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Atom-referenced and stabilized soliton microcomb

Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 2-8页

作者： Rui Niu Shuai Wan tian-peng hua Wei-Qiang Wang Zheng-Yu Wang Jin Li Zhu-Bo Wang Ming Li Zhen Shen Yu Robert Sun Shui-Ming Hu Brent ELittle Sai Tak Chu Wei Zhao Guang-Can Guo Chang-Ling Zou Yun-Feng Xiao Wen-Fu Zhang Chun-hua Dong State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China University of Chinese Academy of Sciences Beijing 100049China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Department of Physics and Materials Science City University of Hong KongHong Kong 999077China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano-optoelectronics School of PhysicsPeking UniversityBeijing 100871China

For the applications of the frequency comb in microresonators,it is essential to obtain a fully frequency-stabilized microcomb laser *** this study,we present a system for generating a fully atom-referenced stabilized soliton *** pump light around 1560.48 nm is locked to an ultra-low-expansion(ULE)*** pump light is then frequency-doubled and referenced to the atomic transition *** repetition rate of the soliton microcomb is injection-locked to an atomic-clockstabilized radio frequency(RF)source,leading to mHz stabilization at 1 *** a result,all comb lines have been frequencystabilized based on the atomic reference and the ULE cavity,achieving a very high precision of approximately 18 Hz at 1 s,corresponding to the frequency stability of 9.5×10^(-14).Our approach provides a fully stabilized microcomb experiment scheme with no requirement of f-2f technique,which could be easily implemented and generalized to various photonic platforms,thus paving the way towards the ultraprecise optical sources for high precision spectroscopy.

关键词： microcavity frequency comb dissipative Kerr solitons fully stabilized microcomb

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Electrochemical anodic oxidation assisted fabrication of memristors

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International Journal of Extreme Manufacturing 2024年第3期6卷 250-272页

作者： Shuai-Bin hua tian Jin Xin Guo School of Materials Science and Engineering State Key Laboratory of Material Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China

Owing to the advantages of simple structure,low power consumption and high-density integration,memristors or memristive devices are attracting increasing attention in the fields such as next generation non-volatile memories,neuromorphic computation and data ***,the deposition of memristive films often requires expensive equipment,strict vacuum conditions,high energy consumption,and extended processing *** contrast,electrochemical anodizing can produce metal oxide films quickly(e.g.10 s) under ambient *** means of the anodizing technique,oxide films,oxide nanotubes,nanowires and nanodots can be fabricated to prepare *** film thickness,nanostructures,defect concentrations,etc,can be varied to regulate device performances by adjusting oxidation parameters such as voltage,current and *** memristors fabricated by the anodic oxidation technique can achieve high device consistency,low variation,and ultrahigh yield *** article provides a comprehensive review of the research progress in the field of anodic oxidation assisted fabrication of ***,the principle of anodic oxidation is introduced;then,different types of memristors produced by anodic oxidation and their applications are presented;finally,features and challenges of anodic oxidation for memristor production are elaborated.

关键词： anodic oxidation anodized aluminium oxide memristor resistive switching electrical properties

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Betaine addition to the diet alleviates intestinal injury in growing rabbits during the summer heat through the AAT/mTOR pathway

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1623-1637页

作者： Zimei Li Junning Pu Xiang Chen Yanbin Chen Xiaoyan peng Jingyi Cai Gang Jia hua Zhao Gang tian Animal Nutrition Institute Sichuan Agricultural UniversityChengduSichuan 611130China

Background The aim of this experiment was to investigate the effect of different levels of betaine(Bet)inclusion in the diet on the intestinal health of growing rabbits under summer heat.A total of 100 weaned Qixing meat rabbits aged 35 d with body weight of 748.61±38.59 g were randomly divided into 5 treatment groups:control group(basal diet)and Bet groups(basal diet+0.75,1.0,1.5 or 2.0 g/kg Bet).The average daily temperature in the rabbitry during the experiment was 30.48°C and the relative humidity was 69.44%.Results Dietary addition of Bet had no significant effect on growth performance and health status of growing rabbits(P>0.05),but it increased ileal secretory immunoglobulin A content compared to the control under summer heat(P<0.05).Addition of 0.75 g/kg Bet up-regulated jejunal IL-4,down-regulated ileal TNF-αexpression(P<0.05).The addition of 1.0 g/kg Bet increased the villi height(VH)in the jejunum(P<0.05).Serum glucose levels were reduced,and the expression of SLC6A20 was up-regulated in jejunum and ileum of rabbits fed with 1.5 g/kg Bet(P<0.05).When added at 2.0 g/kg,Bet reduced serum HSP70 content,increased jejunal VH,and up-regulated duodenal SLC7A6,SLC38A2,mTOR and 4EBP-2 expression(P<0.05).Correlation analysis revealed that intestinal mTOR expression was significantly and positively correlated with SLC7A6,SLC38A2,SLC36A1 and IL-4 expression(P<0.05).Conclusions Dietary addition of Bet can up-regulate the expression of anti-inflammatory factors through the AAT/mTOR pathway,improve the intestinal immune function,alleviate intestinal damage in growing rabbits caused by summer heat,and improve intestinal health.

关键词： AAT/mTOR Betaine Growing rabbits Intestinal injury Summer heat

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Fabrication of Molecularly Imprinted Electrospun Nanofibers with Mono-amidoxime Functional Ligand for Efficient Decontamination of Toxic Organophosphates

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Chinese Journal of Polymer Science 2024年第4期42卷 446-456页

作者： Lan Wang peng Jiang Ya-Lin Niu Jun-peng Cao tian-Ying Guo Key Laboratory of Functional Polymer Materials Ministry of EducationInstitute of Polymer ChemistryCollege of Chemistry and Frontier Science Center for the Creation of New Organic SubstancesNankai UniversityTianjin300071China

There is an urgent imperative to discover practical and efficacious artificial catalysts for the expeditious decontamination of toxic organophosphates. Herein, we propose a novel molecularly imprinted approach utilizing electrospun fiber scaffolds. Specifically, an amidoxime-based functional polymer (PMAOX) has been synthesized, which contains amidoxime groups that can act as nucleophiles and ligands for the formation of catalytic active sites. This polymer was blended with polyacrylonitrile (PAN), a well-processable material, to prepare a nanofiber mat using electrospinning techniques. Then, the amidoxime side groups on fiber surface were further cross-linked after the molecular coordination of templates to complete the molecularly imprinting process. This approach can not only enhance the content of functional molecularly imprinted polymers without affecting structural stability, but also combines surface MI technology to fully expose and leverage the advantages of active sites. The as prepared molecularly imprinted electrospun nanofibers MIF-Zn-PMAOX/PAN-6/4 catalyzes the degradation of paraoxon with a half-life of 32 min, and MIF-Ag-PMAOX/PAN catalyzes the degradation of parathion with a half-life of 18 min. The maximum catalytic rate evidence rate enhancements nearly 3700-fold of the self-hydrolysis. Thus, the mono-amidoxime based molecularly imprinted fibers demonstrate the versatility and superiority as self-detoxifying for organophosphates.

关键词： Organophosphateshydrolysis Electrospinning Molecular imprinting

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Development of SV2A Ligands for Epilepsy Treatment:A Review of Levetiracetam,Brivaracetam,and Padsevonil

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Neuroscience Bulletin 2024年第5期40卷 594-608页

作者： peng-peng Wu Bi-Rong Cao Fu-Yun tian Zhao-Bing Gao Center for Neurological and Psychiatric Research and Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan528400China

Epilepsy is a common neurological disorder that is primarily treated with antiseizure medications(ASMs).Although dozens of ASMs are available in the clinic,approximately 30%of epileptic patients have medically refractory seizures;other limitations in most traditional ASMs include poor tolerability and drug-drug ***,there is an urgent need to develop alternative ***(LEV)is a first-line ASM that is well tolerated,has promising efficacy,and has little drug-drug *** it is widely accepted that LEV acts through a unique therapeutic target synaptic vesicle protein(SV)2A,the molecular basis of its action remains *** so,the next-generation SV2A ligands against epilepsy based on the structure of LEV have achieved clinical *** review highlights the research and development(R&D)process of LEV and its analogs,brivaracetam and padsevonil,to provide ideas and experience for the R&D of novel ASMs.

关键词： Levetiracetam Epilepsy Antiseizure medications Synaptic vesicle protein 2A Brivaracetam Padsevonil

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Floor heave mechanism for gob-side entry retaining with concrete blocks and control method:A case study

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Underground Space 2024年第2期15卷 244-259页

作者： Jiong Wang peng Liu Manchao He Guangyuan Yu huanzhi tian State Key Laboratory for Geomechanics and Deep Underground Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China College of Mining Engineering North China University of Science and TechnologyTangshan 063210China

The issue of significant floor heave deformation in gob-side entry retaining has long been a challenging problem in the context of longwall *** paper studies the floor heave failure mechanism and control method for gob-side entry retaining with concrete blocks in Guizhou Faer Coal Mine in *** on Rankine’s earth pressure theory,the effective shear stress equation for the plastic slip of roadway floor is *** deformation mechanism of floor heave in a retaining roadway with a block wall is revealed in this *** new comprehensive control method is proposed,encompassing roof pre-splitting blasting for pressure relief,reinforcing cables for roof control,double directions control bolts for concrete block,and pliability cushion yielding ***3D numerical calculation model is established,which shows that the new method can effectively reduce the average vertical stress peak value of the entity coal floor by 34.6%and significantly reduce the pressure source causing the roadway floor ***,a multi-parameter real-time online monitoring system for mine pressure was designed,and field tests were carried *** results show that the maximum value of roadway floor heave under the new method is 163 mm,reduced by 66.9%,and the roadway floor heave is effectively *** research findings offer a fresh perspective and new ideas for controlling floor heave in mining operations.

关键词： Gob-side entry retaining Floor heave mechanism Plastic slip Control methods Mine pressure monitoring

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Mechanical properties and microstructure of Mg-treated and Catreated industrial H13 steel after quenching and tempering

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Journal of Iron and Steel Research International 2024年第8期31卷 1987-2001页

作者： Jun-ying Yue Dong Hou De-yong Wang tian-peng Qu Xiang-long Li Jun tian School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina

The effect of magnesium treatment and calcium treatment on the microstructure and mechanical properties of industrial H13 steel after quenching and tempering was *** impact toughness and tensile tests were mainly carried out,and the microstructure was observed by scanning electron microscopy,electron backscattered diffraction,and X-ray *** results show that magnesium treatment is still feasible in industrial *** is mainly manifested in the refinement of lath martensite and *** with calcium treatment,the prior austenite grains and carbides size of industrial H13 steel treated with magnesium decreased by 3.17μm after *** quenching and tempering,the carbides(especially V-rich carbides)in Mg treatment obviously spheroidized and distributed uniformly and increased in quantity *** lath martensite size is reduced from 2.45 to 2.31μ*** suggests that magnesium treatment was able to yield smaller grains and more evenly distributed ***,the impact toughness,yield strength,and ultimate tensile strength of industrial H13 steel with magnesium treatment increased by 28%,65.5 MPa and 123.7 MPa,*** increment of strength mainly comes from dislocation strengthening,grain refinement strengthening,and precipitation strengthening,among which precipitation strengthening accounts for the largest proportion.

关键词： Industrial H13 steel Mg treatment Heat treatment Carbide-Mechanical property

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Co-influence of the start of thermal growing season and precipitation on vegetation spring green-up on the Tibetan Plateau

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Advances in Climate Change Research 2024年第2期15卷 327-337页

作者： Chen-peng WANG Meng-tian huaNG Pan-Mao ZHAI State Key Laboratory of Severe Weather and Institute of Global Change and Polar Meteorology Chinese Academy of Meteorological SciencesBeijing 100081China University of Chinese Academy of Sciences Beijing 100049China

The climate in the Tibetan Plateau(TP)has undergone significant change in recent decades,mainly in thermal and water conditions,which plays a crucial role in phenological changes in vegetation spring ***,how the start of the thermal growing season(SOS-T)and the start of the rainy season(SORS)as key climatic factors affect vegetation green-up remains *** that these factors characterize thermal and water conditions required for vegetation green-up,this study investigated changes in the SOS-T and SORS from 1961 to 2022,using observation-based datasets with long time *** found that the SOS-T and SORS have advanced across the TP in 1961-2022 and have shown a spatial pattern of advancement in the east and delay in the west in ***,the co-effect of temperature and precipitation change on the start of vegetation growing season(SOS-V)in 2000-2022 was *** across TP,the SOS-V had an early onset of 1.3 d per decade during 2000-2022,corresponding to advanced SOS-T and ***,the SOS-V generally occurred nearly at the same time as the SOS-T in the high-altitude meadow region.A substantial delay in the SOS-V relative to the SOS-T was observed in the desert,shrub,grassland and forest regions and generally kept pace with the ***,for 50%of the vegetated regions on the TP,inter-annual variation in the delay in the SOS-V relative to the SOS-T was dominated by precipitation change,which was profound in warm-climate *** study highlights the co-regulation of precipitation and temperature change in the SOS-V in different vegetation cover regions in the TP,offering a scientific foundation for comprehending the impact of climate change and prospects for vegetation phenology on the TP.

关键词： Tibetan Plateau Start of growing season Temperature Precipitation Climate change

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A method for determining the layout of a yaw system based on the Delphi method and the analytic hierarchy process

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Clean Energy 2024年第4期8卷 49-60页

作者： ShuTing Lin Lanxing Lu peng Zhang hua Li School of Mechanical Engineering Sichuan UniversityChengdu 610065China

Wind power technology has been widely used due to its characteristics of environmental protection,sustainability and low *** yaw system plays a vital role in improving the energy capture efficiency of a wind ***,the method of layout determination is lacking in the yaw *** solve this problem,a method that combines the Delphi method and the analytic hierarchy process was proposed in this *** evaluation indexes,including transmission efficiency,ratio range,operating temperature range and others,were identified by screening 18 technical indicators using the Delphi ***,the evaluation system of the yaw system was ***,six configuration schemes were ***’scores of schemes were collected according to the evaluation system and the score matrix of evaluation indexes was *** hierarchical model of the evaluation indexes of the yaw system was established and the comprehensive weight was obtained by using the analytic hierarchy pro*** calculating the comprehensive evaluation score,the comprehensive evaluation result was *** 2Z-X(A)negative mechanism,which achieved the highest score of 0.9227,is the optimal scheme.A new method and specific process are provided for *** research gap in the scheme selection method for yaw systems is filled.

关键词： renewable energy generation wind power yaw system Delphi method analytic hierarchy process

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pH-responsive metal nanoparticles as high contrast theranostic agents for selective imaging and synergistic cancer therapy

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Science China Chemistry 2024年第9期67卷 3063-3070页

作者： Sichao tian Xiaofeng He Xiao Wu Dongxue Hu Qing-hua Xu Department of Chemistry National University of SingaporeSingapore 117543Singapore National University of Singapore(Suzhou)Research Institute Suzhou 215123China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore

The low signal-to-noise ratio(S/N)and single functionality of fluorescence imaging agents have limited their practical *** two-photon excitation(2PE)imaging probes are highly desirable in vivo with larger imaging depth,minor autofluorescence background,and less ***,we developed responsive aggregated gold nanoparticles(Au NPs)as high contrast 2PE imaging agents,capable of emitting red fluorescence upon excitation of near-infrared(NIR)laser and possessing a high signal-to-noise ratio(S/N of 2,475).By forming aggregates in situ inside tumor tissue,doxorubicin hydrochloride(DOX)-loaded mix-charged gold nanoparticles(DOX-MC-Au NPs)were utilized to act as selective fluorescence imaging probes and precise therapy *** high-contrast theranostic agents offer a promising potential for precise cancer imaging and therapy,which might open a new venue to multifunctional and noninvasive theranostics.

关键词： metal nanoparticles two-photon excitation high contrast imaging agents fluorescence imaging cancer therapy

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