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Journal of Geographical Sciences 2025年第1期35卷 112-138页

作者： chen Junxu WANG Yuan ZHAO Zhifang FAN Yunjiang luO Xiaochuan YI lu FENG Siqi YANG Liang Emlyn Yunnan Key Laboratory of Soil Erosion Prevention and Green Development Yunnan University International Joint Research Center for Karstology Yunnan University School of Engineering Westlake University Department of Geography Ludwig Maximilian University of Munich (LMU)

Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB), the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified. This work investigated LMRB's terrestrial water storage anomaly(TWSA) and its spatio-temporal dynamics during 2002–2020. Considering the effects of natural factors and human activities, the respective contributions of climate variability and human activities to terrestrial water storage change(TWSC) were separated. Results showed that:(1) LMRB's TWSA decreased by 0.3158 cm/a.(2) TWSA showed a gradual increase in distribution from southwest of MRB to middle LMRB and from northeast of LRB to middle LMRB. TWSA positively changed in Myanmar while slightly changed in Laos and China. It negatively changed in Vietnam, Thailand and Cambodia.(3) TWSA components decreased in a descending order of soil moisture, groundwater and precipitation.(4) Natural factors had a substantial and spatial differentiated influence on TWSA over the LMRB.(5) Climate variability contributed 79% of TWSC in the LMRB while human activities contributed 21% with an increasing impact after 2008. The TWSC of upstream basin countries was found to be controlled by climate variability while Vietnam and Cambodia's TWSC has been controlled by human activities since 2012.

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Deliberate design of MOF-based pre-catalyst rationalizing the structural reconstruction toward efficient oxygen evolution reaction

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Science China Chemistry 2025年

作者： Yunhui chen Meng tian Zhongqi Zhang Guangzhao Wang Yan Guo Jing Wu Dawei Qi Zhenhua Yan Xiangyu Liu Xi Liu State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia University Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology of Chongqing School of Electronic Information Engineering Yangtze Normal University Frontiers Science Center for New Organic Matter Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) State Key Laboratory of Advanced Chemical Power Sources College of Chemistry Nankai University School of Chemistry and Chemical Engineering In-situ Center for Physical Sciences Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong University

Metal-organic frameworks （MOFs）,that have emerged as promising electrocatalysts in oxygen evolution reaction （OER）,usually undergo structural reconstruction to form metal hydroxides as active ***,it remains a great challenge to design and synthesize ideal MOF-based pre-catalysts for properly cognizing and utilizing the reconstruction process toward efficient OER ***,the well-defined MOF-808 is post-modified by 2-hydroxyphosphonoacetic acid （HPAA） to form a micro-adsorber that enables to capture of metal ions ***3+and Ni2+ions are synergistically anchored into the microadsorber,developing a Fe/Ni-containing pre-catalyst that can be dynamically electrooxidized to be an active and stable dual-site electrocatalyst denoted by R-MOF-HPAA@FeNi with abundant metal *** a result,R-MOF-HPAA@FeNi exhibits an excellent OER performance with a low overpotential of 272 mV and Tafel slope of 35.9 m V dec-1,as well as long-term stability over 300 h at 10 m A *** and theoretical calculations suggest the resulting catalyst mainly follows a lattice oxygen mechanism （LOM） of dual-metal-site mechanism （DMSM）.Owing to the chelating role of HPAA,the post-synthesized MOF-HPAA behaves as a trap to uniformly and firmly adhere Fe3+and Ni2+ions,leading to a functionalized MOF-based pre-catalyst which can be structurally evolved into atomic level-distributed OER electrocatalysts.

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1.56 kV/30 A vertical β-Ga2O3 Schottky barrier diodes with composite edge terminations

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Science China(Information Sciences) 2025年

作者： Yitao FENG Hong ZHOU Sami ALGHAMDI Hao FANG Xiaorong ZHANG Yanbo chen Guotao tian Saud WASLY Yue HAO Jincheng ZHANG Key Lab of Wide Band Gap Semiconductor Materials and Devices School of MicroelectronicsXidian University Center of Excellence in Intelligent Engineering Systems (CEIES) King Abdulaziz University China Resources Microelectronics Limited(Wuxi)

In recent years, large-area wide-bandgap (WBG) semiconductor materials have achieved numerous notable breakthroughs [1, 2]. The ultra-WBG semiconductor β-Ga2O3,with its excellent material properties, is ideally suited for the fabrication of power devices. Moreover, it offers easily obtainable large-area substrates, with reported sizes up to 6 inches, produced through melt-grown crystal growth methods. These characteristics make β-Ga2O3 highly attractive for future low-cost commercialization. Despite these advances, most research has focused on low-current and small-size diodes, with few studies addressing high-current and large-size diodes.

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苦瓜总皂苷对2型糖尿病大鼠肾病组织中蛋白激酶C-α和转化生长因子β表达的影响研究

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湖北中医药大学学报 2016年第5期18卷 5-9页

作者：李易田鲁王港陈伟湖北省鄂东医疗集团黄石市中心医院肾内科湖北黄石435000 湖北理工学院医学院湖北黄石435000

目的探讨分析苦瓜总皂苷对2型糖尿病肾病大鼠蛋白激酶C-α(PKC-α)及转化生长因子β(TGF-β)表达的影响,为苦瓜总皂苷开发和临床2型糖尿病肾病的治疗提供参考。方法雄性SD大鼠48只,随机分为正常对照组、2型糖尿病肾病模型组以及苦瓜总... 详细信息

目的探讨分析苦瓜总皂苷对2型糖尿病肾病大鼠蛋白激酶C-α(PKC-α)及转化生长因子β(TGF-β)表达的影响,为苦瓜总皂苷开发和临床2型糖尿病肾病的治疗提供参考。方法雄性SD大鼠48只,随机分为正常对照组、2型糖尿病肾病模型组以及苦瓜总皂苷治疗组,大鼠左肾切除+链脲佐菌素腹腔注射建立动物模型,模型建立成功后,正常对照组和模型组给予生理盐水灌胃,苦瓜总皂苷治疗组给予苦瓜总皂苷灌胃,分别于实验第4周、第8周处死大鼠各半,测血糖、24h尿蛋白定量;取肾组织做HE染色行肾组织病理观察、RT-PCR以及Western Blot检测肾组织PKC-α和TGF-β蛋白和mRNA表达。结果苦瓜总皂苷治疗组尿蛋白和血清肌酐与模型组比较明显减少,血糖明显升高,差异有显著性(P<0.05);病理组织显示正常对照组肾小球基底膜完整,没有增生,肾脏组织结构整齐,纹理清晰,模型组肾小球基底膜增厚同时伴有一定的系膜细胞增生,苦瓜总皂苷组肾小球基底膜较完整,增生较少,炎症反应也较小;RT-PCR和Western Blot可见:与模型组比较,苦瓜总皂苷治疗组肾脏组织PKC-α和TGF-β蛋白和mRNA表达明显降低(P<0.05)。结论苦瓜总皂苷可抑制糖尿病肾病大鼠肾组织PKC-α和TGF-β的表达,进而保护肾脏,可能有一定的临床应用价值。

关键词：糖尿病肾病苦瓜总皂苷蛋白激酶C-α 转化生长因子β

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Orbitronics for energy-efficient magnetization switching

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Science China(Information Sciences) 2025年第1期68卷 398-399页

作者： Yuxuan YAO Daoqian ZHU Qingtao XIA Jianing LIANG Yuhao JIANG Zhiyang PENG Jiaxu LI chen XIAO Renyou XU Wenwen WANG Xiantao SHANG Shiyang lu Dapeng ZHU Hong-Xi LIU Kaihua CAO Weisheng ZHAO Fert Beijing Institute School of Integrated Circuit Science and Engineering Beihang University National Key Lab of Spintronics Institute of International Innovation Beihang University Qingdao Research Institute Beihang University Truth Memory Corporation

Spin-orbit torque （SOT）,as a promising writing method for magnetic random-access memory （MRAM）,has garnered widespread interest for over a decade [1].Heavy metals,such as β-W,have been broadly adopted as spin current sources,but suffer from phase change at a limited thickness,resulting in a dramatic reduction of the charge-tospin conversion efficiency θSH[2].The thickness limitation leads to stringent etching conditions and large distribution among devices,posing challenges for simultaneously satisfying SOT efficiency,etching-stop margins,and back-end-ofline （BEOL） compatibility.

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The apparent state of droplets on a rough surface

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Science China(Physics,Mechanics & Astronomy) 2009年第2期52卷 233-238页

作者： chen XiaoLing lu tian Key Laboratory for Power Machinery and Engineering of Ministry of Education School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200030China

The factors influencing the state and wetting transition of droplets on a rough surface are both complex and obscure. The change in wetting is directly reflected by changes under the contact condition of the droplets with the surface. The recent study about the wettability of the superhydrophobic surface under the condensing condition arouses the new understanding about the apparent state of droplets on a rough surface. In this work, to validate the existence of droplets in an intermediate state, a microscale pillar topological polydimethylsiloxane (PDMS) surface was manufactured and its wettability under various conditions was studied. According to the experimental data, it is proposed that the wetting state of a rough surface may be embodied using the contact area ratio of a solid/liquid/gas droplet with the projective plane. A general calculation model for the apparent contact angle of droplets is given and expressed diagrammatically. It is found that the measured apparent contact angles of droplets at dif- ferent states on the surface falls within the range predicted by our proposed equation.

关键词： rough surface wettability apparent contact angle condensing condition

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Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-Qiang Jiao Ming Li Xi chen Mei-Ze Xu tian Ding Xiao-Ping Gong Zhuo-Mei Li Xue-Yuan Liu Yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3

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Oncology Research 2025年第1期33卷 103-121页

作者： YAN lu KANG WANG YUANHONG PENG MENG chen LIN ZHONG luJI HUANG FU chenG XINDAN SHENG XIN YANG MANZHAO OUYANG GEORGE A.CALIN ZHIWEI HE China-America Cancer Research Institute Guangdong Medical UniversityDongguan523808China GCP Center Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China Department of Gastrointestinal Surgery Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou510080China Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Oncology Shunde HospitalSouthern Medical University(The First People’s Hospital of Shunde Foshan)Shunde528300China

Background:Immune checkpoint inhibitors play an important role in the treatment of solid tumors,but the currently used immune checkpoint inhibitors targeting programmed cell death-1(PD-1),programmed cell death ligand-1(PD-L1),and cytotoxic T-lymphocyte antigen-4(CTLA-4)show limited clinical efficacy in many breast cancers.B7H3 has been widely reported as an immunosuppressive molecule,but its immunological function in breast cancer patients remains ***:We analyzed the expression of B7H3 in breast cancer samples using data from the Cancer Genome Atlas Program(TCGA)and the Gene Expression Omnibus(GEO)*** were selected using the TarBase,miRTarBase,and miRBase *** regulatory role of the microRNA hsa-miR-214-3p on B7H3 was investigated through dual-luciferase reporter assays,which identified the specific action sites of *** expression levels of B7H3 and hsa-miR-214-3p in human breast cancer tissues and adjacent normal tissues were quantified using Western blotting and quantitative PCR(qPCR).In vitro experiments were performed to observe the effects of modulating the expression of B7H3 or hsa-miR-214-3p on breast cancer cell proliferation and ***,the regulatory impact of hsa-miR-214-3p on B7H3 was ***-linked immunosorbent assays(ELISA)and flow cytometry were employed to assess the effects of co-cultured breast cancer cells and normal human peripheral blood mononuclear cells(PBMCs)on immune cells and associated ***:In breast cancer tissues,the expression level of B7H3 is inversely correlated with that of hsa-miR-214-3p,as well as with the regulatory effects on breast cancercell ***-miR-214-3p was found to inhibit breast cancer cell growth by downregulating ***,our research identified,for the first time,two binding sites for hsa-miR-214-3p on the 3’UTR of B7H3,both of which exert similar effects ***-culture experiments revealed that hsamiR-214-3p

关键词： Breast cancer B7H3 Hsa-miR-214-3p Immunotherapy

Unveiling phosphofructokinase as the key target: an innovative strategy combining pull-down assays with optical imaging for snail-killing mechanism exploration

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Science China Chemistry 2025年

作者： Yuxun lu Weisi Wang Le Yu Yuqiang Zhao Ying chen Yunhai Guo Bingrong luo Yuhua Liu Shizhu Li Liping Duan Ying Zhou Yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and Technology Yunnan University College of Biological and Chemical Engineering Guangxi University of Science and Technology National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector Biology WHO Collaborating Centre for Tropical Diseases National Center for International Research on Tropical Diseases School of Chemistry and Environment Yunnan Minzu University Dali Institute of Schistosomiasis Control

The Pomacea canaliculata, also known as apple snail, is an invasive species in China, posing a serious threat to agricultural production and public health. To prevent its rampant infestation, we developed a highly efficient snail-killing lead compound, 1-(4-chlorophenyl)-3-(pyridin-3-yl)urea (PBQ). However, the killing mechanism of PBQ remains unclear. To elucidate this, two novel compounds, B-PBQ and J-PBQ, were developed through structural modification of PBQ and were used, through both protein pull-down assay and confocal laser scanning microscopy imaging, to identify and confirm that phosphofructokinase(PFK) in the apple snail is the primary target protein of PBQ. Further studies revealed that PBQ successfully inhibits the activity,content, and expression of PFK in apple snail, disrupting the glycolysis pathway and leading to abnormal energy *** disruptions impair the snail’s tolerance to low oxygen, resulting in its efficient eradication. These findings offer a promising direction for developing next-generation PFK-targeted snail-killing pesticides. Furthermore, the strategy of combining pull-down assays with optical imaging used in this work provides a novel approach for the exploration of mechanisms of other pesticide candidates.

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等离子体改性聚酰亚胺热老化的分子模拟

原子与分子物理学报 2025年第1期42卷 95-100页

作者：丁璨田浩博陈琛三峡大学电气与新能源学院宜昌443002

通过反应分子动力学方法模拟聚酰亚胺的热老化过程,以模拟仿真等离子体改性后的聚酰亚胺材料在热裂解后的性能变化情况.通过研究老化过程中气体产生的情况,研究发现随着温度升高,分子链之间的相互作用力减弱,导致材料的致密性下降,弹性... 详细信息

通过反应分子动力学方法模拟聚酰亚胺的热老化过程,以模拟仿真等离子体改性后的聚酰亚胺材料在热裂解后的性能变化情况.通过研究老化过程中气体产生的情况,研究发现随着温度升高,分子链之间的相互作用力减弱,导致材料的致密性下降,弹性模量降低,材料抵抗外应力的能力减弱.同时,由于温度升高使得聚酰亚胺材料相对介电常数上升,材料绝缘性能下降,击穿强度也被削弱.

关键词：反应分子动力学聚酰亚胺热老化