEs)are promising substitutes for current flammable liquid electrolytes to achieve high-safety and high-energy-density lithium metal *** oxide(PEO)based solid polymer electrolytes have attracted increasing attention because of their excellent flexibility,manufacturability,light weight,and low-cost processing,while they often suffer from low ionic con-ductivity at room temperature,low lithium transference number and unsatisfactory interfacial resis-tance,which largely restrain their practical ***,two-dimensional holey silica nanosheets(2D-HSN)as the fillers,together with LiNO_(3) as the electrolyte additive,are introduced in a PEO/poly(-vinylidene fiuoride-co-hexafluoropropylene)(PVDF-HFP)blended polymer matrix to obtain a *** incorporation of HSN filler creates supplementary channels for lithium ion migration and lowers the crystallinity of the polymer,thereby facilitating the movement of lithium *** HSN-based SPE demonstrates higher ionic conductivity up to 3.7 x 10-4 S cm-1 at 30℃,larger Li+transference number close to 0.34,and more stable lithium plating/stripping than that without the fillers,and HSN can promote the formation of more stable solid electrolyte interphase(SEI)*** as-assembled LiFePO4||Li batteries deliver a high specific capacity of 159 mA h g-1 with the capacity retention of 95.5%after 200 cycles at 30℃,as well as superior rate performance and cycling stability compared to that using the blank SPE.

关键词： Vermiculite nanosheets Two-dimensional silica Solid polymer electrolytes FillersLithium metal batteries

Novel phenanthrene/bibenzyl trimers from the tubers of Bletilla striata attenuate neuroinﬂammation via inhibition of NF-κB signaling pathway

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Chinese Journal of Natural Medicines 2024年第5期22卷 441-454页

作者： shao Siyuan SUN Mohan MA Xianjie JIANG Jianwei tian Jinying ZHANG Jianjun YE Fei LI Shuai State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Five novel(9,10-dihydro)phenanthrene and bibenzyl trimers,as well as two previously identified biphenanthrenes and bibenzyls,were isolated from the tubers of Bletilla *** structures were elucidated through comprehensive analyses of NMR and HRESIMS spectroscopic *** absolute configurations of these compounds were determined by calculating rotational energy barriers and comparison of experimental and calculated ECD *** 5b and 6 exhibited inhibitory effects on LPS-induced NO production in BV-2 cells,with IC_(50) values of 12.59±0.40 and 15.59±0.83μmol·L^(-1),respectively.A mechanistic study suggested that these compounds may attenuate neuroinflammation by reducing the activation of the AKT/IκB/NF-κB signaling ***,compounds 3a,6,and 7 demonstrated significant PTP1B inhibitory activities,with IC_(50) values of 1.52±0.34,1.39±0.11,and 1.78±0.01μmol·L^(-1),*** investigation revealed that compound 3a might inhibit LPS-induced PTP1B overexpression and NF-κB activation,thereby mitigating the neuroinflammatory response in BV-2 cells.

关键词： Bletilla striata Phenanthrene/bibenzyl trimer NO inhibition AKT/IκB/NF-κB signaling pathway PTP1B inhibitory effect

Efficacy of Daoyin combined with lower limb robot as a comprehensive rehabilitation intervention for stroke patients: a randomized controlled trial

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Journal of Traditional Chinese Medicine 2024年第3期44卷 530-536页

作者： tian Haolin YANG Yuanbin ZHANG Hu ZHAO Wenjing ZHOU jing tian jingfeng HE Long LI Xuechao SHEN Qinxuan SHUAI Mei Department of First Rehabilitation Wangjing Hospital of China Academy of Chinese Medical SciencesBeijing100102 Department of Rehabilitation Shunyi HospitalBeijing Traditional Chinese Medicine HospitalBeijing101300China School of Biological Science and Medical Engineering Beihang UniversityBeijing100191China

OBJECTIVE: To assess the effectiveness of a comprehensive rehabilitation approach combining Traditional Chinese Medicine Daoyin with lower limb robotics during the recovery phase of stroke ***: Stroke patients meeting the specified criteria were randomly assigned to one of four groups using a random number table: Control group, Daoyin group, lower limb robot group(LLR group), and Daoyin and lower limb robot group(DLLR group). Each group received distinct treatments based on conventional rehabilitation *** treatment duration spanned two weeks with two days of rest per week. Pre-and post-intervention assessments included various scales: Fugl-Meyer Assessment(FMA),Berg balance scale(BBS), Barthel index(BI), Fatigue Scale-14(FS-14), Pittsburgh sleep quality index(PSQI),Hamilton Anxiety Scale(HAMA), and Hamilton Depression Scale(HAMD).RESULTS: Statistically significant differences were observed in the lower limb function measured by FAM between the Control group(15 ± 5) and the DLLR group(18 ± 5)(P = 0.049). In the Barthel index, a statistically significant difference was noted between the Control group(54 ± 18) and the DLLR group(64 ± 11)(P = 0.041).Additionally, significant differences were found in the Berg balance scale between the Control group(21 ± 10)and the DLLR group(27 ± 8)(P = 0.024), as well as between the Control group(21 ± 10) and the LLR group(26 ± 10)(P = 0.048).CONCLUSION: The findings of this study suggest that the combined use of Daoyin and robotics not only enhances motor function in stroke patients but also has a positive impact on fatigue, sleep quality, and mood. This approach may offer a more effective rehabilitation strategy for stroke patients.

关键词： stroke rehabilitation Daoyin lower limb robot randomized controlled trial

A compact route for efficient production of high-purityβ-Ga_(2)O_(3) powder

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Rare Metals 2024年第9期43卷 4573-4584页

作者： Xiao-Wei Zhou Gao-Jie Chen Liang Xu Zhi-Jun shao Cheng Yang Yong-Pan tian Zhuo Zhao School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243032China Low-Carbon Research Institute Anhui University of TechnologyMa'anshan 243032China

The present study has proposed a compact process for the production of high-purityβ-Ga_(2)O_(3)powder by simply using gallium metal and water as the raw *** process basically consists of two essential steps including hydrothermal synthesis of Ga OOH and calcination of Ga OOH for the production of the target product ofβ-Ga_(2)O_(3).Thermodynamic evaluation and systematic experiments were conducted for process parameter optimization.X-ray diffractometer(XRD),scanning electron microscopy(SEM),thermogravimetryDdifferential scanning calorimetry(TG-DSC)and X-ray photoelectron spectroscopy(XPS)were utilized to clarify the reaction mechanisms of the hydrothermal synthesis and transformation of Ga OOH toβ-Ga_(2)O_(3)by *** analysis of the final product ofβ-Ga_(2)O_(3)obtained under the optimal conditions was carried out with inductively coupled plasma mass spectrometry(ICP-MS),and the results showed that the contents of the representative impurities such as Ni,Cu,In,Mn,Co,Zn and Cr are obviously lower than the requirement of 5Nβ-Ga_(2)O_(3)standard,exhibiting excellent application prospect of the proposed process to produce high-purityβ-Ga_(2)O_(3).

关键词： β-Ga_(2)O_(3) Hydrothermal synthesis Calcination Purity Reaction mechanism

Equilibrium Joining Strategies of Retrial Queueing Systems with Two-phase Service and Priority-purchasing

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Acta Mathematicae Applicatae Sinica 2024年

作者： Fan XU Rui-ling tian Qi shao School of Science Yanshan University

This paper considers the customer’s equilibrium joining-balking behavior in a retrial queue with two-phase service and priority-purchasing. If the arriving customer finds the server busy, the customer can make three choices (joining the orbit, purchasing the priority or balking) based on different levels of the system information. We consider two cases:the partially observable case and the fully unobservable case. The customer’s equilibrium strategy for the partially observable case and the fully unobservable case are derived. Then, an algorithm is developed to solve the optimal fee that maximizes the service provider’s profit. Finally, the influence of system parameters on performance measures, equilibrium joining strategies and the service provider’s profits is illustrated by numerical examples.

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In situ regulating intimately connected heterostructure by decomposition of solid solution oxides toward high-efficient water oxidation

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Rare Metals 2024年第4期43卷 1557-1569页

作者： shao-Fei Zhang Xiao-Lu Yin Jin Wang Jian-Li Kang tian-tian Li Jin-Feng Sun Yong-Qiang Meng Jian-Jiang Wang Dian-Long Wang Kai-Qiang Qin Hebei Key Laboratory of Flexible Functional Materials/Hebei Key Laboratory of Material Near-Net Forming Technology School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang050018China Key Laboratory of Advanced Ceramics and Machining Technology/Ministry of Education School of Materials Science and EngineeringTianjin UniversityTianjin300072China Electrochemical Engine Center Department of Mechanical EngineeringPennsylvania State UniversityUniversity ParkPA16802USA

Heterogeneous interfaces produced by interdomain interactions on a nanoscale performs a crucial role in boosting the properties of an electrocatalyst toward oxygen evolution reaction(OER)***,a series of dual-phase electrodes with intimately connected heterointerfaces are prepared by in situ decomposing solid solution oxide of Ni_(x)Co_(y)Fe_(100-x-y)O,which grew on Ni foam massively via an ultrafast combustion ***,with high-reaction kinetics caused by the reduction treatment at 450℃,the less electronegative Fe and Co are more oxyphilic than Ni,which facilitated their co-exsolution and formation of CoFe_2O_4/NiO oxide with enriched oxygen *** from the nanoporous framework,heterojunction structure,and oxygen defects,the self-supporting electrodes present rapid charge/mass transmission and provide abundant active sites for *** optimized sample(R-SNCF4.5)shows low overpotentials of 226 and 324 mV at 10 and100 mA·cm^(-2),a small Tafel slope(46.7 mV·dec^(-1)),and excellent *** assembled R-SNCF4.5//Pt/C/NF electrolyzer demonstrates continuous electrolysis over 50 h at a current density of 10 mA·cm^(-2),under 1.51 *** functional theory(DFT)calculations verify that the strong electronic modulation plays a critical part in the CoFe_2O_4/NiO hybrid by lowering the energy barriers for the ratedetermining steps,and Fe sites are the most active OER sites.

关键词： Rapid combustion Decomposition of solid solution oxide Dual-phase heterostructure Oxygen evolution reaction Theoretical calculation

Remote sensing image encryption algorithm based on novel hyperchaos and an elliptic curve cryptosystem

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Chinese Physics B 2024年第5期33卷 292-304页

作者：田婧希金松昌张晓强杨绍武史殿习 School of Computer Science National University of Defense TechnologyChangsha 410003China Intelligent Game and Decision Laboratory (IGDL) Beijing 100091China School of Information and Control Engineering China University of Mining and TechnologyXuzhou 221116China

Remote sensing images carry crucial ground information,often involving the spatial distribution and spatiotemporal changes of surface *** safeguard this sensitive data,image encryption technology is *** this paper,a novel Fibonacci sine exponential map is designed,the hyperchaotic performance of which is particularly suitable for image encryption *** encryption algorithm tailored for handling the multi-band attributes of remote sensing images is *** algorithm combines a three-dimensional synchronized scrambled diffusion operation with chaos to efficiently encrypt multiple ***,the keys are processed using an elliptic curve cryptosystem,eliminating the need for an additional channel to transmit the keys,thus enhancing *** results and algorithm analysis demonstrate that the algorithm offers strong security and high efficiency,making it suitable for remote sensing image encryption tasks.

关键词： hyperchaotic system elliptic curve cryptosystem(ECC) 3D synchronous scrambled diffusion remote sensing image unmanned aerial vehicle(UAV)

Ada-FFL:Adaptive computing fairness federated learning

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 573-584页

作者： Yue Cong jing Qiu Kun Zhang Zhongyang Fang Chengliang Gao Shen Su Zhihong tian The Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhouChina Pengcheng Lab ShenzhenChina Carnegie Mellon University PittsburghPennsylvaniaUSA Mohamed Bin Zayed University of Artificial Intelligence Abu DhabiUnited Arab Emirates

As the scale of federated learning expands,solving the Non-IID data problem of federated learning has become a key challenge of *** existing solutions generally aim to solve the overall performance improvement of all clients;however,the overall performance improvement often sacrifices the performance of certain clients,such as clients with less *** fairness may greatly reduce the willingness of some clients to participate in federated *** order to solve the above problem,the authors propose Ada-FFL,an adaptive fairness federated aggregation learning algorithm,which can dynamically adjust the fairness coefficient according to the update of the local models,ensuring the convergence performance of the global model and the fairness between federated learning *** integrating coarse-grained and fine-grained equity solutions,the authors evaluate the deviation of local models by considering both global equity and individual equity,then the weight ratio will be dynamically allocated for each client based on the evaluated deviation value,which can ensure that the update differences of local models are fully considered in each round of ***,by combining a regularisation term to limit the local model update to be closer to the global model,the sensitivity of the model to input perturbations can be reduced,and the generalisation ability of the global model can be *** numerous experiments on several federal data sets,the authors show that our method has more advantages in convergence effect and fairness than the existing baselines.

关键词： adaptive fariness aggregation fairness federated learning non-IID