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Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy

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Chinese Chemical Letters 2024年第8期35卷 205-210页

作者： Zhe Li Ping-Zhao Liang Li Xu Fei-Yu Yang tian-bing ren Lin Yuan Xia Yin Xiao-bing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China

Photodynamic therapy(PDT)has emerged as a significant cancer therapy ***,cation-based organic small molecule aggregation-induced emission(AIE)photosensitizers(PSs)attract the wide atten-tion of many scientists,due to improved reactive oxygen species(ROS)production after ***,such PSs tend to localize only the mitochondria,limiting the death way of tumor cells(usu-ally apoptosis)during PDT process,which may affect the therapeutic effect under some ***,we designed a novel water-soluble three positive charge PS,TPAN-18F,which could be distributed uniformly in cell cytoplasm and had distribution in different sub-organelles(mitochondria,endoplasmic reticulum,lysosome).The experimental results showed that TPAN-18F-based PDT process can not only disrupt mitochondrial functions(reducing ATP production and destroying mitochondrial membrane po-tential),but also elevate the intracellular lipid peroxides(LPOs)level,which evoke the non-apoptotic death manner of tumor ***,in vivo studies showed that TPAN-18F-based PDT could effectively inhibit tumor ***,we believe that the construction of TPAN-18F is suggestive for tumor non-apoptotic therapy.

关键词： Water-soluble Three positive charge Photosensitizer Nonapoptotic Tumor therapy

An Integration Strategy to Develop Dual-State Luminophores with Tunable Spectra,Large Stokes Shift,and Activatable Fluorescence for High-Contrast Imaging

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CCS Chemistry 2022年第6期4卷 2153-2164页

作者： Yongchao Liu Lili Teng Chengyan Xu tian-bing ren Shuai Xu Xiaofeng Lou Lin Yuan Xiao-bing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringCollaborative Innovation Center for Chemistry and Molecular MedicineHunan UniversityChangsha 410082

Developing dual-state luminophores(DSLs)with strong fluorescence in both the monomer and aggregate states is urgently needed but remains a huge challenge because most current luminophores are either aggregation-induced emission or aggregation-caused quenching ***,limited by the structural conservation of the few existing DSLs,there are not enough response sites that can be used to customize various activatable fluorescent probes for specific molecular ***,we engineered a general integration strategy for the fabrication of such DSLs with excellent photophysical *** DSLs,with their tunable spectra,a large Stokes shift(>170 nm),and achievable near-infrared(NIR)emission,show great potential for high-contrast ***,DSLs can be used as a universal platform for probe customization due to their activatable fluorescence through protection-deprotection of the phenolic hydroxyl *** on this,an NIR fluorescent probe DSL-Gal was developed for sensing of β-galactosidase in solutions,senescent cells,and liver metastases with high contrast,further confirming the superiority and universal feasibility of DSLs in probe *** integration strategy may provide a novel approach for the generation of other DSLs and have great potential applications in bioimaging.

关键词： dual-state luminophores probe customization probe platform enzyme activity high-contrast imaging

有序组装型荧光小分子探针及其生物成像应用研究进展

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中国科学：化学 2022年第9期52卷 1462-1475页

作者：娄霄峰任天兵徐帅袁林张晓兵湖南大学化学化工学院化学生物传感与计量学国家重点实验室长沙410082

基于小分子探针的荧光成像分析具有灵敏度高、操作简便、响应速度快、样本损伤小和时空分辨率高等优势,是在细胞和活体水平获取生化信息的有力手段.其中,有序组装型小分子荧光探针以其独特的组装方式和识别模式,表现出比传统小分子荧光... 详细信息

基于小分子探针的荧光成像分析具有灵敏度高、操作简便、响应速度快、样本损伤小和时空分辨率高等优势,是在细胞和活体水平获取生化信息的有力手段.其中,有序组装型小分子荧光探针以其独特的组装方式和识别模式,表现出比传统小分子荧光探针更优异的成像性能(如抗扩散能力强、成像对比度高、光稳定性好以及环境干扰小等),从而引起研究工作者的广泛关注.本文总结了几类常见的有机染料聚集体及相应小分子荧光探针在生物成像领域的应用.随后,着重介绍了以2-(2-羟基苯基)-4(1H)-喹唑啉酮(HPQ)及其衍生物为代表的氢键驱动有序组装的有机染料组装体的设计、优化策略及其在生物医学领域应用中的最新进展.最后,对有序组装型荧光小分子探针在设计和应用方面存在的问题进行了讨论,为新型有序组装型荧光小分子探针的设计提供了思路.

关键词：荧光探针自组装有机染料组装体荧光成像

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Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

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Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui ren tian Li Xueer Liu Zelin Zhang Xiaoxuan Chen Weiqiang Chen Kangsheng Li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang tian Sanqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia tian Yanmei Zhao Wenjie ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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环糊精及其衍生物在有机合成中的应用

应用化工 2017年第11期46卷 2232-2235页

作者：田秉仁褚慧敏赵甜黄青王志忠宁夏医科大学药学院宁夏银川750004 宁夏医科大学回医药现代化省部共建教育部重点实验室宁夏银川750004

综述了环糊精及其衍生物在各种有机化学反应中的应用,包括氧化、还原、取代、加成、光催化反应。最后从有机绿色合成的角度,展望了环糊精在有机合成的发展方向。

关键词：环糊精有机合成催化绿色化学

Engineering an asymmetric rhodamine dye suitable for developing ratiometric fluorescent probe

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Smart Molecules

Smart Molecules 2023年第1期1卷 91-96页

作者： Feiyu Yang Peng Lu tian-bing ren Xiao-bing Zhang Lin Yuan State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangshaChina

Fluorescent probes based on rhodamine skeleton are extensively used in biological ***,the construction of ratiometric fluorescent probes based on the rhodamine skeleton without introducing additional fluorophores is still ***,we propose an effective method to construct a rhodamine-based ratiometric fluorescent probe through the regulation of electron cloud density.A ratiometric fluorescent probe RDQF-RB-NTR was successfully constructed for the detection of nitroreductase(NTR).RDQF-RB-NTR exhibits good sensitivity,high selectivity,and ratiometric response to *** imaging experiments showed that RDQF-RB-NTR can rapidly and accurately detect the fluctuation of NTR in cells and difference of NTR levels between normal cells and cancer *** addition,RDQF-RB-NTR was successfully applied to the imaging of NTR in liver tissue slices,and we found that the level of NTR was upregulated in liver cirrhosis.

关键词： fluorescent probe imaging nitroreductase ratiometric probe rhodamine

Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue ren Ying Tang Qi Yang tian-tian Meng Song Li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

基于N∶N网络的斜井跑车防护装置组态监控系统

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安徽理工大学学报（自然科学版） 2016年第5期36卷 30-34页

作者：马天兵杜菲任明远丁雪松安徽理工大学机械工程学院安徽淮南232001

针对斜井运输中跑车事故具有突发性、严重性等特点,设计了一种基于N∶N网络和MCGS组态软件的三档跑车防护装置监控系统,采用三菱FX系列PLC组建N∶N网络实现对输入信号的处理和控制信号的输出,上位机通过MCGS组态软件搭建监视系统,实现... 详细信息

针对斜井运输中跑车事故具有突发性、严重性等特点,设计了一种基于N∶N网络和MCGS组态软件的三档跑车防护装置监控系统,采用三菱FX系列PLC组建N∶N网络实现对输入信号的处理和控制信号的输出,上位机通过MCGS组态软件搭建监视系统,实现对整个运输系统的动态监控,安全可靠,自动化程度较高,在一定程度上预防了斜井跑车事故。

关键词：组态斜井跑车监控