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MeCP2:multifaceted roles in gene regulation and neural development

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Neuroscience Bulletin 2014年第4期30卷 601-609页

作者： tian-lin cheng Zilong Qiu Institute of Neuroscience Shanghai Institutes for Biological SciencesChinese Academy of Sciences

Methyl-CpG-binding protein 2 （MeCP2） is a classic methylated-DNA-binding protein, dysfunctions of which lead to various neurodevelopmental disorders such as Rett syndrome and autism spectrum disorder. Initially recognized as a transcriptional repressor, MeCP2 has been studied extensively and its functions have been expanded dramatically in the past two decades. Recently, it was found to be involved in gene regulation at the post-transcriptional level. MeCP2 represses nuclear microRNA processing by interacting directly with the Drosha/DGCR8 complex. In addition to its multifaceted functions, MeCP2 is remarkably modulated by post- translational modifications such as phosphorylation, SUMOylation, and acetylation, providing more regulatory dimensions to its functions. The role of MeCP2 in the central nervous system has been studied extensively, from neurons to glia. Future investigations combining molecular, cellular, and physiological methods are necessary for defining the roles of MeCP2 in the brain and developing efficient treatments for MeCP2-related brain disorders.

关键词： MeCP2 Rett syndrome central nervous system gene expression regulation post-translationalmodification post-transcriptional regulation glia

Dural enhancement detected by magnetic resonance imaging reflecting the underlying causes of cerebral venous sinus thrombosis

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Chinese Medical Journal 2012年第8期125卷 1513-1516页

作者： tian cheng-lin PU Chuan-qiang Department of Neurology Chinese People's Liberation Army General HospitalBeijing 100853China

Dural enhancement detected by magnetic resonance imaging is a common finding in patients with cerebral venous sinus thrombosis （CVST） and is usually interpreted as a change secondary to CVST. We report two cases of CVST with intense and diffuse dural enhancement that resulted from pachymeningitis in one patient and spontaneous intracranial hypotension in another. Pachymeningitis and spontaneous intracranial hypotension were also determined to be the underlying causes of CVST. The clinical data of these two patients are described. In patients with CVST, dural enhancement is not always a secondary change to CVST. It can be a manifestation of the underlying causes of CVST. When diffuse and intense dural enhancement is revealed, sufficient ancillary tests are warranted to rule out other potential patholooical chanoes of the dura mater those can result in CVST.

关键词： cerebral venous sinus thrombosis magnetic resonance imaging pachymeningitis spontaneous intracranial hypotension

Detailed electronic structure of three-dimensional Fermi surface and its sensitivity to charge density wave transition in ZrTe3 revealed by high resolution laser-based angle-resolved photoemission spectroscopy

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Chinese Physics B 2018年第8期27卷 535-542页

作者： Shou-Peng Lyu Li Yu Jian-Wei Huang cheng-tian lin Qiang Gao Jing Liu Guo-Dong Liu lin Zhao Jie Yuan Chuang-tian Chen Zu-Yan Xu Xing-Jiang Zhou National Laboratory for Superconductivity Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences B eijing 100049China Max-Planck-Institut fiir Festki~rperforschung Heisenbergstrasse 170569 StuttgartGermany Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190China Collaborative Innovation Center of Quantum Matter Beijing 100871China

The detailed information of the electronic structure is the key to understanding the nature of charge density wave （CDW） order and its relationship with superconducting order in the microscopic level. In this paper, we present a high resolution laser-based angle-resolved photoemission spectroscopy （ARPES） study on the three-dimensional （3D） hole-like Fermi surface around the Brillouin zone center in a prototypical quasi-one-dimensional CDW and superconducting system ZrTe3. Double Fermi surface sheets are clearly resolved for the 3D hole-like Fermi surface around the zone center. The 3D Fermi surface shows a pronounced shrinking with increasing temperature. In particular, the quasiparticle scattering rate along the 3D Fermi surface experiences an anomaly near the charge density wave transition temperature of ZrTe3 - 63 K）. The signature of electron-phonon coupling is observed with a dispersion kink at -20 meV; the strength of the electron-phonon coupling around the 3D Fermi surface is rather weak. These results indicate that the 3D Fermi surface is also closely connected to the charge-density-wave transition and suggest a more global impact on the entire electronic structure induced by the CDW phase transition in ZrTe3.

关键词： angle-resolved photoemission spectroscopy ZrTe3, scattering rate electron-phonon coupling

Approximate Gaussian conjugacy： parametric recursive filtering under nonlinearity, multimodality, uncertainty, and constraint, and beyond

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Frontiers of Information Technology & Electronic Engineering 2017年第12期18卷 1913-1939页

作者： tian-cheng lin Jin-ya SU Wci LIU Juan M. CORCHADO School of Sciences University of Salamanca Salamanca 37007 Spain Department of Aeronautical and Automotive Engineering Loughborough University Loughborough LE11 3TU UK De~artment of Electronic and Electrical En.oineering University of She3ff~eld She3ff~eld $1 ~ET UK

Since the landmark work of R. E. Kalman in the 1960s, considerable efforts have been devoted to time series state space models for a large variety of dynamic estimation problems. In particular, parametric filters that seek analytical estimates based on a closed-form Markov-Bayes recursion, e.g., recursion from a Gaussian or Gaussian mixture （GM） prior to a Gaussian/GM posterior （termed ＇Gaussian conjugacy＇ in this paper）, form the backbone for a general time series filter design. Due to challenges arising from nonlinearity, multimodality （including target maneuver）, intractable uncertainties （such as unknown inputs and/or non-Gaussian noises） and constraints （including circular quantities）, etc., new theories, algorithms, and technologies have been developed continuously to maintain such a conjugacy, or to approximate it as close as possible. They had contributed in large part to the prospective developments of time series parametric filters in the last six decades. In this paper, we review the state of the art in distinctive categories and highlight some insights that may otherwise be easily overlooked. In particular, specific attention is paid to nonlinear systems with an informative observation, multimodal systems including Gaussian mixture posterior and maneuvers, and intractable unknown inputs and constraints, to fill some gaps in existing reviews and surveys. In addition, we provide some new thoughts on alternatives to the first-order Markov transition model and on filter evaluation with regard to computing complexity.

关键词： Kalman filter Gaussian filter Time series estimation Bayesian filtering Nonlinear filtering Constrained filtering Gaussian mixture Maneuver Unknown inputs

Selection of Minimal Test Points Set for Integer-Coded Fault Wise Table

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Journal of Electronic Science and Technology of China 2009年第4期7卷 312-316页

作者： Shu-lin tian cheng-lin Yang Bing Long School of Automation engineering University of Electronic Science and Technology of China Chengdu 610054 China

Test points selection for integer-coded fault wise table is a discrete optimization problem. On one hand, traditional exhaustive search method is computationally expensive. On the other hand, the space complexity of traditional exhaustive is low. A tradeoff method between the high time complexity and low space complexity is proposed. At first, a new fault-pair table is constructed based on the integer-coded fault wise table. The fault-pair table consists of two columns： one column represents fault pair and the other represents test points set that can distinguish the corresponding faults. Then, the rows are arranged in ascending order according to the cardinality of corresponding test points set. Thirdly, test points in the top rows are selected one by one until all fault pair are isolated. During the test points selection process, the rows that contain selected test points are deleted and then the dimension of fault-pair table decreases gradually. The proposed test points selection algorithm is illustrated and tested using an integercoded fault wise table derived from a real analog circuit. Computational results suggest show policies are better than the exhaustive strategy.

关键词： Fault-pair table integer-coded fault wise table optimization test points selection.

Role of the PTEN signaling pathway in autism spectrum disorder

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Neuroscience Bulletin 2013年第6期29卷 773-778页

作者： Jing-Wen Lv tian-lin cheng Zi-Long Qiu Wen-Hao Zhou Department of Neonatology Children's Hospital of Fudan University Institute of Neuroscience Shanghai Institute of Biological SciencesChinese Academy of Sciences

Autism is an etiologically heterogeneous group of neurodevelopmental disorders,diagnosed mostly by the clinical behavioral *** concept that the tumor-related gene PTEN plays a critical role in autism spectrum disorder has emerged over the last *** this review,we focus on the essential role of the PTEN signaling pathway in neuronal differentiation and the formation of neural circuitry,as well as genetic mouse models with Pten ***,accumulated data suggest that the effect of PTEN on neural stem-cell development contributes significantly to the pathophysiology of autism spectrum disorders.

关键词： PTEN TSC1/2 autism synapse neural stem cells

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Journal of Genetics and Genomics 2017年第1期44卷 63-66页

作者： BO Yuan tian-lin cheng Kan Yang Xu Zhang Zilong Qiu Institute of Neuroscience Key Laboratory of Primate Neurobiology CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Institute of Chemistry and Bioengineering Donghua University Shanghai 200051 China Shanghai Clinical Research Center Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China

Methyl-CpG binding protein 2 （MeCP2） has a crucial role in transcriptional regulation and neural development （Ausi6 et al., 2014）. Loss of function mutations of MECP2 in human lead to Rett syndrome （RTT）, a severe neurodevelopmental disorders （Amir et al., 1999）, whereas individuals with the chromosomal duplications containing the MECP2 locus showed severe autism-like symptoms （Ramocki et al., 2009）.

关键词： FGF Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors microRNAs

Reversal of Social Recognition Deficit in Adult Mice with MECP2 Duplication via Normalization of MeCP2 in the Medial Prefrontal Cortex

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Neuroscience Bulletin 2020年第6期36卷 570-584页

作者： Bin Yu Bo Yuan Jian-Kun Dai tian-lin cheng Sheng-Nan Xia ling-Jie He Yi-Ting Yuan Yue-Fang Zhang Hua-Tai Xu Fu-Qiang Xu Zhi-Feng Liang Zi-Long Qiu Institute of Neuroscience State Key Laboratory of NeuroscienceChinese Academy of Sciences Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China Department of Molecular and Human Genetics Howard Hughes Medical InstituteBaylor College of MedicineHoustonTX 77030USA Wuhan Institute of Physics and Mathematics Chinese Academy of SciencesWuhan 430071China

Methyl-CpG binding protein 2(MeCP2) is a basic nuclear protein involved in the regulation of gene expression and microRNA *** of MECP2-containing genomic segments causes MECP2 duplication syndrome,a severe neurodevelopmental disorder characterized by intellectual disability,motor dysfunction,heightened anxiety,epilepsy,autistic phenotypes,and early *** of the abnormal phenotypes in adult mice with MECP2 duplication(MECP2-TG) by normalizing the MeCP2 levels across the whole brain has been ***,whether different brain areas or neural circuits contribute to different aspects of the behavioral deficits is still ***,we found that MECP2-TG mice showed a significant social recognition deficit,and were prone to display aversive-like behaviors,including heightened anxiety-like behaviors and a fear generalization *** addition,reduced locomotor activity was observed in MECP2-TG ***,appetitive behaviors and learning and memory were comparable in MECP2-TG and wild-type *** magnetic resonance imaging illustrated that the differences between MECP2-TG and wild-type mice were mainly concentrated in brain areas regulating emotion and social *** used the CRISPR-Cas9 method to restore normal MeCP2 levels in the medial prefrontal cortex(mPFC) and bed nuclei of the stria terminalis(BST) of adult MECP2-TG mice,and found that normalization of MeCP2 levels in the mPFC but not in the BST reversed the social recognition *** data indicate that the mPFC is responsible for the social recognition deficit in the transgenic mice,and provide new insight into potential therapies for MECP2 duplication syndrome.

关键词： MECP2 duplication Medial prefrontal cortex Social recognition deficit CRISPR-Cas9

How to interpret low human chorionic gonadotropin levels in cerebrospinal fluid of patients with intracranial germinoma？

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Chinese Medical Journal 2013年第24期126卷 4809-4810页

作者： CONG Lu tian cheng-lin WANG Xiang-qing DONG Zhao ZHANG Jia-tang YU Sheng-yuan Department of Neurology Chinese People's Liberation Anny General Hospital Beijing 100853 China

Human chorionic gonadotropin （hCG） level in cerebrospinal fluid （CSF hCG） is very useful for thediagnosis of intracranial germinoma. We have previously reported on two patients with germinoma located in the basal ganglia. Their CSF hCG levels were extremely low upon presentation.1 However, significantly increased CSF hCG levels were detected when these two patients had a relapse. The experience acquired in these two cases is helpful to appropriately interpret the CSF hCG levels that are used to detect intracranial germinoma, evaluate the effectiveness of treatment and monitor recurrence.

关键词： germinoma, human chorionic gonadotropin cerebrospinal fluid