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Nuclear Science and Techniques 2024年第1期35卷 18-33页

作者： Xi-Guang Cao Yan-Long Chang Kai Chen Emilio Ciuffoli Li-Min Duan Dong-liang Fang Chao-Song Gao Surja K.Ghorui Peng-Chong Hu Qiang Hu Si-yuan Huang Ze-yu Huang Lei Lang yu-Lan Li Zhi-Jie Li tian-yu liang Jun Liu Chen-Gui Lu Fa-Tai Mai yuan Mei Hao Qiu Xiang-Ming Sun Xiao-Xing Tang Hu-Lin Wang Qian-Ming Wang Le Xiao Mu-yun Xiao Jian-yu Xin Nu Xu Peng Yang Yi-Chen Yang Zhen Yang Zong-Yang yu Dong-liang Zhang Jun-Wei Zhang Cheng-Xin Zhao Dou Zhu NνDEx-100 collaboration Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Lanzhou University Lanzhou 730000China Central China Normal University Wuhan 430079China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Lawrence Berkeley National Laboratory BerkeleyCA 94720USA North China University of Water Resources and Electric Power Zhengzhou 450045China 不详

Observing nuclear neutrinoless double beta (0vββ) decay would be a revolutionary result in particle *** such a decay would prove that the neutrinos are their own antiparticles,help to study the absolute mass of neutrinos,explore the origin of their mass,and may explain the matter-antimatter asymmetry in our universe by lepton number *** propose developing a time projection chamber (TPC) using high-pressure ^(82)SeF_(6) gas and Topmetal silicon sensors for readout in the China Jinping Underground Laboratory (CJPL) to search for neutrinoless double beta decay of82Se,called the NvDEx *** being located at CJPL with the world’s thickest rock shielding,NvDEx combines the advantages of the high Qββ(2.996 MeV) of82Se and the TPC’s ability to distinguish signal and background events using their different topological *** makes NvDEx unique,with great potential for low-background and high-sensitivity 0 vββ***-100,a NvDEx experiment phase with 100 kg of SeF_(6)gas,is being built,with plans to complete installation at CJPL by *** report introduces 0 vββ physics,the NvDEx concept and its advantages,and the schematic design of NvDEx-100,its subsystems,and background and sensitivity estimation.

关键词： Neutrinoless double beta decay Time projection chamber ^(82)SeF_(6) China Jinping Underground Laboratory

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分布驱动无人车在极限工况下的稳定跟踪控制

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机械设计与制造 2024年第10期 126-132页

作者：严运兵黄博文唐学权田良宇武汉科技大学汽车与交通工程学院湖北武汉430065

针对分布式驱动无人车在低附着、高速的极限工况下行驶时偏离目标路径和失稳的现象,提出一种稳定-跟踪联合控制策略,策略包含路径跟踪控制和横向稳定控制,使无人车在提高跟踪精度的同时又使其稳定性得到保障。路径跟踪模块在汽车二自由... 详细信息

针对分布式驱动无人车在低附着、高速的极限工况下行驶时偏离目标路径和失稳的现象,提出一种稳定-跟踪联合控制策略,策略包含路径跟踪控制和横向稳定控制,使无人车在提高跟踪精度的同时又使其稳定性得到保障。路径跟踪模块在汽车二自由度模型的基础上,建立了最优LQR路径跟踪控制器,并引入前馈用以改善稳态误差,其次考虑误差变化的规律和路-车位置关系以及驾驶员预瞄模型,设计了改进的权重参数自适应LQR控制器;稳定性模块基于可以减小系统抖振的滑模模糊控制原理,并结合汽车稳定性参数的实际值与期望值的差值,求解出横摆力矩。其次在分配各轮转矩时建立约束条件,使得轮胎负荷率最小用以提升汽车的操纵稳定性。CarSim/Simulink仿真表明在高速、低附着的换道工况下,改进后的LQR控制器有效地改善跟踪误差,具有良好的鲁棒性。且在加入稳定性控制器后,横摆角速度与质心侧偏角的调节时间变短,极大改善了无人车在极限工况下的稳定性。

关键词：分布式驱动无人车自适应LQR控制极限工况跟踪横摆稳定性控制

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Review Article Li-current collector interface in lithium metal batteries

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Nano Research 2024年第10期17卷 8706-8728页

作者： tian-yu Wang Dingyi Zhao Keyue liang yuzhang Li Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA

Interfaces within batteries,such as the widely studied solid electrolyte interface(SEI),profoundly influence battery *** these interfaces,the solid-solid interface between electrode materials and current collectors is crucial to battery performance but has received less discussion and *** review highlights the latest research advancements on the solid-solid interface between lithium metal(the next-generation anode)and current collectors(typically copper),focusing on factors affecting the Li-current collector interface and improvement strategies from perspectives of current collector substrate(lithiophilicity,crystal facets,mechanical properties,and topological structure),electrolyte chemistry,current density,stacking pressure,SEI,electric field and temperature,and provides a future directions and opportunities on this topic.

关键词： lithium metal anode current collectors Li-current collector interface solid-solid interface improvement strategies

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Current status and prospects of basic research and clinical application of mesenchymal stem cells in acute respiratory distress syndrome

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World Journal of Stem Cells 2023年第4期15卷 150-164页

作者： tian-yu liang Li-Hai Lu Si-yu Tang Zi-Hao Zheng Kai Shi Jing-Quan Liu Emergency and Critical Care Center Intensive Care UnitZhejiang Provincial People's Hospital(Affiliated People's HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina Fourth School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina The Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Respiratory Medicine The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina

Acute respiratory distress syndrome(ARDS)is a common and clinically devastating disease that causes respiratory *** and mortality of patients in intensive care units are stubbornly high,and various complications severely affect the quality of life of *** pathophysiology of ARDS includes increased alveolar–capillary membrane permeability,an influx of protein-rich pulmonary edema fluid,and surfactant dysfunction leading to severe *** present,the main treatment for ARDS is mechanical treatment combined with diuretics to reduce pulmonary edema,which primarily improves symptoms,but the prognosis of patients with ARDS is still very *** stem cells(MSCs)are stromal cells that possess the capacity to self-renew and also exhibit multilineage *** can be isolated from a variety of tissues,such as the umbilical cord,endometrial polyps,menstrual blood,bone marrow,and adipose *** have confirmed the critical healing and immunomodulatory properties of MSCs in the treatment of a variety of ***,the potential of stem cells in treating ARDS has been explored via basic research and clinical *** efficacy of MSCs has been shown in a variety of in vivo models of ARDS,reducing bacterial pneumonia and ischemia-reperfusion injury while promoting the repair of ventilator-induced lung *** article reviews the current basic research findings and clinical applications of MSCs in the treatment of ARDS in order to emphasize the clinical prospects of MSCs.

关键词： Acute respiratory distress syndrome Mesenchymal stem cells Pulmonary edema Inflammatory response Tissue repair Pulmonary fibrosis

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DAIS: a method for identifying spatial domains based on density clustering of spatial omics data

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Journal of Genetics and Genomics 2024年第8期51卷 884-887页

作者： Qichao yu Ru tian Xin Jin liang Wu College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China BGI Research ShenzhenGuangdong 518083China BGI ResearchChongqing 401329China BGI Research ShenzhenGuangdong 518083China BGI Research Chongqing 401329China

In multicellular organisms,the spatial arrangement of cells profoundly influences the biological functions of tissues,underscoring the importance of identifying spatial domains in *** advancements in spatial omics,particularly spatial transcriptomics(ST)(Bressan et al.,2023),have enhanced our understanding of tissue spatial organization(Zhang et al.,2022;tian et al.,2023).

关键词： arrangement identifying domains

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Cr-assisted low-temperature densification of(Ti,Zr,Nb,Ta,Mo)C high-entropy carbides with ultrafine grain and enhanced hardness

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Journal of Advanced Ceramics 2024年第6期13卷 780-788页

作者： Yang Liu Jiaji liang Weiming Guo Shikuan Sun yu tian Hua-Tay Lin School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006China State Key Laboratory of High Performance Tools Guangdong University of TechnologyGuangzhou 510006China School of Material Science and Energy Engineering Foshan UniversityFoshan 528000China

While the use of low-melting-point metals as sintering aids for high-entropy carbide(HEC)ceramics has been well established,their existence can compromise hardness due to residual metallic *** study demonstrates an innovative strategy to meet this challenge,where(Ti,Zr,Nb,Ta,Mo)C high-entropy carbide ceramics with ultrafine grains and enhanced hardness are obtained through chromium(Cr)-metal-assisted spark plasma sintering(SPS)at a temperature as low as 1600℃.The results show that the addition of 5 vol%Cr promotes the formation of highly densified single HEC phase ceramics with a high relative density(98.4%)and an ultrafine-grained microstructure(0.17μm).This low-temperature densification mechanism can be attributed to Cr’s solid-solution effect within the matrix and the increased carbon vacancies generated during *** grain size of the(Ti,Zr,Nb,Ta,Mo)C ceramics with 5 vol%Cr metal addition is significantly smaller than that of Cr-free(Ti,Zr,Nb,Ta,Mo)C ceramics sintered at 2000℃(3.03μm)or via traditional low-temperature liquid-phase sintering(1.3–1.5μm).Importantly,the addition of 5 vol%Cr substantially increased the hardness of the ceramics,with a remarkable increase from 23.57 to 28.16 GPa compared to that of the pure(Ti,Zr,Nb,Ta,Mo)C ceramics,owing to the fine-grain strengthening and solid-solution strengthening *** work highlights the uniqueness of Cr metal as a sintering aid in achieving densification and hardness improvements in(Ti,Zr,Nb,Ta,Mo)C ceramics,offering a promising strategy for improving the properties of HEC materials for further development in the near future.

关键词： solid solution sinterability hardness enhancement (Ti,Zr,Nb,Ta,Mo)C high-entropy carbide(HEC)ceramics

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Polyelectrolyte Complexes and Coacervates Formed by De novo-Designed Peptides and Oligonucleotide

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Chinese Journal of Polymer Science 2024年第9期42卷 1333-1340,I0007页

作者： tian-Hao Ren De-Hai liang Beijing National Laboratory for Molecular Sciences Department of Polymer Science and Engineering and the Key Laboratory of Polymer Chemistry and Physics of the Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

The liquid-liquid phase separation of biopolymers in living cells contains multiple interactions and occurs in a dynamic *** the regulation mechanism is still a *** this work,we designed a series of peptides(XXLY)_(6)SSSGSS and studied their complexation and coacervation behavior with single-stranded ***“X”and“Y”are varied to combine known amounts of charged and non-charged amino acids,together with the introduction of secondary structures and pH *** show that the electrostatic interaction,which is described as charge density,controls both the strength of complexation and the degree of chain relaxation,and thus determines the growth and size of the *** hydrophobic interaction is prominent when the charges are ***,the secondary structures of peptides exhibit profound effect on the morphology of the phases,such as solid phase to liquid phase *** study gains insight into the phase separation under physiological *** is also helpful to create coacervates with desirable structures and functions.

关键词： Polyelectrolyte complex Coacervate Peptides Secondary structure Electrostatic interaction

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Analysis and experimental study on resistance-increasing behavior of composite high efficiency autonomous inflow control device

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Petroleum Science 2024年第2期21卷 1290-1304页

作者： liang-liang Dong yu-Lin Zhang School of Mechatronic Engineering Southwest Petroleum UniversityChengdu610500SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina Oil and Gas Equipment Technology Sharing and Service Platform of Sichuan ProvinceChengdu610500SichuanChina

Bottom water coning is the main reason to reduce the recovery of horizontal bottom water reservoir. By water coning, we mean the oil-water interface changes from a horizontal state to a mound-shaped cone and breaks through to the wellbore. Autonomous inflow control device(AICD) is an important instrument maintain normal production after bottom water coning, however, the resistance increasing ability of the swirl type AICD is insufficient at present, which seriously affects the water control effect. Aiming this problem, this paper designs a multi-stage resistance-increasing and composite type AICD. The separation mechanism of oil-water two phases in this structure, the resistance form of oil-water single phase and the resistance-increasing principle of water phase are analyzed. Establishing the dual-phase multi-stage separation and resistance-increasing model, and verified by measuring the throttling pressure drop and oil-water volume fraction of the AICD, it is found that the composite type AICD has the effect of ICD and AICD at the same time, which can balance the production rate of each well section at the initial stage of production, delay the occurrence of bottom water coning. In the middle and later stages of production, water-blocking can be effectively increased to achieve water control and stable *** structural sensitivity analysis, the influence law of various structural parameters on the water control performance of composite AICD was obtained. The simulation calculation results show that,compared with the existing swirl type AICD, composite AICD has higher sensitivity to moisture content,the water phase throttling pressure drop is increased by 4.5 times on average. The composite AICD is suitable for the entire stage of horizontal well production.

关键词： Water control Flow separation Flow resistance-increasing AICD device Simulation and experiment

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Glutamatergic neurons of piriform cortex delay induction of inhalational general anesthesia

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Fundamental Research 2024年第4期4卷 829-840页

作者： liang Zhou Qipeng Ran Rulan Yi Huanyao Tang yu Zhang tian yu Key Laboratory of Brain Science Zunyi Medical UniversityZunyi 563003China Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563003China Guizhou Key Laboratory of Anesthesia and Organ Protection Zunyi Medical UniversityZunyi 563003China

Since their clinical application in the 1840s,the greatest mystery surrounding general anesthesia(GA)is how different kinds of general anesthetics cause reversible unconsciousness,and the precise neural mechanisms underlying the *** past years,although many studies revealed the roles of cortex,thalamus,brainstem,especially the sleep-wake circuits in GA-induced loss of consciousness(LOC),the full picture of the neural circuit mechanism of GA is still largely *** studies have focused on the importance of other brain ***,we report that the activity of glutamatergic(Glu)neurons in the piriform cortex(PC),a critical brain region for odor encoding,began to increase during the LOC of GA and gradually recovered after recovery of *** lesions of the anterior PC(APC)neurons accelerated the induction time of isoflurane *** and optogenetic activation of APcGlu neurons prolonged isoflurane and sevoflurane anesthesia induction,whereas APcclu neuron inhibition displayed the opposite ***,the modification of APcclu neurons did not affect the induction or emergence time of propofol *** addition,odor processing may be partially involved in the induction of isoflurane and sevofurane GA regulated by APCclu *** conclusion,our findings reveal a critical role of APCGlu neurons in inhalational GA induction.

关键词： Piriform cortex Inhalationalgeneral anesthesia Glutamatergic Induction time odor

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Prediction of ball-on-plate friction and wear by ANN with data-driven optimization

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Friction 2024年第6期12卷 1235-1249页

作者： Alexander KOVALEV yu tian Yonggang MENG State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

For training artificial neural network(ANN),big data either generated by machine or measured from experiments are used as input to"learn"the unspecified functions defining the *** experimental data are fed directly into the optimizer allowing training to be performed according to a predefined loss *** predict sliding friction and wear at mixed lubrication conditions,in this study a specific ANN structure was so designed that deep learning algorithms and data-driven optimization models can be *** ball-on-plate friction and wear data were analyzed using the specific training procedure to optimize the weights and biases incorporated into the neural layers of the ANN,and only two independent experimental data sets were used during the ANN optimization *** the training procedure,the ANN is capable to predict the contact and hydrodynamic pressure by adapting the output data according to the tribological condition implemented in the optimization algorithm.

关键词： machine learning deep learning artificial neural network mixed lubrication

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