检索结果-南通市图书馆

Synthesis of Large Pore Molecular Sieve VPI-5 by Using Various Organic Amines

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 1993年第1期9卷 1-5页

作者： YAO Shang-qing, tian Wen-tong, QIU Shi-lun and PANG Wen-qin (Department of Chemistry, Jilin University, Changchun, 130023)

The molecular sieve VPI-5 was synthesized by using various organic amines (DEA, Di-PA, DBA, DPenA, TBA, DEOA and TEOA) as the structure-directing agent. The use of DPA enlarged the range of the crystallization temperature from 110℃ to 190℃ in the synthesis of VPI-5, while the use of TEOA changed the composition of the reactants in a broad variety. Diamines are the typical amines in the synthesis of VPI-5. Among them DBA and DPA are the most favorite structure-directing agents for the synthesis of VPI-5 molecular sieve.

关键词： VPI-5 Molecular sieve Amines

Scalable synthesis of lipid nanoparticles for nucleic acid drug delivery using an isometric channel-size enlarging strategy

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 2899-2907页

作者： Zesen Ma Haiyang tong Sijin Lin Li Zhou Demeng Sun Baoqing Li Changlin tian Jiaru Chu Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230027China Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of ChinaHefei 230027China Science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230026China Anhui Provincial Key Laboratory of High Field Magnetic Resonance Imaging High Magnetic Field LaboratoryHefei Institute of Physical ScienceChinese Academy of SciencesHefei 230031China Anhui Provincial Engineering Laboratory of Peptide Drugs University of Science and Technology of ChinaHefei 230027China School of Biomedical Engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaSuzhou 215127China

Lipid nanoparticles(LNPs)have emerged as highly effective delivery systems for nucleic acid-based ***,the broad clinical translation of LNP-based drugs is hampered by the lack of robust and scalable synthesis techniques that can consistently produce formulations from early development to clinical *** this work,we proposed a method to achieve scalable synthesis of LNPs by scaling inertial microfluidic mixers isometrically in three ***,a theoretical predictive method,which controls the mixing time to be equal across different chips,is developed to ensure consistent particle size and size distribution of the synthesized *** loaded with small interfering RNA(siRNA)were synthesized at different flow rates,exhibiting consistent physical properties,including particle size,size distribution and encapsulation *** work provides a practical approach for scalable synthesis of LNPs consistently,offering the potential to accelerate the transition of nucleic acid drug development into clinical application.

关键词： lipid nanoparticles nucleic acid delivery microfluidics scalable synthesis consistent particle size

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

宏基因组测序在传染病检测中的应用

海南医学 2024年第10期35卷 1504-1508页

作者：邓炜(综述) 何建安朱丽张然田羽彤刘国平(审校) 长江大学动物科学技术学院湖北荆州434025 深圳国际旅行卫生保健中心(深圳海关口岸门诊部) 广东深圳518000

近年来,随着宏基因组测序技术在分子生物学领域的快速发展,宏基因组测序为传染病致病病原体尤其是未知病原的分型溯源和生物学特性研究提供了更加便捷、高效的手段。该技术相较于传统检测手段具有明显的时效性、灵敏度高等优点。快速、... 详细信息

近年来,随着宏基因组测序技术在分子生物学领域的快速发展,宏基因组测序为传染病致病病原体尤其是未知病原的分型溯源和生物学特性研究提供了更加便捷、高效的手段。该技术相较于传统检测手段具有明显的时效性、灵敏度高等优点。快速、准确、广谱鉴定出病原体,有助于采用针对性的防控措施,是各种传染病预防控制的关键。本综述主要以高通量测序技术进展为基础,探讨宏基因组测序技术在细菌、病毒、真菌以及寄生虫等传染性疾病中的实际运用情况,并讨论了该技术可能面临的挑战和应用前景。

关键词：宏基因组测序高通量测序传染病

维普期刊数据库博看期刊

High-Efficiency Dynamic Scanning Strategy for Powder Bed Fusion by Controlling Temperature Field of the Heat-Affected Zone

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2024年第1期37卷 203-214页

作者： Xiaokang Huang Xiaoyong tian Qi Zhong Shunwen He Cunbao Huo Yi Cao Zhiqiang tong Dichen Li State Key Laboratory of Manufacturing Systems Engineering Xi’an Jiaotong UniversityXian 710049China

Improvement of fabrication efficiency and part performance was the main challenge for the large-scale powder bed fusion(PBF)*** this study,a dynamic monitoring and feedback system of powder bed temperature field using an infrared thermal imager has been established and integrated into a four-laser PBF equipment with a working area of 2000 mm×2000 *** heat-affected zone(HAZ)temperature field has been controlled by adjusting the scanning speed ***,the relationship among spot size,HAZ temperature,and part performance has been *** fluctuation of the HAZ temperature in four-laser scanning areas was decreased from 30.85℃to 17.41℃.Thus,the consistency of the sintering performance of the produced large component has been *** on the controllable temperature field,a dynamically adjusting strategy for laser spot size was proposed,by which the fabrication efficiency was improved up to 65.38%.The current research results were of great significance to the further industrial applications of large-scale PBF equipment.

关键词： Powder bed fusion Efficiency Large-scale Spot size Heat-affected zone(HAZ)

Face recognition trained on a small dataset

在线全文

学校读者我要写书评

暂无评论

Face recognition trained on a small dataset

αDecay in extreme laser fields within a deformed Gamow-like model

OSEC首届兵器工程大会

作者： Yu Chengbo tian tong Institute of Remote Test and Control Chong Qing University of technology

Face recognition has been very successful in recent years with the rapid development of the Convolutional Neural Networks(CNNs). However, the cost of the success is the bigger datasets and the deeper networks. It is beyond the capabilities of most international research groups. In this work, we propose a method that only trains on CASIA Web Face. Our method combine the improved center loss and softmax loss as joint supervision in a network with balance the training data. The benefit of our approach is much easier and useful: we achieve comparable state of the art results on the stand Labeled Faces in the Wild(LFW) and You Tube Faces(YTF) face benchmarks with only 0.8 images.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第2期35卷 131-144页

作者： Qiong Xiao Jun-Hao Cheng Yang-Yang Xu You-tian Zou Jun-Gang Deng tong-Pu Yu Department of Physics National University of Defense TechnologyChangsha 410073China College of Science China Three Gorges UniversityYichang 443002China

In this study, the effect of extreme laser fields on the α decay process of ground-state even–even nuclei was *** the deformed Gamow-like model, we found that state-of-the-art lasers can cause a slight change in the α decay penetration probability of most nuclei. In addition, we studied the correlation between the rate of change of the α decay penetration probability and angle between the directions of the laser electric field and α particle emission for different nuclei. Based on this correlation, the average effect of extreme laser fields on the half-life of many nuclei with arbitrary α particle emission angles was calculated. The calculations show that the laser suppression and promotion effects on the α decay penetration probability of the nuclei population with completely random α particle-emission directions are not completely *** remainder led to a change in the average penetration probability of the nuclei. Furthermore, the possibility of achieving a higher average rate of change by altering the spatial shape of the laser is explored. We conclude that circularly polarized lasers may be helpful in future experiments to achieve a more significant average rate of change of the α decay half-life of the nuclei population.

关键词： αDecay Deformed Gamow-like model Half-lives Extreme laser field Penetration probability

Summary of the Seminar Commemorating the 30^(th) Anniversary of the Release of the White Paper Entitled Human Rights in China

在线全文

学校读者我要写书评

暂无评论

The Journal of Human Rights 2021年第6期20卷 1095-1106页

作者：刘秋岑 tian tong(译) the Institute of Human Rights of Southwest University of Political Science and Law 不详

On November 1,1991,the State Council Information Office of the People’s Republic of China issued its first white paper entitled Human Rights in *** the past 30 years,China’s human rights cause has developed rapidly,and relevant theoretical research has been continuously *** October 15,2021,the Seminar Commemorating the 30;Anniversary of the Release of the White Paper Entitled Human Rights in China was held in *** focused on three topics:the theoretical significance of the white paper,its discourse building and its *** meeting held that the Chinese human rights philosophy emphasized in the white paper is in line with China’s national conditions and development path philosophy,and is a typical achievement of adapting Marxism to Chinese *** the past 30 years since the release of this white paper,China’s human rights cause has completed the basic work of theoretical building and path exploration,and meanwhile,China has established a human rights discourse system and human rights protection system in line with China’s history and development stage,participated in global human rights cooperation,and contributed Chinese wisdom to the advancement of the world’s human rights cause.

关键词： seminar commemorating the 30th anniversary of the release of the white paper Human Rights in China human rights discourse system human rights practice international human rights cooperation

Plasmon coupling-driven enhanced high-order multiphoton excited fluorescent performance of metal-organic frameworks

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第7期17卷 6502-6508页

作者： tong Meng Bo Li Linlin Zeng Xianshun Sun Yupeng tian Hongping Zhou Meng Zhou Dandan Li Institutes of Physical Science and Information Technology Key Laboratory of Structure and Functional Regulation of Hybrid MaterialsMinistry of EducationAnhui UniversityHefei 230601China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China

Accessing high-order multiphoton excited fluorescence(H-MPEF)materials is challenging yet and needs complicated synthesis *** this study,we successfully assembled plasmonic Au nanorods(Au NRs)with multiphoton responsive metalorganic frameworks(MOFs),resulting in a significant several-fold enhancement of *** extent of multiphoton enhancement was found to be strongly dependent on the degree of overlap between the multiphoton excitation wavelength of MOFs and the localized surface plasmon resonance absorbance of Au NRs,indicating the importance of plasmon-induced resonance energy ***,plasmon-induced hot electron transfer played a vital role in enhanced multiphoton activity as ***,the optimum H-MPEF enhancement occurs at the second near-infrared(NIR-II)region,which provides a promising platform for fluorescent *** findings provide a feasible and practical method to fabricate optimized H-MPEF materials for biological imaging using tissue-penetrating NIR-II light.

关键词： metal-organic framework(MOF) plasmon resonance multiphoton activity fluorescence imaging

Antimicrobial activity of linezolid combined with minocycline against vancomycin-resistant Enterococci

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2013年第14期126卷 2670-2675页

作者： WU Jing JIANG tian-tong SU Jian-rong LI Li Department of Clinical Laboratory First Hospital of Fangshan District Beijing 102400 China Department of Clinical LaboratoryBeijing Friendship Hospital Capital Medical University Beijing 100050 China Division of Traditional Chinese MedicineBeijing Friendship Hospital Capital Medical University Beijing 100050 China

Background Vancomycin-resistant Enterococci （VRE） cause serious infections that are difficult to treat. We carried out this study to determine the mutant prevention concentration （MPC） of linezolid when combined with minocycline against VRE strains, to determine the mechanism of drug resistance in vitro, and to provide a theoretical basis for the rational use of drugs against VRE. Methods The minimum inhibitory concentrations （MICs） of linezolid and minocycline against 30 Enterococci （E.） isolates （including 20 VRE strains） were determined by the broth microdilution method. Drug interactions were assessed by the checkerboard microdilution tests and confirmed by time-kill studies. Two vancomycin-susceptible strains N27 and N40 （linezolid MIC, 2 g/ml; minocycline MIC, 4 tJg/ml） and control strains E. faecalis ATCC 29212 and ATCC 51299 were also tested. The MPCs of linezolid and minocycline （alone and combined） were determined using the agar dilution method. Strains showing stable resistance were analyzed by polymerase chain reaction （PCR） amplification of domain V of the 23S rRNA gene. Results Checkerboard titration studies revealed synergistic effects of combination therapy in 26.7% of 30 E. isolates. Antagonism was not observed, The G2576U mutation was detected in stable linezolid-resistant strains of ATCC 29212, N40, and N27 before and after resistance screening, and MIC values increased with the number of G2576U mutations. The MPC of linezolid against E. decreased dramatically when combined with minocycline, and vice versa. Conclusion Linezolid or minocycline alone produce resistant strains; however, their joint use may reduce the MPC of each agent against VRE, thereby decreasing resistant mutants and bacterial infections.

关键词： linezolid minocycline Enterococcus mutation