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SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress in vitro and in vivo

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1205-1216页

作者： Hui Cui Di Sun Sheng Meng tian-ju ma Zi Ye Zhao-Hui Li Medical School of Chinese PLA Beijing 100089China Senior Department of Ophthalmology the Third Medical Center of PLA General HospitalBeijing 100853China

AIM:To explore the effect of silent information regulator factor 2-related enzyme 1(SIRT1)on modulating apoptosis of human lens epithelial cells(HLECs)and alleviating lens opacification of rats through suppressing endoplasmic reticulum(ER)***:HLECs(SRA01/04)were treated with varying concentrations of tunicamycin(TM)for 24h,and the expression of SIRT1 and C/EBP homologous protein(CHOP)was assessed using real-time quantitative polymerase chain reaction(RT-PCR),Western blotting,and *** morphology and proliferation was evaluated using an inverted microscope and cell counting kit-8(CCK-8)assay,*** the SRA01/04 cell apoptosis model,which underwent siRNA transfection for SIRT1 knockdown and SRT1720 treatment for its activation,the expression levels of SIRT1,CHOP,glucose regulated protein 78(GRP78),and activating transcription factor 4(ATF4)were *** potential reversal of SIRT1 knockdown effects by 4-phenyl butyric acid(4-PBA;an ER stress inhibitor)was *** vivo,age-related cataract(ARC)rat models were induced by sodium selenite injection,and the protective role of SIRT1,activated by SRT1720 intraperitoneal injections,was evaluated through morphology observation,hematoxylin and eosin(H&E)staining,Western blotting,and ***:SIRT1 expression was downregulated in TMinduced SRA01/04 ***,in SRA01/04 cells,both cell apoptosis and CHOP expression increased with the rising doses of *** stress was stimulated by TM,as evidenced by the increased GRP78 and ATF4 in the SRA01/04 cell apoptosis *** of SIRT1 by siRNA knockdown increased ER stress activation,whereas SRT1720 treatment had opposite results.4-PBA partly reverse the adverse effect of SIRT1 knockdown on *** vivo,SRT1720 attenuated the lens opacification and weakened the ER stress activation in ARC rat ***:SIRT1 plays a protective role against TM-induced apoptosis in HLECs and slows the progression of cataract in

关键词： silent information regulator factor 2-related enzyme 1 endoplasmic reticulum stress apoptosis human lens epithelial cells cataract

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Capturing metal clusters at the strong-interaction region to reverse Ostwald ripening

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Science China materials 2024年第4期67卷 1363-1364页

作者： Shuheng tian Ding ma Beijing National Laboratory for Molecular Sciences New Cornerstone Science LaboratoryCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

High-temperature interactions induce sintering of metal nanoparticles(NPs) on heterogeneous catalyst surfaces, leading to reduced surface area and active site loss through Ostwald ripening [1]. This irreversible deactivation necessitates costly catalyst replacement, notably impacting metals like copper in hydrogenation and reforming reactions [2].

关键词： catalyst reforming irreversible

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Numerical investigation on characteristics of interfacial wave of liquid film in gas-liquid two-phase flow using OpenFOAM

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Chinese Journal of Aeronautics 2024年第2期37卷 233-248页

作者： Xiaoqi ma Yueshe WANG Jiaming tian State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an 710049China

Liquid film cooling as an advanced cooling technology is widely used in space *** operation of liquid film along the rocket combustion inner wall is crucial for thermal protection of rocket *** stability of liquid film is mainly determined by the characteristics of interfacial wave,which is rarely investigated right *** to improve the stability of thin film has become a hot *** view of this,an advanced model based on the conventional Volume of Fluid(VOF)model is adopted to investigate the characteristics of interfacial wave in gas-liquid flow by using OpenFOAM,and the mechanism of formation and development of wave is revealed intuitively through numerical *** effects from gas velocity,surface tension and dynamic viscosity of liquid(three factors)on the wave are studied *** can be found that the gas velocity is critical to the formation and development of wave,and four modes of droplets generation are illustrated in this ***,a gas vortex near the gas-liquid interface can induce formation of wave easily,so changing the gas vortex state can regulate formation and development of ***’s more,the change rules of three factors influencing on the interfacial wave are obtained,and the surface tension has a negative effect on the formation and development of wave only when the surface tension coefficient is above the critical value,whereas the dynamic viscosity has a positive effect in this ***,the maximum height and maximum slope angle of wave will level off as the gas velocity ***,the maximum slope angle of wave is usually no more than 38°,no matter what happens to the three factors.

关键词： Interfacial wave Gas-liquid Two-phase flow VOF model OpenFOAM

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Hydration lubrication modulated by water structure at TiO2–aqueous interfaces

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Friction 2024年第4期12卷 591-605页

作者： Pingsu ma Yuan LIU Ke HAN Yu tian Liran ma State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China

The nature of solid-liquid interfaces is of great significance in *** advances have been made in lubrication based on hydration ***,a detailed molecular-level understanding is still ***,we investigated water molecule behaviors at the TiO2-aqueous interfaces by the sum-frequency generation vibrational spectroscopy(SFG-VS)and atomic force microscope(AFM)to elucidate the fundamental role of solid-liquid interfaces in *** contributions of water structures and hydration effects were revealed,where water structures played the dominant role in lubrication for TiO2 surfaces of varying hydrophilicity,while hydration effects dominated with the increasing of ion *** lubrication is observed on the initial TiO2 surfaces with strongly H-bonded water molecules compared to the hydrophilic TiO2 surfaces with more disordered *** stable ordered water arrangement with strong hydrogen bonds and the shear plane occurring between the ordered water layer and subsequent water layer may play a significant role in achieving lower *** adsorbed hydrated molecules with the increasing ionic concentration perturb ordered water but lead to the enhancement of hydration effects,which is the main reason for the improved lubrication for both *** work provides more insights into the detailed molecular-level understanding of the mechanism of hydration lubrication.

关键词： hydration lubrication interfacial water structures hydration effects titanium dioxide(TiO2)

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Photoinduced superlubricity on TiO_(2) surfaces

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Friction 2024年第3期12卷 428-438页

作者： Ke HAN Liran ma Yu tian Jianbin LUO State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China Received:16 September 2022/Revised:28 October 2022/Accepted:27 December 2022The author(s)2022.

Superlubricity control is of great interest in both industry and scientific research,and several methods have been proposed to achieve this *** this work,ultraviolet(UV)light was introduced into titanium dioxide(TiO_(2))and silicon nitride(Si_(3)N_(4))tribosystems to accomplish photoinduced *** friction coefficients(COFs)between Si_(3)N_(4) balls and TiO_(2) plates in the mixtures of sulfuric acid(H^(2)SO_(4))solution and glycerol solution were obviously reduced,and the system entered the superlubricity region(COFmation of silica(SiO_(2))layers on the surfaces of Si_(3)N_(4) balls and the elastohydrodynamic effects were determined to be fundamental to the low friction in this experiment,and the enhancement of the combination between the TiO_(2) surface and the hydroxy group of glycerol by UV illumination was the key to the photoinduced superlubricity in this *** findings showed one method for achieving superlubricity by introducing a light field that could be further applied to special working conditions.

关键词： light control friction superlubricity glycerol titanium dioxide(TiO_(2))

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Photo-induced grease/oil switched lubricant for friction regulation

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Friction 2024年第8期12卷 1696-1706页

作者： Zheng ZHANG Shuangxi TANG Liran ma Yu tian State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China

Controllable friction regulation has drawn much interest in both scientific and industrial *** there have been many researches on friction regulation by many physical fields and chemical ***-sensitive materials are promising because it is relatively easy to change their properties compared with ***,a new kind of photo-induced grease/oil switched lubricant is designed and shows great reversibility under ultraviolet(UV)and visible(Vis)*** viscosity can change more than 50 times under different irradiation,and the coefficients of friction(COFs)obviously increase under Vis irradiation and decrease under UV irradiation,which performs better than those of the common *** to the experimental results,the phenomena are contributed to the break and reconstruction of the three-dimensional network inside the *** a switchable grease/oil state under different irradiation,this work provides a new principle for designing a smart lubricant with controllable friction regulation.

关键词： photo-induced spiropyran switched lubricant friction regulation

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Growth,optical dispersion and magnetic behavior of Dy^(3+) doped yttrium iron garnet crystals

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Journal of Rare Earths 2024年第6期42卷 1110-1117,I0004页

作者： Yating Fang Hui Shen Yudie ma Shijie Liao Shuang Xia tian tian Ding Zhou Yunfeng ma Jiayue Xu Institute of Crystal Growth School of Materials Science and EngineeringShanghai Institute of Technology National Engineering Center of Electromagnetic Radiation Control materials School of Electronic Science and EngineeringUniversity of Electronic Science and Technology of China

Y_(3)Fe_(5)O_(12)(YIG)crystals are highly desirable for the fabrication of mid-infrared isolators with the rapid growth of optical communications,although it is rather challenging to grow large size and high-quality single ***^(3+)doping is expected to improve the optical and magneto-optical prope ***,high quality Dy:YIG crystals and the adjustment of Dy^(3+)on the structure and optical behavior of YIG crystal remain unclear,impeding its practical ***,a series of Y_(3-x)Dy_(x)Fe_(5)O_(12)(x=0,0.5,1.0,1.5,3)solid solution crystals was grown by the flux-Bridgman method and single crystals up to 25 mm were *** the introduction of Dy^(3+),lattice parameters are gradually enlarged from 1.2379 nm(YIG)to 1.2420 nm(DyIG).Typical Dy^(3+)absorption peaks are observed around 1070,1265 and 1670 *** refractive index decreases from 2.37(500 nm)to 2.10(2500 nm)for YIG crystal,and it reduces from 2.47(500 nm)to 2.16(2500 nm)for DyIG *** optical bandgaps remain almost unchanged for Dy:YIG *** optical dispersion of the refractive indices was finely fitted by the Wemple and DiDomenico(WDD)and the Sellmeier models,*** the increase of Dy^(3+)content,the saturation magnetization(Ms)decreases significantly from 23.62 emu/g(YIG)to 5.33 emu/g(DyIG).Small coercive field is persisted for this system,endowing small external magnetic *** results provide valuable references for the manipulation of rare earths on the properties of magnetooptical crystals,which is beneficial to the design of high-performance garnet crystals for the application of optical switching and non-reciprocal related devices.

关键词： magneto-optical crystal Yttrium iron garnet Dy^(3+)doping Crystal growth Optical dispersion Rare earths

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Interfacial tribochemical kinetics: A new perspective on superlubricity of diamond-like carbon films

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Science China(Technological Sciences) 2024年第7期67卷 2050-2052页

作者： CHEN WeiQi ma tian-Bao State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

Friction is considered one of the primary challenges affecting the performance of machine operations and is a significant source of energy loss in industrial applications. About 30%of disposable energy is consumed by ... 详细信息

关键词： kinetics friction operations

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Numerical simulation on directional solidification and heat treatment processes of turbine blades

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China Foundry 2024年第5期21卷 476-490页

作者： Ye-yuan Hu ju-huai ma Qing-yan Xu School of materials Science and Engineering Tsinghua UniversityKey Laboratory for Advanced Materials Processing TechnologyMinistry of EducationBeijing 100084China

Study on turbine blades is crucial due to their critical role in ensuring the efficient and reliable operation of aircraft ***-based single crystal superalloys are extensively used in the hot manufacturing of turbine blades due to their exceptional high-temperature mechanical *** hot manufacturing of single crystal blades involves directional solidification and heat *** manufacturing of these blades is time-consuming,capital-intensive,and often insufficient to meet industrial *** simulation techniques have gained widespread acceptance in blade manufacturing research due to their low energy consumption,high efficiency,and rapid turnaround *** article introduces the modeling and simulation of hot manufacturing in single crystal *** discussion outlines the prevalent mathematical models employed in numerical simulations related to blade hot *** encapsulates the advancements in research concerning macro to micro-level numerical simulation techniques for directional solidification and heat treatment ***,potential future trajectories for the numerical simulation of single crystal blade hot manufacturing are also discussed.

关键词： single crystal blades Ni-based superalloy directional solidification heat treatment numerical simulation

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Image super‐resolution via dynamic network

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 837-849页

作者： Chunwei tian Xuanyu Zhang Qi Zhang Mingming Yang Zhaojie ju School of Software Northwestern Polytechnical UniversityXi'anChina National Engineering Laboratory for Integrated Aero‐Space‐Ground‐Ocean Big Data Application Technology Xi'anChina Research&Development Institute Northwestern Polytechnical UniversityShenzhenChina School of Economics and management Harbin Institute of Technology at WeihaiWeihaiChina Tencent AI Lab ShenzhenChina School of Computing University of PortsmouthPortsmouthUK

Convolutional neural networks depend on deep network architectures to extract accurate information for image super‐***,obtained information of these con-volutional neural networks cannot completely express predicted high‐quality images for complex scenes.A dynamic network for image super‐resolution(DSRNet)is presented,which contains a residual enhancement block,wide enhancement block,feature refine-ment block and construction *** residual enhancement block is composed of a residual enhanced architecture to facilitate hierarchical features for image super‐*** enhance robustness of obtained super‐resolution model for complex scenes,a wide enhancement block achieves a dynamic architecture to learn more robust information to enhance applicability of an obtained super‐resolution model for varying *** prevent interference of components in a wide enhancement block,a refine-ment block utilises a stacked architecture to accurately learn obtained ***,a residual learning operation is embedded in the refinement block to prevent long‐term dependency ***,a construction block is responsible for reconstructing high‐quality *** heterogeneous architecture can not only facilitate richer structural information,but also be lightweight,which is suitable for mobile digital *** results show that our method is more competitive in terms of performance,recovering time of image super‐resolution and *** code of DSRNet can be obtained at https://***/hellloxiaotian/DSRNet.

关键词： CNN dynamic network image super‐resolution lightweight network

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