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Site-testing at Muztagh-ata site Ⅰ:ground meteorology and sky brightness

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Research in Astronomy and Astrophysics 2020年第6期20卷 162-174页

作者： Jing Xu Ali Esamdin Jin-xin Hao Jin-Min Bai Ji Yang Xu Zhou Yong-Qiang yao Jin-Liang Hou Guang-xin Pu Guo-Jie Feng Chun-Hai Bai Peng Wei Shu-Guo ma Abudusaimaitijiang Yisikandee Le-tian Wang Xuan zhang Liang Ming Lu ma Jin-zhong Liu Zi-huang Cao Yong-Heng Zhao Lu Feng Jian-Rong shi hua-Lin Chen Chong Pei Xiao-Jun Jiang Jian-Feng Wang Jian-Feng tian Yan-Jie xue Jing-yao hu Yun-Ying Jiang xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Yunnan Observatories Chinese Academy of SciencesKunming 650000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008 China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210008China

Site-testing is crucial for achieving the goal of scientific research and analysis of meteorological and optical observing conditions,one of the associated basic *** one of three potential sites to host the 12-meter Large Optical/infrared Telescope(LOT),the Muztagh-ata site,which is located on the Pamir Plateau in xinjiang,in west China,began its site-testing task in the spring of *** this paper,we firstly start with an introduction to the site and then present a statistical analysis of the ground-level meteorological properties such as air temperature,barometric pressure,relative humidity,and wind speed and direction,recorded by an automatic weather station with standard meteorological sensors for a two-year *** also show the monitoring results of sky brightness during this period.

关键词： site testing meteorological condition optical observing

Site testing at Muztagh-ata site Ⅱ:seeing statistics

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Research in Astronomy and Astrophysics 2020年第6期20卷 175-184页

作者： Jing Xu Ali Esamdin Jin-xin Hao Jin-Min Bai Ji Yang Xu Zhou Yong-Qiang yao Jin-Liang Hou Guang-xin Pu Guo-Jie Feng Chun-Hai Bai Peng Wei Shu-Guo ma Abudusaimaitijiang Yisikandee Le-tian Wang Xuan zhang Liang Ming Lu ma Jin-zhong Liu Zi-huang Cao Yong-Heng Zhao Lu Feng Jian-Rong shi hua-Lin Chen Chong Pei Xiao-Jun Jiang Jian-Feng Wang Jian-Feng tian Yan-Jie xue Jing-yao hu Yun-Ying Jiang xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Yun nan Observatories Chin ese Academy of Scie ncesKun ming 650000China Purple Mountain Observatory Chinese Academy of SciencesNanjing 21000&China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210008China

In this article,we present a detailed analysis of the statistical properties of seeing for the Muztaghata site which is a candidate site for hosting the future Chinese Large Optical/infrared Telescope(LOT)*** measurements were obtained with differential image motion monitors(DIMMs)from April2017 to November 2018 at different heights during different *** median seeings at 11 m and6 m are very close but significantly different from that on the *** mainly analyzed the seeing at11 m monthly and hourly,having found that the best season for observing was from late autumn to early winter and seeing tended to improve during the night only in *** analysis of the dependence on temperature inversion,wind speed and direction also was made and the best meteorological conditions for seeing are given.

关键词： site testing seeing

Site testing campaign for the Large Optical/infrared Telescope of China:overview

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Research in Astronomy and Astrophysics 2020年第6期20卷 81-95页

作者： Lu Feng Jin-xin Hao Zi-huang Cao Jin-Min Bai Ji Yang Xu Zhou Yong-Qiang yao Jin-Liang Hou Yong-Heng Zhao Yu Liu Teng-Fei Song Li-Yong Liu Jia Yin hua-Lin Chen Chong Pei Ali Esamdin Lu ma Chun-Hai Bai Peng Wei Jing Xu Guang-xin Pu Guo-Jie Feng Xuan zhang Liang Ming Abudusaimaitijiang Yisikandee Jian-Rong shi Jian Li Yuan tian Zheng Wang Xia Wang Xiao-Jun Jiang Jian-Feng Wang Jian-Feng tian Yan-Jie xue Jian-sheng Chen Jing-yao hu Zhi-Xia Shen Yun-Ying Jiang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Yunnan Observatories Chinese Academy of SciencesKunming 650216China xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China Purple Mountain Observatory Chinese Academy of SciencesNanjing 210033China University of Chinese Academy of Sciences Beijing 100049China

The Large Optical/infrared Telescope(LOT)is a ground-based 12 m diameter optical/infrared telescope which is proposed to be built in the western part of China in the next *** on satellite remote sensing data,along with geographical,logistical and political considerations,three candidate sites were chosen for ground-based astronomical performance *** sites include:Ali in Tibet,Daocheng in Sichuan and Muztagh-ata in *** until now,all three sites have continuously collected data for two *** this paper,we will introduce this site testing campaign,and present its monitoring results obtained during the period between march 2017 and march 2019.

关键词： techniques telescope-site testing

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)

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Research in Astronomy and Astrophysics 2012年第9期12卷 1197-1242页

作者： Xiang-Qun Cui Yong-Heng Zhao yao-Quan Chu Guo-Ping Li Qi Li Li-Ping zhang Hong-Jun Su Zheng-Qiu yao Ya-Nan Wang Xiao-Zheng xing xin-Nan Li Yong-tian Zhu Gang Wang Bo-zhong Gu A-Li Luo xin-Qi Xu Zhen-Chao zhang Gen-Rong Liu Hao-Tong zhang De-hua Yang Shu-Yun Cao Hai-Yuan Chen Jian-Jun Chen Kun-xin Chen Ying Chen Jia-Ru Chu Lei Feng xue-Fei Gong Yong-hui Hou Hong-Zhuan hu Ning-sheng hu zhong-Wen hu Lei Jia Fang-hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-hua Li Yan Li Ye-Ping Li Guan-QunLiu Zhi-Gang Liu huo-Ming shi Zheng-Hong Tang Qing-sheng Tao Xiang-Yan Yuan Chao Zhai Jing zhang Yan-Xia zhang Yong zhang Ming Zhao Fang Zhou Guo-hua Zhou Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China yzhao @ *** Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Tecfinologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects.

关键词： techniques: wide field telescope - active optics - multi fiber - spectroscopy survey - data reduction

Towards the full realization of the RIBLL2 beam line at the HIRFL-CSR complex

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Science Bulletin 2018年第2期63卷 78-80页

作者： Bao-hua Sun Jian-Wei Zhao xue-Heng zhang Li-Na sheng Zhi-Yu Sun Isao Tanihata Satoru Terashima Yong Zheng Li-hua Zhu Li-Min Duan Liu-Chun He Rong-Jiang hu Guang-Shuai Li Wen-Jian Lin Wei-Ping Lin Chuan-Ye Liu zhong Liu Chen-Gui Lu xin-Wen ma Li-Jun mao Yi tian Feng Wang Meng Wang shi-Tao Wang Jia-Wen Xia Xiao-Dong Xu hu-Shan Xu Zhi-Guo Xu Jian-Cheng Yang Da-Yu Yin You-Jin Yuan Wen-Long Zhan Yu-hu zhang Xiao-Hong Zhou School of Physics and Nuclear Energy Engineering Beihang University Beijing 100191 China International Research Center for Nuclei and Particles in the Cosmos Beijing 100191 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

More than 99%of the mass in the visible universe—the material that makes up ourselves,our planet,stars—is in the atomic *** the matter has existed for billions of years,only over the past few decades have we had the tools and the knowledge necessary to get a basic understanding of the structure and dynamic of *** physicists around the world have made tremendous strides by initiating a broad range of key

关键词： HIRFL-CSR 横梁建筑群排队原子核物理学家试验性世界

Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-Li Luo Hao-Tong zhang Yong-Heng Zhao Gang Zhao Xiang-Qun Cui Guo-Ping Li yao-Quan Chu Jian-Rong shi Gang Wang Jian-Nan zhang zhong-Rui Bai Xiao-Yan Chen Feng-Fei Wang Yan-xin Guo Jian-Jun Chen Bing Du Xiao Kong Ya-Juan Lei Yin-Bi Li Yi-Han Song Yue Wu Yan-Xia zhang xin-Lin Zhou Fang Zuo Peng Du Lin He Wen Hou Yi-Qiao Dong Jian Li Guang-Wei Li Shuang Li Jing Song Yuan tian Meng-xin Wang Yong-hui Hou Zhi-Ying huo Hong-Zhuan hu Ning-sheng hu zhong-Wen hu Lei Jia Fang-hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-hua Li Qi Li Yin-Dun mao Zheng-Hong Tang Qing-sheng Tao Liang-Ping Tu Da-Qing Wang Dan Wang Jian-Ping Wang Lei Wang Shou-Guan Wang Shu-Qing Wang Ya-Nan Wang You Wang Yue-Fei Wang Ming-Zhi Wei Xiang-Xiang xue Xiao-Zheng xing Ling-Zhe Xu xin-Qi Xu Yan Xu De-hua Yang shi-Hai Yang Zheng-Qiu yao Yong Yu hui Yuan Chao Zhai En-Peng zhang Jing zhang Li-Ping zhang Weizhang Yong zhang Zhen-Chao zhang Ming Zhao Fang Zhou Yong-tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong zhang Jian-Rong shi Xiang-Qun Cui yao-Quan Chu Guo-Ping Li zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-xin Chen Li Chen xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao xue-Fei Gong Bo-zhong Gu Yan-xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-hui Hou Wen Hou Hong-Zhuan hu Ning-sheng hu zhong-Wen hu Zhi-Ying huo Lei Jia Fang-hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-hua Li Chang-hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi shi-Yin Shen huo-Ming shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-sheng Tao Yuan tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu xue-Bing Wu Yu-zhong Wu Xiao-Zheng xing Ling-Zhe Xu xin-Qi Xu Yan Xu Tai-sheng Yan De-hua Yang Hai-Feng Yang hui-Qin Yang Ming Yang Zheng-Qiu yao Yong Yu hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng zhang hua-Wei zhang Jian-Nan zhang Li-Pin zhang Wei zhang Yong zhang Yan-Xia zhang Zheng-Chao zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China Department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA Department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany Department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

Consensus statement on layout and delivery of automatic external defibrillator in China

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Journal of Hainan Medical University 2020年第15期26卷 18-23页

作者： Yu Cao Song Chen Yan-Fen Chai Xiao-hui Chen Yu-Guo Chen Shao-Wen Cheng Wen-Wei Cheng Bang-Han Ding Yang Deng Jie Fu Bang-Jiang Fang mai-Ying Fan Li Gui Ping Gong Wei Guo Shu-Bin Guo Liang huang Ji-Yuan Han zhong Ji Xian-Fei Ji xin-Cai Ji Hong-Xu Jin xin-Jun Jiang Wang-Xiang Jiang Jia-Liang Liu Xiao-Ran Liu Zhi Liu Chuan-Zhu Lv Feng Lu Tan-shi Li xin Li Yong Li Shang-Lun Li Shuang-Ming Li Xiao-Gang Li Bao-Jun Li Pei-Wu Li Chun-sheng Li Zhi-Jun Li Chang-Luo Li Xiang-Min Li Yin-Ping Li Zong-Jun Lu Zu-Xun Lu zhong-Qiu Lu Zhi-Qian Luo Xiao-xing Liao Jian-Bo Lei Tao ma Yu ma Yue-Feng ma Qing-Bian ma Lin-Hao ma Jun-Qi ma shi-Nan Nie Jie-Miao Ou-Yang Peng Peng Qiao Pei Shu-Ming Pan Guo-zhong Qing Li-Jie Qin Wu-Ying Qiao Fei Shao Wei Song xing-Yue Song Zhen-Ju Song Rong-Ju Sun De-Ya Shang Du-Juan Sha Gui-Lan Tao Guo-Gang tian Ying-Ping tian Jian-Guang tian Chao-Yang Tong Zi-Ren Tang Meng-Xiong Tang Guo-Ping Wu Zhi Wan Tao Wang xin Wang Peng Wang zhong Wang Tong Wang Ri-xing Wang Yi-xin Wang Xiao-Dan Wang Ling Wu Wei Wei hua Xiang Feng Xu Jun Xu Jie Xu Miao-Rong Xie Shuo-Gui Xu Tie Xu Feng Yu Wen Yi Li-Shan Yang shi-Jiao Yan Jin-Jian yao Shou-Chun Yan xue-zhong Yu Xian-Zhi Ye Xian-Liang Yan Fu-Bing Zhou Rong-Bin Zhou Ming Zhou Qiang Zhou Jin Zhou Ping Zhou Chang-Ju Zhu hua-Dong Zhu Ji-Hong Zhu Hong zhang mao zhang hua zhang Na zhang Guo-Qiang zhang Guo-Xiu zhang Jin-Song zhang Wen-Wu zhang Wen-zhong zhang Jian-Feng zhang Yi-Min Zhu Jun Zeng Yuan Zheng Zhi-Jie Zheng Shen Zhao Yan Zhao Min Zhao Bin Zhao Xiao-Dong Zhao Xiao-Jing Zhao Hong-Ke Zeng sheng-Qiang Zou The Chinese Society of Emergency Medicine Research Unit of Island Emergency Medicine Chinese Academy of Medical SciencesHainan Medical University Key Laboratory of Emergency and Trauma of Ministry of Education Hainan Medical UniversityHaikouHainanChina Emergency and Trauma College Hainan Medical UniversityHaikouHainanChina Department of Emergency Hainan Clinical Research Center for Acute and Critical DiseasesThe Second Affiliated Hospital of Hainan Medical UniversityHaikouHainanChina Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Trauma of Hainan Medical University

*** Sudden cardiac death(SCD)refers to sudden death due to a variety of cardiac *** is manifested as a sudden loss of consciousness,cardiac arrest,and respiratory arrest and generally shows early symptoms that are atypical and not easily detected[1].According to a recent study,nearly 544000 patients suffer from SCD every year in China[2].

关键词： cardiac death respiratory

Expert consensus on the diagnosis and treatment of solid tumors with BRAF mutations

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The Innovation 2024年第6期5卷 100-116页

作者： Wenxian Wang Bin Lian Chunwei Xu Qian Wang Ziming Li Nan Zheng Aijun Liu Jinpu Yu Wenzhao zhong Zhijie Wang Yongchang zhang Jingjing Liu shirong zhang Xiuyu Cai Anwen Liu Wen Li Lili mao Ping Zhan Hongbing Liu Tangfeng Lv Liyun Miao Lingfeng Min Yu Chen Jingping Yuan Feng Wang Zhansheng Jiang Gen Lin Long huang xingxiang Pu Rongbo Lin Weifeng Liu Chuangzhou Rao Dongqing Lv Zongyang Yu Xiaoyan Li Chuanhao Tang Chengzhi Zhou Junping zhang Junli xue hui Guo Qian Chu Rui Meng xuewen Liu Jingxun Wu Rui zhang Jin Zhou Zhengfei Zhu Yongheng Li Hong Qiu Fan Xia Yuanyuan Lu Xiaofeng Chen Jian Feng Rui Ge Enyong Dai Yu Han Weiwei Pan Fei Pang xin huang Meizhen hu Qing Hao Kai Wang Fan Wu Binbin Song Bingwei Xu Liping Wang Youcai Zhu Li Lin Yanru Xie xinqing Lin Jing Cai Ling Xu Jisheng Li Xiaodong Jiao Kainan Li Jia Wei huijing Feng Lin Wang Yingying Du Wang yao xuefei shi Xiaomin Niu Dongmei Yuan Yanwen yao Jianhui huang Yue Feng Yinbin zhang Pingli Sun Hong Wang Mingxiang Ye Dong Wang Zhaofeng Wang Yue Hao Zhen Wang Bin Wan Donglai Lv shengjie Yang Jin Kang Jiatao zhang Chao zhang Wenfeng Li Jianfei Fu Lizhi Wu shijie Lan Juanjuan Ou Lin shi Zhanqiang Zhai Yina Wang Bihui Li zhang zhang Ke Wang xuelei ma zhongwu Li Zhefeng Liu Nong Yang Lin Wu huijuan Wang Gu Jin Guansong Wang Jiandong Wang hubing shi Meiyu Fang Yong Fang Yuan Li Xiaojia Wang Jing Chen Yiping zhang Xixu Zhu Yi Shen shenglin ma Biyun Wang Yong Song Zhengbo Song Wenfeng Fang Yuanzhi Lu Lu Si Department of Chemotherapy Chinese Academy of Sciences University Cancer Hospital(Zhejiang Cancer Hospital)HangzhouZhejiang 310022P.R.China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Melanoma and SarcomaPeking University Cancer Hospital&InstituteBeijing 100142P.R.China Institute of Cancer and Basic Medicine(ICBM) Chinese Academy of SciencesHangzhouZhejiang 310022P.R.China Department of Respiratory Medicine Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210002P.R.China Department of Respiratory Medicine Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjingJiangsu 210029P.R.China Department of Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030P.R.China Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders&National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 200030China Advanced Innovation Center for human Brain Protection Capital Medical UniversityBeijing 200030China Senior Department of Pathology the 7th Medical Center of PLA General HospitalBeijing 100700P.R.China Department of Cancer Molecular Diagnostics Core Tianjin Medical University Cancer Institute and HospitalTianjin 300060P.R.China Guangdong Lung Cancer Institute Guangdong Provincial Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSchool of MedicineGuangzhouGuangdong 510080P.R.China State Key Laboratory of Molecular Oncology Department of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Medical Oncology Lung Cancer and Gastrointestinal UnitHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School

The BRAF gene is an important signaling molecule in human cells that is involved in the regulation of cell growth,differentiation,and *** the BRAF gene mutates,it can lead to abnormal activation of the signaling pathway,which promotes cell proliferation,inhibits cell apoptosis,and ultimately contributes to the occurrence and development of *** mutations are widely present in various cancers,including malignant melanoma,thyroid cancer,colorectal cancer,non-small cell lung cancer,and hairy cell leukemia,among *** is an important target for the treatment of various solid tumors,and targeted combination therapies,represented by BRAF inhibitors,have become one of the main treatment modalities for a variety of BRAF-mutation-positive solid tumors.

关键词： BRAF diagnosis treatment