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World Journal of Emergency Medicine 2022年第3期13卷 248-250页

作者： Chu wang Zhen-zhou wang tian-bing wang Trauma Medicine Center Peking University People's HospitalBeijing 100044China

Dear editor,In 1975,*** Heimlich introduced the Heimlich maneuver[2],which has become the initial treatment for emergency foreign-body airway *** is recommended by American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.[2]During thrusts,airway pressure increases,thereby expelling foreign bodies.

关键词： airway obstruction gastrointestinal

Synthesis of TiO_2 nanoparticles by propane/air turbulent flame CVD process

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Particuology 2009年第3期7卷 204-210页

作者： Hongyong Xie Guilan Gao Zhen tian Naici bing Lijun wang School of Urban Development and Environmental Engineering Shanghai Second Polytechnic University 2360 Jin Hal Road Pudong Shanghai 201209 China

Synthesis of TiO2 nanoparticles by the oxidation of titanium tetrachloride （TiCI4） in high-strength propane/air turbulent flame is investigated tentatively for mass production of TiO2 nanoparticles. Effects of reactor heat flux varying from 247 to 627 kJ/m^2 s, initial TiO2 number density from 2 × 10^20 to 1 × 10^21 m^ 3, and apparent residence time of TiO2 nanoparticles in reactor from 0.06 to 0.9 s, on particle morphology, phase composition, UV absorption and photoluminescence （PL） spectra are studied. The TiO2 nanoparticles synthesized, with mean size of 30-80 nm and futile mass fraction from 0.155 up to 0.575, exhibited a strong PL signal at the wavelength of 370-450 nm, with a wide peak signal at 400-420 nm, reflecting significant oxygen vacancies on the surface of the TiO2 nanoparticles.

关键词： CVD Turbulent flame TiO2 nanoparticles PL spectra

Reversible congestive heart failure associated with hypocalcemia:A case report

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World Journal of Clinical Cases 2021年第34期9卷 10659-10665页

作者： Chu wang Li-Wen Dou tian-bing wang Yang Guo Trauma Rescue&Treatment Center Peking University People's HospitalBeijing 100044China Emergency Department Peking University People's HospitalBeijing 100044China

BACKGROUND Hypoparathyroidism is a rare disease that may occur due to primary or secondary *** estimated incidence in the United States is 24–37/100000 *** heart failure associated with hypocalcemia due to hypoparathyroidism is an even rarer *** SUMMARY Here,we present a 64-year-old woman with congestive heart failure following *** patient was transferred to our emergency department with complaints of rapidly progressive dyspnea,shortness of breath and heaviness of the chest for 4 *** had a history of undergoing thyroidectomy and partial tracheotomy 2 years prior due to a malignant thyroid *** spasms had been present 1 year ago,and cataracts were treated with intraocular lens replacement in both *** tests were within normal ranges,except serum calcium at 1.33 mmol/L(2.20–2.65 mmol/L),ionized calcium at 0.69 mmol/L(1.15–1.29 mmol/L),and parathyroid hormone at<1.0 pg/mL(12–88 pg/mL).Echocardiography revealed an ejection fraction of 28.48%.Cardiac function was quickly reversed by restoring the serum calcium *** improvements were noted with an ejection fraction of up to 48.50%at *** For patients with potential hypocalcemia,monitoring calcium levels and dealing with hypocalcemia in time to avoid serious complications are important.

关键词： Hypoparathyroidism Congestive heart failure Cardiomyopathy Parathyroid hormone Calcium Echocardiography Case report

Changes and significance of serum troponin in trauma patients: A retrospective study in a level I trauma center

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World Journal of Emergency Medicine 2022年第1期13卷 27-31页

作者： Li-wen Dou Zhe Du Ji-hong Zhu tian-bing wang Emergency Department Peking University People’s HospitalBeijing 100044China Trauma Center Peking University People’s HospitalBeijing 100044China

BACKGROUND: Elevated troponin I(TnI) is common among trauma patients. TnI is an indicator of myocardial injury, but clinical diagnosis of blunt cardiac injury cannot be based solely on an increase in TnI. Therefore, this study aims to explore the changes and clinical significance of serum TnI in trauma patients. METHODS: The clinical data of consecutive trauma patients admitted to our trauma center between July 1, 2017 and July 31, 2020 were retrospectively analyzed. According to TnI levels within 24 hours of admission, patients were divided into the elevated and normal TnI groups. According to the TnI levels after 7 days of admission, a graph depicting a change in trend was drawn and then analyzed whether TnI was related to in-hospital mortality. RESULTS: A total of 166 patients(69 and 97 cases with elevated and normal TnI, respectively) were included in this study. The average hospital stay, intensive care time, mechanical ventilation time, and in-hospital mortality were higher in the elevated TnI group than in the normal TnI group(P<0.05). The TnI level of trauma patients gradually increased after admission and peaked at 48 hours(7.804±1.537 ng/mL). Subsequently, it decreased, and then recovered to normal within 7 days. However, 13 patients did not recover. Logistic regression analysis revealed that abnormal TnI at 7 days was independently related to in-hospital mortality. CONCLUSIONS: Trauma patients with elevated TnI levels may have a worse prognosis. Monitoring the changes in serum TnI is important, which can reflect the prognosis better than the TnI measured immediately after admission.

关键词： Trauma Blunt cardiac injury Troponin I Electrocardiography

Growth of Nano-Sb_2O_3 on Mica Substrates and Flame Retardant Properties

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Journal of China University of Mining and Technology 2006年第3期16卷 266-269页

作者： FENG Li LIU Jiong-tian wang bing-guo SONG Shuo-jiang School of Chemical Engineering and Technology China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

In this paper, the Sb2O3 nanoparticles prepared with SbCl3 by the alky hydrolysis, processed with the surfactants, were assembled on mica substrates. The morphology and the assembled behavior of the nano-Sb2O3 on the mica were analyzed by means of TEM. The flame retardant properties of nano-Sb2O3 and Sb2O3/mica complex were studied by combustion test and thermal analysis. The results show that the Sb2O3 nanoparticles are assembled uniformly on the mica substrates. The nano-Sb2O3 was characterized with small size, narrow size distribution, uniform crystal and monodispersed particles. Compared with nano-Sb2O3, the Sb2O3/mica complexes have been achieved the same coordinated effects with Chlorinated Paraffin(CP) and excellent flame retardant properties.

关键词： Sb2O3 nanoparticle mica flame retardant chlorinated-paraffin

Anterior subcutaneous transposition of the ulnar nerve improves neurological function in patients with cubital tunnel syndrome

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Neural Regeneration Research 2015年第10期10卷 1690-1695页

作者： Wei Huang Pei-xun Zhang Zhang Peng Feng Xue tian-bing wang Bao-guo Jiang Department of Trauma and Orthopedics Peking University People’s Hospital

Although several surgical procedures exist for treating cubital tunnel syndrome, the best surgical option remains controversial. To evaluate the efficacy of anterior subcutaneous transposition of the ulnar nerve in patients with moderate to severe cubital tunnel syndrome and to analyze prognostic factors, we retrospectively reviewed 62 patients（65 elbows） diagnosed with cubital tunnel syndrome who underwent anterior subcutaneous transposition. Preoperatively, the initial severity of the disease was evaluated using the Mc Gowan scale as modified by Goldberg： 18 patients（28%） had grade IIA neuropathy, 20（31%） had grade IIB, and 27（42%） had grade III. Postoperatively, according to the Wilson ＆ Krout criteria, treatment outcomes were excellent in 38 patients（58%）, good in 16（25%）, fair in 7（11%）, and poor in 4（6%）, with an excellent and good rate of 83%. A negative correlation was found between the preoperative Mc Gowan grade and the postoperative Wilson ＆ Krout score. The patients having fair and poor treatment outcomes had more advanced age, lower nerve conduction velocity, and lower action potential amplitude compared with those having excellent and good treatment outcomes. These results suggest that anterior subcutaneous transposition of the ulnar nerve is effective and safe for the treatment of moderate to severe cubital tunnel syndrome, and initial severity, advancing age, and electrophysiological parameters can affect treatment outcome.

关键词： nerve regeneration peripheral nerve injury ulnar nerve compression syndrome age motor nerve conduction velocity electrophysiology sensory nerve conduction velocity modified Mc Gowan scale Wilson & Krout criteria anterior transposition ulnar nerve NSFC grant neural regeneration

Exploratory COVID-19 death risk score based on basic laboratory tests and physiological clinical measurements

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World Journal of Emergency Medicine 2022年第6期13卷 453-458页

作者： Gui-ying Dong Fei-fei Jin Qi Huang Chun-bo Wu Ji-hong Zhu tian-bing wang Emergency Department Peking University People’s HospitalBeijing 100044China Trauma Center Peking University People’s HospitalKey Laboratory of Trauma and Neural Regeneration(PekingUniversity)Ministry of EducationBeijing100044China Department of Endocrinology and Metabolism Peking University People’s HospitalBeijing100044China

BACKGROUND:In the event of a sudden shortage of medical resources,a rapid,simple,and accurate prediction model is essential for the 30-day mortality rate of patients with ***:This retrospective study compared the characteristics of the survivals and non-survivals of 278 patients with *** regression analysis was performed to obtain the“COVID-19 death risk score”(CDRS)*** the area under the receiver operating characteristic(AUROC)curve and Hosmer-Lemeshow goodness-of-fit test,discrimination and calibration were *** validation was conducted using a regular bootstrap ***:A total of 63(22.66%)of 278 included patients *** logistic regression analysis revealed that high-sensitivity C-reactive protein(hsCRP;odds ratio[OR]=1.018),D-dimer(OR=1.101),and respiratory rate(RR;OR=1.185)were independently associated with 30-day *** was calculated as follows:CDRS=−10.245+(0.022×hsCRP)+(0.172×D-dimer)+(0.203×RR).CDRS had the same predictive effect as the sequential organ failure assessment(SOFA)and“confusion,uremia,respiratory rate,blood pressure,and age over 65 years”(CURB-65)scores,with AUROCs of 0.984 for CDRS,0.975 for SOFA,and 0.971 for CURB-65,*** CDRS showed good *** AUROC through internal validations was 0.980(95%confidence interval[CI]:0.965-0.995).Regarding the clinical value,the decision curve analysis of CDRS showed a net value similar to that of CURB-65 in this ***:CDRS is a novel,efficient and accurate prediction model for the early identification of COVID-19 patients with poor *** it is not as advanced as the other models,CDRS had a similar performance to that of SOFA and CURB-65.

关键词： COVID-19 30-day mortality Prediction model

One-stage human acellular nerve allograft reconstruction for digital nerve defects

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Neural Regeneration Research 2015年第1期10卷 95-98页

作者： Xue-yuan Li Hao-liang Hu Jian-rong Fei Xin wang tian-bing wang Pei-xun Zhang Hong Chen Department of Hand Surgery Ningbo No.6 Hospital Department of Trauma and Orthopedics Peking University People’s Hospital

Human acellular nerve allografts have a wide range of donor origin and can effectively avoid nerve injury in the donor area. Very little is known about one-stage reconstruction of digital nerve defects. The present study observed the feasibility and effectiveness of human acellular nerve allograft in the reconstruction of 〈 5-cm digital nerve defects within 6 hours after injury. A total of 15 cases of nerve injury, combined with nerve defects in 18 digits from the Department of Emergency were enrolled in this study. After dehridement, digital nerves were reconstructed using human acellular nerve allografts. The patients were followed up for 6-24 months after reconstruction. Mackinnon-Dellon static two-point discrimination results showed excellent and good rates of 89%. Semmes-Weinstein monofilament test demonstrated that light touch was normal, with an obvious improvement rate of 78%. These findings confirmed that human acellular nerve allograft for one-stage reconstruction of digital nerve defect after hand injury is feasible, which provides a novel trend for peripheral nerve reconstruction.

关键词： nerve regeneration peripheral nerve allograft digital nerve nerve conduit nerve recon-struction nerve defect sensory nerve neural regeneration

Identifying critically ill patients at risk of death from coronavirus disease

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World Journal of Emergency Medicine 2021年第1期12卷 18-23页

作者： Wei Guo Lin-yu Ran Ji-hong Zhu Qing-gang Ge Zhe Du Fei-long wang Wei-bo Gao tian-bing wang Trauma Center Peking University People's HospitalBeijing 100044China Department of Pulmonary and Critical Care Medicine Shanghai East HospitalTongji UniversityShanghai 200120China Department of Emergency Peking University People's HospitalBeijing 100044China Department of Critical Care Unit Peking University Third HospitalBeijing 100191China

BACKGROUND:A pandemic of coronavirus disease(COVID-19)has been declared by the World Health Organization(WHO)and caring for critically ill patients is expected to be at the core of battling this ***,little is known regarding an early detection of patients at high risk of ***:This retrospective cohort study recruited consecutive adult patients admitted between February 8 and February 29,2020,to the three intensive care units(ICUs)in a designated hospital for treating COVID-19 in *** detailed clinical information and laboratory results for each patient were *** primary outcome was in-hospital *** predictors were analyzed for possible association with outcomes,and the predictive performance of indicators was assessed from the receiver operating characteristic(ROC)***:A total of 121 critically ill patients were included in the study,and 28.9%(35/121)of them died in the *** non-survivors were older and more likely to develop acute organ dysfunction,and had higher Sequential Organ Failure Assessment(SOFA)and quick SOFA(qSOFA)*** the laboratory variables on admission,we identifi ed 12 useful biomarkers for the prediction of in-hospital mortality,as suggested by area under the curve(AUC)above *** AUCs for three markers neutrophilto-lymphocyte ratio(NLR),thyroid hormones free triiodothyronine(FT3),and ferritin were 0.857,0.863,and 0.827,*** combination of two easily accessed variables NLR and ferritin had comparable AUC with SOFA score for the prediction of in-hospital mortality(0.901 vs.0.955,P=0.085).CONCLUSIONS:Acute organ dysfunction combined with older age is associated with fatal outcomes in COVID-19 *** biomarkers could be used as powerful predictors for the in-hospital mortality.

关键词： Coronavirus disease Neutrophil-to-lymphocyte ratio Mortality Predictor

Electrical stimulation does not enhance nerve regeneration if delayed after sciatic nerve injury: the role of fibrosis

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Neural Regeneration Research 2015年第1期10卷 90-94页

作者： Na Han Chun-gui Xu tian-bing wang Yu-hui Kou Xiao-feng Yin Pei-xun Zhang Feng Xue Department of Trauma and Orthopedics Peking University People’s Hospital

Electrical stimulation has been shown to accelerate and enhance nerve regeneration in sensory and motor neurons after injury, but there is little evidence that focuses on the varying degrees of fibrosis in the delayed repair of peripheral nerve tissue. In this study, a rat model of sciatic nerve transec- tion injury was repaired with a biodegradable conduit at 1 day, 1 week, 1 month and 2 months after injury, when the rats were divided into two subgroups. In the experimental group, rats were treated with electrical stimuli of frequency of 20 Hz, pulse width 100 ms and direct current voltage of 3 V; while rats in the control group received no electrical stimulation after the conduit operation. His- tological results showed that stained collagen fibers comprised less than 20% of the total operated area in the two groups after delayed repair at both 1 day and 1 week but after longer delays, the collagen fiber area increased with the time after injury. Immunohistochemical staining revealed that the expression level of transforming growth factor ~ （an indicator of tissue fibrosis） decreased at both 1 day and 1 week after delayed repair but increased at both 1 and 2 months after delayed repair. These findings indicate that if the biodegradable conduit repair combined with electrical stimulation is delayed, it results in a poor outcome following sciatic nerve injury. One month after injury, tissue degeneration and distal fibrosis are apparent and are probably the main reason why electrical stimulation fails to promote nerve regeneration after delayed repair.

关键词： nerve regeneration peripheral nerve injury electrical stimulation bioabsorbableconduit delayed repair fibroblast collagen fibers transforming growth factor ~ Masson staining neuroprotection immunohistochemistry NSFC grants neural regeneration