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Evaluation of neointimal coverage in patients with coronary artery aneurysm formation after drug-eluting stent implantation by optical coherence tomography

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Chinese Medical Journal 2013年第11期126卷 2092-2097页

作者： tian feng chen yun-dai chen lian sun zhi-jun guo jun jin qin-hua liu chang-n wang jin-da liu hong-bin Department of Cardiology Chinese People's Liberation ArmyGeneral Hospital Beijing 100853 China

Background The vessel healing in patients with coronary artery aneurysms （CAA） that form after drug-eluting stent （DES） implantation is not clear. This study aims to assess the vessel healing in patients with CAA formation after DES implanation. Methods From june 2008 to August 2011, follow-up coronary angiography was conducted on 1160 patients who underwent percutaneous coronary intervention （PCI）. The average period of follow-up was about （18.95±13.05） months. A total of 175 patients who underwent DES implantation into de novo lesions and who underwent coronary angiography and optical coherence tomography （OCT） examination during follow-up were identified. Patients were divided into the CAA group （n=31） and non-CAA group （n=144） based on the results of the coronary angiography. The cardiac events including angina and acute myocardial infarction were noted; in addition, the neointimal thickness and the frequency of strut malapposition and strut uncoverage were also noted. Results A greater proportion of incomplete neointimal coverage （17.17% vs. 1.90%, P 〈0.001） and strut malapposition （18.20% vs. 1.38%, P 〈0.001） were observed in the CAA group. The neointimal thickness in the CAA group was significantly thinner than that in the non-CAA group （（146.6±94.8） μm vs. （192.5＋97.1）μm, P 〈0.001）, as detected via OCT. Patients with CAA formation had a higher frequency of cardiac events including angina pectoris （25.81% vs. 6.25%, P=0.001） and acute myocardial infarction （9.68% vs. 0.13%, P=0.002） and thrombosis （16.13% vs. 0.69%, P 〈0.001）. The longitudinal length of the CAA in the cardiac event group was significantly longer than in the no cardiac event group （（20.0±9.07） mm vs. （12.05±5.38） ram, P=0.005）. Conclusion CAA formation after DES implantation is frequently associated with cardiac events as a result of stent malapposition and incomplete neointimal coverage.

关键词： optical coherence tomography coronary artery aneurysms drug-eluting stent neointimal coverage

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Coronary plaque response after drug eluting stent implantation assessed by serial optical coherence tomography analysis

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Chinese Medical Journal 2011年第22期124卷 3752-3756页

作者： tian feng chen yun-dai chen lian sun zhi-jun liu chang-fu guo jun jin qin-hua wang jin-da GAI Lu-yue Department of Cardiology Chinese People＇s Liberation Army General Hospital Beijing 100853 China

Background In general, percutaneous coronary intervention （PCI） relieves vessel stenosis by implantation of a stent, however, the relationship between plaque characteristics and response after stenting is not clear. Methods We enrolled 68 patients （68 vessels） with diagnosed unstable angina pectoris that prospectively underwent PCI and an optical coherence tomography （OCT） examination was done before and after stenting. Coronary plaques were classified as fibrous, lipid-rich and calcified plaque according to OCT examination, and fibrous cap thickness, lumen eccentricity, stent expansion, stent malapposition, tissue prolapse, thrombosis, dissection and stent symmetry were noted. Results The frequency of prolapse was higher in lipid-rich plaques than fibrous plaques （85% vs. 40%, P 〈0.001）. Dissection most often occurred in fibrous plaque compared with lipid-rich and calcified plaques （60% vs. 32% vs. 29%, P 〈0.001）. The frequency of stent strut malapposition in calcified plaques was higher than firous and lipid-rich plaques （71% vs. 40% vs. 5%, P 〈0.001）. In-stent micro-thrombosis was detected only in lipid-rich plaques, with a frequency of 37% （15/41）. The risk factors of micro-thrombosis after PCI were cap thickness （OR 0.903, 95% CI 0.829-0.985）, lumen eccentricity （OR 1.147, 95% CI 1.012-1.30）, and stent length （OR 1.495, 95% CI 1.032-2.166）. Conclusion Plaque response after PCI is associated with its characteristics, and of those, micro-thrombosis after stenting in lipid-rich plaques was the most significant finding and can be predicted.

关键词： coronary heart disease, optical coherence tomography plaque, stent

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Vessel healings after stenting with different polymers in STEMI patients

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Journal of Geriatric Cardiology 2016年第4期13卷 306-311页

作者： qin-hua jin yun-dai chen feng tian jun guo jing jinG zhi-jun sun Department of Cardiology Chinese PLA General Hospital Beijing China

Background Different stems implantation in ST-segmem elevation myocardial infarction （STEMI） patients may influence the long term prognosis by affecting vessel healings after stenting. The aim of this study was to evaluate the vessel healings after implantation of drug elming stems （DES） with biodegradable or durable polymer or of bare-metal stems （BMS） in patients with ache STEMI. Methods This study included 50 patients, who underwem follow up angiogram and optical coherence tomography （OCT） assessment about one year after percutaneous coronary intervemion （PCI） for STEMI. According to the initial stems types, these patients were classified to durable （n = 19） or biodegradable polymer sirolimus-eluting stems （n = 15）, or BMS （n = 16） groups. The conditions of stem struts coverage and malapposi- tion were analyzed with OCT technique. Results A total of 9003 struts were analyzed： 3299, 3202 and 2502 from durable or biodegradable polymer DES, or BMS, respectively. Strut coverage rate （89.0%, 94.9% and 99.3%, respectively）, malapposition presence （1.7%, 0.03% and 0 of struts, respectively） and average intimal thickness over struts （76 ± 12 μm, 161 ± 30 μm and 292 ± 29 μm, respectively） were significantly differem among different stent groups （all P 〈 0.001）. Conclusions Vessel healing status in STEMI patients is superior after implantation of biodegradable polymer DES than durable polymer DES, while both are inferior to BMS.

关键词： Acute myocardial infarction Biodegradable polymer Optical coherence tomography Uncovered struts

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Thrombosis and morphology of plaque rupture using optical coherence tomography

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Chinese Medical Journal 2013年第6期126卷 1092-1095页

作者： guo jun chen yun-dai tian feng liu hong-bin chen lian sun zhi-jun REn Yi-hong jin qin-hua liu chang-fu HAn Bao-shi GAI Lu-yue YAnG Ting-shu Department of Cardiology Chinese People's Liberation Army General Hospital Beijing 100853 China

Background Thrombosis following plaque rupture is the main cause of acute coronary syndrome, but not all plaque ruptures lead to thrombosis. There are limited in vivo data on the relationship between the morphology of ruptured plaque and thrombosis. Methods We used optical coherence tomography （OCT） to investigate the morphology of plaque rupture and its relation to coronary artery thrombosis in patients with coronary heart disease. Forty-two patients with coronary artery plaque rupture detected by OCT were divided into two groups （with or without thrombus） and the morphological characteristics of ruptured plaque, including fibrous cap thickness and broken cap site, were recorded. Results The fibrous cap of ruptured plaque with thrombus was significantly thinner compared to caps without thrombus （（57.00＋17.00） Bm vs. （96.00＋48.00） Bm; P=0.0076）. Conclusions Plaque rupture associated with thrombosis occurs primarily in plaque covered by a thin fibrous cap. Thick fibrous caps are associated with greater stability of ruptured plaque.

关键词： optical coherence tomography thrombosis plaque rupture

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Optical coherence tomography assessment of edge dissections after drug-eluting stent implantation in coronary artery

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Chinese Medical Journal 2012年第6期125卷 1047-1050页

Background Edge dissections after coronary stent implantation are associated with increased short-term risk of major adverse cardiovascular events. The incidence and outcome of edge dissections after coronary stent implantation were reportedly different using different imaging techniques. We used optical coherence tomography （OCT） to assess the incidence, morphological findings and related factors of edge dissections after drug-eluting stent （DES） implantation. Methods Totally 42 patients with 43 de novo lesions in 43 native arteries undergoing DES implantation with OCT imaging were enrolled in this study. Results nine edge dissections were detected in 43 arteries after DES implantation. There were four morphological patterns of stent edge dissections indentified in this study：（1） superficial intimal tears （n=3）, （2） subintimal dissections （n=4）, （3） split of media （n=1）, （4） disruption of the fibrotic cap of plaque （n=1）. Stent edge expansion and stent expansion were both higher in the group with dissections than those in the group without dissections （1.682±0.425 vs. 1.229±0.285, P=0.0290; 1.507±0.445 vs. 1.174±0.265, P=0.0072）. Conclusions The incidence of stent edge dissections detected by OCT was 21%. Stent edge dissection is related with stent edge expansion and stent expansion.

关键词： optical coherence tomography stent dissections

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai huacheng Cai Lorenzo Calibbi junsong Cang guofu Cao Jianshe Cao Antoine Chance Xuejun chang Yue chang Zhe chang Xinyuan chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che bin chen danping chen Fuqing chen Fusan chen Gang chen guoming chen hua-Xing chen Huirun chen jinhui chen Ji-Yuan chen Kai chen Mali chen Mingjun chen Mingshui chen ning chen Shanhong chen Shanzhen chen Shao-Long chen Shaomin chen Shiqiang chen tianlu chen Wei chen Xiang chen Xiaoyu chen Xin chen Xun chen Xurong chen Ye chen Ying chen Yukai chen Zelin chen Zilin chen Gang chen Boping chen Chunhui chen Hok Chuen cheng huajie cheng Shan cheng Tongguang cheng yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-yun dai Xinchen dai Xuwen dai Antonio De Maria nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-tian Deng zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing normal University Beijing Brown University ProvidenceRI Budker Institute of nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CnRS/InP) Marseille dalian Minzu University DalianLiaoning dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of nuclear Problems of Joint Institute for nuclear Research(DLnP jinR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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Combination therapy reduces the percutaneous coronary intervention acute myocardial infarction incidence of no-reflow after primary in patients with ST-segment elevation

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Journal of Geriatric Cardiology 2015年第2期12卷 135-142页

作者： Shan-Shan ZHOU feng tian yun-dai chen jing wang zhi-jun sun jun guo qin-hua jin Department of Cardiology Chinese PLA General Hospital Fuxing Road 28 Haidian District Beij'ing 100853 China

Background no-reflow is associated with an adverse outcome and higher mortality in patients with ST-segment elevation acute myocardial infarction （STEMI） who undergo percutaneous coronary intervention （PCI） and is considered a dynamic process characterized by multiple pathogenetic components. The aim of this study was to investigate the effectiveness of a combination therapy for the prevention of no-reflow in patient with acute myocardial infarction （AMI） undergoing primary PCI. Methods A total of 621 patients with STEMI who underwent emergency primary PCI were enrolled in this study. Patients with high risk of no-reflow （no-flow score 〉 10, by using a no-flow risk prediction model, n = 216） were randomly divided into a controlled group （n = 108） and a combination therapy group （n = 108）. Patients in the controlled group received conventional treatment, while patients in combination therapy group received high-dose （80 mg） atorvastatin pre-treatment, intracoronary administration of adenosine （140 ~tg/min per kilogram） during PCI procedure, platelet membrane glycoprotein lib/Ilia receptor antagonist （tirofiban, ***/kg bolus followed by 0.15 ~tg/kg per minute） and thrombus aspiration. Myocardial contrast echocardiography was performed to assess the myocardial perfusion 72 h after PCI. Major adverse cardiac events （MACE） were followed up for six months. Results Incidence of no-reflow in combination therapy group was 2.8%, which was similar to that in low risk group 2.7% and was significantly lower than that in control group （35.2%, P 〈 0.01）. The myocardial perfusion （A= 13） values were higher in combination therapy group than that in control group 72 h after PCI. After 6 months, there were six （6.3%） MACE events （one death, two non-fatal MIs and three revasculafizations） in combination therapy group and 12 （13.2%）（four deaths, three non-fatal MIs and five revascularizations, P 〈 0.05） in control group. Conclusions Combination of thrombus aspiration, high-dose stat

关键词： Acute myocardial infarction Myocardial contrast echocardiography no-reflow phenomenon Percutaneous coronary interven-tion ST-elevation myocardial infarction

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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： jun liu dan-dan Li Wei Dong Yu-Qi liu Yang Wu da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi hua jing-Yu He jun Li Bai Du Ting-Hai Du Lin-Lin niu Xue-jun Jiang Bo Cui Jiang-bin chen Yang-Gan wang Hai-Rong wang qin Yu jing He Yi-Lin Mao Xiao-Fang bin Yue Deng Yu-dan tian qing-hua Han da-jin liu Li-qin Duan Ming-jun Zhao Cui-Ying Zhang Hai-Ying dai Ze-hua Li Ying Xiao You-zhi Hu Xiao-Yu huang Kun Xing Xin Jiang Chao-feng liu jing An feng-Chun Li Tao Tao jin-Fa Jiang Ying Yang Yao-Rong Dong Lei Zhang Guang Fu Ying Li Shu-Wei huang Li-Ping Dou Lan-jun sun Ying-Qiang Zhao Jie Li yun Xia jun liu Fan liu Wen-jin He Ying Li Jian-Cong Tan Yang Lin Ya-bin Zhou Jian-Fei Yang guo-qing Ma Hui-jun chen He-Ping liu Zong-Wu liu Jian-Xiong liu Xiao-Jia Luo Xiao-hong bin Ya-nan Yu Hai-Xia dang bing Li Fei Teng wang-Min Qiao Xiao-Long Zhu bing-Wei chen Qi-Guang chen Chun-Ti Shen Yong-Yan wang yun-dai chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of dalian University DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RnA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCnA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at day 30 from baseline)calculatedby WGCnA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

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Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients

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Chinese Medical Journal 2013年第12期126卷 2276-2280页

作者： ZHEnG Ying CAI Guang-yan chen Xiang-mei FU Ping chen Jiang-hua DInG Xiao-qiang YU Xue-qing LIn hong-li liu Jian XIE Ru-juan wang Li-ning nI Zhao-hui liu Fu-you YIn Ai-ping XInG chang-ying wang Li SHI Wei liu Jian-she HE Ya-ni DInG guo-hua LI Wen-ge WU Guang-li MIAO Li-ning chen nan SU Zhen MEI chang-lin ZHAO Jiu-yang GU Yong BAI yun-kai LUO Hui-min LIn Shan chen Meng-hua GOnG Li YAnG Yi-bin YAnG Xiao-ping LI Ying WAn Jian-xin wang nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FAnG jing-ai liu Bi-cheng LI Rong-shan wang Rong ZHAnG jing-hong wang Jian-qin LOU Tan-qi SHAO feng-min MEI feng liu zhi-hong YUAn Wei-jie sun Shi-ren ZHAnG Ling ZHOU Chun-hua chen qin-kai JIA Shun-lian GOnG zhi-feng GUAn Guang-ju XIA tian Zhong liang-bao Department of nephrology State key Laboratory of Kidney Disease Chinese PLA General Hospital Beijing 100853 China nephrology Institute of the Chinese People's Liberation Army Chinese People's Liberation Army Key Laboratory of Nephrology Beijing 100853 China Department of nephrology West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of nephrology First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 China Department of nephrology Zhongshan Hospital Fudan University Shanghai 200032 China Department of nephrology First Affiiated Hospital of Sun Yat-sen University Guangzhou Guangdong 510080 China Department of nephrology First Affiliated Hospital of Dalian Medical University Dalian Liaoning 116011 China Department of nephrology First Affiliated Hospital of Xinjiang Medical University Urumqi Xinjiang 830054 China Department of nephrology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of nephrology First Afftiated Hospital of China Medical University Shenyang Liaoning 110001 China Department of nephrology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China Department of nephrology Second Xiangya Hospital Central South University Changsha Hunan 410000 China Department of nephrology First Affiliated Hospital of Medical College Xi'an Jiaotong University Xi'an Shaanxi 710061 China Department of nephrology First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital) Nanjing Jiangsu 210029 China Department of nephrology Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of nephrology Guangdong Provincial People's Hospital Guangzhou Guangdong 510030 China Department of nephrology Affliated Xiehe Hospital Tongji Medical College Huazhong Science and Technology University Wuhan Hubei 430022 China Department of nephrology Daping Hospital Third Military Medi

Background data on the epidemiology of hypertension in Chinese non-dialysis chronic kidney disease （CKD） patients are *** aim of the present study was to investigate the prevalence,awareness,treatment,and control of hypertension in the non-dialysis CKD patients through a nationwide,multicenter study in *** The survey was performed in 61 tertiary hospitals in 31 provinces,municipalities,and autonomous regions in China （except hong Kong,Macao,and Taiwan）.Trained physicians collected demographic and clinical data and measured blood pressure （BP） using a standardized *** was defned as systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg,and/or use of antihypertensive *** 〈140/90 mmHg and 〈130/80 mmHg were used as the 2 thresholds of hypertension *** multivariate logistic regression with adjustment for sex and age,we analyzed the association between CKD stages and uncontrolled hypertension in non-dialysis CKD *** The analysis included 8927 non-dialysis CKD *** prevalence,awareness,and treatment of hypertension in non-dialysis CKD patients were 67.3%,85.8%,and 81.0%,*** hypertensive CKD patients,33.1% and 14.1% had controlled BP to 〈140/90 mmHg and 〈130/80 mmHg,*** successive CKD stages,the prevalence of hypertension in non-dialysis CKD patients increased,but the control of hypertension decreased （P〈0.001）.When the threshold of BP 〈130/80 mmHg was considered,the risk of uncontrolled hypertension in CKD 2,3a,3b,4,and 5 stages increased 1.3,1.4,1.4,2.5,and 4.0 times compared with CKD 1 stage,respectively （P〈0.05）.Using the threshold of 〈140/90 mmHg,the risk of uncontrolled hypertension increased in advanced stages （P〈0.05）.Conclusions The prevalence of hypertension Chinese non-dialysis CKD patients was high,and the hypertension control was *** successive CKD stages,the risk of uncontrolled hypertension increased.

关键词： non-dialysis chronic kidney disease chronic kidney disease stages hypertension epidemiology

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光学相干断层成像评价药物洗脱支架置入术后晚期支架贴壁不良

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中华心血管病杂志 2009年第7期37卷 585-589页

作者：田峰陈韵岱孙志军陈练刘宏斌杨庭树刘长福金琴花白启才解放军总医院心内科北京100853

目的探讨药物洗脱支架（DES）置入术后晚期支架贴壁不良的特点。方法分析32例（包括51支血管、共置入71个支架）置入DES 1年后[（14．8±5．2）个月]行光学相干断层成像（OCT）检查的患者资料，对支架节段的OCT图像每间隔0．5mm取1帧图... 详细信息

目的探讨药物洗脱支架（DES）置入术后晚期支架贴壁不良的特点。方法分析32例（包括51支血管、共置入71个支架）置入DES 1年后[（14．8±5．2）个月]行光学相干断层成像（OCT）检查的患者资料，对支架节段的OCT图像每间隔0．5mm取1帧图像进行分析，找出贴壁不良的支架金属结构，测量支架到参照血管内壁的距离及支架表面内膜厚度，分析晚期支架贴壁不良的特点。结果OCT检查在7例（21．9％）患者中检出支架贴壁不良，其中4例合并支架段血管的正性重构，1例重叠置入支架，2例发现由血栓覆盖支架金属结构，7例患者随访期间无心脏不良事件发生。97．6％的支架金属结构完全贴壁并不同程度的内膜覆盖，2．4％的支架金属结构贴壁不良，包括1．2％的支架金属结构位于血管分支开口。位于血管分支开口的支架金属结构与其他贴壁不良支架表面的内膜覆盖厚度差异无统计学意义[（O．06±0．05）mm比（0．05±0．03）mm，P〉0．05]。结论晚期支架贴壁不良见于DES置入最初的贴壁不良、血管壁正性重构、重叠置入支架以及支架金属结构位于分支血管开口；贴壁不良的支架金属结构表面亦有不同程度的内膜覆盖。

关键词：冠状动脉疾病体层摄影术,光学相干支架

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