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Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies

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World Journal of Diabetes 2024年第6期15卷 1111-1121页

作者： tong Zhou Yi-Lin Fang tian-tian tian Gui-Xia Wang Department of Endocrinology and Metabolism The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina National-Local Joint Engineering Laboratory of Animal Models for Human Diseases Jilin UniversityChangchun 130021Jilin ProvinceChina School of Public Health Jilin UniversityChangchun 130021Jilin ProvinceChina

Diabetic kidney disease is one of the most severe chronic microvascular complications of diabetes and a primary cause of end-stage renal *** studies have shown that renal inflammation is a key factor determining kidney damage during *** the development of immunological technology,many studies have shown that diabetic nephropathy is an immune complex disease,and that most patients have immune ***,the immune response associated with diabetic nephropathy and autoimmune kidney disease,or caused by ischemia or infection with acute renal injury,is different,and has a complicated pathological *** this review,we discuss the pathogenesis of diabetic nephropathy in immune disorders and the intervention mechanism,to provide guidance and advice for early intervention and treatment of diabetic nephropathy.

关键词： Diabetic kidney disease Immune disorders Pathological mechanism Intervention strategy Kidney damage Diabetic nephropathy Inflammasome Immunoglobulin

Fourth-Order Interference on Polarization Beats with Phase-Conjugation Geometry

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Chinese Physics Letters 2000年第3期17卷 206-208页

作者： ZHANG Yau-Peng SUN Li-Qun TANG tian-tong ZHANG Lu FU Pan-Ming Department of Electronic Science and Technology Xi'an Jiaotong UniversityXi'an 710049 Institute of Physics Chinese Academy of SciencesBeijing 100080

The effect of fourth-order coherence on ultrafast modulation spectroscopy(UMS)with phase-conjugation geome-try(PCUMS)in a cascade three-level system is investigated using chaotic and phase-diffusion *** has been found that the modulation terms of the beat signal depend *** second-order coherence function,and different stochastic models of the laser field affect only the fourth-order coherence *** difference between the PCUMS and UMS is discussed from a physical viewpoint.

关键词： function. MS Polarization

Temperature Dependence of Optically Erased Two-Wave Mixing in Ce:KNSBN

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Chinese Physics Letters 1998年第5期15卷 345-347页

作者： LIU Jin-song LU Ke-qing LIANG Chang-hong ZHANG Du-ying TANG tian-tong Department of Applied Physics Xidian UniversityXi’an 710071 Institute of Electronic and Information Engineering Jiaotong UniversityXi’an 710049

The intensity response of an optically erased photorefractive two-wave mixing to the erase beam is studied by using the coupling wave equation and the band-transport *** concepts of response strength and the minimum response intensity are introduced and their temperature dependence is investigated.A 2-fold increase in the response strength and 4-fold decrease in minimum response intensity have been experimentally observed in Ce:KNSBN at 633 nm when the crystal temperature is raised from 320 to *** experimental results are in agreement with theoretical analysis and show that the response property can be improved by changing the crystal temperature.

关键词： temperature crystal wave

The Main Areas and Mechanism of China-Africa Cooperation from the Perspective of Human Rights——Based on the Analysis of the Forum on China-Africa Cooperation

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The Journal of Human Rights 2021年第4期20卷 673-696页

作者：许尧 tian tong(Translated) the Human Rights Research Center(National Human Rights Education and Training Base)of Nankai University 不详

China-Africa cooperation has a long history and a solid foundation of mutual *** the launch of the Forum on China-Africa Cooperation(FOCAC)in 2000,China and African countries have conducted more comprehensive and institutionalized cooperation,and achieved a series of achievements which have attracted the attention of the international *** the perspective of human rights protection,China-Africa cooperation is mainly concentrated in five areas,namely:poverty alleviation,medical and health,the ecological environment,conflict management,education and cultural *** on the practices in each of these fields,it can be summarized that there are five mechanisms,i.e.,the approach mechanism,material support mechanism,capacitybuilding mechanism,system optimization mechanism,and mechanism for breakthroughs on key *** main areas and mechanism of China-Africa cooperation is a potential network structure and has become a powerful impetus to promote the joint building of a community of shared future between China and Africa.

关键词： the forum on China-Africa cooperation China-Africa cooperation the perspective of human rights a community with a shared future for human beings

Chemical constituents from aerial parts of Scoparia dulcis

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Chinese Herbal Medicines 2023年第1期15卷 151-154页

作者： Yingbo Yang Zhuzhen Han tong tian Qi Liao Jiaran Geng Ying Xiao The SATCM Key Laboratory for New Resources&Quality Evaluation of Chinese Medicine Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghai 201203China Jiangsu Kanion Pharmaceutical Co. Ltd.Lianyungang 222000China

Objective: To study the chemical constituents from the aerial parts of Scoparia ***: Various chromatographic techniques were used to separate the constituents and their structures were elucidated using spectroscopic methods and by comparing their data to those reported in the literatures. The α-glucosidase inhibitory activity assay was used to identify potential α-glucosidase ***: Nine compounds were isolated from the aerial parts of S. dulcis. Their structures were identified as Scoparic zolone(1),(2S)-2,7-dihydroxy-2H-1,4-benzoxazin-3(4H)-one(2),(2R)-7-hydroxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(3),(2R)-7-methoxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(4),(2S)-7-hydroxy-2H-1,4-benzoxazin-3(4H)-one-2-O-β-D-glucopyranoside(5),6-methoxy-benzoxazolin-2(3H)-one(6), 4-acetonyl-3,5-dimethoxy-p-quinol(7), zizyvoside I(8), and3,4-dihydroxy benzeneacetic acid(9). Compound 2 showed the potent α-glucosidase inhibitory activity with an IC50value of(132.8 ± 11.5) μmol/L, which is 28-fold higher than the positive control ***: Compound 1 is a new natural product. Compounds 2 and 9 have not been reported in Scoparia before. Compounds 3, 5, 7, 8 are isolated from Scrophulariaceae for the first time.

关键词： alkaloids chemical constituents α-glucosidase inhibitory activity Scoparia dulcis L.

MYOCARDIAL LESIONS AFTER LONG-TERM ADMINISTRATION OF METHAMPHETAMINE IN RATS

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Chinese Medical Sciences Journal 2008年第4期23卷 239-243页

作者： Shao-hua Yi Liang Ren tian-tong Yang Liang Liu Han Wang Qian Liu Department of Forensic Medicine Tongji Medical College Huazhong University of Science and Technology Wuhan 430030

Objective To demonstrate the myocardial lesion associated with long-term administration of methamphetamine in rats. Methods The experimental models of intoxication of methamphetamine were established in Sprague-Dawley rats. Methamphetamine hydrochloride （3 mg·kg^-1·d^-1） was subcutaneously injected to rats in methamphetarnine-treated group （n = 16）, and normal saline at the same dose was injected to rats in control group （n = 16）. After 1 week and 8 weeks of injection, 8 rats in each group were sacrificed and their hearts were examined with light microscopy and electron microscopy, respectively. Results After 1 week of methamphetamine exposure, loci of contraction band and cellular degeneration were present in subendocardial myocardium. Cellular degeneration, myocytolysis, and contraction band necrosis became prominent and extensive in methamphetamine-treated rats after 8 weeks. Hypertrophy, intracellular vacuolization, and fibrosis were also observed. The ultrastructural feature showed marked swelling and degeneration of mitochondria, enlargement of sarcoplasmic reticulum, and dissolution of myofilaments. No obvious cardiac myocyte lesions were observed in rats of control group. Conclusion Methamphetamine abuse daily for a long time may result in an increased risk of cardiovascular lesions similar to cardiomyopatby.

关键词： methamphetamine myocardial lesion cardiomyopathy

The Tension Balance Structure of China's Human Rights Development Path

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The Journal of Human Rights 2021年第5期20卷 738-746页

作者：齐延平 tian tong(Translated) Center for Science Technology and Human RightsBeijing Institute of Technology the School of Law Beijing Institute of Technology 不详

The human rights white paper has in it the basic concepts of human rights,the form of the human rights system,and the mode of human rights practice in modern *** is based on the tension balance structure between the historical feature and rationality,the cultural feature and similarity,the realistic feature and the common feature of human *** to the historical nature of human rights rather than abstract rationality,and the cultural diversity and equality of human rights rather than one dominant model,and the particularity of human rights rather than universality is the pillar of China’s human rights philosophy,system,and *** human rights development path that combines the top-down leadership of China’s ruling party,the capability of the Chinese government in taking a holistic approach and the bottom-up driving force of the people is very different from the natural evolution path of the West.

关键词： human rights in China historical feature cultural feature realistic feature tension balance structure

Functional properties of defatted chickpea flour heat-induced gels

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 280-286页

作者： Chonghao Bi Aoxue Qie tong Zhou Yi Liu Bin tian School of Artificial Intelligence Beijing Technology and Business UniversityBeijing 100048China

Defatted chickpea flour(DCF),which is a by-product of chickpea oil extraction industry,is rich in nutrients that are beneficial to human *** this study,the effects of temperature and DCF variation on the rheological properties,water holding capacity,freeze-thaw stability and microstructure of DCF heat induced gels were *** results showed that the viscoelasticity,frequency dependence,and resistance strength of heat induced gels increased significantly with the increase of temperature and DCF *** degree of denaturation and water retention of heat induced gels increased significantly with increased variables within the temperature and variation windows of 75℃ to 95℃ and 13%to 21%.The CLSM results revealed that variations of both temperature and DCF variation could cause the proteins in the heat induced gels to aggregate gradually and to form protein *** temperature or variation exceeded certain value(85℃ or 17%),the protein aggregations broke up and the protein clusters became smaller and more ***,the heat induced gels presented better water holding capacity,viscoelasticity,structural stability and gel property at a temperature of 95℃ or a DCF variation of 21%within the present experimental range.

关键词： defatted chickpea flour rheological property freeze-thaw stability water holding capacity microstructure

The Discourse Practice of the White Papers on Human Rights and Their Sociocultural Function: 1991-2021

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The Journal of Human Rights 2021年第6期20卷 1075-1094页

作者：张晗 tian tong(译) Southwest University of Political Science and Law 不详

2021 marks the 30;anniversary of China’s first white paper on human *** sorting and discourse analysis of the white papers over the years since then reveals how China’s expression of“human rights”demonstrates its endogenous power and sense of autonomy in human rights *** a discourse practice,the white papers on human rights have gradually refined the rights to subsistence and development,expanded and expressed social rights,responded to the real needs of society,and charted the progress in the legal protection of human *** white paper on human rights is the official text for understanding China’s human rights cause,as it proceeds from a“practical”perspective to give full play to the social and cultural functions of subject identity,concept cultivation,and communication media and unleash the potential power of multiculturalism,thus laying a solid foundation for enhancing the discourse power of domestic and international human rights.

关键词： human right white papers value goal the role of the government development model rhetorical discourse