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Anticancer effects of saponin and saponin–phospholipid complex of Panax notoginseng grown in Vietnam

Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 795-800页

作者： thu dang kim Hai Nguyen Thanh Duong Nguyen thuy Loi Vu Duc thu Vu Thi Hung Vu Manh Patcharee Boonsiri Tung Bui Thanh Department of Pharmacology and Clinical Pharmacy School of Medicine and PharmacyVietnam National University Department of Pharmaceutics and Pharmaceutical Technology School of Medicine and PharmacyVietnam National University Department of Pharmacology Hanoi University of Pharmacy Department of Pharmacognosy and Traditional Pharmacy School of Medicine and PharmacyVietnam National University Faculty of Biology VNU University of Science Key Laboratory of Enzyme and Protein Technology VNU University of Science Department of Pharmacology School of PharmacyLac Hong University Department of Biochemistry Faculty of MedicineKhon Kaen University

Objective:To evaluate the antitumor activity both in vitro and in vivo of saponin–phospholipid complex of Panax ***:The in vitro cytotoxic effect of saponins extract and saponin–phospholipid complex against human lung cancer NCI-H460 and breast cancer cell lines BT474 was examined using MTS *** in vivo evaluation of antitumor potential,saponin and saponin–phospholipid complex were administered orally in rats induced mammary carcinogenesis by 7,12-dimethylbenz(a)anthracene,for 30 ***:Our data showed that saponin–phospholipid complex had stronger anticancer effect compared to saponin *** IC50 values of saponin–phospholipid complex and saponin extract for NCI-H460 cell lines were 28.47 mg/m L and 47.97 mg/mL,respectively and these values for BT474 cells were 53.18 mg/mL and 86.24 mg/mL,*** vivo experiments,administration of saponin,saponin–phospholipid complex and paclitaxel(positive control) effectively suppressed 7,12-dimethylbenz(a) anthracene-induced breast cancer evidenced by a decrease in tumor volume,the reduction of lipid peroxidation level and increase in the body weight,and elevated the enzymatic antioxidant activities of superoxide dismutase,catalase,glutathione peroxidase in rat breast ***:Our study suggests that saponin extract from Panax notoginseng and saponin–phospholipid complex have potential to prevent cancer,especially breast cancer.

关键词： Panax notoginseng Saponin Saponin–phospholipid complex Breast cancer Antitumor

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Ethanol extracts of Scutellaria baicalensis protect against lipopolysaccharide-induced acute liver injury in mice

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 733-738页

作者： Hai Nguyen Thanh Hue Pham Thi Minh Tuan Anh Le Huong Duong Thi Ly Tung Nguyen Huu Loi Vu Duc thu dang kim Tung Bui Thanh School of Medicine and Pharmacy Vietnam National University Hanoi University of Pharmacy

Objective: To investigated the protective potential of ethanol extracts of Scutellaria baicalensis(S. baicalensis) against lipopolysaccharide(LPS)-induced liver injury. Methods: Dried roots of S. baicalensis were extracted with ethanol and concentrated to yield a dry residue. Mice were administered 200 mg/kg of the ethanol extracts orally once daily for one week. Animals were subsequently administered a single dose of LPS(5 mg/kg of body weight, intraperitoneal injection). Both protein and m RNA levels of cytokines, such as tumor necrosis factor alpha, interleukin-1β, and interleukin-6 in liver tissues were evaluated by ELISA assay and quantitative PCR. C yclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB protein levels in liver tissues were analyzed by western blotting. Results: Liver injury induced by LPS signifi cantly increased necrosis factor alpha, interleukin-1β, interleukin-6, cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB in liver tissues. Treatment with ethanol extracts of S. baicalensis prevented all of these observed changes associated with LPS-induced injury in liver ***: Our study showed that S. baicalensis is potentially protective against LPS-induced liver injury in mice.

关键词： Scutellaria baicalensis Lipopolysaccharide Liver injury Cytokine Nuclear factor-κB

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Vibrational circular dichroism unveils hidden clues

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Light(Science & Applications) 2023年第10期12卷 1987-1989页

作者： dang Du Nguyen Inki kim Department of Biophysics Institute of Quantum BiophysicsSungkyunkwan UniversitySuwon16419Republic of Korea Department of Intelligent Precision Healthcare Convergence Sungkyunkwan UniversitySuwon16419Republic of Korea

Infrared chiral plasmonic metamaterials based on perpendicularly positioned nanorods enable surface-enhanced vibrational circular dichroism for more selective and sensitive identification of protein fingerprints and e... 详细信息

关键词： circular nanorods enable

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Gait Optimization of a Quadruped Robot Using Evolutionary Computation

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Journal of Bionic Engineering 2021年第2期18卷 306-318页

作者： Jihoon kim dang Xuan Ba Hoyeon Yeom Joonbum Bae Mechanical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919South Korea Automatic Control HoChiMinh City University of Technology and Education(HCMUTE)HoChiMinh City 71307Vietnam

Evolutionary Computation(EC)has strengths in terms of computation for gait ***,conventional evolutionary algorithms use typical gait parameters such as step length and swing height,which limit the trajectory deformation for optimization of the foot ***,the quantitative index of fitness convergence is *** this paper,we perform gait optimization of a quadruped robot using foot placement perturbation based on *** proposed algorithm has an atypical solution search range,which is generated by independent manipulation of each placement that forms the foot trajectory.A convergence index is also introduced to prevent premature cessation of *** conventional algorithm and the proposed algorithm are applied to a quadruped robot;walking performances are then compared by gait *** the two algorithms exhibit similar computation rates,the proposed algorithm shows better fitness and a wider search *** evolutionary tendency of the walking trajectory is analyzed using the optimized results,and the findings provide insight into reliable leg trajectory design.

关键词： bionic robot evolutionary computation genetic algorithm gait optimization parameter perturbation convergence index

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Erythrocytes serve as a template to create nanozymes with uniform Fe single-atom sites for healing bacteria-infected wound

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Science China(Life Sciences) 2024年第9期67卷 2048-2050页

作者： Thinh Viet dang Moon Il kim Department of BioNano Technology Gachon UniversitySeongnam 13120Republic of Korea

Bacterial infection is recognized as one of the biggest global health threats,causing millions of people's death every year(Wang et al.,2020).Traditional antibiotics-based therapies have been widely utilized to control this issue(Kohanski et al.,2010);however,their excessive use leads to the emergence of antibioticresistant bacteria,endangering to human health(Levy and Marshall,2004).

关键词： template healing utilized

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Mental Health Literacy of University Students in Vietnam and Cambodia

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International Journal of Mental Health Promotion 2022年第3期24卷 439-456页

作者： Anja Dessauvagie Hoang-Minh dang Tuyet Truong thu Nguyen Bich Hong Nguyen Huong Cao Socheata kim Gunter Groen Hamburg University of Applied Sciences Department of Social WorkHamburgGermany VNU University of Education Center for ResearchInformation and Service in Psychology(CRISP)HanoiVietnam Thai Nguyen University of Agriculture and Forestry Advanced Education Programs OfficeThai Nguyen CityVietnam VNU-HCM University of Social Sciences and Humanities Faculty of EducationHo Chi Minh CityVietnam Thai Nguyen University of Economics and Business Administration Faculty of EconomicsThai Nguyen CityVietnam Vinh University of Technology Education Department of Scientific Management and International PartnershipsVinh CityVietnam Paragon International University Department of Business AdministrationPhnom PenhCambodia

Mental health literacy(MHL)refers to knowledge and attitudes that shape the recognition,management,and prevention of mental *** the topic has been exhaustively researched in Western countries,research from Southeast Asia still is *** studies in this field showed a moderate recognition of mental disorders,a high prevalence of stigmatizing attitudes and a low willingness to seek professional help among Southeastern-Asian *** study explored the level of MHL among university students from different parts of Vietnam and *** with influencing factors(gender,age,study year,educational attainment of the parents,urban/rural origin,ethnicity,personal experiences with mental disorders)were also *** online survey,using a 30-item Vietnamese version of the Mental Health Literacy Scale(MHLS),was conducted at six university sites in Vietnam and *** of 1032 students from different study branches were *** MHL of Vietnamese and Cambodian university students was lower,compared to samples from Australia or the *** and students with a personal experience of mental disorders(self or family)showed a significantly higher *** differences in MHL were found between students from different socioeconomic backgrounds(professional attainment of parents,urban/rural origin).Findings on the influence of ethnicity were *** needs to be improved among the university students of Vietnam and *** health promotion should specifically target male students,students from STEM branches,and international students.

关键词： Help-seeking mental disorders mental health literacy Southeastern Asia stigma university students

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Physical activity and immunity in obese older adults:A systematic bibliographic analysis

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Sports Medicine and Health Science 2023年第3期5卷 181-189页

作者： Novita Intan Arovah dang Thi Anh thu Juni Kurniawaty Hartiah Haroen Department of Sports Science Faculty of Sports ScienceUniversitas Negeri YogyakartaJalan Colombo No 1 KarangmalangYogyakarta55228Indonesia School of Science Faculty of Public HealthHue University of Medicine and Pharmacy06 Ngo QuyenVinh Ninh WardHue CityViet Nam Department of Anaesthesiology Faculty of MedicineUniversitas Gadjah MadaDepartemen Anestesiologi dan Terapi Intensif RSUP Dr.SardjitoJln.Kesehatan No.1SekipYogyakarta55231Indonesia Department of Nursing Faculty of NursingUniversitas PadjajaranHegarmanahKec.JatinangorKabupaten SumedangBandungJawa Barat45363Indonesia

Extensive research has been conducted on the roles of physical activity in immune ***,reviews on the effect of physical activity on immune function among obese older adults are *** study aimed to map the trend and development of the key terms and prominent sources to identify potential research opportunities through a systematic bibliographic analysis.A systematic search was conducted in the Scopus database on the following query:(sport^(*)OR“physical activity”OR exercise)AND(elderly OR“older adult^(*)”OR aging)AND(immun^(*))AND(obes^(*))AND NOT(animal),in March *** timing and citation were descriptively analyzed,followed by the bibliographic coupling and the term co-occurrence analyses for generating network and overlay visualization mapping using the VOSviewers *** search resulted in 426 articles dating back from 1991 to the present and were dominated by authors from Western *** thematic clusters of this research area were generated,covering(1)the impact of physical activity or inactivity on health,(2)physical activity assessments and the use of association and cross-sectional study as the primary type of research,and(3)the physical activity impacts at the population *** future research,more intervention studies are needed to understand how exercise affects immune response in older obese adults and to explore optimal duration,type,and intensity of the exercise,using a multi-omics *** in non-Western populations and systematic reviews are recommended to complement this bibliographic analysis.

关键词： Aging Exercise Sports Obesity Immune responses

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Fabrication and characterization of YVO_4:Eu^(3+) nanomaterials by the microwave technique

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Journal of Rare Earths 2011年第12期29卷 1137-1141页

作者： Tran thu Huong Vu Duc Tu Tran kim Anh Le Thi Vinh Le Quoc Minh Institute of Materials Science Vietnamese Academy of Science and Technology University of Engineering and Technology National University Hanoi Departments of Chemistry Hanoi University of Mining and Geology

Fabrication and characterization of YVO4：Eu^3＋ nanophosphors prepared by microwave （MW） irradiation assisted soft template synthesis were reported. The effects of synthesis conditions such as different powers of MW irradiation, pH values and concentration of reac- tion materials on properties of nanophosphor were also investigated to obtain the controllable size, morphology and high luminescence efficiency. Morphology, crystalline structure, and optical properties were characterized by field emission scanning electron microscopy （FE-SEM）, X-ray diffraction （XRD） and fluorescence spectroscopy, respectively. The results showed that YVOa：Eu^3＋ nanophosphors were obtained by using diethyleneglycol （DEG） as soft template, with pH values in the range of 4 to 12, upon microwave irradiation from 300 to 900 W, at temperature of 80 ℃. The high fluorescent YVOa：Eu^3＋ nanocrystals obtained with size from 15 nm down to 8 nm are more effective to develop an ultrahigh sensitive fluorescent label for biomolecule, cell and tissue.

关键词： microwave synthesis method DEG soft template YVO4:Eu^3+ nanophosphor luminescence rare earths

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Synthesis and characterization of core/shell structured nanophosphors CePO_4:Tb@LaPO_4 by solvothermal method

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Journal of Rare Earths 2011年第12期29卷 1147-1151页

作者： Dinh Xuan Loc Tran Thi kim Chi Tran thu Huong Nguyen Vu Tran kim Anh Wieslaw Strek Le Quoc Minh Institute of Materials Science Vietnam Academy of Science and Technology Institute of Low Temperature and Structure Research Polish Academy of Sciences(PAN) University of Engineering and Technology

Core/shell structured CePO4：Tb（Ⅲ）@LaPO4 and CePOa：Tb（Ⅲ） were successfully synthesized in tris（2-ethylhexyl） phosphate （TEHP） and diethylene glycol （DEG） solvents for comparison of the two techniques in open air and closed reaction vessel. Morphology and crystal structure of the core/shell nanophosphors were determined by using X-ray diffraction （XRD） and transmission electron microscopy （TEM）, which showed that nanophosphors had diameter of about 5-10 nm with the monoclinic monazite phase. The nanophosphors obtained by close vessel procedure showed smaller size, more homogeneity and pure crystallite. The luminescent measurements were done upon the different excitation wavelengths in ultraviolet region and at room temperatm＇e to elucidate the influences of the used solvents and the reaction temperatures. It was found that CePO4：Tb@LaPO4 preparedby the close vessel synthesis showed the intensity of green band of the transfer from 5D4 to 7F5 energy level, which was strongly increased, and the luminescent decay time was 3.2 ms, which was longer than that of naked CePO4：Tb phosphor.

关键词： solvothermal synthesis luminescence CePOn:Tb CePOa:Tb@LaPO4 rare earths

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Modified TiO_(2)/In_(2)O_(3) heterojunction with efficient charge separation for visible-light-driven photocatalytic CO_(2) reduction to C_(2) product

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Journal of Energy Chemistry 2024年第11期98卷 714-720页

作者： Mengfang Liang Xiaodong Shao Ji Yoon Choi Young Dok kim Trang thu Tran Jeongyong kim Yosep Hwang Min Gyu kim Yunhee Cho Sophia Akhtar Hyoyoung Lee Department of Chemistry Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea CO_(2) to Multicarbon Production Center Sungkyunkwan UniversitySuwon 16419Republic of Korea Institute for Quantum Biophysics(IQB) Sungkyunkwan UniversitySuwon 16419Republic of Korea Creative Research Institute Sungkyunkwan UniversitySuwon 16419Republic of Korea Beamline Research Division Pohang Accelerator Laboratory(PAL)Pohang University of Science and TechnologyPohang 37673Republic of Korea Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea

Utilizing sunlight to convert CO_(2) into chemical fuels could address the greenhouse effect and fossil fuel crisis,Heterojunction structure catalysts with oxygen vacancy are attractive in the field of photocatalytic CO_(2) ***,a modified TiO_(2)/In_(2)O_(3)(R-P2 5/In_(2)O_(3-x)) type Ⅱ heterojunction composite with oxygen vacancies is designed for photocatalytic CO_(2) reduction,which exhibits excellent CO_(2) reduction activity,with a C_(2) selectivity of 56.66%(in terms of R_(electron)).In situ Fourier-transform infrared spectroscopy(DRIFTS) and time-resolved photoluminescence(TR-PL) spectroscopy are used to reveal the intermediate formation of the photocatalytic mechanism and photogenerated electron lifetime,*** experimental characterizations reveal that the R-P25/In_(2)O_(3-x) composite shows a remarkable behavior for coupling C-C ***,efficient charge separation contributes to the improved CO_(2) conversion performance of *** work introduces a type Ⅱ heterojunction composite photocatalyst,which promotes understanding the CO_(2) reduction mechanisms on heterojunction composites and is valuable for the development of photocatalysts.

关键词： Heterojunction Oxygen vacancy Photocatalytic CO_(2)reduction C_(2)product Charge separation

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