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Imaging and histopathological findings of lacrimal sac lymphoma

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Chinese Medical Journal 2014年第1期127卷 120-124页

作者： Guo Pengde Yan Fei tian cheng Zhao Pengfei Wang Zhenchang Xian Junfang Department of Radiology Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Patholog Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Radiology Beijing Friendship Hospital CapitalMedical University Beijing 100050 China

Background Lymphoma of the lacrimal sac is rare,often misdiagnosed *** study aimed to investigate the imaging features of these tumors and provide suggestions to aid the *** In this retrospective study,five cases were assessed according to magnetic resonance imaging （MRI）,computed tomography （CT）,and pathological *** five patients underwent MRI and contrast-enhanced T1-weighted imaging （CE-T1WI）,of which four patients underwent dynamic contrast-enhanced （DCE） MRI and three patients underwent *** Four cases and one case had a lymphoma in left and right medial canthus,*** tissue surrounding the eyelids,subcutaneous tissue in the nasal dorsum,and involvement of the entire nasolacrimal canal were demonstrated in all five *** two cases,the mass invaded the extraconal *** one case,the mass invaded the adjacent medial rectus muscle and nasal ***-defined margins were observed in three cases and ill-defined margins in two *** cases showed homogeneous isointense lesions on *** cases showed homogeneous isointensity and one case demonstrated heterogeneous isointensity on *** contrast injection,the lesion showed slight homogeneous isointensity and moderate enhancement in four cases and heterogeneous isointensity and moderate enhancement in one *** the four patients who underwent DCE-MRI,a plateau pattern was revealed in three cases and washout pattern in one *** the three cases who underwent CT,two cases had isointense and one case had hyperintense *** lacrimal duct was remodeled and the surrounding bone *** Tumors of the lacrimal sac showed homogeneous and isointense patterns on T1WI and T2WI with mildto-moderate enhancement and a plateau pattern on *** showed remodeling of the lacrimal duct with bone compression.

关键词： orbit lacrimal sac lymphoma magnetic resonance imaging computed tomography

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基于电网络理论和计算流体力学的血流仿真

计算机仿真 2024年第7期41卷 394-398页

作者：齐天成张嘉惠张怀新上海交通大学船舶海洋与建筑工程学院上海200240 上海交通大学医学院附属仁济医院上海200127

人体的上肢动脉包括肱动脉和桡动脉,两段动脉也经常被作为测得人体血压及脉搏波的关键部位,反映出了丰富的生理病理信息,对此进行研究对心血管疾病的诊断具有着重要意义。对比结合了基于弹性腔的电网络模型法和双向流固耦合计算流体力... 详细信息

人体的上肢动脉包括肱动脉和桡动脉,两段动脉也经常被作为测得人体血压及脉搏波的关键部位,反映出了丰富的生理病理信息,对此进行研究对心血管疾病的诊断具有着重要意义。对比结合了基于弹性腔的电网络模型法和双向流固耦合计算流体力学模型法,分别建立了在相同结构和力学参数下的两种仿真模型,通过两种方法在不同尺度下的优势互补,对人体在健康及动脉粥样硬化状态下的上肢动脉段的血流动力学问题进行了研究。一方面通过电网络模型对动脉脉搏波进行了动态仿真,发现在动脉粥样硬化下脉搏波的主波波峰出现了明显的升高和前滞现象,另一方面通过双向流固耦合计算流体力学法分析了血液流场的局部特性,从而为粥样硬化等心血管疾病的形成机理及预测提供参考。

关键词：电网络计算流体力学粥样硬化上肢动脉

Abscess of Zygomatic Root： A Rare Otogenic Complication

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Chinese Medical Journal 2017年第6期130卷 749-750页

作者： Yao Qin tian-cheng Li Tie-Chuan Cong Yu-He Liu Department of Otolaryngotogy Head and Neck Surgery Peking University First Hospital Beijing 100034 China

To the Editor： Zygomatic root abscess is a rare extracranial otogenic complication. Atypical orogenic symptoms and lack of awareness are responsible for misdiagnosis. Here, we presented a case of zygomatic root absce... 详细信息

关键词： CHOLESTEATOMA

CD8^(+)T细胞在肝细胞癌中的耗竭机制

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生命科学 2024年第7期36卷 887-897页

作者：荆郭詹天诚宋万骞袁永康康宁张强天津中医药大学天津301617

在肝细胞癌(hepatocellular carcinoma,HCC)中,抗原的持续刺激会使CD8^(+)T细胞呈现耗竭状态,具体表现为CD8^(+)T细胞表面抑制性受体(inhibitory receptors,IRs)持续性表达上调及共表达、表观遗传和转录谱发生改变,以及代谢呈现紊乱状态... 详细信息

在肝细胞癌(hepatocellular carcinoma,HCC)中,抗原的持续刺激会使CD8^(+)T细胞呈现耗竭状态,具体表现为CD8^(+)T细胞表面抑制性受体(inhibitory receptors,IRs)持续性表达上调及共表达、表观遗传和转录谱发生改变,以及代谢呈现紊乱状态等,导致CD8^(+)T细胞的增殖功能衰退,免疫功能逐渐丧失,进而引起CD8^(+)T细胞死亡,最终使肿瘤细胞发生免疫逃逸。本文综述了目前对CD8^(+)T细胞耗竭特征及机制的最新研究进展,为靶向耗竭CD8^(+)T细胞的HCC免疫治疗提供借鉴。

关键词： CD8^(+)T细胞耗竭肝细胞癌抑制性受体肿瘤微环境

Extending the trapping lifetime of single atom in a microscopic far-off-resonance optical dipole trap

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Frontiers of physics 2011年第3期6卷 262-270页

作者： Jun HE Bao-dong YANG Yong-jie cheng tian-cai ZHANG Jun-min WANG State Key Laboratory of Quantum Optics and Quantum Optics Devices and Institute of Opto Electronics Shanxi University Taiyuan 030006 China

In our experiment, a single cesium atom prepared in a large-magnetic-gradient magneto optical trap （MOT） can be efficiently transferred into a 1064-nm far-off-resonance microscopic optical dipole trap （FORT）. The efficient transfer of the single atom between the two traps is used to determine the trapping lifetime and the effective temperature of the single atom in FORT. The typical trapping lifetime has been improved from ~ 6.9 s to ~ 130 s by decreasing the background pressure from 1 × 10^-10 Torr to ~ 2 × 10^-11 Torr and applying one-shot 10-ms laser cooling phase. We also theoretically investigate the dependence of trapping lifetimes of a single atom in a FORT on trap parameters based on the FORT beam＇s intensity noise induced heating. Numerical simulations show that the heating depends on the FORT beam＇s waist size and the trap depth. The trapping time can be predicted based on effective temperature measurement of a single atom in the FORT and the intensity noise spectra of the FORT beam. These experimental results are found to be in agreement with the predictions of the heating model.

关键词： magneto optical trap (MOT) far-off-resonance optical dipole trap (FORT) singleatom trapping lifetime release-and-recapture method (R&R) effective temperature

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乳腺癌雌激素调控基因1在肿瘤中的研究进展

中国医刊 2024年第8期59卷 840-843页

作者：武春春田澄韩一丁金玉兰首都医科大学附属北京妇产医院/北京妇幼保健院病理科北京100006

既往研究证实乳腺癌雌激素调控基因1(GREB1)参与激素依赖性肿瘤的发生发展,后续有研究发现GREB1也可参与激素非依赖性肿瘤的病理生理过程。GREB1通过调控细胞增殖、侵袭、转移和耐药等生物学行为,参与肿瘤的发生发展。因此,深入了解GREB... 详细信息

既往研究证实乳腺癌雌激素调控基因1(GREB1)参与激素依赖性肿瘤的发生发展,后续有研究发现GREB1也可参与激素非依赖性肿瘤的病理生理过程。GREB1通过调控细胞增殖、侵袭、转移和耐药等生物学行为,参与肿瘤的发生发展。因此,深入了解GREB1在肿瘤发生发展中的作用机制和功能,可为肿瘤的诊断和治疗提供新方向。

关键词：乳腺癌雌激素调控基因1 肿瘤雌激素雌激素受体

Editorial:Special issue on distributed computing and artificial intelligence

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Frontiers of Information Technology & Electronic Engineering 2016年第4期17卷 281-282页

作者： Juan M.CORCHADO Li WEIGANG Javier BAJO Fei WU tian-cheng LI University of Salamanca Spain University of Brasilia Brazil Polytechnic University of Madrid Spain Zhejiang University China

4:1!Google’s artificial intelligence(AI)program,Alpha Go,has won Go Master Lee Sedol in a best-of-five competition held in Korean March 9-15,*** by many as a landmark moment for AI,the outcome did not come as a surpr... 详细信息

关键词：人工智能分布式计算编辑计算机科学分布式环境智能算法优良组合蒙特卡洛

Characterization of thermal-shock cracks in ceramic bars

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Science China(Physics,Mechanics & Astronomy) 2014年第12期57卷 2205-2208页

作者： XU Xiang Hong tian cheng SHENG Shi Long LIN Zhong Kang SONG Fan State Key Laboratory of Nonlinear Mechanics (LNM) Institute of Mechanics Chinese Academy of Sciences

Experimental analysis of the cracking in the ceramics subsequent to water quenching have been conducted to clarify the uncertainties of cracking in the ceramics when subjected to thermal *** results here indicate that at the critical point of quench temperature,the crack density and the depth reached the minimum and the maximum limits,*** increase of the quench temperature,the crack density increased rapidly before reaching its saturation point,while the crack depth initially decreased rapidly and then increased gradually before reaching its saturation point.

关键词： thermal-shock crack ceramics

NUMERICAL SIMULATION OF FLOW AND HEAT TRANSFER CHARA-CTERISTICS OUTSIDE A PERIODICALLY VIBRATING TUBE

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Journal of Hydrodynamics 2008年第5期20卷 629-636页

作者： JIANG Bo tian Mao-cheng LENG Xue-li TANG Yu-feng PAN Ji-hong School of Energy Source and Power Engineering Shandong University Jinan 250061 China

Fluid flow and heat transfer characteristics outside a vibrating tube were numerically simulated by the dynamic mesh method. The mechanism of heat transfer enhancement via periodic vibration of the tube was explored by using the field synergy principle. It is found that the field synergy angle between fluid velocity vector and temperature gradient vector for a periodically vibrating tube is significantly smaller than that for a stationary tube, and it changes approximately according to the sinusoidal law in a vibration period. The effect of time phase of the vibration on the field synergy angle and convective heat transfer coefficient were also discussed. Results indicate that the vibration can enhance heat transfer and this effect is more remarkable when time phase angle ranges between 50° and 1400 in a half period. Especially when the time phase angle is 90°, the average field synergy angle outside the tube reaches the minimum, which leads to the best heat transfer performance.

关键词： heat transfer enhancement dynamic mesh vibration field synergy Computational Fluid Dynamics (CFD)