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非线性声场下包膜微泡动力学与频率响应分析

物理学报 2024年第7期73卷 224-231页

作者：索鼎杰纪镇祥黄晓雲靳杰闫天翼北京理工大学医学技术学院北京100081 北京理工大学前沿交叉科学研究院北京100081

包膜微泡在非线性声场下的响应对高强度聚焦超声治疗具有重要意义.本文通过耦合Gilmore-Akulichev-Zener模型与脂质包膜的非线性模型,采用KZK方程仿真非线性声场,分析在不同超声频率、不同声压以及不同包膜材料的黏弹性下的微泡动力学... 详细信息

包膜微泡在非线性声场下的响应对高强度聚焦超声治疗具有重要意义.本文通过耦合Gilmore-Akulichev-Zener模型与脂质包膜的非线性模型,采用KZK方程仿真非线性声场,分析在不同超声频率、不同声压以及不同包膜材料的黏弹性下的微泡动力学行为和微泡振荡频率,并进一步对比了实际测量声场与KZK方程仿真声场下的微泡动力学行为和频率响应.研究结果表明:非线性声场会导致微泡壁的瞬时运动速率减小,声压和频率的改变对微泡动力学的影响与在线性声场中类似;包膜材料的不同可以使振荡频率中的谐波分量发生改变,其中包膜材料的弹性对微泡的频率响应影响较小,包膜的初始黏性和初始表面张力对微泡的振荡频率分布影响较大,当初始黏性越小时,二次分谐波的峰值越高,当初始表面张力越大时,主频的峰值越高.本研究进一步阐明非线性超声激励包膜微泡的微泡动力学,为包膜微泡在非线性声场下的频率响应分析奠定理论基础.

关键词：微泡动力学非线性声场包膜微泡频率响应

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数据库参数配置智能调优研究综述

计算机学报 2024年第8期47卷 1901-1921页

作者：李奕言田季坤蒲照李翠平陈红中国人民大学信息学院北京100872 数据库与商务智能教育部工程研究中心北京100872 数据工程与知识工程教育部重点实验室北京100872

数据库系统具有大量的参数,这些参数控制了系统的内存分配、I/O优化、备份与恢复等诸多方面,极大地影响着数据库的性能.随着数据库和应用程序的规模和复杂性的增长,传统依靠数据库管理员手动配置参数的方式已经越来越难以满足用户需求.... 详细信息

数据库系统具有大量的参数,这些参数控制了系统的内存分配、I/O优化、备份与恢复等诸多方面,极大地影响着数据库的性能.随着数据库和应用程序的规模和复杂性的增长,传统依靠数据库管理员手动配置参数的方式已经越来越难以满足用户需求.数据库参数配置智能调优将机器学习技术应用到参数调优领域,依据负载信息、数据库参数和性能,借助机器学习算法推荐一组最优的参数.本文针对现有参数配置智能调优技术,从调优方法、应用情况和未来挑战三个方面依次进行梳理和总结.首先将现有参数调优方法依据所用算法不同分为五类,从原理、技术、优缺点等方面对各类方法进行详细介绍和总结.之后介绍当前工业界主流的参数调优工具,分析参数配置智能调优在实际应用过程中遇到的问题及原因.最后,本文对数据库参数配置智能调优的未来研究方向进行了展望.本文旨在帮助研究者掌握当前数据库参数配置智能调优领域主流方法及面临的问题,以推动后续研究工作的开展.

关键词：机器学习参数调优贝叶斯优化强化学习智能数据库

Tumour response following preoperative chemotherapy is affected by body mass index in patients with colorectal liver metastases

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 331-342页

作者： Hua-Chuan Song Hang-Cheng Zhou Ping Gu Bing Bao Quan Sun tian-Ming Mei Wei Cui Kang Yao Huan-Zhang Yao Shen-Yu Zhang Yong-Shuai Wang Rui-Peng Song ji-Zhou Wang Department of General Surgery Provincial Hospital Affiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Hepatobiliary Surgery The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Pathology The First Affiliated Hospital of University of Science and Technology of ChinaDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastrointestinal Surgery Tongcheng People’s HospitalTongcheng 231400Anhui ProvinceChina Department of Gastrointestinal Surgery Suzhou Hospital Affiliated to Anhui Medical UniversitySuzhou 234000Anhui ProvinceChina Department of General Surgery Xuancheng People’s HospitalXuancheng 242000Anhui ProvinceChina

BACKGROUND Colorectal cancer is the third most prevalent malignancy globally and ranks second in cancer-related mortality,with the liver being the primary organ of *** chemotherapy is widely recommended for initially or potentially resectable colorectal liver metastases(CRLMs).Tumour pathological response serves as the most important and intuitive indicator for assessing the efficacy of ***,the postoperative pathological results reveal that a considerable number of patients exhibit a poor response to preoperative *** mass index(BMI)is one of the factors affecting the tumori-genesis and progression of colorectal cancer as well as prognosis after various antitumour *** studies have indicated that overweight and obese patients with metastatic colorectal cancer experience worse prognoses than those with normal weight,particularly when receiving first-line chemotherapy regimens in combination with *** To explore the predictive value of BMI regarding the pathologic response following preoperative chemotherapy for *** A retrospective analysis was performed in 126 consecutive patients with CRLM who underwent hepatectomy following preoperative chemotherapy at four different hospitals from October 2019 to July *** and multivariate logistic regression models were applied to analyse potential predictors of tumour pathological *** Kaplan-Meier method with log rank test was used to compare progression-free survival(PFS)between patients with high and low ***<24.0 kg/m^(2) was defined as low BMI,and tumour regression grade 1-2 was defined as complete tumour *** Low BMI was observed in 74(58.7%)patients and complete tumour response was found in 27(21.4%)*** rate of complete tumour response was significantly higher in patients with low BMI(29.7%vs 9.6%,P=0.007).Multivariate analysis revealed that low BMI[odds ratio(OR)=4.56,95%confidence interval(CI):1

关键词： Colorectal liver metastases Body mass index Tumour regression grade Preoperative chemotherapy Hepatectomy

Recent advances in chemical protein synthesis:method developments and biological applications

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Science China Chemistry 2024年第4期67卷 1060-1096页

作者： Suwei Dong ji-Shen Zheng yiming Li Huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun Guo Chunmao He Honggang Hu Xuechen Li Yanmei Li Zigang Li Man Pan Shan Tang Changlin tian Ping Wang Bian Wu Chuanliu Wu Junfeng Zhao Lei Liu State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230027China School of Food and Biological Engineering Engineering Research Center of Bio-processMinistry of EducationHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Health Sciences Anhui UniversityHefei 230601China College of Chemistry Central China Normal UniversityWuhan 430079China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China School of Medicine or Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Chemistry The University of Hong KongHong Kong 999077China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Chemical Biology Shanghai Jiao Tong UniversityShanghai 200240China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China Department of Chemistry Xiamen UniversityXiamen 361005China School of Pharmaceutical Science Guangzhou Medical UniversityGuangzhou 511436China

The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and *** protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image *** review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic ***,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse *** applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further ***,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis.

关键词： chemical protein synthesis solid-phase peptide synthesis ligation reactions post-translational modifications mirror-image proteins peptide drugs

β-双亚胺稀土双烷基配合物催化邻甲氧基苯乙烯高间规聚合研究

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高分子学报 2024年第6期55卷 729-737页

作者：王田田孙碧玮吴春姬崔冬梅中国科学院长春应用化学研究所、高分子物理与化学国家重点实验室长春130022 中国科学技术大学应用化学与工程学院合肥230026

设计合成了一类氮原子上含脂肪族取代基的β-双亚胺的配体及其相应的稀土金属配合物1~3.在助催化剂有机硼盐和烷基铝的作用下,将配合物1~3用于催化邻甲氧基苯乙烯(oMOS)聚合中,制得了高间规选择性(rrrr‍>‍99%)聚合物,所得聚合物的玻璃... 详细信息

设计合成了一类氮原子上含脂肪族取代基的β-双亚胺的配体及其相应的稀土金属配合物1~3.在助催化剂有机硼盐和烷基铝的作用下,将配合物1~3用于催化邻甲氧基苯乙烯(oMOS)聚合中,制得了高间规选择性(rrrr‍>‍99%)聚合物,所得聚合物的玻璃化转变温度Tg为-90℃,熔点Tm为240℃.将配合物2用于催化异戊二烯(IP)均聚合,得到了以1,4-结构为主(含量约88.6%)的聚合物,玻璃化转变温度Tg为-57℃.此外,借助DFT理论计算,发现配位模式是决定邻甲氧基苯乙烯聚合物立体选择性的关键.

关键词：稀土催化剂高间规选择性邻甲氧基聚苯乙烯

Predictive value of NLR, Fib4, and APRI in the occurrence of liver failure after hepatectomy in patients with hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 155-165页

作者： tian-Zuo Kuang Meng Xiao Yong-Fan Liu Department of Hepatobiliary Surgery Ji’an Central People’s HospitalJi’an 343000Jiangxi ProvinceChina

BACKGROUND Neutrophil-lymphocyte ratio(NLR),fibrosis index based on four factors(Fib4),aspartate aminotransferase-to-platelet ratio index(APRI)can be used for prognostic evaluation of hepatocellular ***,no study has established an individualized prediction model for the prognosis of hepatocellular carcinoma based on these *** To screen the factors that affect the prognosis of hepatocellular carcinoma and establish a nomogram model that predicts postoperative liver failure after hepatic resection in patients with hepatocellular *** In total,220 patients with hepatocellular carcinoma treated in our hospital from January 2022 to January 2023 were *** were divided into 154 participants in the modeling cohort,and 66 in the validation *** analysis of the changes in NLR,Fib4,and APRI levels in 154 patients with hepatocellular carcinoma before liver resection and at 3 mo,6 mo,and 12 mo postoperatively was *** logistic regression to analyze the influencing factors on the occurrence of liver failure in hepatocellular carcinoma patients,roadmap prediction modeling,and validation,patient work characteristic curves(ROCs)to evaluate the predictive efficacy of the model,calibration curves to assess the consistency,and decision curve analysis(DCA)to evaluate the model’s validity were also *** Binary logistic regression showed that Child-Pugh grading,Surgical site,NLR,Fib4,and APRI were all risk factors for liver failure after hepatic resection in patients with hepatocellular *** modeling cohort built a column-line graph model,and the area under the ROC curve was 0.986[95%confidence in terval(CI):0.963-1.000].The patients in the validation cohort utilized the column-line graph to predict the probability of survival in the validation cohort and plotted the ROC curve with an area under the curve of the model of 0.692(95%CI:0.548-0.837).The deviation of the actual outcome curves from the c

关键词： Hepatocellular carcinoma Hepatic resection Liver failure Influencing factors Columnar graphs

让大学新生做好准备——斯坦福入门研究暑期项目的教育理念、实践举措与实施成效解析

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现代大学教育 2024年第4期40卷 49-57页

作者：田吉王保星华东师范大学教育学系上海260002

就大学生自身成长和大学本科教育目标的实现而言,让大学新生为大学生活做好准备至关重要。作为斯坦福入门研究暑期项目的重要组成部分,利兰德学者计划和大二学院项目积极践行研究与教学统一的教育理念,有效地回应了大学一年级学习前后... 详细信息

就大学生自身成长和大学本科教育目标的实现而言,让大学新生为大学生活做好准备至关重要。作为斯坦福入门研究暑期项目的重要组成部分,利兰德学者计划和大二学院项目积极践行研究与教学统一的教育理念,有效地回应了大学一年级学习前后不同阶段的发展需要。利兰德学者计划在大一开始前实施,聚焦大学生活适应问题,围绕“问题解决”开展课程和研究,促进师生沟通和大学生学习思维训练;大二学院项目则在大一结束后开展,关注专业兴趣探索,在专一主题的探究实践中展开思想交流和反思。以二者为组成要素的斯坦福入门研究暑期项目虽在规模化发展上面临多重挑战,但是,它有效平衡教学与研究的关系,推动自由教育,助力大学新生快速适应大学生活,为学生投身高效的大学学习、实现本科教育目标提供了基础性保障。

关键词：斯坦福大学大学新生斯坦福入门研究学习准备利兰德学者计划大二学院项目

Single-center retrospective study of the diagnostic value of doubleballoon enteroscopy in Meckel’s diverticulum with bleeding

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1043-1054页

作者： tian He Chao Yang jing Wang ji-Sheng Zhong Ai-Hua Li Ya-jing yin Li-Ling Luo Chun-Mei Rao Nian-Fen Mao Qiang Guo Zan Zuo Wen Zhang Ping Wan Yunnan Digestive Endoscopy Clinical Medical Center Department of GastroenterologyThe First People’s Hospital of Yunnan ProvinceThe Affiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Medicine Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina School of Medicine Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina Department of Gastroenterology Qujing Hospital of Traditional Chinese MedicineQujing 655000Yunnan ProvinceChina Department of Gastroenterology Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina

BACKGROUND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract ***,we aimed to evaluate the value of double-balloon enteroscopy(DBE)in MD diagnosis and the prognosis after laparoscopic diverticula *** To evaluate the value of DBE in the diagnosis and the prognosis after laparoscopic diverticula resection for MD with *** The study retrospectively analyzed relevant data from 84 MD patients treated between January 2015 and March 2022 and recorded their clinical manifestations,auxiliary examination,and follow-up after laparoscopic resection of ***(1)Among 84 MD patients complicated with hemorrhage,77 were male,and 7 were female with an average age of 31.31±10.75 *** incidence was higher in men than in women of different ages;(2)Among the 84 MD patients,65(78.40%)had defecated dark red stools,and 50(58.80%)had no accompanying symptoms during bleeding,indicating that most MD bleeding appeared a dark red stool without accompanying symptoms;(3)The shock index of 71 patients(85.20%)was30%;(4)The DBE-positive rate was 100%(54/54),99mTcpertechnetate-positive scanning rate was 78%(35/45)compared with capsule endoscopy(36%)and small intestine computed tomography(19%).These results suggest that DBE and 99mTc-pertechnetate scans had significant advantages in diagnosing MD and bleeding,especially DBE was a highly precise examination method in MD diagnosis;(5)A total of 54 MD patients with hemorrhage underwent DBE examination before *** endoscopy revealed many mucosal manifestations including normal appearance,inflammatory changes,ulcerative changes,diverticulum inversion,and nodular hyperplasia,with ulcerative changes being the most common(53.70%).This suggests that diverticular mucosal u

关键词： Meckel’s diverticulum with bleeding Double-balloon colonoscopy 99mTc-pertechnetate scanning Capsule endoscopy Ectopic gastric mucosa

从地方性概念出发:环境传播研究的学理路径转向——基于跨地方主义的理论视角

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编辑之友 2024年第4期 80-87页

作者：纪莉可天浩武汉大学新闻与传播学院湖北武汉430070

环境议题的全球关切性和地方现实性矛盾,导致全球抑或地方的二元分析路径已不再适用。而跨地方主义所具有的勾连、融合和重构特征,有望弥合全球与地方间的理论断裂。基于此,文章以跨地方主义介入环境传播的研究为核心,围绕这一概念的理... 详细信息

环境议题的全球关切性和地方现实性矛盾,导致全球抑或地方的二元分析路径已不再适用。而跨地方主义所具有的勾连、融合和重构特征,有望弥合全球与地方间的理论断裂。基于此,文章以跨地方主义介入环境传播的研究为核心,围绕这一概念的理论溯源、价值勾连和影响作用等展开讨论。研究发现,跨地方主义在关系连接、公共互构和政治内嵌三个方面对环境传播发挥着重要作用,展现出空间性的理解视域变迁,呈现出空间实践、空间表象和表征性空间等价值维度。

关键词：跨地方主义环境传播学理路径