检索结果-南通市图书馆

Online calculator for predicting the risk of malignancy in patients with pancreatic cystic neoplasms: A multicenter, retrospective study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第37期28卷 5469-5482页

作者： Dong Jiang Zi-Xiang Chen Fu-Xiao Ma Yu-Yong Gong tian pu Jiang-Ming Chen Xue-Qian Liu Yi-Jun Zhao Kun Xie Hui Hou Cheng Wang Xiao-Ping Geng Fu-Bao Liu Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230000Anhui ProvinceChina

BACKGROUND Efficient and practical methods for predicting the risk of malignancy in patients with pancreatic cystic neoplasms(PCNs)are *** To establish a nomogram-based online calculator for predicting the risk of malignancy in patients with *** In this study,the clinicopathological data of target patients in three medical centers were *** independent sample t-test,Mann–Whitney U test or chi-squared test were used as appropriate for statistical *** univariable and multivariable logistic regression analysis,five independent factors were screened and incorporated to develop a calculator for predicting the risk of ***,the concordance index(C-index),calibration,area under the curve,decision curve analysis and clinical impact curves were used to evaluate the performance of the *** Enhanced mural nodules[odds ratio(OR):4.314;95%confidence interval(CI):1.618–11.503,P=0.003],tumor diameter≥40 mm(OR:3.514;95%CI:1.138–10.849,P=0.029),main pancreatic duct dilatation(OR:3.267;95%CI:1.230–8.678,P=0.018),preoperative neutrophil-to-lymphocyte ratio≥2.288(OR:2.702;95%CI:1.008–7.244,P=0.048],and preoperative serum CA19-9 concentration≥34 U/mL(OR:3.267;95%CI:1.274–13.007,P=0.018)were independent risk factors for a high risk of malignancy in patients with *** the training cohort,the nomogram achieved a C-index of 0.824 for predicting the risk of *** predictive ability of the model was then validated in an external cohort(C-index:0.893).Compared with the risk factors identified in the relevant guidelines,the current model showed better predictive performance and clinical *** The calculator demonstrates optimal predictive performance for identifying the risk of malignancy,potentially yielding a personalized method for patient selection and decision-making in clinical practice.

关键词： Pancreatic cystic neoplasms Risk of malignancy Nomogram Model Prediction Calculator

Polyglycolic Acid Fibrous Scaffold Improving Endothelial Cell Coating and Vascularization of Islet

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第7期130卷 832-839页

作者： Yang Li Ping Fan Xiao-Ming Ding Xiao-Hui tian Xin-Shun Feng Hang Yan Xiao-Ming Pan pu-Xun tian Jin Zheng Chen-Guang Ding Wu-Jun Xue Department of Renal Transplantation Center of Nephrology The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine Xi'an Shaanxi 710061 China Department of Rheumatism and Immunology The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine Xi'an Shaanxi 710061 China

Background：Improving islet graft revascularization has become a crucial task for prolonging islet graft *** cells （ECs） are the basis of new microvessels in an isolated islet,and EC coating has been demonstrated to improve the vascularization and survival of an ***,the traditional method of EC coating of islets has low efficiency in *** study was conducted to evaluate the effect of a polyglycolic acid （PGA） scaffold on the efficiency of islet coating by ECs and the angiogenesis in the coated islet ***：A PGA fibrous scaffold was used for EC coating of islet culture and was evaluated for its efficiency of EC coating on islets and islet graft ***：In in vitro experiments,we found that apoptosis index of ECs-coating islet in PGA group （27% ± 8%） was significantly lower than that in control group （83% ± 20%,P 〈 0.05） after 7 days *** index was significantly greater in the PGA group than in the control group at day 7 after ECs-coating （2.07 ± 0.31 vs.1.80 ± 0.23,P 〈 0.05）.vascular endothelial growth factor （VEGF） level in the PGA group was significantly higher than the coating in the control group after 7 days culture （52.10 ± 13.50 ng/ml vs.16.30 ± 8.10 ng/ml,P 〈 0.05）.Because of a tight,circumvallated,adhesive and three-dimensional growth microenvironment,islet cultured in a PGA scaffold had higher coating efficiency showing stronger staining intensity of enzyme than those in the control group after 14 days of culture following *** in vivo study,PGA scaffold significantly prolonged the average survival time of EC-coated islet graft after transplantation compared with control group （15.30 ± 5.60 days vs.8.30 ± 2.45 days,P 〈 0.05）.The angiogenesis and area of survived grafts were more in the PGA group compared with the control group by measuring the mean microvessel density （8.60 ± 1.21/mm2 vs.5.20 ± 0.87/mm2,P 〈 0.05）.In addition,expression of VEGF and tyrosin-protein kinase receptor

关键词： Endothelial Cells Islet Polyglycolic Acid Fibrous Revascularization

在线全文

学校读者我要写书评

暂无评论

养殖户动物疫病防控激励研究进展

华南农业大学学报（社会科学版） 2017年第6期16卷 72-83页

作者：田璞玉郑晶华南农业大学经济管理学院广东广州510642

梳理国内外养殖户层面动物疫病防控激励研究进展,现有文献从经济和非经济因素分析养殖户防控激励。其中,经济因素包括内部和外部经济激励,内部经济激励来自防控措施对疫病损失的规避效果;养殖户疫病防控的外部性产生了公共政策干预和养... 详细信息

梳理国内外养殖户层面动物疫病防控激励研究进展,现有文献从经济和非经济因素分析养殖户防控激励。其中,经济因素包括内部和外部经济激励,内部经济激励来自防控措施对疫病损失的规避效果;养殖户疫病防控的外部性产生了公共政策干预和养殖户之间策略互动两类外部经济激励。非经济激励包含对疫病、风险和补偿的认知和态度,以及文化、声誉和责任感等因素。当前我国疫病防控政策对养殖户的经济激励重视不足、外部和内部经济激励错配,加之没有考虑非经济激励的营造与构建,是造成养殖户防控要素投入不足、疫情隐瞒等公共政策激励不相容的原因。针对动物疫病防控政策的缺陷,从经济与非经济激励两方面提出了矫正建议。

关键词：动物疫病防控行为防控政策养殖户生物安全公共干预

在线全文

学校读者我要写书评

暂无评论

非均匀平面波与Snell定律

纺织高校基础科学学报 2006年第1期19卷 47-49页

作者：浦天舒东华大学理学院上海200051

从电磁波方程出发,讨论了它的非均匀平面波解及此情形下Snell定律的推广.通过定义两个复矢量之间的“夹角”以及复数入射角、反射角和折射角,证明此时Snell定律在形式上仍然成立.此时,波的衰减不是仅取决于媒质的电导率或分离常数的虚部... 详细信息

从电磁波方程出发,讨论了它的非均匀平面波解及此情形下Snell定律的推广.通过定义两个复矢量之间的“夹角”以及复数入射角、反射角和折射角,证明此时Snell定律在形式上仍然成立.此时,波的衰减不是仅取决于媒质的电导率或分离常数的虚部,而是与分离常数和入射角或反射角或折射角之正弦这两个复数的乘积有关.

关键词：非均匀平面波 Snell定律反射和折射

基于多序列比对的网络攻击特征数据提取算法分析

在线全文

学校读者我要写书评

暂无评论

西南师范大学学报（自然科学版） 2015年第7期40卷 113-118页

作者：蒲天银饶正婵田华铜仁学院信息工程学院贵州铜仁554300

网络安全是目前网络工作者研究的主要问题,随着计算机技术的不断发展,网络攻击方式层出不穷.攻击特征自动提取技术是目前网络安全研究的一种重要技术.该文以研究网络攻击特征数据提取算法为切入点,通过几种序列比对自动提取算法的分析,... 详细信息

网络安全是目前网络工作者研究的主要问题,随着计算机技术的不断发展,网络攻击方式层出不穷.攻击特征自动提取技术是目前网络安全研究的一种重要技术.该文以研究网络攻击特征数据提取算法为切入点,通过几种序列比对自动提取算法的分析,引入了一种改进算法,并对其进行应用.应用结果表明,该算法能有效地降低误报率,与其他算法相比有一定的应用价值.

关键词：攻击特征序列比对算法改进

Beneficial Effect of Moderately Increasing Hypothermic Machine Perfusion Pressure on Donor after Cardiac Death Renal Transplantation

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第22期131卷 2676-2682页

作者： Chen-Guang Ding pu-Xun tian Xiao-Ming Ding He-Li Xiang Yang Li Xiao-Hui tian Feng Han Qian-Hui Tai Qian-Long Liu Jin Zheng Wu-Jun Xue Department of Renal Transplantation Nephropathy HospitalThe First Affiliated Hospital of Xi'an Jiaotong UniversityXi'anShaanxi 710061China Institute of Organ Transplantation Xi'an Jiaotong UniversityXi'anShaanxi 710061China

Background:Vascular resistance and flow rate during hypotherrnic machine perfusion (HMP)of kidneys is correlated with graft function. We aimed to determine the effects of increasing HMP pressure versus maintaining the initial pressure on kidney transplantation outcomes. Methods:We retrospectively reviewed the data of 76 primary transplantation patients who received HMP-preserved kidneys from 48 donors after cardiac death between September 1,2013,and August 31,*** pressure was increased from 30 to 40mmHg (1mmHg =0.133kPa)in kidneys with poor flow and/or vascular resistance (increased pressure [IP]group;36 patients);otherwise,the initial pressure was maintained (constant pressure group;40 patients).Finally,the clinical characteristics and transplantation outcomes in both groups were assessed. Results:Delayed graft function (DGF)incidence,1-year allograft,patient survival,kidney function recovery time,and serum creatinine level on day 30 were similar in both groups,with improved flow and resistance in the IP *** patients with DGF,kidney function recovery time and DGF duration were ameliorated in the IP *** logistic regression analysis revealed that donor hypertension (odds ratio [OR]:1.43,95%confidence interval [CI]:1.02-2.06,P =0.035),donor terminal serum creatinine (OR:1.27,95%C7:1.06-1.62,P =0.023),warm ischemic time (OR:3.45,95%CI:1.97-6.37,P =0.002),and terminal resistance (OR:3.12,95%CI:1.76-6.09,P =0.012)were independent predictors of *** proportional hazards analysis showed that terminal resistance (hazard ratio:2.06,95%C1:1.32-5.16,P =0.032)significantly affected graft survival. Conclusion:Increased HMP pressure improves graft perfusion but does not affect DGF incidence or 1-year graft survival.

关键词： Delayed Graft Function Donor after Cardiac Death Hypothermic Machine Perfusion Kidney Transplantation

Isolation and culture of adult Sertoli cells and their effects on the function of co-cultured allogeneic islets in vitro

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2005年第22期118卷 1857-1862页

作者： TENG Yan XUE Wu-jun DING Xiao-ming FENG Xin-shun XIANG He-li JIANG Ya-zhuo tian pu-xun Department of Kidney Transplantation First Affiliated Hospital of Xi＇an Jiaotong University Xi＇an 710061 China

Background Globally, 180 million people suffer from diabetes mellitus. Islet transplantation is believed to be an almost ideal therapy for insulin-dependent patients. How to maintain the viability and the function of isolated human islets is a challenge in clinical practice. Sertoli cells are considered ＇ nurse cells＇ in the seminiferous tubules and have been used in cell graft protocols for neurodegenerative diseases and diabetes in many studies. Many researchers have used immature murine testes as the primarily source of Sertoli cells in islet transplantation because they are easily purified. Mature human Sertoli cells have been seldom investigated. In the present study, we developed a method for the isolation and culture of Sertoli cells derived from adult human testes, and investigated their effects on the function of allogeneic islets when they were cultured together in vitro. Methods Adult Sertoli cells were prepared successfully by two-step enzyme digestion with trypsin, collagenase and hyaluronidase. They were identified by morphological characteristics and their activity was determined by MTT colorimetry over a 28-day culture time in vitro. A glucose-stimulated insulin secretion test was performed to detect the effects of Sertoli cells on allogeneic islets＇ function when they were co-cultured for 21 days in vitro. Results In cultured cells, mature human Sertoli cells accounted for more than 90% of total cells. The activity of Sertoli cells reached 95 % and they remained highly cytoactive for a long time in vitro （P〉0. 05 ）. Compared with the islets cultured alone, the co-cultured islets with allogeneic Sertoli cells maintained higher sensitivity to glucose stimulation for the duration of the experiment （P〈0.01 ）. Conclusions A method of isolation and culture of Sertoli cells from adult testes has been established. Sertoli cells could enhance allogeneic islets＇ function when they were co-cultured in vitro. They could be a helper cell in islet transplanta

关键词： adult Sertoli cells trophic support allogeneic islet transplantation

Predictive Score Model for Delayed Graft Function Based on Easily Available Variables before Kidney Donation after Cardiac Death

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第20期130卷 2429-2434页

作者： Chen-Guang Ding Qian-Hui Tai Feng Han Yang Li Xiao-Hui tian pu-Xun tian Xiao-Ming Ding Xiao-Ming Pan Jin Zheng He-Li Xiang Wu-Jun Xue Department of Renal Transplantation Nephropathy Hospital The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Institute of Organ Transplantation Xi'an Jiaotong University Xi'an Shaanxi 710061 China

Background： How to evaluate the quality of donation after cardiac transplantation in China. Hence, the aim of this study was to develop kidneys before DCD. death （DCD） kidneys has become a critical problem in kidney a simple donor risk score model to evaluate the quality of DCD Methods： A total of 543 qualified kidneys were randomized in a 2：1 manner to create the development and validation cohorts. The donor variables in the development cohort were considered as candidate univariate predictors of delayed graft function （DGF）. Multivariate logistic regression was then used to identify independent predictors of DGF with P 〈 0.05. Date from validation cohort were used to validate the donor scoring model. Results： Based on the odds ratios, eight identified variables were assigned a weighted integer; the sum of the integer was the total risk score for each kidney. The donor risk score, ranging from 0 to 28, demonstrated good discriminative power with a C-statistic of 0.790. Similar results were obtained from validation cohort with C-statistic of 0.783. Based on the obtained frequencies of DGF in relation to different risk scores, we formed tour risk categories of increasing severity （scores 04, 5 9, 10-14, and 15 28）. Conclusions： The scoring model might be a good noninvasive tool for assessing the quality of DCD kidneys before donation and potentially useful for physicians to make optimal decisions about donor organ offers.

关键词： Delayed Graft Function Donation after Cardiac Death Kidney Transplantation Predictive Score

Early Immunosuppressive Exposure of Enteric-Coated-Mycophenolate Sodium Plus Tacrolimus Associated with Acute Rejection in Expanded Criteria Donor Kidney Transplantation

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第11期131卷 1302-1307页

作者： Chen-Guang Ding Li-Zi Jiao Feng Han He-Li Xiang pu-Xun tian Xiao-Ming Ding Xiao-Ming Pan Xiao-Hui tian Yang Li Jin Zheng Wu-Jun Xue Department of Renal Transplantation Nephropathy Hospital The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 China Institute of Organ Transplantation Xi'an Jiaotong University Xi'an Shaanxi 710061 China

Background： lmmunosuppressive agents are still inefficient in preventing biopsy-proven acute rejection （BPAR） alter expanded criteria donor （ECD） kidney transplantation. The aim of this study was to investigate the relationships between early imrnunosuppressive exposure and the development of BPAR. Methods： We performed a retrospective study of 58 recipients of ECD kidney transplantation treated with enteric-coated-mycophenolate sodium, tacrolirnus （Tac）, and prednisone. The levels of mycophenolic acid-area under the curve （MPA-AUC）0-12h and Tac C0 were measured at the 1st week and the 1st month posttransplant, respectively. The correlation was assessed by multivariate logistic regression. Results： The occurrence rates of BPAR and antibody-mediated rejection were 24.1% and 10.3%, respectively. A low level of MPA-AUC0-12h at the 1st week posttransplant was found in BPAR recipients （38.42 ± 8.37 vs. 50.64 ± 13.22, P 〈 0.01）. In addition, the incidence of BPAR was significantly high （P 〈 0.05） when the MPA-AUC0-12h level was 〈30 mg·h-1·L-1 at the 1st week （ 15.0% vs. 44.4%） or the Tac C0 was 〈4 ng/ml at the 1 st month posttransplant （33.3% vs. 21.6%）. Multivariable logistic regression analysis showed that the MPA-AUC 0-12 h at the 1st week （OR： 0.842, 95% CI： 0.784-0.903） and the Tac C0 at the 1st month （OR： 0.904, 95% C7： 0.822-0.986） had significant inverse correlation with BPA R （ P 〈 0.05 ）. Conclusions： Low-level exposure of MPA and Tac C0 in the early weeks posttransplant reflects an increased acute rejection risk, which suggested that MPA-AUC0-12h 〈30 mg·h-1·L -1 and Tac C0 〈4 ng/ml should be avoided in the first few weeks alter transplantation.

关键词： Enteric-Coated-Mycophenolate Sodium Tacrolimus Acute Rejection Expanded Criteria Donor Kidney Transplantation