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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： jian Yang jiang Wu Xueshun Xie Pengfei Xia Jinxin lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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利用重组Pichia pastoris生产腺苷甲硫氨酸

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生物工程学报 2002年第3期18卷 295-299页

作者：李东阳于健田露吉鑫松袁中一中国科学院上海生命科学院生物化学与细胞生物学研究所上海200031

为改造甲醇利用型酵母Pichiapastoris来生产腺苷甲硫氨酸 (SAM ,S adenosyl L methionine) ,我们将一个带有SAM合成酶基因的胞内表达质粒转化入Pichiapastoris菌株GS115 ,经过G418抗性筛选得到一株有两个基因拷贝的转化子。该菌在含有... 详细信息

为改造甲醇利用型酵母Pichiapastoris来生产腺苷甲硫氨酸 (SAM ,S adenosyl L methionine) ,我们将一个带有SAM合成酶基因的胞内表达质粒转化入Pichiapastoris菌株GS115 ,经过G418抗性筛选得到一株有两个基因拷贝的转化子。该菌在含有甲醇和甲硫氨酸的培养基中生长 5d后 ,其细胞内的SAM的产量比原始菌株提高了 30余倍。对该菌生产SAM的培养基中的碳源与氮源进行了优化 ,结果显示碳源的控制对该菌SAM产量的影响很大。在试管水平 ,该菌在含有 0 .75 %的L methionine并且碳源和有机氮源经过一定程度优化的培养基中 ,生长 6d后SAM产量达到 1.5 8g L。

关键词：腺苷甲硫氨酸高产菌重组 SAM合成酶

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Predictive value of a constructed artificial neural network model for microvascular invasion in hepatocellular carcinoma:A retrospective study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 88-100页

作者： Hai-Yang Nong Yong-Yi Cen Shan-Jin lu Rui-Sui Huang Qiong Chen Li-Feng Huang jian-Ning Huang Xue Wei Man-Rong Liu Lin Li Ke Ding Department of Radiology The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Radiology Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Guangxi Clinical Medical Research Center for Hepatobiliary Diseases Affiliated Hospital of Youiiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina Department of Hepatobiliary Surgery The Third Affiliated Hospital of Guangxi Medical UniversityNanning 530031Guangxi Zhuang Autonomous RegionChina

BACKGROUND Microvascular invasion(MVI)is a significant risk factor for recurrence and metastasis following hepatocellular carcinoma(HCC)***,there is a paucity of preoperative evaluation approaches for *** To investigate the predictive value of texture features and radiological signs based on multiparametric magnetic resonance imaging in the non-invasive preoperative prediction of MVI in *** Clinical data from 97 HCC patients were retrospectively collected from January 2019 to July 2022 at our *** were classified into two groups:MVI-positive(n=57)and MVI-negative(n=40),based on postoperative pathological *** correlation between relevant radiological signs and MVI status was ***4.6 software and the mutual information method were employed to identify the top 10 dominant texture features,which were combined with radiological signs to construct artificial neural network(ANN)models for MVI *** predictive performance of the ANN models was evaluated using area under the curve,sensitivity,and *** models with relatively high predictive performance were screened using the DeLong test,and the regression model of multilayer feedforward ANN with backpropagation and error backpropagation learning method was used to evaluate the models’*** The absence of a pseudocapsule,an incomplete pseudocapsule,and the presence of tumor blood vessels were identified as independent predictors of HCC *** ANN model constructed using the dominant features of the combined group(pseudocapsule status+tumor blood vessels+arterial phase+venous phase)demonstrated the best predictive performance for MVI status and was found to be automated,highly operable,and very *** The ANN model constructed using the dominant features of the combined group can be recommended as a noninvasive method for preoperative prediction of HCC MVI status.

关键词： Hepatocellular carcinoma Texture analysis Magnetic resonance imaging Microvascular invasion Pseudocapsule Tumor blood vessels

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即时检测试纸内渗流理论及流动控制研究进展

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渗流力学进展 2015年第2期5卷 16-29页

作者：冯上升陈玧如卢天健徐峰西安交通大学仿生工程与生物力学中心陕西西安西安交通大学航天航空学院多功能材料和结构教育部重点实验室陕西西安西安交通大学航天航空学院机械结构强度与振动国家重点实验室陕西西安马来亚大学生物医学工程系吉隆坡马来西亚西安交通大学生命科学与技术学院生物信息工程教育部重点实验室陕西西安

纸是由纤维素层状无序排布构成的多孔介质。近年来,检测试纸和纸基微流控芯片在疾病诊断、水污染和食品安全的快速检测中的应用受到人们广泛关注。纸内的渗流规律对于解释检测结果和提高检测的准确度和灵敏度都具有重要意义。本文概述... 详细信息

纸是由纤维素层状无序排布构成的多孔介质。近年来,检测试纸和纸基微流控芯片在疾病诊断、水污染和食品安全的快速检测中的应用受到人们广泛关注。纸内的渗流规律对于解释检测结果和提高检测的准确度和灵敏度都具有重要意义。本文概述了纸内渗流理论的研究进展,包括宏观毛细渗流及孔隙结构内微观渗流,并介绍了纸内流动的控制方法及其对检测试纸和纸基微流控芯片检测效果的影响。

关键词：纸基微流控芯片检测试纸渗流流动控制

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Charge and discharge curves:a unique reliable evidence for the electrochemical properties of LiCoO_2

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Journal of University of Science and Technology Beijing 2007年第5期14卷 473-476页

作者： Shijian Yan jian Wang lu Qi Wenhuai tian Department of Materials Physics and Chemistry University of Science and Technology Beijing Beijing 100083 China Department of Applied Chemistry Peking University Beijing 100871 China

X-ray diffraction （XRD）, the traditional characterization method to detect the electrochemical properties of LiCoO2, was doubted. The XRD patterns of three types of LiCoO2, with similar electrochemical properties, present differences. For the same type of LiCoO2, different XRD patterns were obtained when the sample preparing methods were different, because of preferred orienta- tion. The nonstandard method to prepare XRD powder samples can eliminate preferred orientation. The reliable evidence to detect electrochemical properties is still charge and discharge curves.

关键词： LiCoO2 X-ray diffraction (XRD) preferred orientation electrochemical properties

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Development of multifunctional lightweight cellular metals through interdisciplinary efforts

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Chinese Science Bulletin 2009年第20期54卷 3844-3846页

作者： lu tian jian ZHANG QianCheng MOE Key Laboratory for Strength and Vibration School of Aerospace Xi'an Jiaotong University Xi'an 710049 China State Key Laboratory for Mechanical Behavior of Materials School of Material Science and Engineering Xi'an Jiaotong University Xi'an 710049 China

In spite of her phenomenal economic achievement since the historically imperative implementation of the 'open door' policy in

关键词：金属蜂窝多学科多功能轻质保护环境能源资源金融危机工业化

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Recent progress in research and design concepts for the characterization,testing,and photocatalysts for nitrogen reduction reaction

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Carbon Energy 2023年第3期5卷 19-74页

作者： Benteng Sun Shucao lu Yeye Qian Xiaoli Zhang jian tian School of Materials Science and Engineering Shandong University of Science and TechnologyQingdaoChina State Key Laboratory of Crystal Materials Shandong UniversityJinanChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhouChina

The reduction of molecular nitrogen(N_(2))to ammonia(NH_(3))under mild conditions is one of the most promising studies in the energy field due to the important role of NH_(3)in modern industry,production,and *** photocatalytic reduction of N_(2)is expected to achieve clean and sustainable NH_(3)production by using clean solar *** date,the new photocatalysts for photocatalytic reduction of N_(2)to NH_(3)at room temperature and atmospheric pressure have not been fully *** major challenge is to achieve high light-absorption efficiency,conversion efficiency,and stability of ***,the methods for measuring produced NH_(3)are compared,and the problems related to possible NH_(3)pollution in photocatalytic systems are mentioned to provide accurate ideas for measuring photocatalytic *** recent progress of nitrogen reduction reaction(NRR)photocatalysts at ambient temperature and pressure is summarized by introducing charge transfer,migration,and separation in photocatalytic NRR,which provides a guidance for the selection of future *** importantly,we introduce the latest research strategies of photocatalysts in detail,which can guide the preparation and design of photocatalysts with high NRR activity.

关键词： nitrogen reduction reaction photocatalysts produced NH 3 measuring methods reaction mechanism research strategy

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Improved electron capture capability of field-assisted exponential-doping GaN nanowire array photocathode

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Journal of Materials Science & Technology 2020年第7期42卷 54-62页

作者： Lei Liu Feifei lu Sihao Xia Yu Diao jian tian Department of Optoelectronic Technology School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094China

The exponential-doping GaN nanowire arrays(GaN NWAs)photocathode has a"light-trapping effect",and the built-in electric field can promote the concentration of the photogene rated carrier center to the top surface of the ***,in the preparation ofactual NWAs photocathodes,the problem that photons emitted from the sides of the nanowires cannot be effectively collected has been *** proposed field-assisted exponential-doping GaN NWAs can bend the motion trajectory of the emitted electrons toward the collecting *** this study,the quantum efficiency(QE)and collection efficiency(CE)of the external field-assisted exponential-doping GaN NWAs photocathode are derived based on the two-dimensional carrier diffusion equation and the initial energy and angular distribution,*** a field-assisted exponential-doping GaN NWAs with a width d=200 nm and a height H=400 nm,the optimal structural parameters are obtained:the incident angleθ=50°and the nanowire spacing is L=335.6 *** this basis,the field intensity of 0.5 V/μm can maximize the CE of the *** the results show that the field-assisted approach does contribute to the collection of emitted electrons,which can provide theoretical guidance for high-performance electron sources based on exponential-doping GaN NWAs *** field-assisted exponential-doping GaN NWAs cathode is expected to be verified by the experimental results in the future.

关键词： Exponential-doping GaN nanowire array Photocathode Field-assisted Quantum efficiency Electrons collection

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High-efficient electron collection capability of graded Al compositional GaN nanowire arrays cathode

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Journal of Materials Science & Technology 2020年第23期58卷 86-94页

作者： Lei Liu Feifei lu jian tian Xingyue Zhangyang Zhisheng Lv Department of optoelectronic technology School of Electronic and Optical EngineeringNanjing University of Science and TechnologyNanjing 210094PR China

Based on the purpose of solving the"secondary absorption"of adjacent nanowires and the lateral emission in the Ga N nanowire arrays(NWAs)cathode,an exponential-doping and graded Al compositional Ga N NWAs photocathode is proposed,which could generate internal electric field to increase the quantum efficiency(QE)of top surface,and the introduction of an external electric field promote the side-emission electrons to shift toward the collecting *** QE and collection efficiency(CE)of exponential-doping and graded compositional Ga N NWAs under different array structure parameters,incident angles and external electric field intensities are *** results show that although the collection ratio of emitted electrons in the exponential-doping Ga N NWAs is higher,the graded Al compositional photocathode with a stronger built-in electric field can obtain better CE under the application of an external electric field,and the peak value can reach 33.2%in a specific *** electric field has a more significant effect on the CE of uniform-doping Ga N *** solutions provided in this study can make the Ga N NWAs photocathode more suitable for the strict requirements of vacuum electron sources.

关键词： GaN nanowire arrays Graded Al compositional Exponential-doping Electron collection Photocathode

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A new strategy for synthesis of branched cyclic peptide by Asn side-chain hydrazide ligation

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Chinese Chemical Letters 2015年第8期26卷 946-950页

作者： jian lu Xiao-Bo tian Wei Huang CAS Key Laboratory of Receptor Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Medical College of Nanchang University

Here, we report a new strategy for rapid synthesis of branched peptide by side-chain hydrazide ligation at Asn. The hydrazide was converted to thioester at Asn side chain by Na NO2 and thiol reagent, and sequential ligation with an N-terminus Cys-peptide efficiently afforded the branched peptide. A branched cyclic peptide was successfully synthesized by side-chain ligation with a two-Cys-peptide and formation of a disulfide bond. This approach provides a new way for expeditious synthesis of branched peptides and facilitates the design of neopeptides as functional bio-mimics.

关键词： ligation branched sequential reagent disulfide thiol Fmoc retention azide simultaneous

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