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Obesity-Associated GNAS Mutations and the Melanocortin Pathway

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四川生理科学杂志 2021年第8期43卷 1400-1400页

作者： Edson mendes de oliveira 不详

Conclusions:Because pathogenic mutations may manifest with obesity alone,screening of children with severe obesity for GNAS deficiency may allow early diagnosis,improving clinical outcomes,and melanocortin agonists may aid in weight *** mutations that are identified by means of unbiased genetic testing differentially affect GPCR signaling pathways that contribute to clinical *** diseases are clinically more variable than their classic descriptions suggest.(Funded by Wellcome and others.).

关键词： obesity clinical diagnosis

Gastric Leiomyosarcoma Associated with Hypoglycemia in Dog—A Case Report

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Open Journal of Veterinary Medicine 2019年第8期9卷 101-108页

作者： Jéssica Ragazzi Calesso Mariah Castelani Aires de Araujo Thalita Evani Silva de oliveira Izabelle Galiardo Garcia Michelle Campano de Souza Giovana Wingeter Di Santis Carmen Lúcia Scortecci Hilst Patrícia mendes Pereira Mauro José Lahm Cardoso College of Veterinary Medicine Federal University of Minas Gerais (UFMG) Belo Horizonte MG Brazil department of Veterinary Clinics State University of Londrina (UEL) Londrina PR Brazil

Neoplasms of the digestive system are uncommon in dogs, and may be of epithelial, neuroendocrine, hematopoietic and mesenchymal origin. The leiomyosarcoma is a tumor of mesenchymal origin of smooth, malignant, slow-growing muscles. Paraneoplastic syndromes can affect different systems, being the most commonly found: hypercalcemia, hypoglycemia, cachexia and anemia. There are rare cases of mesenchymal tumors of the gastrointestinal tract in dogs that result in hypoglycaemia with clinical signs. The objective of this study is to report a case of gastric leiomyosarcoma associated with clinical hypoglycemia. The patient had neurological signs such as ataxia and seizures associated with hypoglycemia, which did not recur after surgical excision of the tumor. The definitive diagnosis was based on the histopathological and immunohistochemical examination of the tumor.

关键词： Canine Glycemia Neoplasia Paraneoplastic Syndrome

antimicrobial Action and Scaring of 10%Green Banana Shell in Chronic Wounds

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Open Journal of Medical Microbiology 2018年第3期8卷 47-55页

作者： Ana Beatriz Alkimim Teixeira Loyola Rafael Vieira Fernandes Joao Victor Braga mendes Nadir Alves de oliveira Neta Luiz Francisley de Paiva Adriana Rodrigues dos Anjos Mendonca Dênia Amélia Novato Castelli Von Atzingen department of Applied Health Sciences Faculty of Health SciencesThe Universidade do Vale do SapucaíPouso AlegreBrazil Faculty of Medicine Sapucai Valley University(UNIVáS)Pouso AlegreBrazil Laboratory of Microbiological Research Sapucai Valley University(UNIVáS)Pouso AlegreBrazil department of Applied Health Sciences Sapucai Valley University(UNIVAS)Pouso AlegreBrazil department of Bioethics Faculty of Health SciencesSapucai Valley University(UNIVáS)Pouso AlegreBrazil

The percentage of diabetic patients with contaminated lesions increases from 3% to 10%. Treatment with herbal products shows benefits in their use, as well as antioxidant and antifungal activities. Objective: to evaluate the antimicrobial action of 10% banana peel gel and the contraction of diabetic and venous wounds. Methods: individual, analytical, interventional, longitudinal, prospective, randomized study from February to december 2015. Five patients were included in the study;3 with venous ulcer and 2 with diabetic wound. Application of 10% green banana peel gel and weekly samples were performed. After six days, the second collection was performed. The samples were seeded in the Mannitol salt agar culture medium, MacConkey agar and Saboraund agar with chloramphenicol for isolation of cocci and Gram-positive and Gram-negative bacilli;and fungi. The total counts of bacteria were determined by PCA (Plate Count Agar) and measurement of the lesion margin. There was a reduction of microorganisms with the use of the gel in 53.57% of the patients, and reduction of wound areas in 48.1%.

关键词： Musa sapientum Phytotherapy Products with antimicrobial Action Healing Wounds and Injuries

<i>Sitophilus</i>Weevil Reaction in Upland Rice Elite Lines

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American Journal of Plant Sciences 2015年第12期6卷 1916-1919页

作者： Flávia Barbosa Silva Botelho Marcela Pedroso mendes Rodrigo Teixeira de Carvalho Botelho Adriano Teodoro Bruzi Cinthia Souza Rodrigues Natália Botega Alves Heloisa oliveira dos Santos department of Agriculture Federal University of Lavras Lavras Brazil

Insects of the genus Sitophilus are among the most destructive pests in rice storage, and the best strategy to control it is to use resistant genotypes. In this study, 26 upland rice elite lines were evaluated for Sitophilus weevil reaction on grain weight. The seeds were placed in plastic recipients stored in a room with temperature and lightning simulating a warehouse environment. The number of living weevils and the grain weight were obtained in two evaluations, one 35 days after storage, and the other 35 days after infestation. The lines differed statistically for number of living weevils and for grain weight in both evaluations. The correlations between these two characters were -?0.99 and -?0.47 for the first and the second evaluation (P ant in both evaluations and could be successfully used in upland rice breeding programs.

关键词： Oryza Sativa L. Insect Resistance Rice Weevil Plant Breeding

Multimodal brain monitoring in fulminant hepatic failure

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World Journal of Hepatology 2016年第22期8卷 915-923页

作者： Fernando mendes Paschoal Jr Ricardo Carvalho Nogueira Karla de Almeida Lins Ronconi Marcelo de Lima oliveira Manoel Jacobsen Teixeira Edson Bor-Seng-Shu Laboratory for Neurosonology and Cerebral Hemodynamics Department of Neurology Hospital das Clinicas Sao Paulo University Medical School department of Neurology Division of Neurosurgery Hospital das Clinicas Sao Paulo University Medical School

Acute liver failure, also known as fulminant hepatic failure(FHF), embraces a spectrum of clinical entities characterized by acute liver injury, severe hepatocellular dysfunction, and hepatic encephalopathy. Cerebral edema and intracranial hypertension are common causes of mortality in patients with FHF. The management of patients who present acute liver failure starts with determining the cause and an initial evaluation of prognosis. Regardless of whether or not patients are listed for liver transplantation, they should still be monitored for recovery, death, or transplantation. In the past, neuromonitoring was restricted to serial clinical neurologic examination and, in some cases, intracranial pressure monitoring. Over the years, this monitoring has proven insufficient, as brain abnormalities were detected at late and irreversible stages. The need for real-time monitoring of brain functions to favor prompt treatment and avert irreversible brain injuries led to the concepts of multimodal monitoring and neurophysiological decision support. New monitoring techniques, such as brain tissue oxygen tension, continuous electroencephalogram, transcranial Doppler, and cerebral microdialysis, have been developed. These techniques enable early diagnosis of brain hemodynamic, electrical, and biochemical changes, allow brain anatomical and physiological monitoring-guided therapy, and have improved patient survival rates. The purpose of this review is to discuss the multimodality methods available for monitoring patients with FHF in the neurocritical care setting.

关键词： Fulminant hepatic failure Cerebral edema Multimodality methods Intracranial hypertension Liver trans

考虑混凝土拉伸刚度的梁-钢桁梁混凝土半刚性组合节点模型

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钢结构(中英文) 2009年第9期 90-90页

作者： tiago José Limoeiro de oliveira Eduardo de Miranda Batista

对梁-钢桁梁混凝土组合节点提出理论模型。对典型的腹板和底座的节点进行研究,以定义其弯矩-转动性能,包括初始刚度、抗弯强度和旋转能力。借助于4个考虑混凝土刚度和裂缝演化参数的幂函数,所提出的理论模型描述了节点的半刚性响应,并... 详细信息

对梁-钢桁梁混凝土组合节点提出理论模型。对典型的腹板和底座的节点进行研究,以定义其弯矩-转动性能,包括初始刚度、抗弯强度和旋转能力。借助于4个考虑混凝土刚度和裂缝演化参数的幂函数,所提出的理论模型描述了节点的半刚性响应,并考虑混凝土板拉伸刚度的影响。将理论模型与4个十字型试验结果进行对比,其中分别为两个考虑和不考虑腹板角度的节点,很好地验证了所提出的弯矩-转动模型,并表明腹板角度对混凝土开裂过程有很大的影响。同时,试验结果证实了组合半刚性节点,混凝土开裂前和裂缝稳定后的作用以及腹板连接的螺栓实际效应和板中的剪力滞后效应等基本假设。

关键词：半刚性组合节点混凝土拉伸刚度梁-钢桁梁节点试验分析力矩法

EFFECT OF IMPURITIES ON THE DIELECTRIC PROPERTIES OF OLEIC ACID

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Journal of Advanced Dielectrics 2012年第3期2卷 47-54页

作者： F.F.de SOUSA P.T.C.FREIRE J.mendes FILHO A.C.oliveira E.LONGHINOTTI P.H.M.de VASCONCELOS G.D.SARAIVA S.G.C.MOREIRA P.ALCantARA Jr. Faculdade de Cincias Exatas e Naturais Universidade Federal do Para CEP 68.507-970 Maraba-PABrazil departamento de Fisica Universidade Federal do Ceara CEP 60.455-760Fortaleza-CEBrazil Universidade Federal do Ceara Campus do Pici-Bloco 940 Langmuir Lab.de Adsorcao e Catalise CEP 60.000-000 Fortaleza-CEBrazil Faculdade de Educacao Ciencias e Letras do Sertao Central Universidade Estadual do Ceara CEP 63.900-000 Quixada-CEBrazil Faculdade de Fisica Universidade Federal do Para CEP 66.075-110Belem-PABrazil

Temperature dependence of the dielectric constant of oleic acid with different degrees of puritywas measured in the 233-313 K *** was observed that the presence of impurities(palmiticand linolenic acids)strongly influences the dielectric constant,melting point and dipole moment of the oleic *** values of apparent dipole moment and the Kirkwood correlation parameterswere evaluated using the Kirkwood's model and were estimated to be about 1.20,1.61 and 2.27 D,respectively for 60,90 and 97 wt%oleic acid.

关键词： Oleic acid dielectric properties fatty acids Kirkwood's theory.

Adaptability, Stability and Multivariate Selection by Mixed Models

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American Journal of Plant Sciences 2017年第13期8卷 3324-3337页

作者： Alan Junior de Pelegrin Ivan Ricardo Carvalho Andrei Caíque Pires Nunes Gustavo Henrique demari Vinicíus Jardel Szareski Mauricio Horbach Barbosa tiago Corazza da Rosa Mauricio Ferrari Maicon Nardino Osmarino Pires dos Santos Marcos deon Vilela de Resende Velci Queiróz de Souza antonio Costa de oliveira Luciano Carlos da Maia Federal University of Pelotas Center of Genomics and Plant Breeding Avenida Eliseu Maciel Capao do Leao Brazil Federal University of Vicosa Center of Exact and Technological Sciences Vicosa Brazil Federal University of Santa Maria Frederico Westphalen Campus Frederico Westphalen Brazil Federal University of Pampa Campus Dom Pedrito Bagé Brazil

The aim of this work was to estimate the adaptability and stability of grain yield per hectare and percentage of crude protein of maize grains combined in an index, and to establish a multicharacter selection through mixed models based on an objective character and 15 auxiliary traits. The trials were conducted in the 2013/2014 agricultural year in four growing environments of the Rio Grande do Sul, BR state. The experimental design was randomized blocks arranged in a factorial scheme, being four growing sites × 15 single cross maize hybrids, arranged in three repetitions. The genotypic index, composed by the grain yield and the crude protein percentage in the grains, is the best selection strategy to achieve maize superior genotypes. The multivariate genotypes selection, considering grain yield and crude protein, is efficient. The genotypes FORMULA TL®, AS1656PRO®, P30F53Hx®, LG6304YG®and 30F53 are more adapted and stable for grain yield and percentage of crude protein, in the conditions of this study. The mixed models were efficient to employ the multicharacter selection and to contribute for maize genetic breeding.

关键词： Plant Breeding Zea mays L. Phenotypic Index Genetic Parameters Multicharacter

Role of Cognitive Behavioral Therapy in Fibromyalgia: A Systematic Review

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第4期11卷 169-187页

作者： Heloisa Lima Heller Aline Rizzo Borges Luís Otávio Amarante Franco João Pedro de oliveira Aucelio Marcos Igor Albanaz Vargas Rebeca Naoum Lorga Mirella Bastos Sales Natália Vargas Do Nascimento Gabriela Furlan Ribeiro Barbosa Netto Beatriz Carneiro Passos Beatriz Pires Paes Beatriz Toledo mendes Bruna de Paula Gonçalves Sousa Lyra Ciro Moisés oliveira Vieira Dos Santos Gustavo Araújo Do Nascimento Santos Maria Luiza Pimentel de oliveira Matheus Macêdo Da Silva Maurício Silva de Jesus Paulo Ricardo Guimaraes Rocha Storni Tamires Martinelli de oliveira Ferraz Viviane Cristina Uliana Peterle Ana Paula Monteiro Gomides Reis Centro Universitário de Brasília Brasília Brazil Universidade Católica de Brasília Brasília Brazil Centro Universitário Euro Americano Brasília Brazil

A literature search of articles from 2002-2019 was performed using Medline, Embase, Cochrane, LILACS, IBECS, CRD, and Epistemonikos databases, to analyze the effects of Cognitive-Behavioral Therapy (CBT) in the treatment of fibromyalgia. Twenty-seven articles were selected in which CBT was performed exclusively by specialist physicians, associated or not with conventional pharmacological treatment and/or physical exercise. In most articles, CBT worked with self-knowledge and cognitive restructuring, attempting to reduce pain perception, and it showed a general improvement in daily activities by decreasing patient’s limitations, such as morning stiffness. The literature showed significant correlations of CBT in pain processing over time. When CBT was compared to conventional pharmacological therapy, a certain superiority of CBT could be observed concerning the quality of life, catastrophizing, and acceptance of pain. However, when they were simultaneously applied, this improvement in quality of life was not observed.

关键词： Cognitive Behavioral Therapy Fibromyalgia Pain